The ATHENA trial evaluated the drug dronedarone for reducing cardiovascular hospitalization and death in patients with atrial fibrillation. It found that dronedarone reduced the primary composite endpoint of all-cause mortality and cardiovascular hospitalization by 24% compared to placebo. It also decreased cardiovascular death by 30% and the risk of arrhythmia-related death by 45%. However, dronedarone was associated with higher rates of gastrointestinal side effects, skin disorders, and increased creatinine levels.