Hyperglycemic hyperosmolar syndrome (HHS) is a serious condition caused by low insulin levels and high blood glucose levels, resulting in excessive thirst, frequent urination, and dehydration. It predominantly affects older adults with type 2 diabetes and is triggered by illnesses that increase insulin demand. HHS is characterized by hyperglycemia, hyperosmolarity, and alterations in mental status without significant ketosis. Treatment involves fluid replacement, electrolyte management, and insulin administration to restore hydration and metabolic balance while closely monitoring for complications. Lifestyle changes and medical management after recovery can help prevent recurrence of HHS.
Multiple Organ Dysfunction Syndrome (MODS).Pinky Rathee
The presence of altered organ function in a client who is acutely ill such that hemeostasis cannot be maintained without intervention. MODS is present when two or more organs fail .MODS results from SIRS
Diabetic ketoacidosis is a serious complication of diabetes that occurs when your body produces high levels of blood acids called ketones. The condition develops when your body can't produce enough insulin.
When your cells don't get the glucose they need for energy, your body begins to burn fat for energy, which produces ketones. Ketones are chemicals that the body creates when it breaks down fat to use for energy. The body does this when it doesn’t have enough insulin to use glucose, the body’s normal source of energy. When ketones build up in the blood, they make it more acidic.
DKA
HHS
CASE DISCUSSION
DIABETES COMPLICATION
Hyperglycaemia is the main cause leading to dehydration due to osmotic diuresis which, if severe, results in hyperosmolarity. In HHS, unlike diabetic ketoacidosis, there is no significant ketone production and therefore no severe acidosis.
Hyperosmolarity may increase blood viscosity and the risk of thromboembolism. Factors precipitating HHS are infection, myocardial infarction, poor adherence with medication regimens or medicines which cause diuresis or impair glucose tolerance, for example, glucocorticoids.
Multiple Organ Dysfunction Syndrome (MODS).Pinky Rathee
The presence of altered organ function in a client who is acutely ill such that hemeostasis cannot be maintained without intervention. MODS is present when two or more organs fail .MODS results from SIRS
Diabetic ketoacidosis is a serious complication of diabetes that occurs when your body produces high levels of blood acids called ketones. The condition develops when your body can't produce enough insulin.
When your cells don't get the glucose they need for energy, your body begins to burn fat for energy, which produces ketones. Ketones are chemicals that the body creates when it breaks down fat to use for energy. The body does this when it doesn’t have enough insulin to use glucose, the body’s normal source of energy. When ketones build up in the blood, they make it more acidic.
DKA
HHS
CASE DISCUSSION
DIABETES COMPLICATION
Hyperglycaemia is the main cause leading to dehydration due to osmotic diuresis which, if severe, results in hyperosmolarity. In HHS, unlike diabetic ketoacidosis, there is no significant ketone production and therefore no severe acidosis.
Hyperosmolarity may increase blood viscosity and the risk of thromboembolism. Factors precipitating HHS are infection, myocardial infarction, poor adherence with medication regimens or medicines which cause diuresis or impair glucose tolerance, for example, glucocorticoids.
This is a brief discussion on diabetes mellitus as medical emergency that can be encountered in any dental office.
What to do in such conditions is what I've briefly tried to explain over here.
Regards,
Dr. Abhishek Sharma
(M.D.S - 2016 Batch ; Oral & Maxillofacial Surgery)
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Immune dysfunction is another major complication and develops from the direct effects of hyperglycemia on cellular immunity.
DM is a metabolic disorder with an increasing global incidence and prevalence. Poor peri-operative glycaemic control increases the risk of adverse outcomes. Through careful glycemic management in perioperative period, we may reduce morbidity and mortality and improve surgical outcomes.
Intro to hyperglycemic emergencies - hhs vs dkaPritom Das
Some slides are taken from different textbooks of medicine like Davidson, Kumar and Clark and Oxford, and some from other presentations made by respected tutors. I'm barely responsible for compilation of various resources per my interest. These resources are free for use, and I do not claim any copyright. Hoping knowledge remains free for all, forever.
Spirituality and its application in nursing practiceSafad R. Isam
SpiritualityIt is the life force that gives meaning to a how a person understands, views, and lives life.
Spirituality can be
. . . determined by culture
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. . . Influenced by both culture and personal experiences that are opposite to the cultural norm.
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Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
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June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
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This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
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This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
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Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
3. Short-term imbalances in blood glucose levels
ACUTE COMPLICATIONS OF DIABETES
Hyperglycemic
Hyperosmolar
Syndrome
(HHS)
Diabetic
Ketoacidosis (DKA)
Hypoglycemia
4. Hyperglycemic Hyperosmolar Syndrome
HHS is a metabolic disorder of type 2 diabetes resulting from a relative
insulin deficiency initiated by an illness that raises the demand for insulin.
This is a serious condition in which:
hyperosmolarity and hyperglycemia predominate,
with alterations of the sensorium.
5. Hyperglycemic Hyperosmolar Syndrome
At the same time, ketosis is usually minimal or absent.
The basic biochemical defect is the lack of effective insulin (i.e., insulin
resistance).
6. Hyperglycemic Hyperosmolar Syndrome
Persistent hyperglycemia causes osmotic diuresis, which results in losses of water
and electrolytes.
To maintain osmotic equilibrium, water shifts from the intracellular fluid space to
the extracellular fluid space.
With glycosuria and dehydration, hypernatremia and increased osmolarity occur.
8. Causes
HHS often can be traced to
An infection or a precipitating event such as an acute illness (e.g., stroke)
Medications that exacerbate hyperglycemia (e.g., thiazides)
Treatments such as dialysis.
HHS occurs most often in older adults (50 to 70 years of age) who have no known history of
diabetes or who have type 2 diabetes
Occurrence
9. What distinguishes HHS from DKA?
Ketosis and acidosis generally do not occur in HHS,
partly because of differences in insulin levels.
In DKA, no insulin is present, and this promotes the breakdown of stored
glucose, protein, and fat, which leads to the production of ketone bodies and
ketoacidosis.
In HHS, the insulin level is too low to prevent hyperglycemia (and subsequent
osmotic diuresis), but it is high enough to prevent fat breakdown.
12. Assessment and Diagnostic Findings
Diagnostic assessment includes a range of laboratory tests,
including:
blood glucose
electrolytes
BUN
complete blood count
serum osmolality
arterial blood gas analysis
The blood glucose level is usually 600 to 1200 mg/dL,
the osmolality exceeds 320 mOsm/kg.
13. MANAGEMENT
The overall approach to the treatment of HHS is similar
to that of DKA:
Fluid replacement
Correction of electrolyte imbalances
Insulin administration
14. Management
Because patients with HHS are typically older, close
monitoring of volume and electrolyte status is important for
prevention of fluid overload, heart failure, and cardiac
dysrhythmias.
Fluid treatment is started with 0.9% or 0.45% NS, depending
on the patient’s sodium level and the severity of volume
depletion.
15. Management
Central venous or hemodynamic pressure monitoring
guides fluid replacement. Potassium is added to IV fluids
when urinary output is adequate and is guided by continuous
ECG monitoring and frequent laboratory determinations
of potassium
16. Management
Insulin plays a less important role in the treatment of HHS
because it is not needed for reversal of acidosis, as in DKA.
Other therapeutic modalities are determined by the underlying illness and the
results of continuing clinical and laboratory evaluation.
It may take 3 to 5 days for neurologic symptoms to clear, and treatment of
HHS usually continues well after metabolic abnormalities have resolved
17. Management
After recovery from HHS,
Many patients can control their diabetes with
Medical Nutrition Therapy (MNT) alone or
with MNT and oral antidiabetic medications.
Insulin may not be needed once the acute
hyperglycemic complication is resolved.
Frequent SBGM is important in prevention of
recurrence of HHS.