Hydroxychloroquine drug interactions
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This document discusses several important drug interactions with hydroxychloroquine. It notes that hydroxychloroquine can increase serum digoxin levels when taken with heart drugs like digoxin, increasing the risk of side effects. It also warns that hydroxychloroquine may increase the hypoglycemic effects of insulin and antidiabetic drugs, requiring a possible dosage reduction. Additionally, hydroxychloroquine can increase the risk of ventricular arrhythmias when combined with antiarrhythmic drugs and may decrease seizure thresholds when taken with other antimalarial or antiseizure medications.
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This document provides information on anti-hypertensive drugs. It defines classifications of blood pressure and hypertension. It discusses the epidemiology of hypertension in India. It lists risk factors and causes of primary and secondary hypertension. It describes non-pharmacological and pharmacological management of hypertension including classifications of anti-hypertensive drugs like diuretics, ACE inhibitors, ARBs, calcium channel blockers, beta blockers, and alpha blockers. It discusses the pathophysiology of hypertension including the renin-angiotensin-aldosterone system. It provides details on mechanisms of action, uses, adverse effects and contraindications of different anti-hypertensive drug classes.
Ace inhibitor
This document discusses angiotensin converting enzyme (ACE) inhibitors, which are a class of drugs used to treat hypertension and other cardiovascular conditions. It first provides background on hypertension and its classification. It then explains that ACE is responsible for converting angiotensin I to the potent vasoconstrictor angiotensin II, and for breaking down bradykinin. ACE inhibitors work by decreasing angiotensin II production and increasing bradykinin levels, resulting in vasodilation. Common ACE inhibitors listed include captopril, enalapril, and lisinopril. The document notes ACE inhibitors are used to treat hypertension, heart failure, myocardial infarction, and diabetic neuropathy,
Antihypersensitive drugs
Hypertension is defined as either a sustained systolic blood pressure (SBP)of greater than 140 mm Hg or a sustained diastolic blood pressure of greater than 90 mm of Hg.
An agent that reduces high blood pressure is called as an ANTIHYPERTENSIVES.
Prehypertension-systolic between 120 to 139 mm/Hg and diastolic between 80 to 89 mm/Hg.
Tdm of cardiovascual drugs
This document discusses therapeutic drug monitoring (TDM) of drugs used to treat cardiovascular diseases. It focuses on digoxin, which is commonly used to treat congestive heart failure. The document provides details on digoxin's pharmacokinetic parameters, indications, therapeutic range, toxicity, and interactions with other medications. It emphasizes the importance of TDM for digoxin to ensure therapeutic levels are achieved and toxicity is avoided, especially when other medications are involved due to the risk of interactions.
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Geriatrics pharmacology
This document discusses several key aspects of pharmacology in geriatric patients. It notes that 20% of hospitalizations in those over 65 are due to medications. It then covers common diseases in the elderly and how physiological changes can impact drug absorption, distribution, metabolism and excretion. Specific examples are provided of how classes of drugs like benzodiazepines, opioids, antidepressants and antihypertensives are metabolized differently or have increased risks of adverse effects in elderly patients. The document emphasizes the importance of considering an individual's renal and liver function when dosing medications in geriatric patients.
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Hypertension-ppt (1).pptx
Hypertension is high blood pressure that can lead to severe heart and other health problems if left untreated. It is often asymptomatic until advanced stages. Treatment may involve lifestyle changes like exercise and diet or medications to lower blood pressure. While those with hypertension can usually exercise moderately, untreated hypertension can impair exercise ability. Managing hypertension is important for reducing health risks in older adults.
Hypertension-ppt (1).pptx
Hypertension is high blood pressure that can lead to severe heart and other health problems if left untreated. It is often asymptomatic until advanced stages. Treatment may involve lifestyle changes like exercise and diet or medications to lower blood pressure. While those with hypertension can usually exercise moderately, untreated hypertension can impair exercise ability. Managing hypertension is important for reducing health risks in older adults.
Hypertension-ppt (1).pptx
Hypertension is high blood pressure that can lead to severe heart and other health problems if left untreated. It is often asymptomatic until advanced stages. Treatment may involve lifestyle changes like exercise and diet or medications to lower blood pressure. While those with hypertension can usually exercise moderately, untreated hypertension can impair exercise ability. Managing hypertension is important for reducing health risks in older adults.
Vasoactive drugs
Vasoactive drugs act on the heart and circulatory system by affecting adrenergic receptors. They can be classified as vasopressors, inotropes, or vasodilators. Common vasoactive drugs include adrenaline, noradrenaline, dopamine, dobutamine, milrinone, vasopressin, nitroglycerine, and nitroprusside. Each drug has distinct mechanisms of action and indications for use. Careful consideration of dosing and side effects is important when using these powerful cardiovascular medications.
Pharmacology positive-positive inotropicagentsfixed
This document provides an overview of positive inotropic agents used to treat heart failure. It defines cardiac glycosides like digoxin, which increase the force of myocardial contraction. It also discusses phosphodiesterase inhibitors like milrinone which have positive inotropic and vasodilating effects. Side effects and nursing implications of these drugs are outlined.
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Allopurinol, a uric acid synthesis inhibitor acts by inhibiting Xanthine oxidase competitively as well as non- competitively, Whereas Oxypurinol is a non-competitive inhibitor of xanthine oxidase.
PGx Analysis in VarSeq: A User’s Perspective
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
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Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
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Hydroxychloroquine drug interactions
- 2. HEART DRUGS › Hydroxychloroquine+Digoxin › Increase in serum digoxin level Increase in risk of side effects from digoxin
- 3. INSULIN AND ANTIDIABETIC DRUGS › Hydroxychloroquine+Insulin/Antidiabetic Drugs › Increase in hypoglycemic activity, the risk of low blood sugar › There can be a need for your doctor to reduce your dosage of insulin or antidiabetic drugs. › Examples of antidiabetic drugs: Chlorpropamide Glipizide Glimepiride Glyburide Repaglinide
- 4. ANTIARITHMOGENIC DRUGS (THE DRUGS THAT AFFECT THE HEART RHYTHM) › Hydroxychloroquine+ Antiarithmogenic Drugs › Increase in the risk of inducing ventricular arrhythmia › Examples of these drugs Amiodarone Moxifloxacin Chlorpromazine
- 5. THE OTHER ANTIMALARIAL DRUGS › hydroxychloroquine +Mefloquine › Decrease in convulsion threshold › Increase in the risk of seizures
- 6. ANTISEIZURE DRUGS › hydroxychloroquine+ Antiseizure Drugs › Taking these drugs together can make the antiseizure drugs less effective. Phenytoin Carbamazepine
- 7. IMMUNOSUPPRESSANT DRUGS Hydroxychloroquine+Methotrexate No information. However, it may increase your risk of side effects. Hydroxychloroquine+Cyclosporine The amount of cyclosporine may increase. This may increase your risk of side effects from cyclosporine.
- 8. AGALSIDASE › Hydroxychloroquine+AgalsidaSE › (Theoretically) the risk of inhibiting intracellular α- galactosidase activation
- 9. REFERENCES › Rx Media Pharma 2018 › https://www.healthline.com/health/hydroxychloroquine-oral- tablet#interactions