Alzheimer's disease is a progressive neurodegenerative disease that causes loss of neurons and synapses in the brain. The main pathological hallmarks are extracellular amyloid beta plaques and intraneuronal neurofibrillary tangles. Current treatments only temporarily improve cognitive symptoms but do not stop progression of the disease. New treatments are needed to both maintain cognitive abilities and halt the underlying disease process.

1. ALZHEIMER’S DISEASE:
PATHOPHYSIOLOGY AND TREATMENT
Presented by: Fariha Fatima
JR-1
Department of Pharmacology

2. INTRODUCTION:
• Alzheimer’s disease (AD) is the commonest progressive, dementing
neurodegenerative disease in elderly, which affects innumerable
people each year, and these numbers are likely to further increase as
the population ages.
• In addition to the financial burden of AD on health care system, the
disease has powerful emotional impact on caregivers and families of
those afflicted.

3. Aloysius ”Alois” Alzheimer
• German psychiatrist
• Described symptoms + pathology
• Neuronal loss
• Plaques
• Tangles
Cipriani et al. (2011) Neurological Sciences, 32(2), 275-279.
1864-1913

10. PATHOPHYSIOLOGY:
• Alzheimer’s disease is characterized by the loss of neurons and
synapses in the cerebral cortex and certain subcortical regions.
• This loss results in gross atrophy of the affected regions , including
degeneration in the temporal lobe and parietal lobe and parts of frontal
cortex and cingulated gyrus.

13. • The main pathological hallmarks of Alzheimer’s disease includes:
extracellular deposition of ß-amyloid (Aß) plaques,
intraneuronal neurofibrillary tangles.
Loss of cortical cholinergic neurones in AD probably accounts for
memory impairment.

17. • Further research, particularly in the genetic domain, led to
identification of APP and Presenilin genes (APP, PSEN1, and
PSEN2) and mutations in these genes as cause of rare forms of
early-onset familial AD.
• On other hand, ε4 allele of apolipoprotein E gene (APOE) has been
recognized as a major risk factor for late-onset AD.

18. • Later, insight into the molecular pathogenesis of AD came
through many transgenic mouse models and tissue culture studies
of AD which led to the proposition of the “amyloid cascade
hypothesis”.

20. • However, there is growing evidence for the role of additional factors
such as oxidative stress, neuroinflammation, and mitochondrial
dysfunction in the pathogenesis of AD.

21. DIAGNOSIS:
• Detailed patient history
• Information from family and friends
• Laboratory tests like:
Rule out vit B12 and folate deficiency
Rule out hypothyroidism with TFT tests
Blood cell count , serum electrolyte and LFT
• Other diagnostic tests:
CT, PET or MRI scans may aid diagnosis.

23. • Currently, clinical diagnosis of AD is based on the National Institute of
Neurological Disorders and Stroke—Alzheimer’s Disease and Related
Disorders Association (NINCDS–ADRDA) criteria.
• As the diagnostic criteria is based on the appearance of clinical
symptoms, the time when AD pathology has progressed sufficiently
they fail to detect subjects at preclinical stage.

24. Therefore, there is a growing need for the development of measures
which can detect patients at an early stage.
Various biomarkers in AD can at least partly serve this purpose.
They can detect the patients with AD in their preclinical stage, monitor
the disease progression.

26. TREATMENT:
There is NO CURE for
Alzheimer’s disease!!!

27. • Improving symptomatic decline by improving cognitive
function, daily activities, and behavior
• Current therapy
• Arrests the neurodegenerative molecular process
• Research needed
Primary goals of therapy are:

28. TARGETS OF DRUG ACTION FOR A.D.

31. Future of AD Research
1. Symptomatic Treatments:
- Nicotinic-receptor Agonists/Antagonists
- Serotonin-receptor Agonists/Antagonists
2. Disease-modifying Treatments:
- Inhibition of amyloid formation
- beta and gamma-secretase inhibitors
- Inhibition of abeta aggregation
- Tau phosphorylation inhibitors

32. The “Do-It-Yourself” Approach:
- Diet control
- Use of exercise
- Stress control
- Herbal remedies

33. CONCLUSION:
• Cholinergic agents initially improve and transiently maintain cognitive
abilities in patients with mild-to-moderate AD.
• Cognitive abilities worsen over time, indicating treatment does not
stop (but may delay) the progression of AD.
• New treatments that maintain cognitive ability and stop the
progression of AD are needed .