This document summarizes several hormones and related compounds involved in the endocrine system. It discusses hormones released by the hypothalamus and pituitary gland, including corticotropin-releasing hormone, somatotropin-releasing hormone, somatostatin, thyrotropin-releasing hormone, and gonadotropin-releasing hormone. It also describes hormones produced by the pituitary gland, such as ACTH, MSH, prolactin, growth hormone, TSH, and LH/FSH. Additionally, it covers insulin, glucagon, thyroid hormones, parathyroid hormone, gastrointestinal hormones like gastrin and cholecystokinin, and the structures and functions of
metabolic effect of different hormones i.e insulin, glucagon, epinephrine and cortisol with their short introduction, structures, biosynthesis, mechanism of action and individual action on carbohydrate , lipid and protein metabolism.
metabolic effect of different hormones i.e insulin, glucagon, epinephrine and cortisol with their short introduction, structures, biosynthesis, mechanism of action and individual action on carbohydrate , lipid and protein metabolism.
Vitamine B1 Thaimine Pyrophosphate ,Types of cofactors ,Co enzymes, The functional role of Co enzymes is to act as transporters of chemical group, Chemistry,
Co enzyme: thiamine Pyrophosphate
introduction
pituitary gland hormone
factor affecting secretion
function
regulation of secretion of prolactin
causes and symptoms of hypoprolactinaemia
causes and symptoms of hyperprolactinaemia
diagnosis
treatment
mechanism of prolactin
role of prolactin
uses
Vitamine B1 Thaimine Pyrophosphate ,Types of cofactors ,Co enzymes, The functional role of Co enzymes is to act as transporters of chemical group, Chemistry,
Co enzyme: thiamine Pyrophosphate
introduction
pituitary gland hormone
factor affecting secretion
function
regulation of secretion of prolactin
causes and symptoms of hypoprolactinaemia
causes and symptoms of hyperprolactinaemia
diagnosis
treatment
mechanism of prolactin
role of prolactin
uses
This note will be helpful for Pharmacy Students searching for analogues and inhibitors of various hormones in human body.
- anterior Pituitary hormones
- hormone functions
-inhibitors
-similar working drugs
-one day assignment size
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
6. Hypothalamus hormons (releasing factors)
International Union of Pure
and Applied Chemistry –
IUPAC (1974) classification
Corticoliberin
{corticostatin}
Somatoliberin
Somatostatin
Thyroliberin
Gonadoliberin
{prolactoliberin}
Prolactostatin
{melanoliberin}
{melanostatin}
7. Corticoliberin – corticotropin-releasing hormone
НООС-Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-
His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-
Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-
Glu-Ile-Ile-NH2
{corticostatin – not discoverd yet, but some corticostatin-like
funcions are released by glucocorticoids}
8. Somatoliberin – somatotropin-releasing hormon
НООС-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-
Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-
Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-
Gly-Ala-Arg-Ala-Arg-Leu-NH2
(acromegalia)
dicovered in 1964, final sequence of amino acids dicoversd
in 1981
10. Thyroliberin – thyrotropin-releasing hormone
(discovered in 1970) consists of 3 amino acids. But its
synthesis started with preprothyroliberin, which consists of
242 amino acid residue (AAR)
12. {prolactoliberin – prolactin-releasing hormon is not
discoverd yet, but it is proved, that prolactin secretion
stimulating function is released by thyroliberin and
vasoactive intestinal peptid [VIP]}
Prolactostatin
consists of 56 AAR –
function: decrease the production of prolactin
13. {melanoliberin - stimulate release of the
melanocytstimulating hormone in animals – but not
discovered yet in human}
{melanostatin – inhibit stimulate release of the
melanocytstimulating hormone in animals – but not
discovered yet in human}
14. There are also other active compounds
P substance , gastroliberating peptide, vasoactive peptide,
YY peptide, secretin, histidine-methionin-27 peptide,
Y neuropeptide, neurotesin, motilin, catacalcin, galanin,
calcitonin, angiotensin-І and angiotensin-ІI,
α-atrium natriuretic peptide-32,
brain atrium natriuretic peptide-32,
cholecist octapeptid
and other
possible (for sure) there are other hormones
we do not know yet…
15. Most of releasing hypophistropic hormones (liberins and
statins) are secreted by neurons of hypothalamus, which are
located in
paraventricular nucleus (thyroliberin, corticoliberin)
nucleus arcuatus (somatoliberin, prolactin, [dofamin])
anterior part of hypothalamus (somatostatin)
anterior-optical part of hypothalamus (gonadoliberin)
17. Main groups of pituitary (hypophysis) hormones:
proopiomelanocortin group
somatotropin-prolactin-chorionic-somatotropin group
glycoproteinic hormones
posterior pituitary hormones
20. Pro-opiomelanocortin (POMC)
is a precursor polypeptide with 241 amino acid residues (AAR).
POMC is synthesized from the 285-amino-acid-long polypeptide
precursor pre-pro-opiomelanocortin (pre-POMC),
by the removal of a 44-amino-acid-long signal peptide sequence
during translation.
22. Lipotropin. β-Lipotropin (Gamma lipotropin)
is a hormone produced by the cleavage of POMC. The anterior pituitary
gland produces the pro-hormone POMC, which is then cleaved again to
form adrenocorticotropin (ACTH) and β-lipotropin (β-LPH).
β-Lipotropin is a 90-AAR polypeptide that is the carboxy-
termonal fragment of POMC.
It stimulates melnocytes to produce melanin, and can also be cleaved into
smaller peptides. In humans, γ-lipotropin, β-MSH, and β- endorphin, are
all possible fragments of β-lipotropin.[1]
β-Lipotropin also performs lipid-mobilizing functions such
as lipolysis and steroidogenesis. β-Lipotropin is the predominant opioid
of the anterior human and rat pituitary gland. It is found in essentially
equimolar concentrations to that of corticotropin. Evidence shows that β-
Lipotropin is metabolized into endorphins that can greatly affect mood
and behavior and is thus regarded as a prohormone.
23. γ-Lipotropin (Gamma lipotropin)
γ-lipotropin is the amono-terminal peptide fragment of β-lipotropin. In
humans, it has 56 amino acids. Gamma lipotropin is identical to the first
56 amino acid sequences of β-lipotropin. It can be cleaved to
β-melanocyte stimulating hormone.
Lipotropin has also, under its alternate name AOD-9604 (Anti-Obesity
Drug-9604).
Allegations have arisen around the use of the drug and its administration
to players of sports teams as a supplement, including weekly
administration to players. The matters are currently under investigation
due to the relationship between Lipotropin and growth hormones, as
noted by medical staff.
24. Melanocyte-Stimulating hormones (MSH)
α-MSH:
Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val
β-MSH (human):
Ala-Glu-Lys-Lys-Asp-Glu-Gly-Pro-Tyr-Arg-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-
Pro-Lys-Asp
β-MSH (porcine):
Asp-Glu-Gly-Pro-Tyr-Lys-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp
γ-MSH:
Tyr-Val-Met-Gly-His-Phe-Arg-Trp-Asp-Arg-Phe-Gly
An increase in MSH will cause darker skin in humans. MSH increases in
humans during pregnancy. This, along with increased estrogenes, causes
increased pigmentation in pregnant women. Cushing’s syndrome due to
excess adrenocorticotropic hormone (ACTH) may also result in
hyperpigmentation, such as acanthosis nigricans in the axilla.
30. INSULIN
Frederic Sanger (1955) – 51 amino acid residue
5.7 kdalton A-chain consist of 21 and B-chain of 30AAR
(secreted by β-c elle of Langergance insulas)
Insulin regulate the blood glucose level
Primary structure of insulin in different animal is different
31. Space forms of insulin
Insulin exist in mono-, bis-, and hexamer forms. Hexameric
form is stabilised by Zn2+ ions through histidin amino acid
(His10) in B-chain in each insulin molecule.
32. Insulin synthesis in ribosomes
1 signal peptid synthesis
2 preproinsulin synthesis
3 signal peptid cleavege
4 transport to Golgi
apparatus
5 proinsulin transforming into
insulin granulas
6 secretion of insulin
33. Amino acid sequence of porcine proinsilin
A chain is shown in red, the B chain in blue, the connecting peptide (C-
peptide) in yellow.
41. GASTROINTESTINAL HORMONES
GASTRIN
Is produced by G-cells of stomach, mainli located in antral part, and by
D-cells of pancreas. Main form of gastin are:
Gastrin-34 or “Big- Gastrin” – polipeptide of 34AAR,
Gastrin-17 або “Little Gastrin”, - 17AAR
(pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-
Asp-Phe-NH2), and Gastrin-14 or “MiniGastrin” – 14AAR.
All gastrins are homological in chemical structure of there active part of
5AAR (which bond with speciphic garstrin-receptors)
...-Gly-Trp-Met-Asp-Phe-NH2.
But rhe gastrin activity show simply fourAAR
…-Trp-Met-Asp-Phe-NH2
This part made the arteficial – pentagastrin –
Gastrin-34 secreted mainly by pancreas,
Gastrin-17 and Gastrin-14 – mainly in spomach.
42. Forms of Gastrin and artificial - pentagastrin
Big-Gastrin
Little-Gastrin
Mini-Gastrin
Pentagastrin
44. CHOLECYSTOKININ
.
Cholecystokinin (CCK or CCK-PZ) is similar to gastrin – they have
identical sequenses ofAAR:
...-Gly-Trp-Met-Asp-Phe-...
Cholecystokinin was discovered “twice”. First time in 1928, in mucose
part of stomach as peptide which regulate contraction of gall bladder, and
bile injection into duodenum, and based on this property was named
Cholecystokinin; (chole – bile, kýstis – vesica; kieō – to move).
In 1943, – in mucose of thin intestine was fined peptide, which could
stimulate pancreatic secretion – for this property was named
pancreozymin. In 60-th was determined the absolute similarity of
Cholecystokinin an Pancreozymin.
45. Cholecystokinin forms
Cholecystokinin [CCK] othe word: pancreosimin, – like gastrin, has some variants:
Cholecystokinin-58 (CCK58),
Cholecystokinin-58-desnonopeptide (means CCK58 whithout nine AAR – (1-49)-CCK58),
Cholecystokinin-39 (CCK39),
Cholecystokinin-33 (CCK33),
Cholecystokinin-25 (CCK25),
Cholecystokinin-18 (CCK18),
Cholecystokinin-8 (CCK8),
Cholecystokinin-7 (CCK7)
Cholecystokinin-5 (CCK5)
Cholecystokinin-4 (CCK4)
Mainly typical Cholecystokinins are
Cholecystokinin-33,
Cholecystokinin-12
Cholecystokinin-8.
Sequence of AAR in Cholecystokinin-33is:
H-Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-lle-Lys-Asn-Leu-GIn-Ser-Leu-Asp-Pro-Ser-His-Arg-
lle-Ser-Asp-Arg-Asp-Tyr- Met-Gly-Trp-Met-Asp-Phe-OH.
Cholecystokinin-8 makes 60-70% of all compounds o the class
46. SECRETIN
Molecular weigh – 3,1 kD (3055 D).
Consists of 27 AAR (amidid С ending of valin) :
H2N–His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-
Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-
Leu-Val-CONH2.
Molecule of secretin has helix-like formation in region of 5
and 13AAR.
Secretin is similar to:
glucagone (similar sequence of 14 AAR), also it has similar to
gactric inhibitin peptide [GIP] (similar sequence of 10 AAR),
there some similarity with vasoactive intestinal peptide [VIP]
(similar sequence of 7AAR).