The document discusses transfusion triggers and when to transfuse red blood cells. It summarizes that the decision to transfuse should be based on individual patient factors like comorbidities, hemodynamics, and rate of bleeding rather than a single hemoglobin threshold. While guidelines recommend transfusion at Hb <7 or <10, clinical trials found higher transfusion triggers were not associated with better outcomes and increased risks. Physiologic compensation for anemia through increased cardiac output and dissolved oxygen delivery means lower hemoglobin levels may be tolerated without transfusion in some cases.
RKB – A Semantic Knowledge Base For RNA (RNA ontology consortium meeting)Michel Dumontier
Increasingly sophisticated knowledge about RNA structure and function requires an inclusive knowledge representation that facilitates the integration of independently-generated information arising from such efforts as genome sequencing projects, microarray analyses, structure determination and RNA SELEX experiments. While RNAML, an XML-based representation, has been proposed as an exchange format for a select subset of information, it lacks machine-understandable semantics that make it arbitrarily user-extensible, as is the case for formal logic based languages. Here, we describe an RNA knowledge base (RKB) for structure-based knowledge using RDF/OWL Semantic Web technologies. RKB contains basic terminology for nucleic acid composi-tion along with context/model-specific representation of structural features such as sugar conformations, base pairings and base stackings. RKB is populated with RNA PDB entries and MC-Annotate structural annotation. The use of semantic web technologies addresses the reality of diverse interests of the RNA Ontology Consortium and supports knowledge discovery over independently-published RNA knowledge.
This example, that we presented at the WLF2 Conference in Rome, constitutes a complete and fully developed which included the following phases:
probabilistic behaviour forecast,
behaviour monitoring (which luckily allowed to actually “see happen” what we had predicted a few years earlier),
Risk Based Decision Making (RBDM), and finally
implementation of mitigative and crisis management plan.
Interestingly, in a curious turn of events, while doing some reconnaissance work on the landslide, two of us almost lost our lives in a helicopter crash. Risk managers are unfortunately not immune to risks...and somehow it was a good lesson for us to be in the “victim role” that day.
SecurVoice Call Recording is the most advanced and powerful call recording solution. Interfaced to all the major automation software systems for event integration.
RKB – A Semantic Knowledge Base For RNA (RNA ontology consortium meeting)Michel Dumontier
Increasingly sophisticated knowledge about RNA structure and function requires an inclusive knowledge representation that facilitates the integration of independently-generated information arising from such efforts as genome sequencing projects, microarray analyses, structure determination and RNA SELEX experiments. While RNAML, an XML-based representation, has been proposed as an exchange format for a select subset of information, it lacks machine-understandable semantics that make it arbitrarily user-extensible, as is the case for formal logic based languages. Here, we describe an RNA knowledge base (RKB) for structure-based knowledge using RDF/OWL Semantic Web technologies. RKB contains basic terminology for nucleic acid composi-tion along with context/model-specific representation of structural features such as sugar conformations, base pairings and base stackings. RKB is populated with RNA PDB entries and MC-Annotate structural annotation. The use of semantic web technologies addresses the reality of diverse interests of the RNA Ontology Consortium and supports knowledge discovery over independently-published RNA knowledge.
This example, that we presented at the WLF2 Conference in Rome, constitutes a complete and fully developed which included the following phases:
probabilistic behaviour forecast,
behaviour monitoring (which luckily allowed to actually “see happen” what we had predicted a few years earlier),
Risk Based Decision Making (RBDM), and finally
implementation of mitigative and crisis management plan.
Interestingly, in a curious turn of events, while doing some reconnaissance work on the landslide, two of us almost lost our lives in a helicopter crash. Risk managers are unfortunately not immune to risks...and somehow it was a good lesson for us to be in the “victim role” that day.
SecurVoice Call Recording is the most advanced and powerful call recording solution. Interfaced to all the major automation software systems for event integration.
Discussion of oxygen delivery and consumption principles in critical illness with the golden rules of resuscitation
Edward Omron MD, MPH, FCCP
Pulmonary, Critical Care, and Internal Medicine
Morgan Hill, CA 95037
This symposium provides an overview of the (r)evolution in intensive care medicine. The programme is based on lectures of 20 minutes where each speaker presents in two 10 minute talks (in der Beschränkung zeigt sich erst der Meister) the good things that happened in the last 40 years in critical care vs our mistakes or what is missing with respect to that topic. At the end of the session the speakers participate in an interactive round table discussion with online voting to get the audience involved. Will be discussed: Theoretical concepts, basic physiology and pathophysiology, monitoring, and future directions.
PiCCO tidak hanya memberikan informasi tentang curah jantung (CO) tapi bisa memberi pengukuran untuk menilai preload, kontraktilitas, afterload, dan air paru ekstravaskular (ELWI)
Right atrial pressure as back-pressure for venous returnscanFOAM
A presentation by Per Möller at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All available content from SSAI2017: https://scanfoam.org/ssai2017/
Delivered in collaboration between scanFOAM, SSAI & SFAI.
Safe and Sustainable: Balancing Infection Control and Environmental Health (U...Harriet Hopf
Goals:
1. Dispel the misconceptions associated with single use disposable devices, equipment, and supplies
2. Describe the differences between linear and circular supply chains
3. Apply risk reduction principles, including comprehensive cost-benefit assessments to purchasing decisions
Infection Control Considerations for COVID-19: Lessons LearnedHarriet Hopf
Participants should be able to:
-Apply infection control principles to protect themselves and their patients
-Select anesthesia equipment and supplies that reduce vulnerability to supply chain interruptions during a pandemic
An elevator pitch is a brief, persuasive speech that sparks interest. It is useful when introducing yourself, networking, asking for resources, and claiming credit for accomplishments. A good elevator pitch takes time to develop and practice to deliver effectively. In this talk, I cover how to capture your accomplishments and distill them into elevator pitches.
Giving Constructive Feedback to GME TraineesHarriet Hopf
Review of effective techniques for providing feedback. Considering stakes, situational complexity, trainee resistance, and mentor skill when preparing for giving feedback.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
for beginners, providing thorough training in areas such as SEO, digital communication marketing, and PPC training in Noida. After finishing the program, students receive the certifications recognised by top different universitie, setting a strong foundation for a successful career in digital marketing.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Dr. Vinod Kumar Kanvaria
Exploiting Artificial Intelligence for Empowering Researchers and Faculty,
International FDP on Fundamentals of Research in Social Sciences
at Integral University, Lucknow, 06.06.2024
By Dr. Vinod Kumar Kanvaria
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
1. The Transfusion Trigger:
When Should You
Give Red Cells?
Harriet W. Hopf, MD
Professor of Anesthesiology
University of Utah
2. Goals
To understand
the effect of anemia on oxygen transport
mechanisms that compensate for anemia
the risks of transfusion
the concept of a transfusion trigger
3. Objective
Participants will be able persuasively to
defend their decision to transfuse / not to
transfuse red cells
5. Why Transfuse Red Cells?
To maintain O2 delivery to organs
To prevent inadequate O2 consumption
6. How Do We Measure Need?
Ideal
Tissue oxygen
Good-- but not practical
O2ER (VO2/DO2)
Madjdpour and Spahn. BJA 2005; 95:33-42
Real
Hemoglobin
Hemodynamics
7. Physiologic Effects of Anemia
Why is there a wide range of “normal” and
“acceptable” hemoglobin?
8. Physiologic Effects of Anemia
Compensate by increased cardiac output
CO = HR X SV
HR increases 4 bpm / g Hb
SV increases as well
Increased contractility (active)
Decreased SVR (passive)
Increased venous return (passive)
Weiskopf et al. Transfusion 2003; 43: 235-40
9. Physiologic Effects of Anemia
Under anesthesia, no HR increase
Increased CO is from increased SV
Majdpour and Spahn. BJA 2005; 95:33-42.
18. What if you can’t transfuse?
Administer 100% oxygen
Equivalent to 1-1.5 g/dL Hb
1 g Hb fully saturated = 1.34 mL O2
PaO2 500 mm Hg = 1.5 mL O2
PaO2 300 mm Hg = 0.9 mL O2
Weiskopf et al. Anesthesiology, 96(4), 871-7, 2002.
24. What if you can’t transfuse?
Maximize CaO2
FiO2 1.0
Hyperbaric oxygen (intermittent)
Minimize VO2
Intubate
Paralyze
Sedate
Cool (?) to 35.5C
25. What if you can’t transfuse?
Maximize CO
Volume
Goal is isovolemia
Consider TEE guidance
Don’t measure Hb!
Don’t use dopamine
Increased VO2 mostly cardiac
29. Risks of Transfusion
Cancer recurrence
Surgical site infection
Mortality
Role for leucoreduction?
Old vs. new blood?
Koch et al, NEJM 358:1229, 2008
Weiskopf et al, Anesth. 104:911, 2006
Majdpour and Spahn. BJA 2005; 95:33-42.
30. Transfusion Guidelines
Are there guidelines?
ASA Guidelines, Anesth 105:198-208, 2006.
Are they based on data?
“strongly agree” transfuse < 6 g/dL
“strongly agree” don’t transfuse >10g/dL
How good are physicians at following them?
32. Transfusion Trigger
Really a TARGET not a TRIGGER
Healthy patient
7 g / dL
Cardiopulmonary disease
10 g / dL (?8-9)
Prevent tachycardia
33. What does this mean?
Healthy patient, Hb 14 g/dL
Assume 500 mL (1 unit) whole blood loss = 1
g/dL Hb decrease
Assume volume replaced
EBL >3500 mL before consider transfusion
34. How low can you go?
Unmedicated, healthy volunteers at rest
Hb 5 g / dL
No VO2-DO2 dependency
Fatigued
Mild cognitive impairment
Slightly slower and less accurate
Still in normal range
Reversed by RBC transfusion at Hb 7 g/dL
Reversed by 100% O2 via NRB
Weiskopf et al. Anesthesiology, 96(4), 871-7, 2002.
35. What about surgical patients?
Anemia increases 30-day mortality, CV
complications, and LOS
Non-cardiac surgery
Polycythemia similar effects
Wu et al. JAMA 297:2481, 2007 (98% men)
Colorectal surgery
~50% women but not analyzed separately
Leichtle et al, J Am Coll Surg 212:187, 20011
Cardiac surgery
Koch et al, Crit Care Med 34:1608, 2008
36. How Should We Manage Anemia?
Is anemia a marker for disease or inherently
causative?
Preoperative treatment:
2 weeks oral iron (200 mg) reduces transfusion
9.4 vs 27.4%, p<0.05
Okuyama et alSurg Today 35:36, 2005
ESA reduces transfusion, increases DVT
Laupacis and Fergusson, Transfus Med 8:309, 1998
37. How Should We Manage Anemia?
Is anemia a marker for disease or inherently
causative?
Risk-adjusted, propensity-matched
≥4 U blood predicts increases:
Mortality
Infection
LOS
Dunne et al, J Surg Res 102:237, 2002
38. Critical Care Transfusion RCT
838 patients, Hb <9 g/dL, within 72 h of
admit
Trigger <7 Target 7-9
Trigger <10 Target 10-12
Hebert et al. NEJM, 1999; 340:409-17.
39. Critical Care Transfusion RCT
Trigger
<7 g / dL <10 g/dL P value
30d Mortality
Overall 18.7 23.3 0.11
APACHE II
8.7 16.1 0.03
<21
Age <55 yr 5.7 13 0.02
CV Disease 20.5 22.9 0.69
40. Table 3. Unadjusted Rates of Outcomes and Adjusted Results of Cox Regression Predicting 30-Day
Death and Death or Recurrent Myocardial Infarction Using Transfusion as a Time-Dependent
Covariate.
HCT 25% best cut-off for transfusion
Rao, S. V. et al. JAMA 2004;292:1555-1562
Copyright restrictions may apply.
41. Individualize
Transfusion target (7 vs. 10 vs. 8…)
Acute vs. chronic anemia
Rate of bleeding
Hemodynamics
What about ADLs?
Should target differ in men and women?
42. Summary
Transfusions of RBC can be life-saving
Also cause serious morbidity and mortality
Individualize therapy
Underlying disease
Adequacy of compensatory responses
Rate of bleeding
Starting point
Editor's Notes
1.5 with 500 mmHg or 1.34 with 1 g Hb
Table 3. Unadjusted Rates of Outcomes and Adjusted Results of Cox Regression Predicting 30-Day Death and Death or Recurrent Myocardial Infarction Using Transfusion as a Time-Dependent Covariate