This document provides information on various bead-based tissue homogenizers. It describes the types of grinding beads available, including stainless steel, zirconium oxide, zirconium silicate, and glass, ranked in order of density. It also outlines different types of sample chamber movement, sample sizes and throughput capacities, motion speeds, cooling designs, specific low-throughput and high-throughput homogenizer models, and options for pre-filled tubes for homogenization.

1. Lab equipment and reagents
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WISBIOMED
-bead based tissue homogenizers

2. Bead Based Tissue Homogenizers
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 High density beads in a closed sample chamber with tissue
samples
 Homogenizer agitate sample vessels
 Beads in the sample chamber move fast to shred tissue
samples, or grind up sample pieces

3. Types of Grinding Beads
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 Stainless steel: high density
 Zirconium Oxide: high density, inert surface
 Zirconium Silicate:
 Glass:
 Density: stainless steel>Zirconium Oxide>Zirconium
Silicate>Glass

4. Types of sample chamber movement
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 Linear motion: entire sample chamber moves front left to
right or up down. HT-01 Homogenizer
 S shape motion:TissueLyzer, GenoGrinder
 3D motion: Precellys, Minilys, Powerlyzer,TissueRaptor

5. Sample size and through-put
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 Low through-put: one to three samples per run: BeadBug,
Minilys, CryoGrinder
 High through-put: Precellys, BulletBlender
 Sample tube size:
 Single tube design: for optimal performance
 Flexible tube size: defined sample chamber size, fit different
size tubes, plates
 Combination design: for different size tubes

6. Motion Speed
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 Low speed: less than 2000 RPM: BeadBug, BulletBlender,
HT-01
 High speed:Minilys, Precellys,
 Variable speed: user set speed: Precellys

7. Cooling Design
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 No cooling and require softened tissue samples to start with:
BeadBug, Minilys, BulletBlender
 No cooling, but work with frozen solid tissue samples:
Minilys, Precellys
 Built-in dry ice cooling: BulletBlender Gold
 Attached dry ice or liquid nitrogen cooling: Precellys with
Cryolys

8. Low through put homogenizers
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 BeadBug: for one to three 2ml tube, room temperature
operation
 Minilys: for upto three 2ml tubes, or one 7ml tube
 CryoGrinder: manually process one sample at a time, work
with CryoCooler with liquid nitrogen
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9. Bullet Blender Storm
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 Models for 2ml tubes, 5ml tubes and 50ml tubes
 Each works only one type of tube size
 Up to 24 samples per run
 Built-in cooling fan to facilitate air circulation
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10. Bullet Blender Gold
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 Models for 2ml, 5ml or 50ml tubes
 With built in dry ice bucket for cooling
 Fixed tube size design
 Extra sound insulation resulting a quiet operation
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11. High Through Put Homogenizer
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 Fixed sample chamber for 2ml, 5ml, 15ml or 30ml or 96
well plates
 Linear motion
 Room temperature operation
 website

12. Precellys Homogenizer
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 Models for 2ml tubes, 7ml tubes and 0.5ml tubes
 High through put
 Speed from 5000 to 6500 RPM
 Optional cooling unit with dry ice or liquid nitrogen
 www.precellys.com

13. Pre-filled Tubes for homogenization
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 Pre-filled tubes with beads
 Sterilized, RNase free, DNase free
 Bulk packaged beads and tubes
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