This document provides an overview of common hip and pelvis conditions, including trauma, fractures, infections, and causes of spontaneous hip pain. It describes clinical exams and imaging used to diagnose conditions like slipped femoral epiphysis, Legg-Calve-Perthes disease, septic arthritis, psoas abscess, tuberculosis, and hip impingement. Physical exam findings and characteristic features of various hip injuries and diseases are outlined.
Clinical examination of the spine/back covering the following sections:
INSPECTION
PALPATION
MOVEMENTS
MEASUREMENTS
SPECIAL TESTS
(Neurological examination covered separately in another slideshow : SPINE EXAMINATION - PART 2)
Clinical examination of the spine/back covering the following sections:
INSPECTION
PALPATION
MOVEMENTS
MEASUREMENTS
SPECIAL TESTS
(Neurological examination covered separately in another slideshow : SPINE EXAMINATION - PART 2)
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
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16. z
After minor trauma of the hip
Persistent groin pain in the elderly with nl xrays
Consider a CT
17. z
Spontaneous hip pain in children
Slipped Femoral Epiphysis
Calve-Legg-Perthes disease
Psoas abscess
Septic arthritis of the hip
TB of the hip
18. z
Infection of the hip
Onset slow or rapid, TB vs bacteria
CBC, ESR, Temp, CRP quantitative
Plain x-rays likely nl depending on length of time
US essential in diagnosis
Physical exam
19. z
Physical exam
psoas abscess
Able to ambulate
Walks hunched over
Doesn’t like hip extension
Rotation of the hip is not bothersome
US of the hip AND pelvis gets you the diagnosis
21. z
Physical exam
TB of the hip
Able to ambulate
Doesn’t like hip extension
Hip rotation is painful at extremes
US is positive for fluid in the hip
X-RAY NL EARLY ON
22. z
Physical exam of the hip
septic arthritis
Unable to ambulate
Painful motion in any direction
Fluid in the hip joint
23. z
Calve-Legg-Perthes of the hip
Spontaneous pain in a 5-10
year old
Painful limp, usually unilateral
Lacks rotation
25. z
Spontaneous pain in an adult
Back related
Sacroiliac
Trochanteric bursitis
Avascular necrosis
Osteoarthritis
TB of the hip
Hip impingement
26. z
Hip pain related to the spine
Felt in the buttock
Tender in the spine, SI joint,
buttock
Spine x-rays may or may not
be positive
Piriformis syndrome= buttock
pain as well but rare
29. z
Trochanteric Bursitis
Lateral hip pain
Painful to lay on that side
Nl hip x-rays
Tender to direct palpation over
the hip
Nl hip exam except painful
Responds to cortisone shot
Inject with the hip passively
abducted to create more space
30. z
AVN
Spontaneous pain in the groin
HIV
Steroids
Idiopathic
Can have nl x-rays
Early diagnosis by MRI
Trendelenburg gait or antalgic
gait
32. z
Osteoarthritis of the hip
Spontaneous groin pain
May have nl x-rays early on
Loss of rotation of the hip
Trendelenburg gait
Causes include acetabular
abnormal development,
impingement, old age
Loss of motion in all directions as
disease progresses
Painful rotation early on
33. z
TB of the hip
Spontaneous groin pain
Able to ambulate
NL x-rays
Elevated ESR most of the time
Limited motion
HIGH index of suspicion
US of the HIP, aspiration, biopsy
Drug treatment!
Erosions on both sides of the joint is
characteristic of late TB
34. z
Hip impingement
Cause of much of osteoarthritis of
the hip
Pain in 20-30 year old, especially
athletes
Both femoral and acetabular
abnormalities alone or combined
Early on painful flexion and
internal rotation
X-rays are abnormal to the trained
eye
there is no scientific basis for the author’s chosen threshold of
1 cm and 2 cm of ramus overlap on internal rotation when
deciding to proceed with anterior and/or posterior stabilization
for LC-1 injuries.24 We have no proof that had these particular
injuries gone untreated, that displacement would have
occurred, and we make no recommendation on the need for
surgical stabilization in these cases.
there is no scientific basis for the author’s chosen threshold of
1 cm and 2 cm of ramus overlap on internal rotation when
deciding to proceed with anterior and/or posterior stabilization
for LC-1 injuries.24 We have no proof that had these particular
injuries gone untreated, that displacement would have
occurred, and we make no recommendation on the need for
surgical stabilization in these cases.