Hexaxim, Sanofi Pasteur hexavalent vaccine with DPT + IPV + Hib + hep B for Indian children.
DTaP versus DTwP, components of DPT, latest studies from 2016 and 2017 regarding DTaP vaccines.
Influenza in Children Recommendations for Prevention &Treatment Ashraf ElAdawy
1. Seasonal influenza is caused by influenza viruses that mainly affect the respiratory system. While it can affect people of all ages, children, elderly, and immunocompromised individuals are most at risk of serious complications.
2. Influenza viruses are classified into types A, B, and C based on antigenic differences. Influenza A viruses are further subtyped by their surface proteins hemagglutinin and neuraminidase.
3. Influenza spreads through respiratory droplets from coughs and sneezes. Symptoms include fever, cough, sore throat, and body aches. While most people recover in a week, influenza can cause serious illness requiring hospitalization, especially in high-risk
The Adolescent Girls' Anaemia Control Programme: A decade of programming expe...POSHAN
This presentation was made by Preetu Mishra (UNICEF) in the session on 'Implementation research on delivery of interventions during pre-pregnancy through lactation' at the POSHAN Conference "Delivering for Nutrition in India Learnings from Implementation Research", November 9–10, 2016.
For more information about the conference visit our website: www.poshan.ifpri.info
This document discusses Meningococcal Meningitis, caused by the bacteria Neisseria meningitidis. It describes the different serogroups of N. meningitidis, symptoms of meningococcal disease including meningitis, bacteremia and other focal infections. Risk factors and populations are identified. Diagnosis involves culture, antigen detection and PCR testing of CSF, blood and other fluids. Treatment involves antibiotics like penicillin or third generation cephalosporins. Prevention includes vaccination, especially with conjugate vaccines, isolation of cases and prophylaxis of close contacts. Complications can be severe and include death in 20-30% of cases without treatment.
This presentation is a part 2/4 of series of presentation on Paediatric immunization.This presentation aims at helping the pediatric trainees and practitioners to brush up their knowledge in Immunization. The schedule is based on the Universal Immunisation Programme. I have tried to cover as much as possible in terms of individual vaccines and hope it is beneficial to the reader.
Hi Guys,
This presentation talks about Tuberculosis diagnosed in mother in the antenatal period, its treatment, implications on mother and fetus, the various protocols available currently regarding the neonatal management . Special focus being in major issues like breastmilk feeding, BCG, AKT prophylaxis, mother-child isolation.
Hope you find it useful.
P.S. - Please checkout my youtube channel - 'NEONATOHUB' & Facebook page 'Neonatohub' for lectures on neonatology.
- The document summarizes plans for Measles Immunization Day and an MR (measles-rubella) vaccination campaign in India on March 16, 2019. It discusses measles and rubella diseases, the WHO goal to eliminate measles and control rubella by 2020, and details of the MR vaccine, including its benefits, administration, storage, adverse reactions and contraindications. The campaign aims to vaccinate over 95% of children aged 9 months to 15 years to boost population immunity against both diseases. Careful planning and coordination is underway between health departments and other stakeholders to make the campaign a success.
This document provides information about community acquired pneumonia (CAP) in children. It defines CAP and lists the most common bacterial and viral causes. Risk factors for CAP include malnutrition, low birth weight, lack of breastfeeding, and lack of measles immunization. The pathophysiology of pneumonia involves four stages: congestion, red hepatization, grey hepatization, and resolution. Management of CAP involves classifying cases as pneumonia or severe pneumonia based on clinical features like fast breathing and chest indrawing. Investigations include blood tests and chest x-rays. Treatment depends on the classification and includes antibiotics. Complications can be pulmonary or extra-pulmonary. Prevention strategies are also discussed but not described.
The document discusses asthma in preschool-aged children who experience wheezing. It defines asthma as a chronic inflammatory airway disorder and notes that many cells and mediators are involved. Preschool wheezing is common but not all wheezing is asthma; phenotypes must be considered to determine if wheezing is intermittent or persistent asthma. Diagnosis involves symptoms, family history, allergy testing and lung function responses. Guidelines recommend treatment based on impairment, risk and control.
Influenza in Children Recommendations for Prevention &Treatment Ashraf ElAdawy
1. Seasonal influenza is caused by influenza viruses that mainly affect the respiratory system. While it can affect people of all ages, children, elderly, and immunocompromised individuals are most at risk of serious complications.
2. Influenza viruses are classified into types A, B, and C based on antigenic differences. Influenza A viruses are further subtyped by their surface proteins hemagglutinin and neuraminidase.
3. Influenza spreads through respiratory droplets from coughs and sneezes. Symptoms include fever, cough, sore throat, and body aches. While most people recover in a week, influenza can cause serious illness requiring hospitalization, especially in high-risk
The Adolescent Girls' Anaemia Control Programme: A decade of programming expe...POSHAN
This presentation was made by Preetu Mishra (UNICEF) in the session on 'Implementation research on delivery of interventions during pre-pregnancy through lactation' at the POSHAN Conference "Delivering for Nutrition in India Learnings from Implementation Research", November 9–10, 2016.
For more information about the conference visit our website: www.poshan.ifpri.info
This document discusses Meningococcal Meningitis, caused by the bacteria Neisseria meningitidis. It describes the different serogroups of N. meningitidis, symptoms of meningococcal disease including meningitis, bacteremia and other focal infections. Risk factors and populations are identified. Diagnosis involves culture, antigen detection and PCR testing of CSF, blood and other fluids. Treatment involves antibiotics like penicillin or third generation cephalosporins. Prevention includes vaccination, especially with conjugate vaccines, isolation of cases and prophylaxis of close contacts. Complications can be severe and include death in 20-30% of cases without treatment.
This presentation is a part 2/4 of series of presentation on Paediatric immunization.This presentation aims at helping the pediatric trainees and practitioners to brush up their knowledge in Immunization. The schedule is based on the Universal Immunisation Programme. I have tried to cover as much as possible in terms of individual vaccines and hope it is beneficial to the reader.
Hi Guys,
This presentation talks about Tuberculosis diagnosed in mother in the antenatal period, its treatment, implications on mother and fetus, the various protocols available currently regarding the neonatal management . Special focus being in major issues like breastmilk feeding, BCG, AKT prophylaxis, mother-child isolation.
Hope you find it useful.
P.S. - Please checkout my youtube channel - 'NEONATOHUB' & Facebook page 'Neonatohub' for lectures on neonatology.
- The document summarizes plans for Measles Immunization Day and an MR (measles-rubella) vaccination campaign in India on March 16, 2019. It discusses measles and rubella diseases, the WHO goal to eliminate measles and control rubella by 2020, and details of the MR vaccine, including its benefits, administration, storage, adverse reactions and contraindications. The campaign aims to vaccinate over 95% of children aged 9 months to 15 years to boost population immunity against both diseases. Careful planning and coordination is underway between health departments and other stakeholders to make the campaign a success.
This document provides information about community acquired pneumonia (CAP) in children. It defines CAP and lists the most common bacterial and viral causes. Risk factors for CAP include malnutrition, low birth weight, lack of breastfeeding, and lack of measles immunization. The pathophysiology of pneumonia involves four stages: congestion, red hepatization, grey hepatization, and resolution. Management of CAP involves classifying cases as pneumonia or severe pneumonia based on clinical features like fast breathing and chest indrawing. Investigations include blood tests and chest x-rays. Treatment depends on the classification and includes antibiotics. Complications can be pulmonary or extra-pulmonary. Prevention strategies are also discussed but not described.
The document discusses asthma in preschool-aged children who experience wheezing. It defines asthma as a chronic inflammatory airway disorder and notes that many cells and mediators are involved. Preschool wheezing is common but not all wheezing is asthma; phenotypes must be considered to determine if wheezing is intermittent or persistent asthma. Diagnosis involves symptoms, family history, allergy testing and lung function responses. Guidelines recommend treatment based on impairment, risk and control.
Antibiotic use in neonates. Protocols , Rationale, Antibiotic stewardship and newer agents, NICU microbiological profile. A grand presentation by Dr. Maskey in TUTH.
Growth charts in Neonates- Preterm and termSujit Shrestha
Growth charts in Newborn, Preterm and term neonates. All historically used charts in NICU are discussed here.
Presented by Dr Sujit, in Sir Ganga Ram Hospital
This document provides an overview of the approach to cough in children. It begins with background on cough and the cough reflex pathway. It then discusses classifications of cough based on duration, quality, and etiology. The document outlines the important components of history taking and physical examination for a child with cough. It recommends investigations such as chest X-ray, pulmonary function tests, and bronchoscopy if needed. The document concludes with guidelines for managing cough in children based on its underlying cause.
Acute respiratory infections such as pneumonia are a major cause of mortality and morbidity worldwide, especially in developing countries. Pneumonia is responsible for 3.9 million deaths annually, with Bangladesh, India, Indonesia and Nepal accounting for 40% of global mortality. Clinical assessment of children with suspected acute respiratory infection focuses on respiratory rate, chest indrawing, fever, and other signs of respiratory distress. Children are classified as having very severe disease, severe pneumonia, pneumonia, or no pneumonia. Treatment depends on the child's age, weight, and severity of illness, and may involve antibiotics, respiratory support, and symptomatic care. Prevention strategies center on immunization, nutrition, sanitation, and reducing indoor air pollution.
contains about the introduction , causative agents , transmission , clinical features , diagnosis , management and guidelines in Nepal , breaking the chain of transmission
This document discusses perinatal asphyxia, including:
- The pathophysiology of hypoxia and ischemia on fetal and newborn tissues
- Diagnostic criteria and incidence rates for perinatal asphyxia
- Recent trends in management, including therapeutic hypothermia and other supportive treatments
- Long-term outcomes depend on severity of injury, with severe HIE carrying high risks of death or disability
The RNTCP has updated its guidelines for the programmatic management of drug resistant TB in 2017. The key updates include:
1. Expanding the criteria for screening presumptive drug resistant TB cases to include contacts of microbiologically confirmed TB patients, people living with HIV/AIDS, diabetes, malnutrition, cancer and those on immunosuppressants.
2. Introducing a new diagnostic algorithm for pulmonary, extra-pulmonary and pediatric TB that places more emphasis on rapid molecular testing.
3. Establishing district drug resistant TB centers to decentralize drug resistant TB treatment and bring care closer to patients.
4. Revising treatment regimens for drug sensitive TB, mono/poly drug resistant
This document provides an overview of hypoxic-ischemic encephalopathy (HIE) in neonates. It defines HIE and discusses its etiology, pathophysiology, diagnosis, clinical staging, assessment tools, and management including hypothermia therapy. HIE results from a hypoxic or ischemic insult to the fetal or neonatal brain. The pathophysiology involves both primary neuronal damage during the insult and secondary damage over subsequent hours and days. Diagnosis is based on evidence of metabolic acidosis during birth and early onset of neurological abnormalities. Hypothermia therapy, involving whole body cooling to 33-35°C for 72 hours, is now standard treatment and reduces mortality and disability by attenuating secondary brain injury.
This document provides guidelines for the diagnosis and treatment of malaria. It discusses the life cycle and transmission of the Plasmodium parasites that cause malaria. It outlines recommendations for diagnosing malaria via microscopy or rapid diagnostic tests. For treatment, it recommends artemisinin-based combination therapies as first-line treatment for uncomplicated malaria and artesunate as first-line parenteral treatment for severe malaria. It also provides guidance on managing recurrent or resistant infections and complications of severe malaria.
1) Premature infants are at high risk of invasive fungal infections like candidiasis due to their relatively underdeveloped immune systems. Candida species are the most common cause, with C. albicans causing most neonatal infections.
2) Fungal colonization is common in VLBW infants and increases their risk of invasive infection. The GI tract is usually the initial site of colonization, which can progress to candidemia in 7-24% of cases.
3) Invasive candidiasis accounts for up to 12% of late-onset neonatal sepsis and carries a high mortality rate of 30%. Risk factors include low birth weight, broad spectrum antibiotic use, and central venous catheters
This study examined the frequency of Hepatitis B and Hepatitis C in 130 thalassemia major patients receiving regular blood transfusions at a hospital in Lahore, Pakistan. The results found that 8 patients (6.2%) were positive for Hepatitis B and 27 patients (20.8%) were positive for Hepatitis C, while 95 patients (73%) tested negative. Patients who received more than 20 blood transfusions had a higher rate of infection than those receiving fewer transfusions. The prevalence of Hepatitis C in this study was higher than found in other regional studies, possibly due to Pakistan starting screening for Hepatitis C later than Hepatitis B. Improving donor screening, patient education, and vaccination programs were recommended.
Acute respiratory tract infection control programme IMNCI pneumonia Dr GRKgrkmedico
The document provides guidelines for classifying and treating acute respiratory infections (ARI) in children under 5 years old. It outlines signs and symptoms of different severity levels of pneumonia, including cough or cold, pneumonia, severe pneumonia, and very severe disease. Conditions are classified based on respiratory rate, chest indrawing, difficulty breathing, and other danger signs. Treatments range from symptomatic relief at home to hospitalization and intravenous antibiotics for severe or very severe cases.
This document provides information about nocturnal enuresis (bedwetting), including its definition, epidemiology, etiology, diagnosis, and treatment. Nocturnal enuresis is defined as involuntary voiding during sleep at least twice a week for at least three months in a child aged 5 years or older. It affects more boys than girls and is often familial. Primary enuresis is caused by delayed cortical maturation while secondary enuresis can be caused by medical conditions. Treatment involves pharmacotherapy with desmopressin, imipramine, or anticholinergics as well as behavioral techniques like conditioning and alarms.
This document discusses neuroregression in children. It begins by outlining key points about neurometabolic disorders, including that they cause diverse neurological manifestations and require a systematic clinical, biochemical and imaging approach for diagnosis. It then discusses various inborn errors of metabolism classified by pathway and organelle. Clinical features of different conditions are provided, along with details about common neonatal and childhood presentations of neuroregression. The challenges in diagnosis and important clues are reviewed. Investigations and the objectives of evaluation are described. Broad management approaches and considerations for specific conditions like Hurler disease and Niemann-Pick disease type A are highlighted.
Hyponatremia is very common in critically ill children, occurring in 20-45% of PICU admissions. It is usually caused by impaired free water excretion leading to dilutional hyponatremia from water retention and intake of hypotonic fluids. Other potential causes include inappropriate vasopressin secretion, redistribution of sodium and water in conditions like sepsis, use of hypotonic intravenous fluids, and underlying illnesses or medications. The diagnosis involves measuring plasma and urine osmolality and sodium levels, and clinically assessing volume status, to determine if the hyponatremia is hypovolemic, hypervolemic, or euvolemic in nature.
This document discusses lactation failure among urban and rural mothers in India. It notes that while breastfeeding initiation is nearly universal, very few children are put to breast within the first hour after birth. Several barriers to optimal breastfeeding practices are discussed, including inadequate knowledge, low socioeconomic status, maternal age, education level, and work status. Other barriers include place of delivery, type of delivery, social customs, lack of health education, and psychological factors like stress. The document advocates for initiatives like Baby Friendly Hospitals to support breastfeeding.
This document discusses protocols for treating neonatal seizures. It defines seizures and classifies them as epileptic, non-epileptic, or EEG-only seizures. It describes different types of seizures including subtle, clonic, tonic, and myoclonic seizures. It then outlines the AIIMS, IAP, and Nelson protocols for treating neonatal seizures, which involve maintaining vital signs, checking glucose, administering anti-seizure medications like phenobarbital and phenytoin, and in refractory cases using additional medications. It provides guidance on weaning anti-seizure medications and monitoring the infant neurologically before discharge.
The new kid on the block - hexavalent vaccinesGaurav Gupta
This document summarizes a presentation on hexavalent vaccines given by Dr. Gaurav Gupta. It discusses the efficacy, safety, and immunogenicity data from clinical trials of hexavalent vaccines compared to whole-cell and other combination vaccines. Indian data is presented from a clinical trial of a hexavalent vaccine administered at 6, 10, and 14 weeks of age showing high rates of seroprotection and a favorable safety profile. Schedules using hexavalent vaccines that include vaccination at birth allow for a simplified 0, 3, +/-1 year immunization schedule for hepatitis B.
Antibiotic use in neonates. Protocols , Rationale, Antibiotic stewardship and newer agents, NICU microbiological profile. A grand presentation by Dr. Maskey in TUTH.
Growth charts in Neonates- Preterm and termSujit Shrestha
Growth charts in Newborn, Preterm and term neonates. All historically used charts in NICU are discussed here.
Presented by Dr Sujit, in Sir Ganga Ram Hospital
This document provides an overview of the approach to cough in children. It begins with background on cough and the cough reflex pathway. It then discusses classifications of cough based on duration, quality, and etiology. The document outlines the important components of history taking and physical examination for a child with cough. It recommends investigations such as chest X-ray, pulmonary function tests, and bronchoscopy if needed. The document concludes with guidelines for managing cough in children based on its underlying cause.
Acute respiratory infections such as pneumonia are a major cause of mortality and morbidity worldwide, especially in developing countries. Pneumonia is responsible for 3.9 million deaths annually, with Bangladesh, India, Indonesia and Nepal accounting for 40% of global mortality. Clinical assessment of children with suspected acute respiratory infection focuses on respiratory rate, chest indrawing, fever, and other signs of respiratory distress. Children are classified as having very severe disease, severe pneumonia, pneumonia, or no pneumonia. Treatment depends on the child's age, weight, and severity of illness, and may involve antibiotics, respiratory support, and symptomatic care. Prevention strategies center on immunization, nutrition, sanitation, and reducing indoor air pollution.
contains about the introduction , causative agents , transmission , clinical features , diagnosis , management and guidelines in Nepal , breaking the chain of transmission
This document discusses perinatal asphyxia, including:
- The pathophysiology of hypoxia and ischemia on fetal and newborn tissues
- Diagnostic criteria and incidence rates for perinatal asphyxia
- Recent trends in management, including therapeutic hypothermia and other supportive treatments
- Long-term outcomes depend on severity of injury, with severe HIE carrying high risks of death or disability
The RNTCP has updated its guidelines for the programmatic management of drug resistant TB in 2017. The key updates include:
1. Expanding the criteria for screening presumptive drug resistant TB cases to include contacts of microbiologically confirmed TB patients, people living with HIV/AIDS, diabetes, malnutrition, cancer and those on immunosuppressants.
2. Introducing a new diagnostic algorithm for pulmonary, extra-pulmonary and pediatric TB that places more emphasis on rapid molecular testing.
3. Establishing district drug resistant TB centers to decentralize drug resistant TB treatment and bring care closer to patients.
4. Revising treatment regimens for drug sensitive TB, mono/poly drug resistant
This document provides an overview of hypoxic-ischemic encephalopathy (HIE) in neonates. It defines HIE and discusses its etiology, pathophysiology, diagnosis, clinical staging, assessment tools, and management including hypothermia therapy. HIE results from a hypoxic or ischemic insult to the fetal or neonatal brain. The pathophysiology involves both primary neuronal damage during the insult and secondary damage over subsequent hours and days. Diagnosis is based on evidence of metabolic acidosis during birth and early onset of neurological abnormalities. Hypothermia therapy, involving whole body cooling to 33-35°C for 72 hours, is now standard treatment and reduces mortality and disability by attenuating secondary brain injury.
This document provides guidelines for the diagnosis and treatment of malaria. It discusses the life cycle and transmission of the Plasmodium parasites that cause malaria. It outlines recommendations for diagnosing malaria via microscopy or rapid diagnostic tests. For treatment, it recommends artemisinin-based combination therapies as first-line treatment for uncomplicated malaria and artesunate as first-line parenteral treatment for severe malaria. It also provides guidance on managing recurrent or resistant infections and complications of severe malaria.
1) Premature infants are at high risk of invasive fungal infections like candidiasis due to their relatively underdeveloped immune systems. Candida species are the most common cause, with C. albicans causing most neonatal infections.
2) Fungal colonization is common in VLBW infants and increases their risk of invasive infection. The GI tract is usually the initial site of colonization, which can progress to candidemia in 7-24% of cases.
3) Invasive candidiasis accounts for up to 12% of late-onset neonatal sepsis and carries a high mortality rate of 30%. Risk factors include low birth weight, broad spectrum antibiotic use, and central venous catheters
This study examined the frequency of Hepatitis B and Hepatitis C in 130 thalassemia major patients receiving regular blood transfusions at a hospital in Lahore, Pakistan. The results found that 8 patients (6.2%) were positive for Hepatitis B and 27 patients (20.8%) were positive for Hepatitis C, while 95 patients (73%) tested negative. Patients who received more than 20 blood transfusions had a higher rate of infection than those receiving fewer transfusions. The prevalence of Hepatitis C in this study was higher than found in other regional studies, possibly due to Pakistan starting screening for Hepatitis C later than Hepatitis B. Improving donor screening, patient education, and vaccination programs were recommended.
Acute respiratory tract infection control programme IMNCI pneumonia Dr GRKgrkmedico
The document provides guidelines for classifying and treating acute respiratory infections (ARI) in children under 5 years old. It outlines signs and symptoms of different severity levels of pneumonia, including cough or cold, pneumonia, severe pneumonia, and very severe disease. Conditions are classified based on respiratory rate, chest indrawing, difficulty breathing, and other danger signs. Treatments range from symptomatic relief at home to hospitalization and intravenous antibiotics for severe or very severe cases.
This document provides information about nocturnal enuresis (bedwetting), including its definition, epidemiology, etiology, diagnosis, and treatment. Nocturnal enuresis is defined as involuntary voiding during sleep at least twice a week for at least three months in a child aged 5 years or older. It affects more boys than girls and is often familial. Primary enuresis is caused by delayed cortical maturation while secondary enuresis can be caused by medical conditions. Treatment involves pharmacotherapy with desmopressin, imipramine, or anticholinergics as well as behavioral techniques like conditioning and alarms.
This document discusses neuroregression in children. It begins by outlining key points about neurometabolic disorders, including that they cause diverse neurological manifestations and require a systematic clinical, biochemical and imaging approach for diagnosis. It then discusses various inborn errors of metabolism classified by pathway and organelle. Clinical features of different conditions are provided, along with details about common neonatal and childhood presentations of neuroregression. The challenges in diagnosis and important clues are reviewed. Investigations and the objectives of evaluation are described. Broad management approaches and considerations for specific conditions like Hurler disease and Niemann-Pick disease type A are highlighted.
Hyponatremia is very common in critically ill children, occurring in 20-45% of PICU admissions. It is usually caused by impaired free water excretion leading to dilutional hyponatremia from water retention and intake of hypotonic fluids. Other potential causes include inappropriate vasopressin secretion, redistribution of sodium and water in conditions like sepsis, use of hypotonic intravenous fluids, and underlying illnesses or medications. The diagnosis involves measuring plasma and urine osmolality and sodium levels, and clinically assessing volume status, to determine if the hyponatremia is hypovolemic, hypervolemic, or euvolemic in nature.
This document discusses lactation failure among urban and rural mothers in India. It notes that while breastfeeding initiation is nearly universal, very few children are put to breast within the first hour after birth. Several barriers to optimal breastfeeding practices are discussed, including inadequate knowledge, low socioeconomic status, maternal age, education level, and work status. Other barriers include place of delivery, type of delivery, social customs, lack of health education, and psychological factors like stress. The document advocates for initiatives like Baby Friendly Hospitals to support breastfeeding.
This document discusses protocols for treating neonatal seizures. It defines seizures and classifies them as epileptic, non-epileptic, or EEG-only seizures. It describes different types of seizures including subtle, clonic, tonic, and myoclonic seizures. It then outlines the AIIMS, IAP, and Nelson protocols for treating neonatal seizures, which involve maintaining vital signs, checking glucose, administering anti-seizure medications like phenobarbital and phenytoin, and in refractory cases using additional medications. It provides guidance on weaning anti-seizure medications and monitoring the infant neurologically before discharge.
The new kid on the block - hexavalent vaccinesGaurav Gupta
This document summarizes a presentation on hexavalent vaccines given by Dr. Gaurav Gupta. It discusses the efficacy, safety, and immunogenicity data from clinical trials of hexavalent vaccines compared to whole-cell and other combination vaccines. Indian data is presented from a clinical trial of a hexavalent vaccine administered at 6, 10, and 14 weeks of age showing high rates of seroprotection and a favorable safety profile. Schedules using hexavalent vaccines that include vaccination at birth allow for a simplified 0, 3, +/-1 year immunization schedule for hepatitis B.
This document discusses the effectiveness data from 19 years of surveillance on the SP HEXAVALENT DTaP-IPV-HB-Hib vaccine. It notes that the best way to compare pertussis vaccines is based on effectiveness data rather than immunological markers. It references a 2008 Swedish surveillance study that is commonly used to evaluate the effectiveness of pertussis vaccines. The study found that after the introduction of the acellular pertussis vaccine, there was a decrease in reported pertussis cases in Sweden.
This document discusses the introduction of two new meningococcal immunization programs in England, including vaccination against meningococcal group B disease. It provides data on trends in meningococcal disease cases over time, outlines the age distribution of invasive meningococcal disease, and discusses the role of serogroup B vaccines in the UK. It summarizes evidence from clinical trials demonstrating the immunogenicity and tolerability of the MenB vaccine Bexsero, and reviews data showing that prophylactic paracetamol can reduce fever following vaccination without impacting the vaccine's immunogenicity.
The document discusses the time interval for booster vaccination following re-exposure to rabies in previously vaccinated individuals. It reviews 19 studies involving over 3300 vaccinees to examine antibody response over time. The results showed that 0.07-0.14% of individuals had an inadequate antibody response at 1-3 months after initial vaccination. Therefore, the document concludes that a booster dose is recommended 3 months after the primary vaccination course for individuals re-exposed to rabies. This time interval is proposed to the WHO expert group for consideration in updating guidelines.
The document summarizes WHO recommendations for routine childhood vaccinations. It provides a table outlining the recommended vaccines for children, adolescents, and sometimes adults. For each vaccine, it lists the number of doses recommended and any special considerations. Some key recommendations include BCG vaccination for all newborns in high tuberculosis burden countries, 3 doses of hepatitis B vaccine for all children worldwide, and a primary series of 3 doses of oral polio vaccine (OPV) plus 2 doses of inactivated polio vaccine (IPV) for polio immunization.
Bacterial vaccines have helped eliminate or reduce several infectious diseases. Common bacterial vaccines protect against diphtheria, tetanus, pertussis, pneumococcal disease, Hib, meningococcal meningitis, typhoid, cholera and more. Vaccines work through active immunization by vaccination or passive immunization using antibodies. Ongoing research continues to develop new vaccines and improve vaccine effectiveness.
Potential advantages of booster containing PCV regimen - Professor Shabir MadhiWAidid
This slideset, realized by Professor Shabir Madhi on the occasion of the 11th ISPPD held in Melbourne last April, evaluates the potential advantages of booster containing PCV dosing schedule.
To learn more, visit www.waidid.org!
The document discusses pediatric immunizations, including objectives related to medical knowledge, communication, patient care, and systems-based practice. It lists several vaccine-preventable diseases like diphtheria, pertussis, Hib, and polio. Common childhood vaccines discussed include DTaP, IPV, hepatitis B, Hib, and combination vaccines. Vaccine schedules and contraindications are also reviewed. The document aims to educate medical professionals about childhood immunizations.
A cost-effectiveness analysis was conducted on a potential group B Streptococcus (GBS) vaccine for the UK. The analysis found that a GBS vaccine is likely to be a cost-effective intervention based on recent UK data on disease burden and healthcare costs. A GBS vaccine covering 5 major serotypes could prevent hundreds of cases of neonatal and maternal GBS disease annually in the UK and gain thousands of quality-adjusted life years at a reasonable cost. Global analyses also indicate GBS vaccination could significantly reduce disease burden worldwide and be very cost-effective in many countries according to WHO guidelines. More research is still needed to define cost-effectiveness in lower-income settings.
Designing vaccines for specific populations and germs - Slides by Professor E...WAidid
The presentation given by Professor Susanna Esposito at ECCMID 2019. A view on vaccines recommendations, combined vaccinations and impact of vaccination practices in the eradication of major infectious diseases.
To learn more, please visit www.waidid.org
This document summarizes evidence and guidelines around the evaluation and management of possible early-onset neonatal sepsis. It finds that restricting unnecessary evaluation and antibiotics is important. Clinical monitoring can identify red flags and is often sufficient for well-appearing late preterm and term infants, especially with serial exams over 12 hours. While tests have limited predictive value, stopping antibiotics by 36 hours for reassuring infants is recommended. Several adjuvant therapies like exchange transfusions, immunoglobulins, and colony stimulating factors show promise but require more research before routine use.
This document summarizes the WHO's position on vaccination recommendations for children. It includes:
1) A table outlining the recommended ages, doses, and intervals for various routine childhood vaccines.
2) Footnotes providing details on booster considerations, co-administration, and catch-up schedules.
3) Clarification that national immunization schedules should be based on local epidemiological factors in addition to these guidelines. The document is intended to help countries develop appropriate vaccination schedules.
Vaccinology is the study of vaccines and vaccination. Vaccines work by inducing immunity through administering live attenuated, killed, or antigenic portions of infectious agents. This stimulates both the innate and adaptive immune system. Vaccination can elicit humoral, cellular, or both immune responses. Key principles of immunization include following recommended doses, intervals between live vaccines, and that missed doses do not require restarting the full schedule. The document then discusses several specific vaccines including varicella, hepatitis A, typhoid, human papillomavirus, and meningococcal vaccines. It provides details on strains, schedules, indications, and contraindications for each vaccine.
Dr. Gaurav Gupta RV 5 Patiala CME 18 feb 2018Gaurav Gupta
Comparing the 4 available Rotavirus vaccines in the Indian context, Rotateq (RV5), Rotavac/ Rotasure (116E), Rotarix (RV1), and Rotasiil (BRV-PV), with special reference to Rotateq.
Newer vaccines provide protection against additional diseases. The document discusses several newer vaccines including dengue, pentavalent, HPV, measles-rubella (MR), Japanese encephalitis (JE), oral cholera, HIV, malaria, leprosy, tuberculosis, and cancer vaccines. Many of these vaccines have been added to national immunization programs in recent decades to further reduce mortality from vaccine-preventable diseases.
The Indian Academy of Pediatrics Advisory Committee on Vaccines and Immunization Practices (IAP ACVIP) met in August 2013 to revise the 2013 IAP Immunization Timetable and issue recommendations on newly licensed vaccines. Major changes included recommending whole-cell pertussis vaccines over acellular pertussis vaccines for the primary infant series due to evidence of faster waning of immunity from acellular vaccines. The committee also recommended immunizing pregnant women with the Tdap vaccine during the third trimester. The administration schedule for the rotavirus vaccine RV1 was revised from 6 and 10 weeks to 10 and 14 weeks based on evidence that this schedule results in a stronger immune response.
Current challenges in pertussis prevention gaurav gupta - sept 2016Gaurav Gupta
Pentaxim, Hexaxim, India, pertussis, whooping cough, vaccine, 2 component, 5 component.
Talk for Chandigarh, India about whole cell pertussis versus acellular pertussis vaccine -
NEWER VIRAL VACCINE ICLUDED RECENT ADVACES IN THE VACCINE DEVELOPMENT And as per WHO 2023 data pipeline vaccine detail like HIV, TB, DENGUE, HPV,FLU VACCINE AND ALSO EMPHASIS ON THE COVID VACCINE AND AS PER LATEST 2023 GOEVENMENT OF INDIA AND WORLD HEALTH ORGANISATION
Similar to Hexaxim rtm dr. gaurav gupta 04 aug 2017 (20)
Impact of Social Media on Mental Health.pptxGaurav Gupta
## Social Media: The Ups and Downs for Young Minds
**Uncover the impact of social media on children's mental health.**
This presentation explores the complex relationship between social media and the developing minds of children. We'll delve into:
* **The positive connections:** How social media fosters friendships, self-expression, and access to information.
* **The potential pitfalls:** Increased anxiety, depression, body image issues, and cyberbullying.
* **Strategies for healthy use:** Explore practical tips for parents and educators to promote safe and balanced social media habits in children.
**Equip yourself with the knowledge to guide young people in navigating the social media landscape.**
Good evening everyone, and thank you for joining me today. Today we’ll be exploring the impact of social media on the mental health of children and adolescents. Social media is an undeniable part of our lives, and pediatricians are in a unique position to guide parents and children in navigating this digital landscape.
How AI will transform Pediatric Practice - Feb 2024Gaurav Gupta
Creating a concise and compelling summary for a SlideShare presentation on "How AI Will Transform Pediatric Practice" involves highlighting key points that emphasize AI's potential benefits, challenges, and future implications in pediatric healthcare. Here's a structured summary that could be effectively used in your SlideShare:
---
**Title: Transforming Pediatric Practice: The Role of AI**
**Introduction:**
- Briefly introduce the current state of pediatric practice, emphasizing the importance of accurate diagnosis, personalized treatment, and efficient healthcare delivery.
- Introduce Artificial Intelligence (AI) as a transformative tool in medicine, with a focus on pediatrics.
**AI's Impact on Diagnostics:**
- Highlight how AI algorithms enhance diagnostic accuracy in pediatric care, enabling early detection of diseases through pattern recognition in imaging, genomics, and clinical data.
- Discuss case studies where AI has successfully identified pediatric conditions earlier and more accurately than traditional methods.
**Personalized Treatment Plans:**
- Explain how AI contributes to the development of personalized medicine in pediatrics, considering the unique genetic, environmental, and lifestyle factors of each child.
- Provide examples of AI systems recommending customized treatment protocols and monitoring disease progression in real-time.
**Operational Efficiency and Patient Care:**
- Illustrate AI's role in streamlining administrative tasks, scheduling, and patient flow, allowing healthcare professionals to focus more on patient care.
- Discuss AI-powered virtual health assistants and chatbots that provide 24/7 support and guidance to caregivers, answering questions and offering advice based on medical guidelines.
**Challenges and Ethical Considerations:**
- Address the challenges of integrating AI into pediatric practice, including data privacy, ethical considerations, and the need for robust training data.
- Discuss the importance of balancing AI tools with human oversight to ensure compassionate and empathetic patient care.
**The Future of AI in Pediatrics:**
- Envision a future where AI not only supports clinical decision-making but also predicts health outcomes, identifies potential public health crises, and contributes to global pediatric health research.
- Highlight the importance of interdisciplinary collaboration in developing AI tools that are ethical, equitable, and truly beneficial for child health.
**Conclusion:**
- Summarize the transformative potential of AI in pediatric practice, emphasizing its role in enhancing healthcare delivery, improving patient outcomes, and paving the way for innovative treatment approaches.
- Call to action for healthcare professionals, researchers, and technologists to collaborate in harnessing the power of AI for the betterment of pediatric healthcare.
Latest GINA guidelines for Asthma & COVIDGaurav Gupta
What are the changes from 2019 onwards till 2022, in the GINA guidelines for developing countries like India.
Includes COVID guidelines and also a FUN QUIZ !
Talk about why these guidelines have changed - use of ICS - formoterol combination for treating even intermittent asthma
Dr Naveen Kini, Pediatrician from Bengaluru talks about WHAT is podcasting, HOW we can listen to podcasts, WHY doctors should create podcasts and much more. Co-hosted with Dr Gaurav Gupta. In arrangement with dIAP and CMIC. This is PART 1 - we discuss how to create a simple free & easy podcast in part 2 - check the presentation on slideshare under my account
Podcast creation for doctors (Pediatricians)Gaurav Gupta
To create a doctor podcast, one must first develop a clear concept focused on a specific medical area of interest. Then, choose an attention-grabbing name related to the topic and register the podcast on major platforms like Apple Podcasts and Spotify to reach a wide audience. Basic recording equipment like a computer and quality microphone are sufficient to produce clear audio. Promoting the podcast through one's website, social media, and practice's blog is key to growing the listener base.
Rotavirus vaccines in India - Whats new in 2021 Gaurav Gupta
This document provides information on Rotavirus gastroenteritis (RVGE) and rotavirus vaccines in India, with a focus on vaccine 116E. It discusses how RVGE is a major cause of childhood diarrhea and mortality in India. It summarizes clinical trial results showing the 116E vaccine is effective at preventing severe RVGE, has a good safety profile with no increased risk of intussusception compared to other vaccines, and provides broad protection against circulating rotavirus strains in India. Phase 3 and 4 trials demonstrated 116E is well-tolerated and effective in preventing severe RVGE in Indian children when administered in a 3-dose schedule.
Hep a Live & Inactivated vaccines in IndiaGaurav Gupta
dIAP presentation for GSK - Havrix and comparison of Live and inactivated Hepatitis A vaccines in Dec 2020.. Online discussion about the various Hep A vaccines available and their pros and cons
Prevention of influenza in relation to COVID 19 - the TWINDEMICGaurav Gupta
What is the concern about the TWINDEMIC of COVID 19 & Influenza?
My talk on the digital IAP platform in Dec 2020 for the pediatricians across the country
Top 10 practical questions about Flu Vaccine in India!Gaurav Gupta
What does a practising paediatrician want to to know about the Flu vaccination? Talk for Abbott Vaccines (Influvac Tetra) in Oct 2020 about common queries that doctors have about the flu vaccine in India, including how it may help in COVID-19?
Helping doctors avoid COVID in their Office PracticeGaurav Gupta
Tips for doctors and their patients to avoid Coronavirus during OPD practice in India. From a Pediatrician's perspective. How can we take supplements prophylactic medicines like Vit D, Vit C, Zinc, etc. and medicines like HCQ or Ivermectin to prevent COVID during seeing patients in our practice.
Digital eye strain - Computer vision syndrome for students during Online clas...Gaurav Gupta
Dr. Poonam Gupta, Eye Specialist from Charak Clinics, Mohali, talks with Aakash Institute about Computer vision syndrome, Digital Vision Syndrome, Eye fatigue in students doing online classes during the lockdown. How to prevent it and treat with with simple steps including the 20-20-20 rule etc.
Prevenar e cme june 2020 & FAQs & COVID Clinic QuestionsGaurav Gupta
Lockdown E-CME & Webinars - this one is on Pfizer vaccine - Prevenar,
We have also discussed the common questions on Pneumonia & how to run clinical practice during COVID shutdown
Digital waste management pedicon 2020 Indore, preconference workshopGaurav Gupta
What is important and relevant about Digital waste management pedicon 2020 Indore, preconference workshop. How to dispose of your printers, computers, mobile phones, relevant to India
How to Advertise yourself with simple office tools PEDICON 2020 Indore workshop 8 jan, 2020. How to use whatsapp, blogs, youtube facebook to advertise yourself online
Zyvac TCV - The Indian Typhoid Conjugate VaccineGaurav Gupta
The document discusses a new typhoid conjugate vaccine called Zyvac-TCV developed by Zydus Vaccines. It provides details of a phase II/III clinical trial conducted to evaluate the immunogenicity and safety of Zyvac-TCV compared to another licensed typhoid conjugate vaccine. The results showed that Zyvac-TCV was non-inferior in inducing seroconversion and had a comparable safety profile. No serious adverse events were reported for either vaccine. The document concludes that Zyvac-TCV met the immunogenicity and safety endpoints for efficacy.
Dr. Gaurav Gupta - Should you be buying an E-bike this Diwali?
Dr RP Bansal- Feeding difficulties in the newborn
Dr Nivedita- Tips on how to Continue Breast Feeding
Dr Ridhi- Teething tips
Dr Arushi - First afebrile seizure
Dr Amit - Mesentric lymphadenopathy
Dr Gunjan - Acute events following immunization plus update on BCG adenitis
Dr Sandip Jain- Tips for examining children
Dr Diljot - Mefenemic acid as an antipyretic
Dr Jaskaran- colicky infant : knowledge , attitude and practices
Dr Shailesh - School se chutti kitne din karayein ?
Dr Gaurav- Is it oral Herpes? Visual Quiz
At the four front of flu vaccination - Quadrivalent Flu Vaccination in India ...Gaurav Gupta
Is flu vaccination needed in India? Is there any benefits of Quadrivalent Flu vaccination over Trivalent Flu vaccination? Any safety & efficacy data about Vaxiflu 4 by Zydus Vaccines. All discussed in a Presentation in Panchkula, in September 2019
Meningococcal disease sep 2019 National Epidemiology & Indian recommendationsGaurav Gupta
This document discusses meningococcal disease in India, including past outbreaks, current epidemiology and surveillance data, and recommendations for vaccination. It notes that while India has a poor surveillance system and diagnostic challenges, meningococcal disease is present and the country has seen outbreaks every 6-8 years. Surveillance data from 2012-2016 shows several states regularly report over 100 cases annually. Current recommendations from the Indian Academy of Pediatrics advise vaccination for high-risk groups, international travelers, and Hajj/African meningitis belt pilgrims. While antibiotics can treat the disease, vaccination is an effective prevention strategy given unknowns around antibiotic resistance and underdiagnosis.
Japanese encephalitis - Sep 2019 India epidemiology - Is vaccination needed?Gaurav Gupta
1) Japanese encephalitis (JE) is a viral disease spread by mosquitoes that is endemic in many parts of Asia and the Pacific. India reports the highest number of JE cases annually, with an estimated actual number between 15,000-20,000 cases per year.
2) JE vaccination is the most important preventive measure according to WHO and IAP guidelines. The national vaccination program in India recommends routine vaccination with two doses of JE vaccine for children up to 15 years of age in endemic areas.
3) While mosquito and pig control efforts have not proven reliable at controlling JE, vaccination is currently the single most effective public health approach for prevention in India given the disease burden.
Research in pediatrician office - my story! NORC Aug 2019 New DelhiGaurav Gupta
Presented in NORC - Aug 2019 - National Original Research convention, discussion of Flu like illnesses and the Flu vaccination and drug utilization reviews and prescription audits and various other original research presented and published by Dr. Gaurav Gupta in his years of clinical practice, including yellow fever, Complementary medicines, drug costs and prescriptions analysis
Kosmoderma Academy, a leading institution in the field of dermatology and aesthetics, offers comprehensive courses in cosmetology and trichology. Our specialized courses on PRP (Hair), DR+Growth Factor, GFC, and Qr678 are designed to equip practitioners with advanced skills and knowledge to excel in hair restoration and growth treatments.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
DECLARATION OF HELSINKI - History and principlesanaghabharat01
This SlideShare presentation provides a comprehensive overview of the Declaration of Helsinki, a foundational document outlining ethical guidelines for conducting medical research involving human subjects.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
6. COMPONENT COMPANY EFFICACY
1C Amvax, JNIH 71 TO 78%
2C SKB 59%
2C Pasteur Merieux 85%
3C SKB (GSK) 84 %
4C LEDERLE - an european vacc .
not marketed
79 %
5C Connaught (Pasteur) 85 %
DTwP VARIOUS countries 36 TO 96 %
Summary of vaccine efficacy: Cochrane 2012 (and 14)
7. Statements of Vaccines Experts/Health Authorities regarding number of
Pertussis components in licensed vaccines:
• “There are now only 3 broadly distributed acellular pertussis vaccines: the
French 2-component, the Belgian 3-component, and the Canadian 5-
component vaccines. National surveillance data have clearly demonstrated
the ability of each vaccine to accomplish excellent control of pertussis.”
Plotkin et al.
VACCINES 6th
ed.
• The European scientific panel on childhood immunization does not discuss
the number and types of acP vaccines components, since effectiveness data
have not shown any significant differences.”
European CDC
• “Point estimate of vaccine efficacy ranged from 80% to 85% for vaccines
currently licensed in the United States. Confidence intervals for vaccine
efficacy overlap, suggesting that none of the vaccines is significantly more
effective than the other.”
CDC Pink Book
12th ed.
• “long-term large scale use of licensed 2-component aP-containing vaccines
(primarily in Sweden and Japan) and of 1-component aP vaccine in the
national Danish immunization programme, all of these aP-containing vaccines
demonstrated high levels of effectiveness in preventing pertussis irrespective
of antigen content.”
WHO Pertussis
Vaccines
Position Paper 7
10. Combination vaccines – Why not?
• Adverse effects maybe more common
• Reduced Immunogenicity
• May have lesser shelf life
• Technically difficult
• Expensive
11. Hexavalent Vaccines across the World
• Hexavac – discontinued
• Infanrix Hexa – GSK – with lyophilised Hib
• Hexaxim – Fully liquid 6 in 1 with DPT + Hep B
+ Hib + IPV (HEXAVAC contained a smaller amount - 5 μg of the
hepatitis B antigen produced in Saccharomyces cerevisiae yeast. In contrast,
Hexaxim contains 10 μg of the hepatitis B antigen (HBsAg) produced in
Hansenula polymorpha yeast)
13. Efficacy
• As compared to other aP vaccines
• As compared to wP vaccines, specifically
against Pertussis
14. HEXAXIM® immunogenicity assessment - Overview
● 8 primary series studies
● 3 primary schedules (6, 10 & 14 weeks; 2, 3 & 4 and 2, 4 & 6 months)
● With or without hepatitis B vaccination at birth
● versus different control vaccines:
• wP-based combination vaccines
• PENTAXIM® + standalone hepatitis B vaccine
• INFANRIX-HEXA (DTaP-IPV-HBV//Hib***)
• Concomitantly with other routine pediatric vaccines
*Tritanrix®-HepB/Hib **CombAct-HIB® *** Infanrix Hexa®
15. 0
20
40
60
80
100
D T PT FHA PV1 PV2 PV3 HBsAg Hib
Immunogenicity v/s wP vaccines
HEXAXIM® induces high immune responses similar
to those of wP-based combination vaccines
Seroprotection/seroconversion rates after the 3rd dose of HEXA or a wP-based combination
vaccine in infants vaccinated at 6,10 &14 weeks of age
(South Africa)1 (No HepB vaccine at birth, no concomitant vaccine)
Seroprotection/
Seroconversionrates(%)
D T PT FHA PV1,2,3 HBsAg Hib
0.01 IU/mL 4-fold increase
(pertussis antigens)
1/dil 8 10 mIU/mL 0.15 µg/mL
98 96 100 100
94
83
93
58
100
93
99 100 100 98 96 95 95
100
HEXAXIM® 1
n=220
DTwP//Hib* + OPV + Hep B vaccine 1
n=212
* CombAct-HIB® [1] Madhi et al. PIDJ, 2011;30(4)
16. 0
20
40
60
80
100
D T PT FHA PV1 PV2 PV3 HBsAg Hib
The immune response to all HEXAXIM® antigens is high and similar
to that of PENTAXIM® co-administered with standalone hepatitis B vaccine
Seroprotection/
Seroconversionrates(%)
D T PT FHA PV1,2,3 HBsAg Hib
0.01 IU/mL 4-fold increase
(pertussis antigens)
1/dil 8 10 mIU/mL 0.15 µg/mL
100 100 100 100
92 93 93 90
100 100 100 100 100 100 99 100
95 97
HEXAXIM®
n=260
PENTAXIM® + Hep B vaccine
n=271
[5] Tregnagui et al. PIDJ, 2011;30(6)
Seroprotection/Seroconversion rates after the 3rd dose of HEXA or PENTA
in infants vaccinated at 2, 4 & 6 months of age
(Argentina)5 (No Hep B vaccine at birth, no concomitant vaccine)
Immunogenicity Vs PENTAXIM®
18. HEXAXIM® safety assessment - Overview
Evaluated in 20 clinical trials in more than 6000 infants and toddlers
● 18,000 doses administered to > 6000 infants in 20 clinical trials
● With or without hepatitis B vaccination at birth
● versus different control vaccines:
• wP-based combination vaccines
• PENTAXIM® + standalone hepatitis B vaccine
• INFANRIX-HEXA (DTaP-IPV-HBV//Hib***)
• Concomitantly with other routine pediatric vaccines
[19] Sanofi Pasteur. Data on file
19. Solicited reactions after any dose of HEXAXIM® or DTwP-HepB//Hib*
in infants vaccinated at 2,4 & 6 months of age (Mexico & Peru)3 (No concomitant vaccine)
0
20
40
60
80
100
Pain Red Swell A Fever Vom Crying Somnol Anor Irr
The reactogenicity of HEXAXIM® is consistently lower than that of
wP-based combination vaccines
Gr3: grade 3 *Tritanrix®-HepB/Hib [3] Macias et al. PIDJ, 2012;31(8)
78 94
59 71
17 36
3 6
43 67
1 6
75 93
4 6
30 31
2 3
78 92
3 5
57 69
5 6 3 5
82 92
46 59
6 10
Reactionincidence(%)
HEXAXIM®
n=1422
DTwP-HepB//Hib*
n=711
Any Gr3 Any Gr3 Any Gr3 Any Gr3 Any Gr3 Any Gr3 Any Gr3 Any Gr3 Any Gr3
Pain Redness Swelling Fever Vomiting Crying Somnolence Anorexia Irritability
Tolerability Vs. wP vaccines
21. IMMUNOGENICITY AND SAFETY OF
DTaP-IPV-HB-PRP-T COMBINED
VACCINE GIVEN AT 6, 10 AND 14
WEEKS OF AGE IN INFANTS FROM
INDIA, WHO PREVIOUSLY RECEIVED
A DOSE OF HEP B VACCINE AT BIRTH
Presenting Author: Prof Sanjay Lalwani
Date : 23 January 2016
Venue : PEDICON – Hyderabad
WHO Universal Trial Number (UTN): U1111-1127-6936
22. Safety: Solicited reactions from D0 to D7, any
grade, after each injection (in %)
22
19%
4.60%
10.30%
13.80%
3.40% 3.40%
11.90%
0.60%
6.50%
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Tenderness Erythema Swelling
Post Dose 1 Post Dose 2 Post Dose 3
7.5%
9.8%
16.1%
9.8%
6.9%
22.4%
8.6%
3.4%
9.8%
3.4% 3.4%
16.7%
7.1%
3.0%
7.7%
3.0% 3.0%
12.5%
0.0%
10.0%
20.0%
30.0%
40.0%
50.0%
60.0%
70.0%
80.0%
90.0%
100.0%
Fever Vomiting Abnormal
Crying
Drowsiness Loss of
appetite
Irritability
Post Dose 1 Post Dose 2 Post Dose 3
54.6% experienced at least 1 solicited
systemic reaction.
Most frequently reported systemic
reaction was irritability (36.2%)
19.0% of subjects reported fever ; no
Grade 3 fever reported
Injection site reactions
37.9% experienced at least 1 solicited
injection site reaction, most frequent being
tenderness (30.5%).
2.9% of subjects reported Grade 3 reactions
The incidence lowered with successive
doses with no Grade 3 reaction reported
after the third dose
Systemic reactions
23. Safety in primary and booster series
Key points
Better tolerated than wP-based combination vaccines
Comparable to other licensed aP-based combination
vaccines (PENTAXIM®, Infanrix Hexa)
The safety and reactogenicity - not affected by the
administration of hepatitis B vaccine at birth
* Infanrix® Hexa
25. Higher performance and safety of acellular pertussis vaccine versus
whole cell vaccine.
Acceptable efficacy in high risk adults as well.
Study provides evidence in favor of introduction of acellular vaccine in
the National Program
26. HB vaccination at birth, then comparing immunogenicity and safety of
Hexaxim at 2, 4, 6 months of age v/s Pentaxim at 2, 4, 6 months &
standalone HB vaccine at 1 and 6 months.
4 consecutive doses of HB-containing vaccine in the Hexaxim group
(i.e. birth, 2, 4, 6 months) versus three HB-containing vaccine doses
in the Pentaxim and HB group (i.e. birth, 1, 6 months).
Hexaxim at 2, 4, 6 months induced anti-HB seroprotective titers that
were slightly higher than following monovalent HB vaccine at 0, 1, 6
month, with no difference in reactogenicity.
http://dx.doi.org/10.1016/j.vaccine.2017.05.062
28. WHO position paper on Hepatitis B
2017
The birth dose should be followed by 2 or 3 additional doses to complete
the primary series.
Both of the following options are considered appropriate:
(i) a 3-dose schedule - birth dose + first and third doses of DTP-containing
vaccine; OR
(ii) a 4 dose schedule - birth dose + 3 doses, usually given with other routine
infant vaccines; NO HARM. The interval between doses should be at least
4 weeks.
There are no differences in the seroprotection outcomes (anti-HBs
antibody concentrations, seroprotection rates of vaccinees) of schedules
with intervals of 1, 2, or 5 months between primary doses.
Longer intervals between doses appear to increase the final anti-HBs
antibody concentrations, but not the seroconversion rates
7 JULY 2017, 92th YEAR / 7 JUILLET 2017, 92e ANNÉE No 27, 2017, 92, 369–392
32. Hepatitis B antigen: Source
Produced using the patented Hansenula
polymorpha yeast expression system:
● Consistent high quality and reliable supply
● No need for methanol as solvent (used with
other yeast expression system)5
Manufactured and controlled in Sanofi
Pasteur’s state-of-the-art facility in Argentina
● Completely dedicated to this new hepatitis B
antigen
Produced exclusively for use in HEXAXIM®
[5] Celik. Biotechnol Adv, 2012;30(5) [6] Shouval. J Hepatol, 2003;39(Suppl1)