1) Herpes simplex virus type 1 and 2 are common viruses that cause infections both above and below the waist. They establish latent infections in sensory ganglia.
2) Primary HSV infections typically cause oral lesions and gingivostomatitis with symptoms like fever and pain. Recurrent infections can be triggered by factors like stress and menstruation, causing lesions like recurrent herpes labialis.
3) HSV infections in immunocompromised patients can cause large, painful ulcers over nonkeratinized sites that may disseminate without treatment. Diagnosis involves virus culture, PCR, or biopsy while management focuses on antiviral therapy.
AIDS is defined as a condition indicative of a defect in cell-mediated immunity occurring in a person with no known cause for immunodeficiency other than the presence of HIV.
CDC defined AIDS as
“The occurrence of one or more group of life-threatening opportunistic infections, malignancies, neurologic diseases and other specific illness in patients with HIV infection or with CD4 counts less than 200/cu mm”
AIDS is defined as a condition indicative of a defect in cell-mediated immunity occurring in a person with no known cause for immunodeficiency other than the presence of HIV.
CDC defined AIDS as
“The occurrence of one or more group of life-threatening opportunistic infections, malignancies, neurologic diseases and other specific illness in patients with HIV infection or with CD4 counts less than 200/cu mm”
the most common viral infections that affects the maxillofacial area
sources( burket's oral medicine 11th ed,oral and maxillofacial pathology neville 2e )
Tuberculosis is a disease characterized by granulomatous lesions caused by Mycobacterium Tuberculosis. A German scientist Robert Koch discovered the causative organism of TB in 1882.
Since time immemorial, it has been a global health problem. TB has shown a decline in its prevalence globally; however, it is still highly prevalent in Asian countries.
TB is usually overlooked in the differential diagnosis of oral lesions as it is supposed to be a rare entity.
Oral manifestations of TB occur either due to infected sputum or due to hematogenous spread.
TB is an age old disease and has been known to mankind for thousands of years.
PULP POLYP
CHORNIC HYPERPLASTIC PULPITIS
PROLIFERATIVE PULPITIS
It’s a type of irreversible pulpitis
It is a pulpal inflammation due to an extensive carious exposure of young pulp.
Its characterized by the development of granulation tissue, covered by epithelium & resulting from long standing, low grade irritation.
Majority of HIV infected individuals show oral manifestations of infection. Early diagnosis and treatment will improve the lifespan of HIV infected individuals.
the most common viral infections that affects the maxillofacial area
sources( burket's oral medicine 11th ed,oral and maxillofacial pathology neville 2e )
Tuberculosis is a disease characterized by granulomatous lesions caused by Mycobacterium Tuberculosis. A German scientist Robert Koch discovered the causative organism of TB in 1882.
Since time immemorial, it has been a global health problem. TB has shown a decline in its prevalence globally; however, it is still highly prevalent in Asian countries.
TB is usually overlooked in the differential diagnosis of oral lesions as it is supposed to be a rare entity.
Oral manifestations of TB occur either due to infected sputum or due to hematogenous spread.
TB is an age old disease and has been known to mankind for thousands of years.
PULP POLYP
CHORNIC HYPERPLASTIC PULPITIS
PROLIFERATIVE PULPITIS
It’s a type of irreversible pulpitis
It is a pulpal inflammation due to an extensive carious exposure of young pulp.
Its characterized by the development of granulation tissue, covered by epithelium & resulting from long standing, low grade irritation.
Majority of HIV infected individuals show oral manifestations of infection. Early diagnosis and treatment will improve the lifespan of HIV infected individuals.
seminar briefly covers the oral findings and treatment related to hsv virus like erythema multiforme, SJS, Varicella zoster, epstein barr virus, infectious mononucleosis
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
3. HSV-1, HSV-2
an α-herpesvirus
is a ubiquitous virus, and 65% of adults in the United States older than age 70
are seropositive for it.
In general, infections above the waist are caused by HSV-1
below the waist by HSV-2
with changing sexual practices, it is not uncommon to culture HSV-2 from oral
lesions and vice versa.
The primary infection, which occurs on initial contact with the virus, is acquired
by inoculation of the mucosa, skin, and eye with infected secretions.
The virus then travels along the sensory nerve axons and establishes chronic,
latent infection in the sensory ganglion (such as the trigeminal ganglion).4
4. ➤ The most common sites of infection are the oral and genital
mucosa and the eye.
➤ HSV infection of the cornea (keratitis) is a major cause of
blindness in the world.
➤ HSV-1 or -2 may cause herpes whitlow, an infection of the
fingers when virus is inoculated into the fingers through a
break in the skin.
5. ➤ herpes gladiatorum (infections of the skin spread through the
sport of wrestling)
➤ herpes encephalitis,
➤ HSV esophagitis,
➤ HSV pneumonia
➤ neonatal and disseminated infection.
➤ HSV is an important etiologic agent in erythema multi- forme
➤ HSV has been recovered in the endoneurial fluid of 77% of
patients with Bell palsy.
6. CLINICAL MANIFESTATIONS
1) PRIMARY GINGIVOSTOMATITIS
generally occur in children and teenagers and young adults
There is a one to three day viral prodrome of
fever loss of appetite
malaise myalgia
that may also be accompanied by headache and nausea.
Oral pain leads to poor oral intake, and patients may require
hospitalization for hydration.
The disease is self-limiting in otherwise normal patients and resolves
within 10–14 days, typical for a viral illness.
7. ORAL FINDINGS
Within a few days of the prodrome, erythema and clusters of vesicles
and/or ulcers appear
keratinized mucosa of the hard palatal mucosa, attached gingiva and
dorsum of the tongue
nonkeratinized mucosa of the buccal and labial mucosa, ventral tongue,
and soft palate.
Vesicles break rapidly down to form ulcers that are usually 1–5 mm and
coalesce to form larger ulcers with scalloped borders and marked
surrounding erythema.
The gingiva is often erythematous, and the mouth is extremely painful,
causing difficulty with eating.
Pharyngitis causes swallowing difficulties.
8.
9. CLINICAL MANIFESTATIONS
2) RECRUDESCENT ORAL HSV
INFECTION
Reactivation of HSV may lead to asymptomatic shedding of HSV,
in the saliva and other secretions, an important risk factor for
transmission; it may also cause ulcers to form.
Asymptomatic shedding of HSV is not associated with sys-
temic signs and symptoms and occurs in 8%–10% of patients
following dental treatment.
important triggers for reactivation of HSV.
Fever ultraviolet radiation
trauma,stress menstruation
10. Recrudescent HSV on the lips is called recurrent herpes labialis
(RHL)
occurs in 20%–40% of the young adult population.
prodrome of itching, tingling, or burning approximately 50% of
the time, followed in succession by the appearance of papules,
vesicles, ulcers, crusting, and then resolution of lesions.
Pain is generally present only within the first two days.
One common presentation is the complaint of pain in the
gingiva one to two days after a scaling and prophylaxis or
other dental treatment. Lesions appear as 1–5 mm painful
vesicles but more often ulcers on the marginal gingiva.
11.
12. CLINICAL MANIFESTATIONS
3( HSV IN IMMUNOCOMPROMISED
PATIENTS
occur at any site intraorally and may form ulcers that may be several
centimeters in size and may last several weeks or months if
undiagnosed and untreated.
These ulcers are painful and similar to those seen in immunocompetent
patients except that they may be larger and often occur on
nonkeratinized sites. They appear slightly depressed with raised
borders.
The presence of 1–2 mm vesicles or satellite ulcers at the edges of the
main ulcer is a helpful sign.
If undiagnosed and left untreated, RIH infection may disseminate to other
sites and cause severe infections.
13.
14. DIFFERENTIAL DIAGNOSIS
1-CV infections (especially [HFM] disease) but ulcers are not clustered and
generalized gingival inflammation usually is not present. A viral culture or a
cytology smear identifies HSV.
2-NUG , but there is usually a precipitating cause, such as fever or dental treatment.
Cultures are positive for HSV, and lesions of NUG are widespread and diffuse rather
than localized, as is often seen in RIH.
3-Traumatic ulcers on the palatal mucosa (from pizza burns) may resemble RIH.
in immunocompromised hosts
4-can be differentiated from aphthous ulcers when necessary with a cytology
specimen or culture.
5- CMV infection, fungal infection, and neutropenia must also be
considered.biopsy, culture, and blood tests.
6-Erythema multiforme, often triggered by a prior HSV infection may appear as
multiple, coalescent ulcers.
15. LABORATORY DIAGNOSIS
1- HSV isolation by cell culture is the gold standard test. high
sensitivity and specificity it needs specialized equipment, is
expensive
2- PCR from swabs has been shown to detect HSV antigen three to
four times more often than culture
3- scrapings from the base of lesions. These can be stained with
Wright, Giemsa or Papanicolaou
4-serology alone to diagnose recurrent infection is not advised.
5- HSV lesions are not generally biopsied However, if a scraping or
biopsy is obtained, it will show the presence of multinucleated giant
epithelial cells at the edge of the ulcer.
16. MANAGEMENT PRIMARY HSV
INFECTION
Management is directed
pain control
supportive care
definitive treatment.
The use of acyclovir at 15 mg/kg
five times reduces the duration of fever,
reduces HSV shedding, halts the progress of lesions, improves oral
intake, and reduces the incidence of hospital admissions.
Valacyclovir
famciclovir
17. RECRUDESCENT HSV
RHL can often be suppressed by reducing tissue damage,using sunscreen.
Topical antiviral medications
5% acyclovir cream
1% penciclovir cream
10% docosanol cream
five to eight times a day at the first prodrome or sign of a lesion.
Systemic therapy
valacyclovir (2 g every 12 hours for one day)
famciclovir (1500 mg single dose)
intraoral lesions
500–1000 mg valacyclovir three times a day
400–800 mg of acyclovir for 7–10 days.
18. HSV IN IMMUNOCOMPROMISED
PATIENTS
treated with systemic antivirals to prevent dissemination to
other sites.
Acyclovir-resistant HSV is most frequently seen in this group of
patients, In such cases, foscarnet or cidofovir is effective.
The dosage of the acyclovir family of drugs should be adjusted
for age and renal health.