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WHAT ARE HERBS
 Herbs are any plants used for food, flavoring,
medicine, or fragrances for their savory or aromatic
properties. Culinary use typically distinguishes herbs
from spices.
 Herbs refers to the leafy green or flowering parts of a
plant (either fresh or dried), while spices are
produced from other parts of the plant (usually
dried), including seeds, berries, bark, roots and fruits.
HERBS
• Herbs have a variety of uses including culinary,
medicinal, and in some cases, spiritual. General usage
of the term "herb" differs between culinary herbs
and medicinal herbs. In medicinal or spiritual use any
of the parts of the plant might be considered "herbs",
including leaves, roots, flowers, seeds, root bark,
inner bark (and cambium), resin and pericarp.
• Large amounts of these herbs may lead to toxic
overload that may involve complications, some of a
serious nature, and should be used with caution.
Complications can also arise when being taken with
some prescription medicines.
WHAT ARE MEDICINAL PLANT
• Medicinal plants are plants that have a recognized
medical use.
• Their use ranges the production of mainstream
pharmaceutical products to herbal medicine
preparations.
• Herbal medicine is one of the oldest forms of medical
treatment in human history and could be considered
one of the forerunners of the modern pharmaceutical
trade.
DEFINITION of HERBAL MEDICINE
 The art or practice of using herbs and herbal
preparations to maintain health and to prevent, alleviate,
or cure disease.
• A plant or plant part or an extract or mixture of these
used in herbal medicine.
HERBAL MEDICINE
 Herbal medicinal products are defined as any
medicinal product, exclusively containing as active
ingredients one or more herbal substances, one or
more herbal preparations, or a combination of the
two.
CLASSIFICATION OF HERBAL
PRODUCTS
• Generally, herbal products are classified as medicinal
products if they claim therapeutic or prophylactic
indication, and are not considered as medicinal products
when they do not make these claims.
• Products not classified as medicinal in most cases belong
to the food or cosmetic areas, although they sometimes
contain plants which have pharmacological properties.
• .
• For example, senna pods (from Cassia plants, used
as laxatives) can be marketed as food in Belgium.
• Specific categories of non-medicinal products exist
in some Member States, such as the so-called
‘therapeutic supplement products’ in Austria.
• In Ireland, Spain and the United Kingdom, there
exist preparations defined as medicinal products,
which are under specific conditions exempt from
licensing requirements
Herbal Medicinal Products
Herbal medicinal products are medicinal products where
the active ingredient consists exclusively of herbal
substances or herbal preparations. Herbal medicinal
products are covered by Directive 2001/83/EC on the
Community code relating to medicinal products for
human use ("Directive on human medicinal products")
and Directive 2001/82/EC on the Community code
relating to veterinary medicinal products ("Directive on
veterinary medicinal products)."
DEFINITIONS
The term herbal substance denotes whole or parts of
plants, algae, fungi and lichens. The material is usually
dried but sometimes fresh, and is defined by
specifying the species' full scientific name and the
plant part used. Herbal preparations, such as powders,
extracts, distillates and press juices, are products
obtained by processing herbal substances. The
complete definitions can be found in the MPA’s
provisions (LVFS 2006:3) on traditional herbal
medicinal products for human use, or in Directive
2001/83/EC.
HERBAL DRUG PREPARATION
The various herbal drug preparations are :
 Extracts
 Prepared drugs
 Herbal Tea
SOURCES OF HERBS
Culinary herbs
Medicinal herbs
Sacred herbs
Herbal cosmetics
CULINARY HERBS
 Culinary herbs are probably the most useful to herb gardeners,
having a wide range of uses in cooking.
 These herbs, because of their strong flavors, are generally
used in small quantities to add flavor. Parsley, produced in the
largest amount, is used mostly as a garnish.
 Other popular culinary herbs include chives, thyme, savory,
marjoram, mint, and basil.
Example of Culinary herbs
MEDICINAL HERBS
 Medicinal plants, also called medicinal herbs, have been discovered
and used in traditional medicine practices since prehistoric
times. Plants synthesise hundreds of chemical compounds for
functions including defence against insects, fungi, diseases,
and herbivorous mammals.
 Numerous phytochemicals with potential or established biological
activity have been identified. However, since a single plant contains
widely diverse phytochemicals, the effects of using a whole plant as
medicine are uncertain.
 Further, the phytochemical content and pharmacological actions, if
any, of many plants having medicinal potential remain un assessed by
rigorous scientific research to define efficacy and safety.
Herbal cosmetics
 The word cosmetic was derived from the Greek word“kosm
tikos” meaning having the power, arrange, skill in
decorating .he origin of cosmetics forms a continuous
narrative throughout the history of man as they developed.
 Herbal Cosmetics, here in after referred as Products, are
formulated, using various permissible cosmetic ingredients
to form the base in which one or more herbal ingredients
are used to provide defined cosmetic benefits only, shall be
called as “Herbal Cosmetics.
 The herbal cosmetics are the preparations containing
phytochemical from a variety of botanical sources, which
influences the functions of skin and provide nutrients necessary
for the healthy skin or hair.
 The natural herbs and their products when used for their
aromatic value in cosmetic preparation are termed as herbal
cosmetics
 The increased demand for the natural product has created new
avenues in cosmeceutical market.
 The legal requirement and the regulatory procedures for herbal
cosmetics are same as that for other chemical ingredients used
in cosmetic formulations
EXAMPLE OF HERBAL COSMETICS
SACRED HERBS
 Herbs are used in many religions – such as
in Christianity (myrrh (Commiphora myrrha), ague root (Aletris
farinosa) and frankincense (Boswellia spp)).
 In Hinduism a form of basil called Tulsi is worshipped as
a goddess for its medicinal value since the Vedic times. Many
Hindus have a Tulsi plant in front of their houses.
SELECTION / IDENTIFICATION AND
AUTHENTIFICATION
 Where applicable, the species or botanical variety selected for
cultivation should be the same as that specified in the national
pharmacopoeia or recommended by other authoritative national
documents of the end-user's country.
 In the absence of such national documents, the selection of species
or botanical varieties specified in the pharmacopoeia or other
authoritative documents of other countries should be considered.
 In the case of newly introduced medicinal plants, the species or
botanical variety selected for cultivation should be identified and
documented as the source material used or described in traditional
medicine of the original country.
PROCESSING OF CRUDE DRUG
 COLLECTION OF DRUGS
• Medicinal plant materials should be collected during the appropriate
season or time period to ensure the best possible quality of both source
materials and finished products.
•It is well known that the quantitative concentration of biologically active
constituents varies with the stage of plant growth and development.
•The best time for collection (quality peak season or time of day) should
be determined according to the quality and quantity of biologically active
constituents rather than the total vegetative yield of the targeted medicinal
plant parts.
•In general, the collected raw medicinal plant materials should not come
into direct contact with the soil. If underground parts (such as the roots)
are used, any adhering soil should be removed from the plants as soon as
they are collected.
•Collected material should be placed in clean baskets, mesh bags, other
well aerated containers.
 After collection, the raw medicinal plant materials may be subjected to
appropriate preliminary processing, including elimination of undesirable
materials and contaminants, washing (to remove excess soil), sorting and
cutting.
•The collected medicinal plant materials should be protected from insects,
rodents, birds and other pests, and from livestock and domestic animals. •If
the collection site is located some distance from processing facilities, it may
be necessary to air or sun-dry the raw medicinal plant materials prior to
transport.
•If more than one medicinal plant part is to be collected, the different plant
species or plant materials should be gathered separately and transported in
separate containers. Cross-contamination should be avoided at all times.
•Collecting implements, such as machetes, shears, saws and mechanical
tools, should be kept clean and maintained in proper condition.
•Those parts that come into direct contact with the collected medicinal
plant materials should be free from excess oil and other contamination.
HARVESTING
• Medicinal plants should be harvested during the optimal season or time
period to ensure the production of medicinal plant materials and
finished herbal products of the best possible quality.
•Care should be taken to ensure that no foreign matter, weeds or toxic
plants are mixed with the harvested medicinal plant materials.
•Medicinal plants should be harvested under the best possible
conditions, avoiding dew, rain or exceptionally high humidity.
•If harvesting occurs in wet conditions, the harvested material should
be transported immediately to an indoor drying facility so as to prevent
any possible deleterious effects due to increased moisture levels, which
promote microbial fermentation.
•Cutting devices, harvesters, and other machines should be kept clean
and adjusted to reduce damage and contamination from soil and other
materials.
 If the underground parts (such as the roots) are used, any adhering
soil should be removed from the medicinal plant materials as soon
as they are harvested.
 The harvested raw medicinal plant materials should be transported
promptly in clean, dry conditions they may be placed in clean
baskets, dry sacks, trailers, hoppers or other well-aerated containers
and carried to a central point for transport to the processing facility.
 All containers used at harvest should be kept clean and free from
contamination by previously harvested medicinal plants and other
foreign matter.
 When containers are not in use, they should be kept in dry
conditions, in an area that is protected from insects, rodents, birds
and other pests, and domestic animals.
 Decomposed medicinal plant materials should be identified and
discarded during harvest, post-harvest inspections and processing,
in order to avoid microbial contamination and loss of product
quality.
The following general rules for collection of crude drugs:
• Roots and rhizomes are collected at the end of the vegetation period,
i.e. usually in the autumn.
• In most cases they must be washed free of adhering soil and sand. Bark
is collected in the spring.
• Leaves and herbs are collected at the flowering stage. Flowers are
usually gathered when fully developed. Fruits and seeds are collected
when fully ripe.
Methods of collection
• Medicinal plants must be largely collected by hand.
• With cultivation on a large scale, it may be possible to use modern
agricultural harvesters, but in many cases, e.g. barks, manual collection
is unavoidable. Thus, the cost of drug production is largely the cost of the
labor involved.
As per WHO Guidelines
1. Medicinal plants/herbal drugs should be harvested when they are at the best
possible quality for the proposed use.
2. Damaged plants or parts plants need to be excluded.
3. Medicinal plants/herbal drugs should be harvested under the best possible
conditions avoiding wet soil, dew, rain or exceptionally high air humidity. If
harvesting occurs in wet conditions possible adverse effects on the medicinal
plant/herbal drug due to increased moisture levels should be counteracted.
4. Cutting devices or harvesters must be adjusted such that contamination from
soil particles is reduced to a minimum. 5. The harvested medicinal
plant/herbal drug should not come into direct contact with the soil. It must
be promptly collected and transported in dry, clean conditions.
6. During harvesting, care should be taken to ensure that no toxic weeds mix
with harvested medicinal plants/herbal drugs.
7. All containers used during harvesting must be clean and free of
contamination from previous harvests. When containers are not in use, they
must be kept in dry conditions free of pests and inaccessible to mice/rodents,
livestock and domestic animals.
8. Mechanical damage and compacting of the harvested medicinal plant/herbal
drug that would result in undesirable quality changes must be avoided.
9. Freshly harvested medicinal plants/herbal drugs must be delivered as quickly
as possible to the processing facility in order to prevent thermal degradation.
10. The harvested crop must be protected from pests, mice/rodents, livestock
and domestic animals. Any pest control measures taken should be documented.
DRYING
 When medicinal plant materials are prepared for use in dry
form, the moisture content of the material should be kept as
low as possible in order to reduce damage from mould and
other microbial infestation. Medicinal plants can be dried in a
number of ways
1. In the open air (shaded from direct sunlight)
2. Placed in thin layers on drying frames, wire-screened
rooms or buildings.
3. By direct sunlight, if appropriate.
4. In drying ovens/rooms and solar dryers.
5. By indirect fire; baking; lyophilization; microwave; or
infrared devices.
6. Vacuum drying
7. Spray dryer: Examples: Papaya latex and pectin’s, etc.
The most common method for preserving plant material is drying.
 Enzymatic processes take place in aqueous solution. Rapid removal of the water
from the cell will, therefore, largely prevent degradation of the cell constituents.
•Drying also decreases the risk of external attack, e.g. by moulds. leaves may
contain 60-90% water, roots and rhizomes 70-85%,and wood 40-50%. The lowest
percentage, often no more than 5-10%, is found in seeds.
To stop the enzyme processes, the water content must be brought to about 10 %.
The plant material is spread out on shallow trays, which are placed on mobile
racks and passed into a tunnel where they meet a stream of warm air.
The air temperature is kept at 20-40 °C for thin materials such as leaves, but is
often raised to 60-70 °C for plant parts that are harder to dry, e.g. roots and barks.
 When the crude drug has been collected under primitive conditions, without
access to a drier, it must be dried in the open.
STORAGE OF CRUDE DRUGS
1.Storage facilities for medicinal material should be well aerated, dry
and protected from light, and, when necessary, be supplied with air-
conditioning and Humidity control equipment as well as facilities to
protect against rodents, insects.
2. The floor should be tidy, without cracks and easy to clean. Medicinal
material should be stored on shelves which keep the material a
sufficient distance from the walls; measures should be taken to prevent
the occurrence of pest infestation.
3. Continuous in-process quality control measures should be
implemented to eliminate substandard materials, contaminants and
foreign matter prior to and during the final stages of packaging.
4. Processed medicinal plant materials should be packaged in clean,
dry boxes, sacks, bags or other containers in accordance with standard
operating procedures and national and/or regional regulations of the
producer and the end-user countries.
5. Materials used for packaging should be non-polluting, clean, dry and
in undamaged condition and should conform to the quality
requirements for the medicinal plant materials concerned. Fragile
medicinal plant materials should be packaged in rigid containers.
6. Dried medicinal plants/herbal drugs, including essential oils, should
be stored in a dry, well-aerated building, in which daily temperature
fluctuations are limited and good aeration is ensured
7. Fresh medicinal plant materials should be stored at appropriate low
temperatures, ideally at 2-8°C; frozen products should be stored at less
than -20°C.
8. Small quantity of crude drugs could be readily stored in air tight,
moisture proof and light proof container such as tin, cans, covered
metal tins or amber glass containers.
9. Wooden boxes and paper bags should not be used for storage of
crude drugs.
PRESERVATION OF PLANT MATERIAL
The plant material must first be preserved so that the
active compounds will remain unchanged during
transport and storage. The cells of living plants
contain not only low molecular-weight compounds
and enzymes, but they also have many kinds of
barriers that keep these constituents apart. When the
plant dies, the barriers are quickly broken down and
the enzymes then get the opportunity to promote
various chemical changes in the other cell
constituents, e.g. by oxidation or hydrolysis.

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Herbs as raw materials.ppt

  • 1.
  • 2. WHAT ARE HERBS  Herbs are any plants used for food, flavoring, medicine, or fragrances for their savory or aromatic properties. Culinary use typically distinguishes herbs from spices.  Herbs refers to the leafy green or flowering parts of a plant (either fresh or dried), while spices are produced from other parts of the plant (usually dried), including seeds, berries, bark, roots and fruits.
  • 3. HERBS • Herbs have a variety of uses including culinary, medicinal, and in some cases, spiritual. General usage of the term "herb" differs between culinary herbs and medicinal herbs. In medicinal or spiritual use any of the parts of the plant might be considered "herbs", including leaves, roots, flowers, seeds, root bark, inner bark (and cambium), resin and pericarp. • Large amounts of these herbs may lead to toxic overload that may involve complications, some of a serious nature, and should be used with caution. Complications can also arise when being taken with some prescription medicines.
  • 4. WHAT ARE MEDICINAL PLANT • Medicinal plants are plants that have a recognized medical use. • Their use ranges the production of mainstream pharmaceutical products to herbal medicine preparations. • Herbal medicine is one of the oldest forms of medical treatment in human history and could be considered one of the forerunners of the modern pharmaceutical trade.
  • 5. DEFINITION of HERBAL MEDICINE  The art or practice of using herbs and herbal preparations to maintain health and to prevent, alleviate, or cure disease. • A plant or plant part or an extract or mixture of these used in herbal medicine.
  • 6. HERBAL MEDICINE  Herbal medicinal products are defined as any medicinal product, exclusively containing as active ingredients one or more herbal substances, one or more herbal preparations, or a combination of the two.
  • 7. CLASSIFICATION OF HERBAL PRODUCTS • Generally, herbal products are classified as medicinal products if they claim therapeutic or prophylactic indication, and are not considered as medicinal products when they do not make these claims. • Products not classified as medicinal in most cases belong to the food or cosmetic areas, although they sometimes contain plants which have pharmacological properties. • .
  • 8. • For example, senna pods (from Cassia plants, used as laxatives) can be marketed as food in Belgium. • Specific categories of non-medicinal products exist in some Member States, such as the so-called ‘therapeutic supplement products’ in Austria. • In Ireland, Spain and the United Kingdom, there exist preparations defined as medicinal products, which are under specific conditions exempt from licensing requirements
  • 9. Herbal Medicinal Products Herbal medicinal products are medicinal products where the active ingredient consists exclusively of herbal substances or herbal preparations. Herbal medicinal products are covered by Directive 2001/83/EC on the Community code relating to medicinal products for human use ("Directive on human medicinal products") and Directive 2001/82/EC on the Community code relating to veterinary medicinal products ("Directive on veterinary medicinal products)."
  • 10. DEFINITIONS The term herbal substance denotes whole or parts of plants, algae, fungi and lichens. The material is usually dried but sometimes fresh, and is defined by specifying the species' full scientific name and the plant part used. Herbal preparations, such as powders, extracts, distillates and press juices, are products obtained by processing herbal substances. The complete definitions can be found in the MPA’s provisions (LVFS 2006:3) on traditional herbal medicinal products for human use, or in Directive 2001/83/EC.
  • 11. HERBAL DRUG PREPARATION The various herbal drug preparations are :  Extracts  Prepared drugs  Herbal Tea
  • 12. SOURCES OF HERBS Culinary herbs Medicinal herbs Sacred herbs Herbal cosmetics
  • 13. CULINARY HERBS  Culinary herbs are probably the most useful to herb gardeners, having a wide range of uses in cooking.  These herbs, because of their strong flavors, are generally used in small quantities to add flavor. Parsley, produced in the largest amount, is used mostly as a garnish.  Other popular culinary herbs include chives, thyme, savory, marjoram, mint, and basil.
  • 15. MEDICINAL HERBS  Medicinal plants, also called medicinal herbs, have been discovered and used in traditional medicine practices since prehistoric times. Plants synthesise hundreds of chemical compounds for functions including defence against insects, fungi, diseases, and herbivorous mammals.  Numerous phytochemicals with potential or established biological activity have been identified. However, since a single plant contains widely diverse phytochemicals, the effects of using a whole plant as medicine are uncertain.  Further, the phytochemical content and pharmacological actions, if any, of many plants having medicinal potential remain un assessed by rigorous scientific research to define efficacy and safety.
  • 16. Herbal cosmetics  The word cosmetic was derived from the Greek word“kosm tikos” meaning having the power, arrange, skill in decorating .he origin of cosmetics forms a continuous narrative throughout the history of man as they developed.  Herbal Cosmetics, here in after referred as Products, are formulated, using various permissible cosmetic ingredients to form the base in which one or more herbal ingredients are used to provide defined cosmetic benefits only, shall be called as “Herbal Cosmetics.
  • 17.  The herbal cosmetics are the preparations containing phytochemical from a variety of botanical sources, which influences the functions of skin and provide nutrients necessary for the healthy skin or hair.  The natural herbs and their products when used for their aromatic value in cosmetic preparation are termed as herbal cosmetics  The increased demand for the natural product has created new avenues in cosmeceutical market.  The legal requirement and the regulatory procedures for herbal cosmetics are same as that for other chemical ingredients used in cosmetic formulations
  • 18. EXAMPLE OF HERBAL COSMETICS
  • 19. SACRED HERBS  Herbs are used in many religions – such as in Christianity (myrrh (Commiphora myrrha), ague root (Aletris farinosa) and frankincense (Boswellia spp)).  In Hinduism a form of basil called Tulsi is worshipped as a goddess for its medicinal value since the Vedic times. Many Hindus have a Tulsi plant in front of their houses.
  • 20. SELECTION / IDENTIFICATION AND AUTHENTIFICATION  Where applicable, the species or botanical variety selected for cultivation should be the same as that specified in the national pharmacopoeia or recommended by other authoritative national documents of the end-user's country.  In the absence of such national documents, the selection of species or botanical varieties specified in the pharmacopoeia or other authoritative documents of other countries should be considered.  In the case of newly introduced medicinal plants, the species or botanical variety selected for cultivation should be identified and documented as the source material used or described in traditional medicine of the original country.
  • 21. PROCESSING OF CRUDE DRUG  COLLECTION OF DRUGS • Medicinal plant materials should be collected during the appropriate season or time period to ensure the best possible quality of both source materials and finished products. •It is well known that the quantitative concentration of biologically active constituents varies with the stage of plant growth and development. •The best time for collection (quality peak season or time of day) should be determined according to the quality and quantity of biologically active constituents rather than the total vegetative yield of the targeted medicinal plant parts. •In general, the collected raw medicinal plant materials should not come into direct contact with the soil. If underground parts (such as the roots) are used, any adhering soil should be removed from the plants as soon as they are collected. •Collected material should be placed in clean baskets, mesh bags, other well aerated containers.
  • 22.  After collection, the raw medicinal plant materials may be subjected to appropriate preliminary processing, including elimination of undesirable materials and contaminants, washing (to remove excess soil), sorting and cutting. •The collected medicinal plant materials should be protected from insects, rodents, birds and other pests, and from livestock and domestic animals. •If the collection site is located some distance from processing facilities, it may be necessary to air or sun-dry the raw medicinal plant materials prior to transport. •If more than one medicinal plant part is to be collected, the different plant species or plant materials should be gathered separately and transported in separate containers. Cross-contamination should be avoided at all times. •Collecting implements, such as machetes, shears, saws and mechanical tools, should be kept clean and maintained in proper condition. •Those parts that come into direct contact with the collected medicinal plant materials should be free from excess oil and other contamination.
  • 23. HARVESTING • Medicinal plants should be harvested during the optimal season or time period to ensure the production of medicinal plant materials and finished herbal products of the best possible quality. •Care should be taken to ensure that no foreign matter, weeds or toxic plants are mixed with the harvested medicinal plant materials. •Medicinal plants should be harvested under the best possible conditions, avoiding dew, rain or exceptionally high humidity. •If harvesting occurs in wet conditions, the harvested material should be transported immediately to an indoor drying facility so as to prevent any possible deleterious effects due to increased moisture levels, which promote microbial fermentation. •Cutting devices, harvesters, and other machines should be kept clean and adjusted to reduce damage and contamination from soil and other materials.
  • 24.  If the underground parts (such as the roots) are used, any adhering soil should be removed from the medicinal plant materials as soon as they are harvested.  The harvested raw medicinal plant materials should be transported promptly in clean, dry conditions they may be placed in clean baskets, dry sacks, trailers, hoppers or other well-aerated containers and carried to a central point for transport to the processing facility.  All containers used at harvest should be kept clean and free from contamination by previously harvested medicinal plants and other foreign matter.  When containers are not in use, they should be kept in dry conditions, in an area that is protected from insects, rodents, birds and other pests, and domestic animals.  Decomposed medicinal plant materials should be identified and discarded during harvest, post-harvest inspections and processing, in order to avoid microbial contamination and loss of product quality.
  • 25. The following general rules for collection of crude drugs: • Roots and rhizomes are collected at the end of the vegetation period, i.e. usually in the autumn. • In most cases they must be washed free of adhering soil and sand. Bark is collected in the spring. • Leaves and herbs are collected at the flowering stage. Flowers are usually gathered when fully developed. Fruits and seeds are collected when fully ripe. Methods of collection • Medicinal plants must be largely collected by hand. • With cultivation on a large scale, it may be possible to use modern agricultural harvesters, but in many cases, e.g. barks, manual collection is unavoidable. Thus, the cost of drug production is largely the cost of the labor involved.
  • 26. As per WHO Guidelines 1. Medicinal plants/herbal drugs should be harvested when they are at the best possible quality for the proposed use. 2. Damaged plants or parts plants need to be excluded. 3. Medicinal plants/herbal drugs should be harvested under the best possible conditions avoiding wet soil, dew, rain or exceptionally high air humidity. If harvesting occurs in wet conditions possible adverse effects on the medicinal plant/herbal drug due to increased moisture levels should be counteracted. 4. Cutting devices or harvesters must be adjusted such that contamination from soil particles is reduced to a minimum. 5. The harvested medicinal plant/herbal drug should not come into direct contact with the soil. It must be promptly collected and transported in dry, clean conditions.
  • 27. 6. During harvesting, care should be taken to ensure that no toxic weeds mix with harvested medicinal plants/herbal drugs. 7. All containers used during harvesting must be clean and free of contamination from previous harvests. When containers are not in use, they must be kept in dry conditions free of pests and inaccessible to mice/rodents, livestock and domestic animals. 8. Mechanical damage and compacting of the harvested medicinal plant/herbal drug that would result in undesirable quality changes must be avoided. 9. Freshly harvested medicinal plants/herbal drugs must be delivered as quickly as possible to the processing facility in order to prevent thermal degradation. 10. The harvested crop must be protected from pests, mice/rodents, livestock and domestic animals. Any pest control measures taken should be documented.
  • 28. DRYING  When medicinal plant materials are prepared for use in dry form, the moisture content of the material should be kept as low as possible in order to reduce damage from mould and other microbial infestation. Medicinal plants can be dried in a number of ways 1. In the open air (shaded from direct sunlight) 2. Placed in thin layers on drying frames, wire-screened rooms or buildings. 3. By direct sunlight, if appropriate. 4. In drying ovens/rooms and solar dryers. 5. By indirect fire; baking; lyophilization; microwave; or infrared devices. 6. Vacuum drying 7. Spray dryer: Examples: Papaya latex and pectin’s, etc.
  • 29. The most common method for preserving plant material is drying.  Enzymatic processes take place in aqueous solution. Rapid removal of the water from the cell will, therefore, largely prevent degradation of the cell constituents. •Drying also decreases the risk of external attack, e.g. by moulds. leaves may contain 60-90% water, roots and rhizomes 70-85%,and wood 40-50%. The lowest percentage, often no more than 5-10%, is found in seeds. To stop the enzyme processes, the water content must be brought to about 10 %. The plant material is spread out on shallow trays, which are placed on mobile racks and passed into a tunnel where they meet a stream of warm air. The air temperature is kept at 20-40 °C for thin materials such as leaves, but is often raised to 60-70 °C for plant parts that are harder to dry, e.g. roots and barks.  When the crude drug has been collected under primitive conditions, without access to a drier, it must be dried in the open.
  • 30. STORAGE OF CRUDE DRUGS 1.Storage facilities for medicinal material should be well aerated, dry and protected from light, and, when necessary, be supplied with air- conditioning and Humidity control equipment as well as facilities to protect against rodents, insects. 2. The floor should be tidy, without cracks and easy to clean. Medicinal material should be stored on shelves which keep the material a sufficient distance from the walls; measures should be taken to prevent the occurrence of pest infestation. 3. Continuous in-process quality control measures should be implemented to eliminate substandard materials, contaminants and foreign matter prior to and during the final stages of packaging. 4. Processed medicinal plant materials should be packaged in clean, dry boxes, sacks, bags or other containers in accordance with standard operating procedures and national and/or regional regulations of the producer and the end-user countries.
  • 31. 5. Materials used for packaging should be non-polluting, clean, dry and in undamaged condition and should conform to the quality requirements for the medicinal plant materials concerned. Fragile medicinal plant materials should be packaged in rigid containers. 6. Dried medicinal plants/herbal drugs, including essential oils, should be stored in a dry, well-aerated building, in which daily temperature fluctuations are limited and good aeration is ensured 7. Fresh medicinal plant materials should be stored at appropriate low temperatures, ideally at 2-8°C; frozen products should be stored at less than -20°C. 8. Small quantity of crude drugs could be readily stored in air tight, moisture proof and light proof container such as tin, cans, covered metal tins or amber glass containers. 9. Wooden boxes and paper bags should not be used for storage of crude drugs.
  • 32. PRESERVATION OF PLANT MATERIAL The plant material must first be preserved so that the active compounds will remain unchanged during transport and storage. The cells of living plants contain not only low molecular-weight compounds and enzymes, but they also have many kinds of barriers that keep these constituents apart. When the plant dies, the barriers are quickly broken down and the enzymes then get the opportunity to promote various chemical changes in the other cell constituents, e.g. by oxidation or hydrolysis.