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Sandra Saju
• Inflammation of the liver.
• Causes:
INFECTIOUS
•Viral
•Bacterial
•Fungal
•Parasitic
NON-INFECTIOUS
•Drugs
•Alcohol
•Autoimmune
•Metabolic
There are 5 viruses that causes viral hepatitis:
1. HAV
2. HBV
3. HCV
4. HDV
5. HEV
HEPATITIS-B VIRUS
 DNA, Enveloped virus.
 Family : Hepadnaviridae
Genus: Orthohepadnaviridae
 Circular genome, Partial double stranded DNA.
 Replication through a RNA intermediate form by Reverse transcription .
 Replicates in Liver.
 Virion is also called Dane particle.
 HBsAg= Surface anitigen,
 HBcAg = Core protein
 HBeAg =secreted antigen
 Can cause acute or chronic infections.
https://www.evaidya.com/Health-Articles/all-
you-need-to-know-about-hepatitis-b/
Viral Factors
• Virus is labile to drying.
• Less sensitive to detergents than other enveloped viruses.
• Virus is shed during asymptomatic periods.
• 10 % of HBV cause chronic infection with potential shedding.
Disease Mechanism
• Inoculation
• Incubation period ;2 to 6 months after inoculation of virus.
• Virus goes to Liver through viremia.
• Replication in hepatocytes(within 3 days).
• Induces viremia.
• Transmitted in various body
secretions.
• Cycle repeats.
TRANSMISSION
Parenteral - Sharing of needles between drug abusers,
exposure to infected blood and various body fluids, as well as
through saliva, menstrual, vaginal, and seminal fluids.
Sexual transmission.
Perinatal – Vertical transmission from mother to child.
symptoms
WhoIs at Risk?
• Babies of mothers with chronic HBV infection.
• IV drug abusers.
• People with multiple sex partners.
• Health care personnel.
• Non-vaccinated children.
• People who receive blood transfusion or organ transplant.
• People with HIV or other STDs.
DIAGNOSIS
 Blood is tested for HBsAg and/ or HBeAg.
 Liver Ultrasound scan.
 Liver biopsy.
 Anti- HBc IgM in blood indicates recent acute
infection.
TREATMENT
There is no treatment to eliminate the virus from the body.
Acute Inflammation usually is cleared spontaneously while chronic inflammation has to
be treated to reduce risk of cirrhosis and liver cancer.
Treatments to ease the symptoms:
• Lamivudine
• Adefovir dipivoxil
• Famciclovir
Liver Transplant - A liver transplant surgery may be necessary if chronic Hepatitis B causes
severe liver damage that can lead to liver failure.
Diseased or injured liver is removed and replaced with a healthy one from a donor.
COMPLICATIONS
• Scarring of the liver (cirrhosis).
• Liver cancer.
• Liver failure. Acute liver failure is a condition in which the vital
functions of the liver shut down. When that occurs, a liver transplant
is necessary to sustain life.
• Other conditions. kidney disease, inflammation of blood vessels or
anemia.
http://www.theayurveda.org/ayurveda/herbal-medicine/herbal-remedies-cure-hepatic-
disease-liver-cirrhosis/
PREVENTION
 Active Immunization with vaccine
 Passive Immunization with HB Immunoglobulin containing HBsAb
(prepared from sera of patients who have recovered from hepatitis B).
• Use protection while having sex.
• Don't share needles.
• Wear latex or plastic gloves if you have to touch blood.
• Don't share toothbrushes or razors.
• Don't get a tattoo, or make sure that the needles used have been
cleaned properly and are sterile.
video
https://www.youtube.com/watch?v=9xSJckErbcc
REFERENCES
• Medical Microbiology, 7th edition, Murray, Rosenthal, Pfaller. [Pages ;586,593]
• http://www.slideshare.net/fabiogrubba/hepatitis-b-virus-hbv-26747359?qid=f31168f6-08c0-4e74-ace7-
185c79421d15&v=&b=&from_search=2
• http://www.who.int/mediacentre/factsheets/fs204/en/
• http://www.mayoclinic.org/diseases-conditions/hepatitis-b/basics/complications/con-20022210

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Hepatitis b

  • 2. • Inflammation of the liver. • Causes: INFECTIOUS •Viral •Bacterial •Fungal •Parasitic NON-INFECTIOUS •Drugs •Alcohol •Autoimmune •Metabolic
  • 3. There are 5 viruses that causes viral hepatitis: 1. HAV 2. HBV 3. HCV 4. HDV 5. HEV
  • 4. HEPATITIS-B VIRUS  DNA, Enveloped virus.  Family : Hepadnaviridae Genus: Orthohepadnaviridae  Circular genome, Partial double stranded DNA.  Replication through a RNA intermediate form by Reverse transcription .  Replicates in Liver.  Virion is also called Dane particle.  HBsAg= Surface anitigen,  HBcAg = Core protein  HBeAg =secreted antigen  Can cause acute or chronic infections. https://www.evaidya.com/Health-Articles/all- you-need-to-know-about-hepatitis-b/
  • 5. Viral Factors • Virus is labile to drying. • Less sensitive to detergents than other enveloped viruses. • Virus is shed during asymptomatic periods. • 10 % of HBV cause chronic infection with potential shedding.
  • 6.
  • 7. Disease Mechanism • Inoculation • Incubation period ;2 to 6 months after inoculation of virus. • Virus goes to Liver through viremia. • Replication in hepatocytes(within 3 days). • Induces viremia. • Transmitted in various body secretions. • Cycle repeats.
  • 8. TRANSMISSION Parenteral - Sharing of needles between drug abusers, exposure to infected blood and various body fluids, as well as through saliva, menstrual, vaginal, and seminal fluids. Sexual transmission. Perinatal – Vertical transmission from mother to child.
  • 10. WhoIs at Risk? • Babies of mothers with chronic HBV infection. • IV drug abusers. • People with multiple sex partners. • Health care personnel. • Non-vaccinated children. • People who receive blood transfusion or organ transplant. • People with HIV or other STDs.
  • 11. DIAGNOSIS  Blood is tested for HBsAg and/ or HBeAg.  Liver Ultrasound scan.  Liver biopsy.  Anti- HBc IgM in blood indicates recent acute infection.
  • 12. TREATMENT There is no treatment to eliminate the virus from the body. Acute Inflammation usually is cleared spontaneously while chronic inflammation has to be treated to reduce risk of cirrhosis and liver cancer. Treatments to ease the symptoms: • Lamivudine • Adefovir dipivoxil • Famciclovir Liver Transplant - A liver transplant surgery may be necessary if chronic Hepatitis B causes severe liver damage that can lead to liver failure. Diseased or injured liver is removed and replaced with a healthy one from a donor.
  • 13. COMPLICATIONS • Scarring of the liver (cirrhosis). • Liver cancer. • Liver failure. Acute liver failure is a condition in which the vital functions of the liver shut down. When that occurs, a liver transplant is necessary to sustain life. • Other conditions. kidney disease, inflammation of blood vessels or anemia.
  • 15. PREVENTION  Active Immunization with vaccine  Passive Immunization with HB Immunoglobulin containing HBsAb (prepared from sera of patients who have recovered from hepatitis B). • Use protection while having sex. • Don't share needles. • Wear latex or plastic gloves if you have to touch blood. • Don't share toothbrushes or razors. • Don't get a tattoo, or make sure that the needles used have been cleaned properly and are sterile.
  • 17. REFERENCES • Medical Microbiology, 7th edition, Murray, Rosenthal, Pfaller. [Pages ;586,593] • http://www.slideshare.net/fabiogrubba/hepatitis-b-virus-hbv-26747359?qid=f31168f6-08c0-4e74-ace7- 185c79421d15&v=&b=&from_search=2 • http://www.who.int/mediacentre/factsheets/fs204/en/ • http://www.mayoclinic.org/diseases-conditions/hepatitis-b/basics/complications/con-20022210