Hepatitis B virus (HBV) is a DNA virus that causes hepatitis B. It replicates in liver cells and can lead to both acute and chronic infections. HBV is transmitted through bodily fluids and can be spread through sexual contact, sharing needles, or from mother to child during birth. While acute HBV infection may clear spontaneously, chronic HBV requires treatment to prevent progression to cirrhosis or liver cancer. Vaccination provides effective prevention against HBV infection.