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DISEASE OF LIVER & KIDNEY
Dr Tahmasub Faraz Tayyab
BDS, FCPS (OMFS)
DISEASES OF LIVER
VIRAL HEPATITIS
Hepatitis A
28-nm RNA virus
Mode of Transmission: Fecal-oral
Diagnostic marker: Anti-HAV
Treatment: Immunoglobulin
Once treated, patient develops life time immunity
DISEASES OF LIVER
Hepatitis B
 42-nm DNA virus
 Mode Of Transmission: parenteral and sexual
contact
 Diagnostic Markers:
• Anti –HBc: (acute)
• HBsAg: (Acute/Chronic/Infectious)
• HBeAg: Infectious
• Anti-HBs: (Recovery/Immunity)
• Anti-HBcIg: Ongoing or past infection
• Treatment: Hepatitis B Immunoglobulin
DISEASES OF LIVER
Hepatitis C
 38-50-nm RNA virus
 Mode of transmission: Parentera
 Diagnostic marker: Anti-HCV, HCV RNA (PCR)
DISEASES OF LIVER
Hepatitis D
 Occurs only in patients with pre-exisiting HBV
 May cause fulminate liver failure
 Mode of Transmission: Through needles in drug
abusers
DISEASES OF LIVER
Hepatitis E
 32-nm RNA virus
 Mode of transmission: Fecal-oral
 Diagnostic Marker: Anti-HEV
 No Treatment is currently used
DISEASES OF LIVER

CHRONIC LIVER DISEASE
 Patient PT, APTT, INR and bleeding time should be
monitered
 Most Commonly drugs that are metabolized in liver
• Local anesthetic: Articaine, lidocaine,
mepivacaine, prilocaine and bupivacaine
• Analgesics: Aspirin, acetaminophen, codeine,
meperidine.
• Sedatives: Diazepam, midazolam
• Antibiotics: Ampicillin, pencillin, clindamycin,
erythromycin, tetracycline.
RENAL DISEASES
 Glomarulonephritis (nephritic syndrome)
 Nephrotic syndrome
 Acute renal failure
 Chronic renal failure
 Renal Vascular diseases
Hypertension
Heamolytic uraemic syndrome
Thrombotic thrombocytopenic purpura
 Renal tubular diseases
Renal tubular acidosis
fanconi syndrome
cystonosis
 Inherited kidney diseases
Autosomal dominant polycystic kidney disease
Autosomal recessive polycystic kidney disease
Medullay cystic disease
Alport’s syndrome
Hyperoxaluria
RENAL DISEASES
 Renal failure
Acute renal failure
Chronic renal failure
1
PATIENTS RECEIVING HAEMODIALYSIS
 Consult patient physician.
 Review patient record.
 Avoid drugs that depend on renal metabolism or
excretion.
 Do not use AV-shunt.
 Avoid use of nephrotoxic drugs.
 Defer dental care until day after dialysis.
 Consider antibiotic prophylaxis.
 Look for signs of secondary hyperparathyroidism.
 Screening for hep. B, C, HIV.
 Take necessary precaution if unable to screen.
PATIENTS WITH ORGAN TRANSPLANT
 Defer treatment until patient primary care physician
or transplant surgeon clears the patient for dental
care.
 Review patient record.
 Avoid use of nephro/ hepatotoxic drugs.
 Consider use of supplemental corticosteroids.
 Screening of hep. B,C. and HIV.
 Take necessary precautions if unable to screen.
 Watch for presence of cyclosporine induced
gingival hyperplasia. Emphasize importance of oral
hygiene.
 Consider use of prophylactic antibiotics.
CROSS INFECTION PROTOCOL
From infected patient to other patient
 Use disposable materials.
 Disinfect surfaces
A-halogen compounds
1. iodophor
2. hypochlorite(bleach)
B-aldehydes
1. formaldehyde
2. glutraldehyde
 Sterilize reuseable instrument
A- with heat
B- with ethylene oxide gas
CROSS INFECTION PROTOCOL
From infected patient to dental staff
 Learn to recognize individual likely to be carriers
 Use barrier techniques e.g. gloves, face mask , eye
protection, aprons. During surgery , when handling
contaminated objects and during clean up.
 Promptly dispose off sharp objects into well labeled
protective containers.
 Dispose of needles immediately after use or resheathe
in use instruments.
 Use an instrument to place a scalpal blade on or take
one off a blade handle.
 Ensure hep B vaccination of dental staff.
Dental management of disease of liver & kidney
Dental management of disease of liver & kidney
Dental management of disease of liver & kidney

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Dental management of disease of liver & kidney

  • 1.
  • 2. DISEASE OF LIVER & KIDNEY Dr Tahmasub Faraz Tayyab BDS, FCPS (OMFS)
  • 4. VIRAL HEPATITIS Hepatitis A 28-nm RNA virus Mode of Transmission: Fecal-oral Diagnostic marker: Anti-HAV Treatment: Immunoglobulin Once treated, patient develops life time immunity
  • 5. DISEASES OF LIVER Hepatitis B  42-nm DNA virus  Mode Of Transmission: parenteral and sexual contact  Diagnostic Markers: • Anti –HBc: (acute) • HBsAg: (Acute/Chronic/Infectious) • HBeAg: Infectious • Anti-HBs: (Recovery/Immunity) • Anti-HBcIg: Ongoing or past infection • Treatment: Hepatitis B Immunoglobulin
  • 6. DISEASES OF LIVER Hepatitis C  38-50-nm RNA virus  Mode of transmission: Parentera  Diagnostic marker: Anti-HCV, HCV RNA (PCR)
  • 7. DISEASES OF LIVER Hepatitis D  Occurs only in patients with pre-exisiting HBV  May cause fulminate liver failure  Mode of Transmission: Through needles in drug abusers
  • 8. DISEASES OF LIVER Hepatitis E  32-nm RNA virus  Mode of transmission: Fecal-oral  Diagnostic Marker: Anti-HEV  No Treatment is currently used
  • 9.
  • 11.
  • 12. CHRONIC LIVER DISEASE  Patient PT, APTT, INR and bleeding time should be monitered  Most Commonly drugs that are metabolized in liver • Local anesthetic: Articaine, lidocaine, mepivacaine, prilocaine and bupivacaine • Analgesics: Aspirin, acetaminophen, codeine, meperidine. • Sedatives: Diazepam, midazolam • Antibiotics: Ampicillin, pencillin, clindamycin, erythromycin, tetracycline.
  • 13. RENAL DISEASES  Glomarulonephritis (nephritic syndrome)  Nephrotic syndrome  Acute renal failure  Chronic renal failure  Renal Vascular diseases Hypertension Heamolytic uraemic syndrome Thrombotic thrombocytopenic purpura  Renal tubular diseases Renal tubular acidosis fanconi syndrome cystonosis  Inherited kidney diseases Autosomal dominant polycystic kidney disease Autosomal recessive polycystic kidney disease Medullay cystic disease Alport’s syndrome Hyperoxaluria
  • 14.
  • 15. RENAL DISEASES  Renal failure Acute renal failure Chronic renal failure
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  • 22. 1
  • 23. PATIENTS RECEIVING HAEMODIALYSIS  Consult patient physician.  Review patient record.  Avoid drugs that depend on renal metabolism or excretion.  Do not use AV-shunt.  Avoid use of nephrotoxic drugs.  Defer dental care until day after dialysis.  Consider antibiotic prophylaxis.  Look for signs of secondary hyperparathyroidism.  Screening for hep. B, C, HIV.  Take necessary precaution if unable to screen.
  • 24. PATIENTS WITH ORGAN TRANSPLANT  Defer treatment until patient primary care physician or transplant surgeon clears the patient for dental care.  Review patient record.  Avoid use of nephro/ hepatotoxic drugs.  Consider use of supplemental corticosteroids.  Screening of hep. B,C. and HIV.  Take necessary precautions if unable to screen.  Watch for presence of cyclosporine induced gingival hyperplasia. Emphasize importance of oral hygiene.  Consider use of prophylactic antibiotics.
  • 25. CROSS INFECTION PROTOCOL From infected patient to other patient  Use disposable materials.  Disinfect surfaces A-halogen compounds 1. iodophor 2. hypochlorite(bleach) B-aldehydes 1. formaldehyde 2. glutraldehyde  Sterilize reuseable instrument A- with heat B- with ethylene oxide gas
  • 26. CROSS INFECTION PROTOCOL From infected patient to dental staff  Learn to recognize individual likely to be carriers  Use barrier techniques e.g. gloves, face mask , eye protection, aprons. During surgery , when handling contaminated objects and during clean up.  Promptly dispose off sharp objects into well labeled protective containers.  Dispose of needles immediately after use or resheathe in use instruments.  Use an instrument to place a scalpal blade on or take one off a blade handle.  Ensure hep B vaccination of dental staff.