This white paper outlines best practices and recommendations for optimizing HDX technology with Citrix Receiver 3 and XenDesktop 5.5, highlighting over 150 enhancements designed to improve user experience over both LAN and WAN. Key features such as HDX MediaStream, real-time audio and video capabilities, and WAN optimization are discussed, along with implementations for IT administrators. The paper aims to provide practical guidelines for deploying and optimizing Citrix virtualized environments and stresses the importance of testing configurations in a non-production environment.