Paper: http://ceur-ws.org/Vol-2882/paper20.pdf YouTube: https://youtu.be/CVelQl5Luf0 Quoc-Huy Trinh, Minh-Van Nguyen, Thiet-Gia Huynh and Minh-Triet Tran : HCMUS-Juniors 2020 at Medico Task in MediaEval 2020: Refined Deep Neural Network and UNet for Polyps Segmentation. Proc. of MediaEval 2020, 14-15 December 2020, Online. The Medico: Multimedia Task focuses on developing an efficient and accurate framework to computer-aided diagnosis systems for automatic polyp segmentation to detect all types of polyps in endoscopic images of the gastrointestinal (GI) tract. We are HCMUS-team approach a solution, which includes combination Residual module, Inception module, Adaptive Convolutional neural network with Unet model and PraNet to semantic segmentation all types of polyps in endoscopic images. We submit multiple runs with different architecture and parameters in our model. Our methods show potential results in accuracy and efficiency through multiple experiments.