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Follow Atifa Ambreen:
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SUBSCRIBE ...
.
Email for inquiries: atifa.ambreen@gmail.com
Cells involved in Immunity
White blood cells, also called leukocytes, circulate throughout the body in blood and lymphatic vessels. They are stored in lymphoid organs such as the thymus, spleen, bone marrow, and lymph nodes. The main cells of the immune system are lymphocytes (T cells, B cells, NK cells), phagocytes (monocytes, macrophages), granulocytes (neutrophils, basophils, eosinophils), and dendritic cells. Lymphocytes develop from bone marrow and have roles in destroying compromised cells or producing antibodies. Phagocytes surround and destroy pathogens through phagocytosis. Granulocytes contain granules and have roles in attacking bacteria. Dendritic cells
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Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
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Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Efficacy of Avartana Sneha in Ayurveda
Avartana Sneha is a unique method of Preparation of Sneha Kalpana in Ayurveda, mainly it is indicated for the Vataja rogas.
Journal Article Review on Rasamanikya
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
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- 1. Reagents Time Xlol 30 minute 100 % alcohol 3 minute 85 % alcohol 2 minute Methylated spirit 2 minute Tap water 1 minute Hematoxylin 5-7 minute Tap water 30 sec Acid alcohol 15 sec Tap water 30 sec Ammonia water 2-3 times Tap water Few sec Eosin 3-5 minute Tap water 30 sec 50 % alcohol Dip 70& alcohol Dip 95% alcohol Dip 100% alcohol Dip xylol Mount Canada Balsom HAEMATOXYLIN & EOSIN STAIN PROCEDURE