VOGIN IP 2021 Workshop “Hoe kom ik nu aan de full-text? – Actueler dan ooit, ...Guus van den Brekel
Thuiswerken en off-campus toegang tot wetenschappelijk informatie en bibliotheekdiensten is crucialer dan ooit door Corona. Daarnaast is toegang tot tijdschriften erg prijzig en veel instituten hebben niet de middelen om een licentie op alles te nemen. Vooral organisaties buiten de academische wereld worstelen met toegang tot onderzoek. Bovendien moeten de organisaties met toegang de vraag stellen, wat zullen we doen als we plotseling de toegang tot een reeks tijdschriften verliezen omdat het abonnement is geannuleerd? Als de bibliotheek een artikel niet kan leveren, weten we dat onze gebruikers andere manieren zullen gebruiken om de pdf te krijgen. Echter, deze andere manieren bespreken we bijna nooit. Hoeveel verschillende manieren zijn er precies? Hoe werken ze? Hoe kan ik het groeiende aantal open access-artikelen -die her en der verspreid zijn over het web- op de meest efficiënte manier vinden?
Deelnemers aan de workshop leren over alle mogelijke manieren en hulpmiddelen en krijgen tips om de full-tekst te vinden van wetenschappelijke publicaties. We bespreken “best practices” van bibliotheek-tools en diensten (Linkresolvers, Discovery, LeanLibrary, LibX, Apps, etc.) en testen vooral alle alternatieve tools zoals EndNote Click (voorheen Kopernio), Unpaywall, CORE Discovery, OpenAccess-Button, LibKey Nomad, Google Scholar-Button en andere extensies of bookmarklets.
How to get the PDF-file inside and outside the collection of the library
ALL OPTIONS
(Download the PDF to make use of the clickable LINKS and IMAGES in the Infographic!)
Seminar 1 from ReachOut to Research (R2R)
Small seminar about library services supporting research & technology
Reachout to Research : library support services.
See also Seminar 2: https://www.slideshare.net/digicmb/the-user-the-technology-the-library-and-why-to-go-in-between
http://lanyrd.com/2013/r2ruit/
VOGIN IP 2021 Workshop “Hoe kom ik nu aan de full-text? – Actueler dan ooit, ...Guus van den Brekel
Thuiswerken en off-campus toegang tot wetenschappelijk informatie en bibliotheekdiensten is crucialer dan ooit door Corona. Daarnaast is toegang tot tijdschriften erg prijzig en veel instituten hebben niet de middelen om een licentie op alles te nemen. Vooral organisaties buiten de academische wereld worstelen met toegang tot onderzoek. Bovendien moeten de organisaties met toegang de vraag stellen, wat zullen we doen als we plotseling de toegang tot een reeks tijdschriften verliezen omdat het abonnement is geannuleerd? Als de bibliotheek een artikel niet kan leveren, weten we dat onze gebruikers andere manieren zullen gebruiken om de pdf te krijgen. Echter, deze andere manieren bespreken we bijna nooit. Hoeveel verschillende manieren zijn er precies? Hoe werken ze? Hoe kan ik het groeiende aantal open access-artikelen -die her en der verspreid zijn over het web- op de meest efficiënte manier vinden?
Deelnemers aan de workshop leren over alle mogelijke manieren en hulpmiddelen en krijgen tips om de full-tekst te vinden van wetenschappelijke publicaties. We bespreken “best practices” van bibliotheek-tools en diensten (Linkresolvers, Discovery, LeanLibrary, LibX, Apps, etc.) en testen vooral alle alternatieve tools zoals EndNote Click (voorheen Kopernio), Unpaywall, CORE Discovery, OpenAccess-Button, LibKey Nomad, Google Scholar-Button en andere extensies of bookmarklets.
How to get the PDF-file inside and outside the collection of the library
ALL OPTIONS
(Download the PDF to make use of the clickable LINKS and IMAGES in the Infographic!)
Seminar 1 from ReachOut to Research (R2R)
Small seminar about library services supporting research & technology
Reachout to Research : library support services.
See also Seminar 2: https://www.slideshare.net/digicmb/the-user-the-technology-the-library-and-why-to-go-in-between
http://lanyrd.com/2013/r2ruit/
Presentation made at Faculty of Political Sciences Method & Ethics meeting of the Department of Third World studies (modified with regards to feedback received)
This presentation shows some use of Scopus Analitical Tools for citation tracking, explains why Scientists and Researchers should focus more on Social Networks. It touches the subject of Library Toolbars, RSS, Personal Start Pages, Netvibes and OpenSearch Plugins
http://kulibrarians.g.hatena.ne.jp/kulibrarians/20170222
Presentation by Marta Teperek (University of Cambridge)
- Open Research 101: An Introduction for STEM PhD students (2016)
CC BY 4.0
British Library Labs Roadshow - Sussex Humanities Lablabsbl
Presentation given by Mahendra Mahey, Manager of British Library Labs on Friday 5th of May, at Sussex Humanities Lab, 2017 as part of the BL Labs Roadshow 2017
British Library Labs Roadshow 2017 at the University of Birminghamlabsbl
Presentation given by Mahendra Mahey, Manager of British Library Labs at the College of Arts and Law, the University of Birmingham on Wednesday 10th of May, 2017.
Presentation made at Faculty of Political Sciences Method & Ethics meeting of the Department of Third World studies (modified with regards to feedback received)
This presentation shows some use of Scopus Analitical Tools for citation tracking, explains why Scientists and Researchers should focus more on Social Networks. It touches the subject of Library Toolbars, RSS, Personal Start Pages, Netvibes and OpenSearch Plugins
http://kulibrarians.g.hatena.ne.jp/kulibrarians/20170222
Presentation by Marta Teperek (University of Cambridge)
- Open Research 101: An Introduction for STEM PhD students (2016)
CC BY 4.0
British Library Labs Roadshow - Sussex Humanities Lablabsbl
Presentation given by Mahendra Mahey, Manager of British Library Labs on Friday 5th of May, at Sussex Humanities Lab, 2017 as part of the BL Labs Roadshow 2017
British Library Labs Roadshow 2017 at the University of Birminghamlabsbl
Presentation given by Mahendra Mahey, Manager of British Library Labs at the College of Arts and Law, the University of Birmingham on Wednesday 10th of May, 2017.
30+ Tips on how to improve your research impact : PhD Day 2016 Talk @UMCGGuus van den Brekel
Talk on PhD-Day 2016, September 16th 2016
Together with an overview of the worldwide ranking of universities, plus an insight in the “battle” for the researcher, you will get 30+ tips on how to possibly improve your research impact.
The tips will involve practical actions to be taken before ánd after publishing your research. Scientific communication does not stop áfter publishing your research paper. Many strategies can be used to draw attention to your research, to try and improve the reach, and possibly even, the impact of it long-term. Innovations in scholarly communications, like the use of alternative (web)tools, are changing the research environment. It needs an open and more pro-active role of the researcher.
The use of research profiles, author identifiers, open access & data, social media and altmetrics, are just a few topics that will be addressed in this talk.
30+ Tips how to improve your research impact : (presentation Scientific Writing course GSMS 2017)
Together with an overview of the worldwide ranking of universities, plus an insight in the “battle” for the researcher, you will get 30+ tips on how to possibly improve your research impact.
The tips will involve practical actions to be taken before ánd after publishing your research.
Scientific communication does not stop áfter publishing your research paper. Many strategies can be used to draw attention to your research, to try and improve the reach, and possibly even, the impact of it longterm. Innovations in scholarly communications, like the use of alternative (web)tools, are changing the research environment. It needs an open and more pro-active role of the researcher.
The use of research profiles, author identifiers, open access & data, social media and altmetrics, are just a few topics that will be addressed in this talk.
30+ Tips how to improve your research impact : (presentation Kolff days 2016)
Together with an overview of the worldwide ranking of universities, plus an insight in the “battle” for the researcher, you will get 30+ tips on how to possibly improve your research impact.
The tips will involve practical actions to be taken before ánd after publishing your research.
Scientific communication does not stop áfter publishing your research paper. Many strategies can be used to draw attention to your research, to try and improve the reach, and possibly even, the impact of it longterm. Innovations in scholarly communications, like the use of alternative (web)tools, are changing the research environment. It needs an open and more pro-active role of the researcher.
The use of research profiles, author identifiers, open access & data, social media and altmetrics, are just a few topics that will be addressed in this talk.
Publication Strategy: Helping Academics to Increase the Impact of their Res...Fintan Bracken
This presentation was given at the CONUL / ANLTC Seminar "Supporting the activities of your research community – issues and initiatives" Royal Irish Academy, Dublin in December 2014.The talk looked at methods of helping researchers to improve the impact of their research.
This is a presentation that I gave during a UK tour in Sept/Oct 2014 at a number of UK universities
Many of us nowadays invest significant amounts of time in sharing our activities and opinions with friends and family via social networking tools. However, despite the availability of many platforms for scientists to connect and share with their peers in the scientific community the majority do not make use of these tools, despite their promise and potential impact and influence on our future careers. We are being indexed and exposed on the internet via our publications, presentations and data. We also have many more ways to contribute to science, to annotate and curate data, to “publish” in new ways, and many of these activities are as part of a growing crowdsourcing network. This presentation will provide an overview of the various types of networking and collaborative sites available to scientists and ways to expose your scientific activities online. Many of these can ultimately contribute to the developing measures of you as a scientist as identified in the new world of alternative metrics. Participating offers a great opportunity to develop a scientific profile within the community and may ultimately be very beneficial, especially to scientists early in their career.
With the flourishing environment of platforms for sharing data, establishing an online profile and engaging in scientific discourse through alternative modes of publishing and participation, there are numerous potential benefits. However, while many scientists invest significant amounts of time in sharing their activities and opinions with friends and family the majority do not make use of the new opportunities to participate in the developing social web of science, despite the potential impact and influence on future careers. We now have many new ways to contribute to science outside of the classical publishing model. These include the ability to annotate and curate data, to “publish” in new ways on blogs and micropublishing sites, and many of these activities can be as part of a growing crowdsourcing network. Our efforts in this area are already being indexed and exposed on the internet via our publications, presentations and data and increasingly we are being quantified. This presentation will provide an overview of the various types of networking and collaborative sites available to scientists and ways to expose their scientific activities online. Many of these can ultimately contribute to the developing metrics of a scientist as identified in the new world of alternative metrics. Participation offers a great opportunity to develop a scientific profile within the community and may ultimately be very beneficial, especially to scientists early in their career.
Workshop “Hoe kom ik nu aan de full-text?”
Dankzij het hybride werken is lang niet iedereen elke dag meer te vinden “on campus”, maar ook voor mensen thuis moet de toegang tot wetenschappelijke informatie en bibliotheekdiensten goed geregeld zijn. De bibliotheek heeft hierin een taak om bronnen zo bereikbaar mogelijk te houden, waar onze gebruikers ook werken. Daarnaast is de opkomst van open access publiceren de laatste jaren ook in een stroomversnelling geraakt. Dat een groot deel van het wetenschappelijk werk nu open access beschikbaar is, is natuurlijk erg mooi, maar de open access-artikelen zijn her en der verspreid over het web. Wat is de meest efficiënte manier om deze publicaties te vinden?
Ook niet onbelangrijk is dat toegang tot tijdschriften erg prijzig is en veel instituten hebben niet de middelen om een licentie op alle bronnen te nemen. Vooral organisaties buiten de academische wereld worstelen met toegang tot onderzoek. Bovendien moeten de organisaties met toegang de vraag stellen, wat zullen we doen als we plotseling de toegang tot een reeks tijdschriften verliezen om het abonnement is geannuleerd? Als de bibliotheek een artikel niet kan leveren, dan weten we dat onze gebruikers andere manieren zullen gebruiken om de pdf te krijgen. Echter, deze andere manieren bespreken we bijna nooit. Hoeveel verschillende manieren zijn er precies? Hoe werken ze?
Deelnemers van de workshop leren over alle mogelijke manieren, hulpmiddelen en krijgen tips om de full-tekst te vinden van wetenschappelijke publicaties. We bespreken “best practices” van bibliotheek-tools en diensten (Linkresolvers, Discovery, LeanLibrary, LibX, Apps, etc.) en testen we vooral alle alternatieve tools zoals EndNote Click (voorheen Kopernio), Unpaywall, CORE Discovery, OpenAccess-Button, LibKey Nomad, Google Scholar-Button en andere extensies of bookmarklets.
De tools die we willen laten zien zijn maar beperkt beschikbaar op smartphones of tablets. Neem daarom als het kan een laptop mee waarop in Edge, Chrome of FireFox extensies geïnstalleerd mogen worden.
The Trail of the Data : Why the library should be the central pivot bringing ...Guus van den Brekel
The purpose of this talk is to explain, emphasize and discuss the growing importance of being abled to identify, track, record and analyse all research related data inside ánd outside the academic hospital environment. The goal is to aim for better insight of the data trail, contributing to research integrity, research impact and societal relevance. The medical library plays a crucial role as partner in collaboration with key stakeholders inside the hospital, and within the university research community. Because of it's unique wide and overall perspective, it has the opportunity to see new possibilities and needs to grasp these new tasks and set new relationships with partners that were previously out of scope.
Background:
The use and development of various research- or healthcare-related datasystems is growing exponentially over the last years. Technical innovations make it possible to much more easily either integrate data systems or create live interacton and data-exchange with sources inside and outside the University Medical Center Groningen (UMCG). The medical library is trying to pro-actively initiate more awareness, discussion, procedures plus guidelines.
Summary and activities:
From the perspective of the medical library in it's role of managing and facilitating the current research information systems (CRIS, in our case “Pure”), combined with the growing expertise in research analytics and impact, we clearly see the urgency of bringing together healthcare data-systems in the hospital with other research-related systems. This is needed in order to be able to comply to research integrity, legal and ethical requirements, but also to enable better use of the research data for analytical purposes to support various processes in academic career development and research assessment.
Identifying relations between research output and healthcare data is one thing, but actually creating and registering these relationships in the research information systems is a task where the library can take a leading role.
In the UMCG it is mandatory to register each scientific project in which (new or existing) data and/or biomaterials of human subjects (patients and/or healthy volunteers) are involved. The library has been involved –together with many other stakeholders- in the development of this internal "Research Register" and the UMCG data catalogue, with the main focus to make integration possible with Pure for research output and authors.
In order to improve visibility and findability in general, the library advised in creating publishing guidelines for several UMCG affiliations including the Cohort and Biobank Coordination Hub (with 150+ UMCG Cohorts & Biobanks) with focus on making relations and connection possible between the data systems, research output and other research-related items.
The library is co-admin for the UMCG for all clinical trials registered at ClinicalTrials.gov. Together with Research Office we are working on research
Into The User Environment 2022! EAHIL2022 plenary presentationGuus van den Brekel
“ Into the User Environment Now!» was the title of my first plenary presentation at an EAHIL conference.
It pictured how -back in 2006- how users and the information landscape changed rapidly, and what we needed to do about it as medical libraries, to keep up the pace, to not loose the connection with the user.
Technologies to embrace, actions to take…
This update pictures where things went right, wrong or very different! And it discusses where we are now in 2022, with a peek into possible futures, from the perspective of a medical library in a Dutch academic hospital, facilitating patient care, education ánd research support.
Biography and Bibliography
Guus van den Brekel is medical information specialist at the Central Medical Library of the University Medical Center Groningen (UMCG), in north of the Netherlands. His work includes developing, maintaining of library services and tools for staff and students, as well as innovation. As such he is also the ‘go-between’ for the IT-departments regarding library systems and services. Research Impact and Support is his major focus currently. He is coordinator for the UMCG’s current research information system (PURE). In general, he is always on the lookout for tools & services that make the workflow of hospital staff, researchers, teachers and students easier and more efficient. #eahil2022
Workshop “Hoe kom ik nu aan de full-text? – Actueler dan ooit, met het huidig...Guus van den Brekel
VOGIN-IP Workshop 2022
Thuiswerken en off-campus toegang tot wetenschappelijk informatie en bibliotheekdiensten is crucialer dan ooit door Corona. Daarnaast is toegang tot tijdschriften erg prijzig en veel instituten hebben niet de middelen om een licentie op alles te nemen. Vooral organisaties buiten de academische wereld worstelen met toegang tot onderzoek. Bovendien moeten de organisaties met toegang de vraag stellen, wat zullen we doen als we plotseling de toegang tot een reeks tijdschriften verliezen omdat het abonnement is geannuleerd? Als de bibliotheek een artikel niet kan leveren, weten we dat onze gebruikers andere manieren zullen gebruiken om de pdf te krijgen. Echter, deze andere manieren bespreken we bijna nooit. Hoeveel verschillende manieren zijn er precies? Hoe werken ze? Hoe kan ik het groeiende aantal open access-artikelen -die her en der verspreid zijn over het web- op de meest efficiënte manier vinden?
Deelnemers aan de workshop leren over alle mogelijke manieren en hulpmiddelen en krijgen tips om de full-tekst te vinden van wetenschappelijke publicaties. We bespreken “best practices” van bibliotheek-tools en diensten (Linkresolvers, Discovery, LeanLibrary, LibX, Apps, etc.) en testen vooral alle alternatieve tools zoals EndNote Click (voorheen Kopernio), Unpaywall, CORE Discovery, OpenAccess-Button, LibKey Nomad, Google Scholar-Button en andere extensies of bookmarklets.
Breng laptops, smartphones en/of tablets mee en zorg dat in ieder geval Chrome, Edge en/of Firefox beschikbaar is.
ALLE MANIEREN OM DE FULL-TEXT TE VINDEN VAN WETENSCHAPPELIJKE ARTIKELEN
(MÉT OF ZÓNDER HULP VAN EEN BIBLIOTHEEK! )
Het bespreken van alternatieve manieren om aan een pdf te komen van een wetenschappelijk artikel
buiten de goed-bedoelde diensten van de bibliotheek om, is een mooi voorbeeld van de
spreekwoordelijke “olifant in de kamer”! We wéten dat onze gebruikers andere opties gebruiken als wij (de
bibliotheek) ze de gewenste artikelen niet kunnen leveren, maar dat laten we eigenlijk vaak onbesproken.
Hoeveel manieren zijn er nu eigenlijk en hoe werken ze? En welke tools bieden we als bibiotheek onze
klanten nu aan?
google doc: bit.ly/FULL-TEXT Guus van den Brekel & Robin Ottjes, CMB UMCG 21 maart 2019
How to get the pdf? : with ór without the help of your libraryGuus van den Brekel
Presentation at UiT Library, October 15th 2018
All possible ways, tools and tips for users to find the full-text of scientific publications, including an overview of (licensed) access tools used by libraries worldwide.
Tools included (but not limited to): LeanLibrary, Kopernio, Open Access Button, AnywhereAccess, KeyLib, Easyproxy, Unpaywall, Google Scholar button
Alternative OA databases: Dimensions, 1Findr, BASE, CORE, DOAJ, OpenDOAR, OSF Preprints, Zenodo, BioRxiv etc.
The University Library and the Central Medical Library are testing a new tool: Lean Library. You can install this tool in your browser. It provides quick and easy access to databases, e-journals and ebooks, and to articles in open access. The library in your browser...! You can download this browser extension for off-campus library access for free (not yet available for mobile devices).
Slides: https://lnkd.in/gTKY9qQ
Info: https://lnkd.in/gW6tdsM
download: https://lnkd.in/eGHkNwq
ALLE MANIEREN OM DE FULL-TEXT TE VINDEN VAN WETENSCHAPPELIJKE ARTIKELEN
(MÉT OF ZÓNDER HULP VAN EEN BIBLIOTHEEK! )
Het bespreken van alternatieve manieren om aan een PDF te komen van een wetenschappelijk artikel buiten de talrijke diensten van de bibliotheek om, is een mooi voorbeeld van de spreekwoordelijke “olifant in de kamer”! We wéten dat onze gebruikers andere opties gebruiken, als wij (de bibliotheek) ze de gewenste artikelen niet kunnen leveren via de bibliotheeksystemen of -tools, maar dat laten we eigenlijk vaak onbesproken. Hoeveel manieren zijn er nu eigenlijk en hoe werken ze?
In deze workshop bespreken we “best practices” van bibliotheek-tools en diensten (Linkresolvers, Discovery, LeanLibrary, LibX, Apps, etc.) en testen we vooral alle alternatieve tools zoals Kopernio, Unpaywall, OpenAccess-Button, Scholar-Button en andere extenties of bookmarklets.
Breng laptops, smartphones en/of tablets mee en zorg dat in ieder geval Chrome en/of Firefox beschikbaar is.
ALLE MANIEREN OM DE FULL-TEKST TE VINDEN VAN WETENSCHAPPELIJKE ARTIKELEN (MET OF ZONDER HULP VAN DE BIBLIOTHEEK…)
KNVI 2017 congres Track 3.3
#knvi, #knvi17, #knvi2017, cmbumcg, kopernio, leanlibrary, oa_button, openaccess, pdf, scholar button, umcg, unpaywall
Visibility and societal impact : UMCG research output, Altmetric and PureGuus van den Brekel
Pilot project on Altmetrics in UMCG, by Central Medical Library, UMCG. Presentation at Seminar Altmetrics for research evaluation… or not?
Date: 16 NOV 2016
Wednesday November 16th 2016, experts in altmetrics will gather to discuss about this topic and how altmetrics can support Open Science. Several providers with different kind of altmetric tools will provide practical solutions and present use cases.
https://www.surf.nl/en/agenda/2016/11/seminar-altmetrics-for-research-evaluation...-or-not/index.html
Keeping up to date & comparing journal apps. the stockholm workshop 2016Guus van den Brekel
Workshop 1: Comparing journal apps and Keeping up to date
Beskrivning: The aim of this workshop is an extensive update of the numerous possibilities for librarians and medical professionals to keep up to date about medical scientific publications and news. The latest developments of content aggregation and curation offer opportunities for librarians to not just keep up to date, but also to share and publish the acquired knowledge among colleagues and patrons.
After this workshop, participants will be able to keep up to date more efficiently and have a broad knowledge of a wide range of tools for advising patrons. Supporting and facilitating medical professionals in education, patient-care and research is the main focus for medical and health librarians. We constantly have to attempt to make their workflow more efficient and easier. To be able to advise patrons about efficient ways of keeping up to date, we have to know ourselves what tools are out there. Because if we do not advise them, they will (have to) find out themselves, with a risk of missing out on relevant resources or possibilities. No one tool fits all. It is all about knowing in detail what a patron wants and match it with tools that can facilitate that requirement most efficiently. And the options for them to choose from are almost limitless either for free or via commercial parties.
In this workshop we will go more into more detail on these possibilities. I will cover the scope of common practices and possibilities as completely as possible, showcased by various licensed and free web tools. Email alerts, Saved search, RSS and Readers, Table of Contents, Apps by Publishers and content providers will be discussed, but Journal Apps plus Web Media content aggregation and curation will take the main part of this course.
Inför workshoppen: No prior knowledge required. Bringing your own mobile device(s) will enhance the hands-on learning effect.
Workshopledare: Guus van den Brekel
Tid & lokal: 8.30 - 12.00 Strix, von Eulers väg 4 b
Antal deltagare: 30
We want to:
explore the benefits of implementing altmetric data in the hospital,
map all stakeholders and interested parties
increase awareness of additional methods of measuring impact tools,
Increase awareness of tools to influence visibility of the umcg research & it's output
discuss current use of bibliometrics in evaluations including the growing interest in measuring/visualising the "societal impact" of scientific research.
Social Media, Keeping up to date, Pure and more : The Leiden talkGuus van den Brekel
Talk for a group of colleagues of Walaeus Library of the Leiden University Medical Center and others.
November 5th 2015 14:30-17:00
PIctures: https://www.facebook.com/digicmb/media_set?set=a.10156217814035603.1073741882.868270602
Comparing journal apps : Tromsø presentation with BrowZine Web previewGuus van den Brekel
My slides from the presentation on comparing Journal Apps for the University of Tromsø staff, inclusing the preview slides from the web version of BrowZine (to be launched July 2015)
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
GSMS PhD Development Speaker Series: how to improve your research impact? and who is talking about (or using) your research? 2
1. H O W T O
I M P R O V E
Y O U R
R E S E A R C H
I M P A C T ?
W H O I S
T A L K I N G
A B O U T
Y O U R
R E S E A R C H
?
30+ tips to use befóre,
whíle and áfter writing
Altmetric UMCG Dashboard
“Societal Relevance”
2. IMPACT AND VISIBILITY
FOR YOUR RESEARCH
0:00 75:00 min
Pure
Open Access
Altmetrics
3 0 + T I P S
ORCID
3. 30+ tips to use befóre,
whíle and áfter writing
H O W T O
I M P R O V E
Y O U R
R E S E A R C H
I M P A C T ?
4. PROMOTEFORIMPACT!
Guus van den Brekel
Central Medical Library,
University Medical Center
Groningen
GSMS PhD Development
Speaker Series
February 28th 2018
HOW TO IMPROVE YOUR RESEARCH IMPACT?
5. W H Y ?
• Performance funding policy
UMCG
• The "Worldwide Race on
Ranking of Universities"
• The "Universal Battle for the
Researchers" (and their
citations)
6. HOW TO IMPROVE YOUR RESEARCH IMPACT:
30+ TIPS
• BEFORE Publishing
• AFTER Publishing
7. B E F O R E P U B L I S H I N G ( W H I L E
W R I T I N G )
• WHAT to INCLUDE in article?
• WHAT to publish
• WHERE to publish
• HOW to publish
• WHO to publish with
8. WHAT to INCLUDE in article
• Use unique name ( if possible), and consistently throughout your career
• Use the standardized institutional affiliation, using no abbreviations ( "University of
Groningen, University Medical Center Groningen")
• Repeat key phrases in the abstract while writing naturally
• Assign keywords to the manuscript ( MESH, Web of Science ...)
• Use more references
• Publish a longer paper
• Papers with a larger number of "callouts" are likely to get a higher number of citations
• Avoid using a question type of title
BEFORE PUBLISHING (WHILE WRITING)
9. WHAT to INCLUDE in article
• Get an ORCID ID, connect it to PURE and use it consistantly in all articles
BEFORE PUBLISHING (WHILE WRITING)
http://orcid.org
http://pure.rug.nl/admin
http://www.umcg.nl/cmb or www.rug.nl/cmb
ORCID
• Already 905 researchers UMCG registered
• Total at RUG: 1389
19. Measuring impact is generally based on past performance, but
with new tools and new indicators it is possible to measure it
sooner and –very interesting- even look in future & predict
(Trends-module Scival, Elsevier)
20. WHAT to publish
• Write a review paper
• Present a working paper ( before & after articles are
published)
B E F O R E P U B L I S H I N G ( W H I L E
W R I T I N G )
21. WHERE to publish
• Publish in a journal with high impact
• Publish across disciplines
• Publish in journals everyone in your discipline reads
• Publish in a journal that is included in many
abstracting & indexing services
B E F O R E P U B L I S H I N G ( W H I L E
W R I T I N G )
Web of Science, Journal Citation Reports, InCites (Clarivate)
Scopus, CiteScore, Scival (Elsevier)
http://www.rug.nl/umcg/library
22. HOW to publish
I N C R E A S E S C I T A T I O N R A T E S
B E F O R E P U B L I S H I N G ( W H I L E
W R I T I N G )
openaccess.umcg.nl
• The Open Access Citation Advantage Service
http://sparceurope.org/oaca/
Open Access
25. • Only corresponding authors are eligible for the openaccess deals
• Use your umcg-computer & email for submitting
• Use correct affiliation detail and order:
University of Groningen, University medical center groningen,
Dept.......
• During submission it is important to choose the correct route.
Details on submission process per publisher at openaccess.nl
• If you do NOT choose for open access, please send us your “final
author version” The library will make it GREEN in Pure
• For all info & support : openaccess@umcg.nl
O P E N A C C E S S G O L D E N T I P S
openaccess.umcg.nl
26. WHO to publish with
• publish with international authors across multiple institutions
• Team-authored articles get cited more
• Publish papers with Nobel laureates ;-)
• Collaborate with corporate sector
B E F O R E P U B L I S H I N G ( W H I L E
W R I T I N G )
27. S C H O L A R L Y C O M M U N I C A T I O N
D O E S N O T S T O P A F T E R
P U B L I S H I N G Y O U R A R T I C L E
29. P R O F I L E
• Make a unique phrase that reflects your research interest & use it
throughout your career
• Keep your corporate & professional profile pages & publication
lists up to date
• Get an ORCID ID, connect it to PURE and use it consistantly in all
articles
• Use online CV option in PURE
• Use academic social networking sites ( ResearchGate, Academia,
Mendeley, Google Scholar, ImpactStory...
30. D I S S E M I N A T E
• Self-archive articles and research output
(PURE, post-print, pdf, open access repository)
• Share your research data ( open data)
• Publicize yourself ( link your latest articles to your
email signature)
31. P R O M O T E
• Start a blog ( Wordpress, Blogger are extremely good indexed in major
search engines
• Use Linkedin to promote
• Use SEO techniques on corporate & institute websites
• Contribute to Wikipedia
• Create a podcast, screencast or video and publish on YouTube, Vimeo ...
• Use Twitter & Other social media to share your findings
• Use DOI's in all communications
32. T R A C K A N D E N G A G E
• Set alerts on new citations
• Engage in discussions on the web and in
• Post publication peer review sites
• Use research analytic tools to monitor …
33. P O S T P U B L I C A T I O N P E E R
R E V I E W
• Pubmed Commons http://www.ncbi.nlm.nih.gov/pubmedcommons
• PubPeer https://pubpeer.com
• Frontiers http://www.frontiersin.org/SearchData.aspx?sq=Groningen&ht=1
• Open Review (ResearchGate)
https://www.researchgate.net/publicliterature.OpenReviewInfo.html
• publons.com https://publons.com/institution/5963/
34. T R A C K A N D E N G A G E
• Track "mentions" about your articles on the Web
(Altmetrics)
37. WHY?
W E W A N T T O
• E X P L O R E T H E B E N E F I T S O F I M P L E M E N T I N G
A L T M E T R I C D A T A I N T H E H O S P I T A L ,
• M A P A L L S T A K E H O L D E R S A N D I N T E R E S T E D P A R T I E S
• I N C R E A S E A W A R E N E S S O F A D D I T I O N A L M E T H O D S
O F M E A S U R I N G I M P A C T T O O L S ,
• I N C R E A S E A W A R E N E S S O F T O O L S T O I N F L U E N C E
V I S I B I L I T Y O F T H E U M C G R E S E A R C H & I T ' S O U T P U T
• D I S C U S S C U R R E N T U S E O F B I B L I O M E T R I C S I N
E V A L U A T I O N S I N C L U D I N G T H E G R O W I N G I N T E R E S T
I N M E A S U R I N G / V I S U A L I S I N G T H E " S O C I E T A L
I M P A C T " O F S C I E N T I F I C R E S E A R C H .
38. W H A T ?
• ONE DASHBOARD TO TRACK AND MONITOR ALL ACTIVITIES
AROUND ALL SCIENTIFIC PUBLICATION OF THE UMCG
• ACCESS FOR EVERY AUTHOR/RESEARCHER FOR A PERSONAL
TRACKING AND ALERTING
• OVERVIEWS ON UMCG, RESEARCH INSTITUTES AND
PROGRAMME LEVEL
• INTEGRATION WITH PURE, AS SOURCE FOR DOI'S AND THE
RESEARCH STRUCTURE
• INCLUDING THE "DONUTS" ON THE RESEARCH DATABASE
PORTAL AND UMCG.NL
• EXPLORE THE ALTMETRIC API AND POSSIBLE APPLIED USE IN
RUG.NL, UMCG.NL AND RELATED WEBSITES,
HERE’S THE LINK TO A SHARED PRESENTATION:
HTTPS://WWW.ICLOUD.COM/KEYNOTE/000_T8X3BHJJDDJHW1BGYSS3Q#CUSTOM -GRONINGENBENM -
24SEPTEMBER2015
49. USED
SOURCES
• The Open Access Citation Advantage Service
http://sparceurope.org/oaca/
• Effective Strategies for Increasing Citation
Frequency by Nader Ale Ebrahim
http://papers.ssrn.com/sol3/Papers.cfm?abstra
ct_id=2344585
• https://library.leeds.ac.uk/researcher-citations
• 101 Innovations in scholary communications
:survey
• Elsevier "Effective strategies for increasing
citation"
http://dx.doi.org/10.5539/ies.v6n11p93
50. I F Y O U W A N T T O B E S E E N A S A N E X P E R T . . .
. . . T H E N Y O U R E X P E R T I S E H A S T O B E S E E N
L O R C A N D E M P S E Y H T T P : / / W W W . S L I D E S H A R E . N E T / L I S L D / T H E - I N S I D E - O U T - L I B R A R Y