Brendel Group Presentation: 19 Nov 2013
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The document discusses cytochrome P450 (CYP) genes that were found in the genome of the paper wasp Polistes dominula. CYP genes encode oxidation enzymes and play important roles in insects, including metabolizing exogenous compounds and regulating endogenous compounds like juvenile hormone and ecdysone. The analysis of P. dominula found many differentially expressed CYP genes. CYP genes have been associated with caste determination in other social insects through their links to juvenile hormone.
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- 1. Cytochrome P450 genes in the Polistes dominula genome Daniel Standage, Brendel Group Meeting, 19 Nov 2013
- 2. Motivation Differential expression analysis in paper wasp Initially found 123 differentially expressed gene loci Manual examination found many CYP genes Results pending BLAST2GO enrichment test HyCGD
- 3. Cytochrome P450 (CYP) Oxidation enzyme RH + O2 + NAD(P)H + H+ ROH + H2O + NADP+ Found in most (all) organisms Broad functional spectrum “Substrate promiscuity” High copy number
- 4. CYPs in Insects 1,744 distinct insect CYPs (Feb 2010) +/- 100 CYP genes per species common CYPs functions in insects Degradation of exogenous chemical compounds Odorants Sex pheromones Toxins and xenobiotics Synthesis / degradation of endogenous compounds Juvenile hormone Ecdysone
- 5. CYPs in social insects Functions not well characterized CYPs often associated with juvenile hormone (JH) JH, ecdysone, and vitellogenin implicated in caste determination DE analysis has identified 3+ CYP genes with caste- dependent differential expression
- 6. CYPs in Solenopsis invicta Subtractive hybridization to identify DE genes Found 3 genes, 2 of which are CYPs Developmentally regulated Caste-specifically regulated
- 7. CYPs in H. sjostedti Identified by differential display Expression induced by JH analogue 42% AA identity with CYP6X1; named CYP6AM1 CYP6AM1 repressed after JHA treatment
- 8. CYPs in R. flavipes Goal: sample CYP4 diversity with degenerate PCR Identified seven novel CYP4 genes JH-induced differentiation influences expression