The Greater Mekong region has exceptionally high biodiversity due to its diverse habitats and annual flood pulses. It is home to over 20,000 plant and 1,200 animal species, many of which are rare or threatened. However, human activities like dam construction and deforestation are threatening biodiversity by obstructing fish migrations and reducing habitats. This is problematic because the region's rich biodiversity underpins the livelihoods of over 55 million people and economies of countries through fishing and tourism. Regional cooperation is needed to balance conservation and development goals to sustainably manage the biodiversity that supports the environment, society and economy of the Mekong region.