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200707683
Case No. 1
A 34 year old male patient.
C.R.F. was maintained on C.H.D.
The donor was his brother , Same blood group.
HLA & DR mismatch
PRA : class I= 4% (DNS) class II= zero%
Renal transplant 19th Jan., 2008
50%
Operative details
Artery internal iliac artery
Vein external iliac vein
Ischemia time : 45 minutes
Immediate duiresis &
Smooth immediate postoperative course
Maintained on steroid , CSA, AZA
S.Cr. On discharge : 1.1mg/dl
One month Post transplantation
• oliguria
• ↑ S.cr.1.1 →3.2 mg/dl
Clinical picture:
Differential
diagnosis:
?rejection
?Obstruction
?Vascular occlusion
Graft Doppler & U.S.
Patchy perfusion Absent diastolic flow
Basal
On day of event
BiopsyBiopsy
Picture of Acute Humoral Rejection
Focal +ve C4d StainingATN like picture
Marked right Lower limb oedema.
Doppler US
Sluggish flow in the deep venous system
Next Day:
MRA
Thrombosed graft vein.
Thrombosed RT external iliac vein.
Patent IVC Patent graft artery
Thrombosed RT common femoral vein.
OPTIONS FOR TREATMENT:
Local injection of streptokinase
Exploration & thrombectomy
Graft nephrectomy
GRAFT VEIN THROMBOSIS
Systemic injection of streptokinase
Combined local & systemic injection of streptokinase
Follow up MRA
Angiography was done
Local injection of streptokinase 750 000 IU
Systemic injection of Streptokinase 100 000IU/hr
LMWH Plus oral anti-coagulant
LMWH stopped when target INR 2-3 achieved
GRAFT VEIN THROMBOSIS
CurrentlyCurrently
Recovered graft functionRecovered graft function::
S. cr = 0.8 mg/dlS. cr = 0.8 mg/dl
UU.O.P = 5 L/day.O.P = 5 L/day
Patient under treatment of CMV
disease
Graft vein thrombosis
RVT has incidence of 0.55:3.4%
One third of early allograft losses.
One case reported just compression
of the vein due to abnormal position of
the graft
(Nephron 1996;73:480-481)
diagnosis time management reference
Renal vein
compression
3rd
day Exploration&
nephropexy
Nephron
1996
Partial
thrombosis
of graft vein
11months Selective intra-
arterial
administration
of
streptokinase
Nephrol
Dial
Transplant
1998
Renal vein
thrombosis
8th
day Exploration&
thrombectomy
Nephrol
Dial
Transplant
2006
•Number of transplanted cases : 1969
•2003:
one case suffered from both graft artery &
vein thrombosis managed by nephrectomy
•2008
One case of graft vein thrombosis managed by
local & systemic injection of streptokinase
Conclusion:
Close follow up
Early detection & diagnosis
Perfect intervention & cooperation
Recent advances in treatment of
vascular rejection
=Good outcome
graft vein thrombosis after renal transplantation

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graft vein thrombosis after renal transplantation

  • 1. 200707683 Case No. 1 A 34 year old male patient. C.R.F. was maintained on C.H.D. The donor was his brother , Same blood group. HLA & DR mismatch PRA : class I= 4% (DNS) class II= zero% Renal transplant 19th Jan., 2008 50%
  • 2. Operative details Artery internal iliac artery Vein external iliac vein Ischemia time : 45 minutes Immediate duiresis &
  • 3. Smooth immediate postoperative course Maintained on steroid , CSA, AZA S.Cr. On discharge : 1.1mg/dl
  • 4. One month Post transplantation • oliguria • ↑ S.cr.1.1 →3.2 mg/dl Clinical picture: Differential diagnosis: ?rejection ?Obstruction ?Vascular occlusion
  • 5. Graft Doppler & U.S. Patchy perfusion Absent diastolic flow Basal On day of event
  • 6. BiopsyBiopsy Picture of Acute Humoral Rejection Focal +ve C4d StainingATN like picture
  • 7. Marked right Lower limb oedema. Doppler US Sluggish flow in the deep venous system Next Day:
  • 8. MRA Thrombosed graft vein. Thrombosed RT external iliac vein. Patent IVC Patent graft artery Thrombosed RT common femoral vein.
  • 9. OPTIONS FOR TREATMENT: Local injection of streptokinase Exploration & thrombectomy Graft nephrectomy GRAFT VEIN THROMBOSIS Systemic injection of streptokinase Combined local & systemic injection of streptokinase
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 17. Angiography was done Local injection of streptokinase 750 000 IU Systemic injection of Streptokinase 100 000IU/hr LMWH Plus oral anti-coagulant LMWH stopped when target INR 2-3 achieved GRAFT VEIN THROMBOSIS
  • 18. CurrentlyCurrently Recovered graft functionRecovered graft function:: S. cr = 0.8 mg/dlS. cr = 0.8 mg/dl UU.O.P = 5 L/day.O.P = 5 L/day Patient under treatment of CMV disease
  • 19.
  • 20. Graft vein thrombosis RVT has incidence of 0.55:3.4% One third of early allograft losses. One case reported just compression of the vein due to abnormal position of the graft (Nephron 1996;73:480-481)
  • 21. diagnosis time management reference Renal vein compression 3rd day Exploration& nephropexy Nephron 1996 Partial thrombosis of graft vein 11months Selective intra- arterial administration of streptokinase Nephrol Dial Transplant 1998 Renal vein thrombosis 8th day Exploration& thrombectomy Nephrol Dial Transplant 2006
  • 22. •Number of transplanted cases : 1969 •2003: one case suffered from both graft artery & vein thrombosis managed by nephrectomy •2008 One case of graft vein thrombosis managed by local & systemic injection of streptokinase
  • 23. Conclusion: Close follow up Early detection & diagnosis Perfect intervention & cooperation Recent advances in treatment of vascular rejection =Good outcome