8. A personalized approach to desensitization: precision-based
immune modulation & clinical context. A, The adaptive
response can be considered as a “pyramid,” with antibodies
at the apex. Plasma cells form the middle tier while B cells
at their various stages of development are at the base in
close and continual interaction with their T-cell
counterparts.
9. • B, Patient-level factors affecting the
desensitization approach. Defining the
appropriate approach to desensitization
depends on the patient's clinical status, their
overall immunological risk, and donor related
factors. and donor-related factors.
30. Am J Transplant. 2019, in press
Bariatric Surgery and Immunosuppression
31. Am J Transplant. 2019, in press
Bariatric Surgery and Immunosuppression
32. Am J Transplant. 2019, in press
Bariatric Surgery and
Immunosuppression
33. Immune check point inhibitors
• The therapy targets immune checkpoints, key
regulators of the immune system that when
stimulated can dampen the immune response to an
immunologic stimulus. Some cancers can protect
themselves from attack by stimulating immune
checkpoint targets. Checkpoint therapy can block
inhibitory checkpoints, restoring immune system
function.
34.
35. • PDL-1 expression on the allograft lymphocytes has
been suggested as a marker of rejection after
treatment with ICIs.