The document outlines key success criteria and best practices for clinical commissioning groups under the new NHS framework. It discusses the need to design sustainable patient pathways through collaborative relationships. Commissioning groups will need to make intelligent use of data combined with GP experience to define "waste free" pathways and ensure compliance with guidelines. A multi-dimensional approach is recommended that involves needs assessment, evidence-based practice, service redesign, and choosing optimal treatment locations through modeling and trend analysis. Operational excellence is seen as integral to effectively implementing the new GP commissioning framework.