Glycomet tablets contain metformin hydrochloride as the active ingredient. Metformin is used along with diet and exercise to treat type 2 diabetes by improving glucose tolerance and lowering blood glucose levels. It works by decreasing the amount of glucose absorbed from food and produced by the liver. Common side effects include headache, nausea, and diarrhea. Lactic acidosis is a rare but serious potential side effect, especially in patients with kidney or liver problems. Metformin should be used cautiously during pregnancy and is classified as pregnancy category B.

1. Metformin Tablets
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Glycomet Tablets (Metformin Hydrochloride) is
used along with a proper diet and exercise in the
treatment of type 2 diabetes. It improves glucose
tolerance in patients with type 2 diabetes,
lowering both basal and postprandial plasma
glucose.

2. Glycomet Tablets
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Glycomet Tablets are manufactured
by USV Limited
(Website: www.usvindia.com )

3. Metformin Hydrochloride Tablets – Brand Names
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Metformin Hydrochloride tablets are
available as Glucophage, Glycomet,
Glycomet SR, Exermet, Exermet XR,
Fortamet, Actoplus Met, Avandamet,
Glucophage, Glumetza and Riomet.

4. Active Ingredient
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The active ingredient contained in Glycomet
is Metformin Hydrochloride. Each tablet
contains 250 mg, 500 mg, 850 mg or 1000
mg of Metformin hydrochloride IP

5. Chemical Structure
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The structure of Metformin Hydrochloride is
given below:

6. Uses of Glycomet Tablets
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Glycomet (Metformin Tablets) is indicated
along with diet and exercise, to improve
glycaemic control in adults with type 2
diabetes mellitus.
Glycomet can be used together with a
sulphonylurea or insulin to improve
glycaemic control in adults. Metformin
tablets help to control the amount of glucose
(sugar) in your blood.
This medicine decreases the amount of
glucose you absorb from your food and the
amount of glucose made by your liver.

7. Storage Instructions
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Glycomet (Metformin Tablets) have to
be stored at controlled room temperature
i.e. from 20°C to 25°C (68°F to 77°F)
with excursions permitted between 15°
to 30°C (59° to 86°F). Store in a cool,
dry place away from light.
Keep this as well as all other medicines
away from children and pets.

8. Metformin Dosage
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➢ The normal adult starting dose is one 500
mg tablets three times daily. This dose or
alternatively one 850mg tablet twice daily may
be enough to provide good diabetic control.
➢ When Metformin therapy is used along with
with sulphonylurea or insulin therapy
patients must have their blood-sugar levels
monitored due to the possibility of
hypoglycaemia occurring.
The dosage of Glycomet tablets (Metformin
Hydrochloride) is given below:

9. Warnings
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The risk of lactic acidosis increases with
the degree of renal dysfunction,
impairment of creatinine clearance and
the patient's age.
Since impaired hepatic function can
significantly limit the ability to clear
lactate, metformin should generally be
avoided in patients with clinical or
laboratory evidence of hepatic disease.

10. Warnings
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Patients must be warned against
excessive alcohol intake either acute or
chronic when taking metformin, since
alcohol consumption potentiates the
effect of metformin on lactate
metabolism.
Administration of Glycomet Tablets
should be temporarily discontinued two
days prior to any intravascular
radiocontrast study and not restarted
until renal function has normalised.

11. Glycomet Tablets
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Contraindications
Glycomet tablets are contraindicated in patients
with a hypersensitivity to Metformin
Hydrochloride or any other component of this
medication.
Glycomet (Metformin Tablets) is contraindicated
in patients with a history of ketoacidosis with or
without coma or with significant renal impairment.
They are also contraindicated in cases of severe
hepatic dysfunction, excessive alcohol intake
either acute or chronic, cardiovascular collapse
and in disease states associated with hypoxemia

12. Glycomet Tablets
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Contraindications
Glycomet tablets are contraindicated in patients
during stress conditions e.g. severe infections,
trauma, or surgery or the recovery stage
Thereafter.
States associated with lactic acidosis e.g. shock
or pulmonary insufficiency.
Patients with a history of lactic acidosis
irrespective of the precipitating factors and
patients suffering from severe dehydration.

13. Glycomet Side Effects
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➢ Glycomet side effects can include headache or
muscle pain, weakness, gastrointestinal upset,
including cramps, mild nausea, vomiting, diarrhea
increased flatulence, gas, and stomach pain.
➢The most serious potential side effect of metformin
use is lactic acidosis; this complication is very rare,
and the vast majority of these cases seem to be
related to comorbid conditions, such as impaired
liver or kidney function, rather than to the Metformin
itself.
➢ Call your doctor at once in case you have any
other serious side effect such as: Feeling short of
breath, even with mild exertion; Swelling or rapid
weight gain; or Fever, chills, body aches, flu
symptoms.

14. Glycomet Overdose
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Adverse reactions of a more intense character
including epigastric discomfort, nausea and
vomiting followed by diarrhoea, drowsiness,
weakness, dizziness, malaise and headache may
be observed.
In case these symptoms persist, lactic acidosis
must be excluded.
Hypoglycaemia has not been seen even with
ingestion of up to 85g metformin although lactic
acidosis has occurred in such circumstances.
Hypoglycaemia can occur if excessive amounts
of Metformin tablets (Glycomet) are taken with a
sulphonylurea, insulin or alcohol.

15. Overdose
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Metformin tablets must be discontinued
and proper supportive therapy instituted.
Metformin can be dialysable with a
clearance of up to 170mL/min under good
haemodynamic conditions.

16. Glycomet During Pregnancy
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Glycomet (Metformin Hydrochloride tablets) has
been classified by the US FDA as Pregnancy
Category B.
There are no adequate and well-controlled
studies for Metformin tablets conducted in
pregnant women. Recent information strongly
suggests that abnormal blood glucose levels
during pregnancy are associated with the higher
incidence of congenital abnormalities.
Most experts recommend that insulin be used
during pregnancy to maintain the blood glucose
levels as close to normal as possible. Metformin
tablets should not be used in pregnancy unless
clearly required.

17. Glycomet Tablets
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Glycomet Tablets click here
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Glycomet (Metformin Tablets) by USV
Limited, India.