2. GROUP MEMBERS
Wajid Hanif Butt dp 305-060
Afzal Ali Shah dp 305-040
Khizar Nabeel Ali dp 305-026
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3. Clopidogrel
Clopidogrel is a potent oral antiplatelet
agent often used in the treatment of coronary
artery disease, peripheral vascular disease,
and cerebrovascular disease.
Clopidogrel is used for: Reducing the risk of
stroke or heart attack in patients who have
already had a heart attack or stroke, or have
other circulatory problems due to narrowing
and hardening of the arteries. I
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7. Dosage forms and administration
Clopidogrel bisulfate (clopidogrel
hydrogen sulfate), most commonly under
the trade names Plavix, as 75 mg oral
tablets.
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8. History
It is marketed by Bristol-Myers Squibb and
Sanofi-Aventis under the trade names
Iscover and Plavix respectively, by Sun
Pharmaceuticals under the trade name
Clopilet and by Ranbaxy Laboratories under
the trade name Ceruvin. It works by blocking
a receptor called P2Y12.
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9. Clinical Trials
Recent Myocardial Infarction (MI), Recent Stroke or Established
Peripheral Arterial Disease
Plavix Aspirin
Patients 9599 9586
IS (fatal or not) 438 (4.6%) 461 (4.8%)
MI (fatal or not) 275 (2.9%) 333 (3.5%)
Other vascular death 226 (2.4%) 226 (2.4%)
Total 939 (9.8%) 1020 (10.6%)
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11. Clinical Pharmacology
Mechanism of Action
Clopidogrel is an inhibitor of platelet aggregation.
Clopidogrel selectively inhibits the binding of
adenosine diphosphate (ADP) to its platelet receptor
and the subsequent ADP-mediated activation of the
glycoprotein GPIIb/IIIa complex, thereby inhibiting
platelet aggregation.
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12. Pharmacokinetics and Metabolism
Absorption Rapidly absorb after oral
administration
Metabolism
Highly metabolized in liver & Rapidly
hydrolyzed into its carboxylic acid
derivatives
Distribution Distribute through out the body with
peak plasma level 3 mg/L
Elimination Through urine
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14. Drug Interaction
Aspirin
Plavix potentiated the effect of aspirin on collagen-
induced platelet aggregation.
Heparin
Coadministration of heparin had no effect on
inhibition of platelet aggregation
Warfarin
Because of the increased risk of bleeding, the
concomitant administration of warfarin with Plavix
should be undertaken with caution
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15. Contra indication
Hypersensitivity to the drug substance or any
component of the product
Active pathological bleeding such as peptic
ulcer or intracranial hemorrhage
Pregnancy
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