this presentation includes all about the anti-plate drug including its history, side effects, dosage limits, etc.

1. Clopidogrel
(Anti platelet)

2. Introduction:
Clopidogrel is a potent oral antiplatelet agent often used in
the treatment of coronary artery disease, peripheral vascular
disease, and cerebrovascular disease.
 Clopidogrel is used for: Reducing the risk of stroke or heart
attack in patients who have already had a heart attack or
stroke, or have other circulatory problems due to narrowing
and hardening of the arteries

3. Systematic (IUPAC) name:
Methyl 2-(2-chlorophenyl)-2-(6,7-
dihydrothieno[3,2-c]pyridin-5(4H)-
yl)acetate
 Formula C16H16ClNO2S
 Mol. Mass 321.82 g/mol

4. Brand name:
Brands available in Pakistan
• Lowplat 75 mg Pharmevo -(PVT)
• Clopid 75 mg Ferozsons (LAB LTD)
• Noclot 75 mg CCL Pharmaceutical
• Ogrel Plus-81 75mg Bosch Pharmaceutical
LTD

5. Dosage forms and administration:
Clopidogrel bisulfate (clopidogrel hydrogen
sulfate), most commonly under the trade names
Plavix, as 75 mg oral tablets.

6. History:
is marketed by Bristol-Myers Squibb and Sanofi-
Aventis under the trade names Iscover and Plavix
respectively, by Sun Pharmaceuticals under the
trade name Clopilet and by Ranbaxy Laboratories
under the trade name Ceruvin. It works by
blocking a receptor called P2Y12.

7. Clinical trials:
 Recent Myocardial Infarction (MI), Recent Stroke or
Established Peripheral Arterial Disease
Plavix Aspirin
• Patients 9599 9586
• IS (fatal or not) 438 (4.6%) 461 (4.8%)
• MI (fatal or not) 275 (2.9%) 333 (3.5%)
• Other vascular death 226 (2.4%) 226 (2.4%)
• Total 939 (9.8%) 1020 (10.6%)

8. Clinical pharmacology:
Mechanism of Action
 Clopidogrel is an inhibitor of platelet aggregation.
Clopidogrel selectively inhibits the binding of adenosine
diphosphate (ADP) to its platelet receptor and the
subsequent ADP-mediated activation of the glycoprotein
GPIIb/IIIa complex, thereby inhibiting platelet
aggregation.

9. Pharmacokinetics and Metabolism:
Absorption
Metabolism
Distribution
elimination
Rapidly absorb after oral administration
Highly metabolized in liver & Rapidly
hydrolyzed into its carboxylic acid
derivatives.
Distribute through out the body with peak
plasma level 3 mg/l
Through urine

10. Adverse reaction:
Chest Pain
Fatigue
Edema
Hypertension
Dyspepsia
Neutropenia
Epistaxis
Bronchitis

11. Drug interaction:
 Aspirin
Plavix potentiated the effect of aspirin on collagen
induced platelet aggregation.
 Heparin
Coadministration of heparin had no effect on inhibition of
platelet aggregation
 Warfarin
Because of the increased risk of bleeding, its
administration should be undertaken with caution