Generic Metformin Tablets 
Glycomet (Generic Metformin Tablets) and Exermet 
XR or Glycomet SR (Metformin Extended Release...
Generic Metformin Tablets 
Chemical Structure (Metformin) 
© The Swiss Pharmacy, Geneva Switzerland
Generic Metformin Tablets 
Generic Metformin is an oral antihyperglycemic 
drug used in the treatment of type 2 diabetes i...
Generic Metformin Tablets 
Active Ingredient 
The active pharmaceutical ingredient 
contained in Glycomet, Exermet 
XR and...
Generic Metformin Tablets 
Strengths and Versions 
Generic Metformin (normal Immediate 
Release) is available in strengths...
Generic Metformin Tablets 
Strengths and Versions 
The terms XR, ER and SR are 
equivalent and refer to the same type 
of ...
Generic Metformin Tablets 
Recommended Dosage 
Adult Dosage (Generic Metformin): 
The normal starting dose of Glycomet tab...
Generic Metformin Tablets 
Recommended Dosage 
Adult Dosage (Generic Metformin XR): 
The usual initial dose for Glycomet S...
Generic Metformin Tablets 
Contraindications 
Glycomet, Glycomet SR and 
Exermet XR are contraindicated in 
patients with ...
Generic Metformin Tablets 
Contraindications 
Glycomet, Glycomet SR and Exermet XR 
are contraindicated in patients with t...
Generic Metformin Tablets 
Side Effects of Generic Metformin 
The most commonly observed side effects 
associated with the...
Generic Metformin Tablets 
Side Effects of Generic Metformin 
Lactic Acidosis: 
Lactic acidosis is a rare, but serious, 
m...
Generic Metformin Tablets 
Warnings And Precautions 
➔Lactic acidosis is a rare, but serious metabolic 
complication that ...
Generic Metformin Tablets 
Warnings And Precautions 
➔Vitamin B12 deficiency: Metformin may lower 
Vitamin B12 levels. Mea...
Generic Metformin Tablets 
Overdose Symptoms 
Overdose of Metformin Hydrochloride has 
occurred, including ingestion of am...
Generic Metformin Tablets 
Overdose Treatment 
Metformin HCl is dialysable with a 
clearance of up to 170 mL/min under 
go...
Generic Metformin Tablets 
Glycomet and Glycomet SR Tablets 
manufactured by USV Limited 
Exermet XR Tablets 
manufactured...
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Generic Metformin Tablets for Treatment of Type 2 Diabetes (Non-Insulin Dependent Diabetes)

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Glycomet (Generic Metformin Tablets) and Exermet XR or Glycomet SR (Metformin Extended Release Tablets) are used to treat type 2 diabetes mellitus (non-insulin dependent diabetes) in adults, when diet and exercise alone does not result in adequate control of blood glucose levels. Generic Metformin is also used in the treatment of polycystic ovary syndrome (PCOS).

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Generic Metformin Tablets for Treatment of Type 2 Diabetes (Non-Insulin Dependent Diabetes)

  1. 1. Generic Metformin Tablets Glycomet (Generic Metformin Tablets) and Exermet XR or Glycomet SR (Metformin Extended Release Tablets) are used to treat type 2 diabetes mellitus (non-insulin dependent diabetes) in adults, when diet and exercise alone does not result in adequate control of blood glucose levels. Generic Metformin is also used in the treatment of polycystic ovary syndrome (PCOS). © The Swiss Pharmacy, Geneva Switzerland
  2. 2. Generic Metformin Tablets Chemical Structure (Metformin) © The Swiss Pharmacy, Geneva Switzerland
  3. 3. Generic Metformin Tablets Generic Metformin is an oral antihyperglycemic drug used in the treatment of type 2 diabetes in adults, particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycaemic control. © The Swiss Pharmacy, Geneva Switzerland
  4. 4. Generic Metformin Tablets Active Ingredient The active pharmaceutical ingredient contained in Glycomet, Exermet XR and Glycomet SR is Metformin Hydrochloride. © The Swiss Pharmacy, Geneva Switzerland
  5. 5. Generic Metformin Tablets Strengths and Versions Generic Metformin (normal Immediate Release) is available in strengths of 250mg, 500 mg , 850 mg and 1000 mg as Glycomet Tablets manufactured by USV Limited . It is also available as an Extended Release (XR or ER) or Sustained Release, also called Slow Release (SR) version in the form of Exermet XR available in strengths of 500 mg and 1000 mg manufactured by Cipla Limited and Glycomet SR manufactured by USV Limited. © The Swiss Pharmacy, Geneva Switzerland
  6. 6. Generic Metformin Tablets Strengths and Versions The terms XR, ER and SR are equivalent and refer to the same type of product. There is no difference in effectiveness between the Normal and the Extended Release Generic Metformin preparations, but the XR version was introduced mainly to counteract the most common gastrointestinal side effects. © The Swiss Pharmacy, Geneva Switzerland
  7. 7. Generic Metformin Tablets Recommended Dosage Adult Dosage (Generic Metformin): The normal starting dose of Glycomet tablets (Metformin Hydrochloride tablets) is 500 mg twice a day or 850 mg once a day, given with meals. Dosage increases should be made in increments of 500 mg weekly or 850 mg every 2 weeks, up to a total of 2000 mg per day, given in divided doses. Patients that require additional glycemic control, may be given a maximum daily dose of 2550 mg per day. Doses above 2000 mg may be better tolerated given three times a day with meals. © The Swiss Pharmacy, Geneva Switzerland
  8. 8. Generic Metformin Tablets Recommended Dosage Adult Dosage (Generic Metformin XR): The usual initial dose for Glycomet SR or Exermet XR (Metformin Hydrochloride extended-release tablets) is 500 mg given orally, once or twice daily, after meals. Dosage increases should be made in increments of 500 mg weekly, up to a maximum of 2000 mg daily in divided doses. If glycemic control is not achieved with maximum recommended dosages of Metformin 500 mg XR, patients should be switched to conventional Metformin Hydrochloride tablets and may receive up to a maximum of 2550 mg per day in divided doses. © The Swiss Pharmacy, Geneva Switzerland
  9. 9. Generic Metformin Tablets Contraindications Glycomet, Glycomet SR and Exermet XR are contraindicated in patients with the following conditions: ➔Hypersensitivity to Metformin Hydrochloride or to any inactive ingredient present in the medication. ➔Contraindicated in cases of Renal dysfunction, e.g., serum creatinine 1.5 mg/dL or more in males, 1.4 mg/dL or more in females or abnormal creatinine clearance © The Swiss Pharmacy, Geneva Switzerland
  10. 10. Generic Metformin Tablets Contraindications Glycomet, Glycomet SR and Exermet XR are contraindicated in patients with the following conditions: ➔Contraindicated in cases of Metabolic acidosis, including Diabetic ketoacidosis with or without coma. Diabetic ketoacidosis should be treated with insulin. ➔Patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials, because use of such products may result in acute alteration of renal function. © The Swiss Pharmacy, Geneva Switzerland
  11. 11. Generic Metformin Tablets Side Effects of Generic Metformin The most commonly observed side effects associated with the use of Generic Metformin and Generic Metformin XR were Diarrhea, Nausea, Vomiting, Flatulence, Asthenia, Indigestion, Abdominal Discomfort and Headache. The uncommon side effects include abnormal stools, hypoglycemia, myalgia, lightheaded, dyspnea, nail disorder, rash, sweating increased, taste disorder, chest discomfort, chills, flu syndrome, flushing, palpitation. © The Swiss Pharmacy, Geneva Switzerland
  12. 12. Generic Metformin Tablets Side Effects of Generic Metformin Lactic Acidosis: Lactic acidosis is a rare, but serious, metabolic complication that can occur due to Metformin accumulation during treatment with Generic Metformin and Generic Metformin XR. When it has occurred with Metformin, it is generally accepted that the lactic acidosis was usually in patients whose conditions contraindicated the use of Metformin, particularly those with renal impairment. © The Swiss Pharmacy, Geneva Switzerland
  13. 13. Generic Metformin Tablets Warnings And Precautions ➔Lactic acidosis is a rare, but serious metabolic complication that can occur due to Metformin accumulation during treatment with Generic Metformin and Generic Metformin XR. ➔Temporarily discontinue Generic Metformin and Generic Metformin XR in patients undergoing radiologic studies with intravascular administration of iodinated contrast materials or any surgical procedures necessitating restricted intake of food or fluids. ➔Metformin is known to be substantially excreted by the kidney, and the risk of metformin accumulation and lactic acidosis increases with the degree of impairment of renal function. Thus, patients with serum creatinine levels above the upper limit of normal for their age should not receive Generic Metformin and Generic Metformin XR. © The Swiss Pharmacy, Geneva Switzerland
  14. 14. Generic Metformin Tablets Warnings And Precautions ➔Vitamin B12 deficiency: Metformin may lower Vitamin B12 levels. Measure hematologic parameters annually. ➔Before initiating treatment with Generic Metformin and Generic Metformin XR and at least annually thereafter, assess renal function and verify as normal. ➔Concomitant medication(s) that may affect renal function or result in significant hemodynamic change or may interfere with the disposition of metformin, such as cationic drugs that are eliminated by renal tubular secretion. © The Swiss Pharmacy, Geneva Switzerland
  15. 15. Generic Metformin Tablets Overdose Symptoms Overdose of Metformin Hydrochloride has occurred, including ingestion of amounts greater than 50 grams. Hypoglycaemia was reported in approximately 10% of cases, but no causal association with Metformin Hydrochloride has been established. Lactic acidosis has been reported in approximately 32% of Metformin overdose cases. © The Swiss Pharmacy, Geneva Switzerland
  16. 16. Generic Metformin Tablets Overdose Treatment Metformin HCl is dialysable with a clearance of up to 170 mL/min under good haemodynamic conditions . Therefore, haemodialysis may be useful for removal of accumulated medicine from patients in whom Metformin overdosage is suspected. © The Swiss Pharmacy, Geneva Switzerland
  17. 17. Generic Metformin Tablets Glycomet and Glycomet SR Tablets manufactured by USV Limited Exermet XR Tablets manufactured by Cipla Limited For more information click here © The Swiss Pharmacy, Geneva Switzerland

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