"Global Cancer Biosimilars Market Opportunity Outlook" Report Highlight & Findings:
Introduction & Mechanism of Cancer Biosimilars
Global Cancer Biosimilars Market Dynamics
FDA & EMA Guidelines on Development & Marketing of Biosimilars
Cancer Biosimilars Clinical Pipeline by Company, Indication & Phase
Cancer Biosimilars Clinical Pipeline: 100 Biosimilars
Marketed Cancer Biosimilars Clinical Insight
Marketed Cancer Biosimilars: 15 Biosimilars
Global cancer biosimilars market opportunity outlookKuicK Research
"Global Cancer Biosimilars Market Opportunity Outlook" Report Highlight & Findings:
Introduction & Mechanism of Cancer Biosimilars
Global Cancer Biosimilars Market Dynamics
FDA & EMA Guidelines on Development & Marketing of Biosimilars
Cancer Biosimilars Clinical Pipeline by Company, Indication & Phase
Cancer Biosimilars Clinical Pipeline: 100 Biosimilars
Marketed Cancer Biosimilars Clinical Insight
Marketed Cancer Biosimilars: 15 Biosimilars
Cancer targeted therapy market & clinical insight 2015KuicK Research
“Cancer Targeted Therapy Market & Clinical Insight” Report Highlight:
Introduction & Categorization of Cancer Targeted Therapies
Mechanism of Cancer Targeted Tyrosine Kinase, Vaccines, Oncogenes Inhibitors, Monoclonal Antibodies
Cancer Targeted Therapy Clinical Pipeline by Company, Indication & Phase
Clinical Insight on More Than 1200 Cancer Targeted Therapies in Pipeline
Clinical Insight & Patent Analysis of Marketed Cancer Targeted Therapies
Global Cancer Targeted Therapeutics Market Dynamics
Future Prospects of Cancer Targeted Therapies
Us biosimilars market opportunity & clinical pipeline analysisRajesh Sarma
“US Biosimilars Market Opportunity & Clinical Pipeline Analysis” Report Highlight:
US Biosimilars Market Introduction
US Biosimilars Regulatory Scenario
Unique Features of US Biosimilars Market
Impact of Biosimilars in US Market
Impact of Reimbursement Policies on US Biosimilars Market
Zarxio: First Approved Biosimilar in US
US Biosimilar Clinical Pipeline By Company, Indication & Phase
US Biosimilar Clinical Pipeline: 104 Biosimilars
Marketed Biosimilars: 1 Biosimilar
Currently, when a patient wants to be treated for a pathology, depending on the country, a doctor or a pharmacist can propose different types of drug: an originators, a generic or a biosimilar with the aim of bringing the best solution to the patient.
In the same time, authorities, learning societies, patient associations, national and European unions work closely together to set up regulations that will help bring the most efficient drugs at the lowest price on the market and take care of the patient.
Global cancer immunotherapy market outlook 2020KuicK Research
"Global Cancer Immunotherapy Market Outlook 2020" Report Highlight:
Introduction & Classification of Cancer Immunotherapy
Global Cancer Immunotherapy Pipeline by Company, Indication & Phase
Marketed Cancer Immunotherapies Clinical Insight & Patent Analysis by Company & Indication
Global Cancer Immunotherapy Pipeline: 1834 Drugs
Marketed Cancer Immunotherapies: 113 Drugs
Cancer Monoclonal Antibodies Pipeline: 622 Cancer mAb
Cancer Vaccines Pipeline: 312 Vaccines
Marketed Cancer mAb: 36 mAb
Marketed Cancer Vaccines: 12 Vaccines
Cancer targeted therapy market & clinical insight 2015KuicK Research
“Cancer Targeted Therapy Market & Clinical Insight” Report Highlight:
Introduction & Categorization of Cancer Targeted Therapies
Mechanism of Cancer Targeted Tyrosine Kinase, Vaccines, Oncogenes Inhibitors, Monoclonal Antibodies
Cancer Targeted Therapy Clinical Pipeline by Company, Indication & Phase
Clinical Insight on More Than 1200 Cancer Targeted Therapies in Pipeline
Clinical Insight & Patent Analysis of Marketed Cancer Targeted Therapies
Global Cancer Targeted Therapeutics Market Dynamics
Future Prospects of Cancer Targeted Therapies
Global cancer biosimilars market opportunity outlookKuicK Research
"Global Cancer Biosimilars Market Opportunity Outlook" Report Highlight & Findings:
Introduction & Mechanism of Cancer Biosimilars
Global Cancer Biosimilars Market Dynamics
FDA & EMA Guidelines on Development & Marketing of Biosimilars
Cancer Biosimilars Clinical Pipeline by Company, Indication & Phase
Cancer Biosimilars Clinical Pipeline: 100 Biosimilars
Marketed Cancer Biosimilars Clinical Insight
Marketed Cancer Biosimilars: 15 Biosimilars
Cancer targeted therapy market & clinical insight 2015KuicK Research
“Cancer Targeted Therapy Market & Clinical Insight” Report Highlight:
Introduction & Categorization of Cancer Targeted Therapies
Mechanism of Cancer Targeted Tyrosine Kinase, Vaccines, Oncogenes Inhibitors, Monoclonal Antibodies
Cancer Targeted Therapy Clinical Pipeline by Company, Indication & Phase
Clinical Insight on More Than 1200 Cancer Targeted Therapies in Pipeline
Clinical Insight & Patent Analysis of Marketed Cancer Targeted Therapies
Global Cancer Targeted Therapeutics Market Dynamics
Future Prospects of Cancer Targeted Therapies
Us biosimilars market opportunity & clinical pipeline analysisRajesh Sarma
“US Biosimilars Market Opportunity & Clinical Pipeline Analysis” Report Highlight:
US Biosimilars Market Introduction
US Biosimilars Regulatory Scenario
Unique Features of US Biosimilars Market
Impact of Biosimilars in US Market
Impact of Reimbursement Policies on US Biosimilars Market
Zarxio: First Approved Biosimilar in US
US Biosimilar Clinical Pipeline By Company, Indication & Phase
US Biosimilar Clinical Pipeline: 104 Biosimilars
Marketed Biosimilars: 1 Biosimilar
Currently, when a patient wants to be treated for a pathology, depending on the country, a doctor or a pharmacist can propose different types of drug: an originators, a generic or a biosimilar with the aim of bringing the best solution to the patient.
In the same time, authorities, learning societies, patient associations, national and European unions work closely together to set up regulations that will help bring the most efficient drugs at the lowest price on the market and take care of the patient.
Global cancer immunotherapy market outlook 2020KuicK Research
"Global Cancer Immunotherapy Market Outlook 2020" Report Highlight:
Introduction & Classification of Cancer Immunotherapy
Global Cancer Immunotherapy Pipeline by Company, Indication & Phase
Marketed Cancer Immunotherapies Clinical Insight & Patent Analysis by Company & Indication
Global Cancer Immunotherapy Pipeline: 1834 Drugs
Marketed Cancer Immunotherapies: 113 Drugs
Cancer Monoclonal Antibodies Pipeline: 622 Cancer mAb
Cancer Vaccines Pipeline: 312 Vaccines
Marketed Cancer mAb: 36 mAb
Marketed Cancer Vaccines: 12 Vaccines
Cancer targeted therapy market & clinical insight 2015KuicK Research
“Cancer Targeted Therapy Market & Clinical Insight” Report Highlight:
Introduction & Categorization of Cancer Targeted Therapies
Mechanism of Cancer Targeted Tyrosine Kinase, Vaccines, Oncogenes Inhibitors, Monoclonal Antibodies
Cancer Targeted Therapy Clinical Pipeline by Company, Indication & Phase
Clinical Insight on More Than 1200 Cancer Targeted Therapies in Pipeline
Clinical Insight & Patent Analysis of Marketed Cancer Targeted Therapies
Global Cancer Targeted Therapeutics Market Dynamics
Future Prospects of Cancer Targeted Therapies
Global cancer immunotherapy market outlook 2020KuicK Research
"Global Cancer Immunotherapy Market Outlook 2020" Report Highlight:
Introduction & Classification of Cancer Immunotherapy
Global Cancer Immunotherapy Pipeline by Company, Indication & Phase
Marketed Cancer Immunotherapies Clinical Insight & Patent Analysis by Company & Indication
Global Cancer Immunotherapy Pipeline: 1834 Drugs
Marketed Cancer Immunotherapies: 113 Drugs
Cancer Monoclonal Antibodies Pipeline: 622 Cancer mAb
Cancer Vaccines Pipeline: 312 Vaccines
Marketed Cancer mAb: 36 mAb
Marketed Cancer Vaccines: 12 Vaccines
Global breast cancer monoclonal antibodies market outlook 2020 1KuicK Research
" Global Breast Cancer Monoclonal Antibodies Market Outlook 2020" Report Highlights:
Breast Cancer Monoclonal Antibodies Mechanism
Global Breast Cancer Monoclonal Antibody Market Analysis
Breast Cancer Monoclonal Antibodies Pipeline by Company & Phase
Breast Cancer Monoclonal Antibodies Pipeline: 62 mAb
Majority Breast Cancer Monoclonal Antibodies in Preclinical Phase: 17 mAb
Marketed Breast Cancer Monoclonal Antibodies: 6 mAb
Global breast cancer monoclonal antibodies market outlook 2020KuicK Research
" Global Breast Cancer Monoclonal Antibodies Market Outlook 2020" Report Highlights:
Breast Cancer Monoclonal Antibodies Mechanism
Global Breast Cancer Monoclonal Antibody Market Analysis
Breast Cancer Monoclonal Antibodies Pipeline by Company & Phase
Breast Cancer Monoclonal Antibodies Pipeline: 62 mAb
Majority Breast Cancer Monoclonal Antibodies in Preclinical Phase: 17 mAb
Marketed Breast Cancer Monoclonal Antibodies: 6 mAb
Cancer immunotherapy market & clinical pipelineKuicK Research
“Cancer Immunotherapy Market & Clinical Pipeline Insight” Report Highlights:
Cancer Immunotherapy Market Overview
Cancer Immunotherapy Market Dynamics
Cancer Immunotherapy Pipeline: 1080 Drug in Clinical Pipeline
Cancer Monoclonal Antibodies Clinical Pipeline by Phase & Country
Cancer Vaccine Clinical Pipeline by Phase & Country
Oncolytic Viruses Clinical Pipeline by Phase & Country
Cancer Cytokine Therapy Clinical Trial Insight by Phase & Country
Cancer Cell Therapy Clinical Trial Insight by Phase & Country
Currently there are 605 Cancer Monoclonal Antibodies, 289 Cancer Vaccines, 40
Oncolytic Viruses Drugs, 64 Cytokines Therapies & 82 Cell Therapies are in Clinical
Pipeline
Cancer immunomodulators market & pipeline insight 2020KuicK Research
"Cancer Immunomodulators Market & Pipeline Insight 2020" Report Highlights:
Introduction & Need of Cancer Immunomodulators
Cancer Immunomodulators Mechanism
Cancer Immunomodulators Clinical Pipeline By Company, Indication & Phase
Cancer Immunomodulators Clinical Pipeline: 747 Cancer Immunomodulators Drugs
Majority Cancer Immunomodulators in Preclinical Phase: 300 Marketed Cancer Immunomodulators Clinical Insight
Marketed Cancer Immunomodulators: 47
Cancer Immunomodulators Drug Patent Analysis
Pharmacovigilance Risk Management for BiosimilarsCovance
This paper focuses on pharmacovigilance (PV) and risk management for biosimilars, the issues and challenges faced in monitoring their safety and possible solutions.
Biosimilars or follow-on-biologics are highly similar versions of reference biologics derived from living organisms such as plants and animals. The development of biosimilars and validation with reference biologics play a significant role in the commercialization of biosimilars. Economic pricing of biosimilars, ease in development and a quick approval process are some key driving factors that drive the growth of this market. Effective and timely formulated regulations facilitate the viability and balance between original and biosimilar products. Moreover, a favorable regulatory environment and the establishment of IPR protections are factors that boost the market growth.
Global cancer antibody drug conjugates market and pipeline insight 2022KuicK Research
“Global Cancer Antibody Drug Conjugate Market and Clinical Pipeline Insight 2022” report highlights:
Impetus of Antibody Drug Conjugates
Mechanism of Cancer Antibody Drug Conjugates
Global Cancer Antibody Drug Conjugate Clinical Pipeline Overview
Marketed Cancer Antibody Drug Conjugate Clinical Insight
Global Cancer Antibody Drug Conjugate Pipeline by Company, Indication , Mode of Action, Formulation and Phase
Global antibody drug conjugate market & pipeline insight2020KuicK Research
" Global Antibody Drug Conjugate Market & Pipeline Insight 2020" Report Highlight:
Global Antibody Drug Conjugates Market Overview
Mechanism of Antibody Drug Conjugates
Global Antibody Drug Conjugates Clinical Pipeline by Company, Indication & Phase
Global Antibody Drug Conjugates Clinical Pipeline: 148 ADC
Marketed Antibody Drug Conjugates Clinical Insight: 8 ADC
Antibody Drug Conjugates Patent Analysis
Global Antibody Drug Conjugates Market Future Prospects
Cancer nanomedicine market & pipeline insight 2015KuicK Research
“Cancer Nanomedicine Market & Pipeline Insight 2015” Report Highlight
Nanomedicine for Cancer Therapies
Cancer Nanoparticles Drug Delivery Systems Classification
Mechanism of Cancer Nanomedicine Therapy
Cancer Nanomedicine Clinical Pipeline Overview
Cancer Nanomedicine Clinical Pipeline by Company, Indication & Phase
Cancer Nanomedicine Clinical Pipeline: 79 Drugs
Marketed Cancer Nanomedicine: 8 Drugs
“Europe Biosimilars Market & Pipeline Insight” Report Highlight:
Biosimilars Market Overview & Trend Analysis by Country
Biosimilars Introduction Timeline in Europe
Biosimilars Development & Market Authorization Guidelines
Biosimilars Clinical Pipeline by Phase, Indication, Company & Country
Marketed Biosimilars Clinical Insight by Phase, Indication, Company & Country
Europe Biosimilars Pipeline: 93 Biosimilars
Marketed Biosimilars: 18 Biosimilars (17 Approved by EMA & 1 in Ukraine)
Global cancer monoclonal antibodies marketKuicK Research
“Global Cancer Monoclonal Antibodies Market & Pipeline Insight” Report highlights:
Cancer Monoclonal Antibodies Market Overview
Emerging Market Dynamics: Favorable Parameters, Challenges & Growth Outlook
Cancer Monoclonal Antibodies Pipeline by Phase, Indication, Company & Country
Cancer Monoclonal Antibodies in Pipeline: 605
Majority Cancer Monoclonal Antibodies Preclinical Phase: 258
Marketed Cancer Monoclonal Antibodies: 34
Cancer Monoclonal Antibodies Patent Analysis
“India Baby Care Market Outlook 2018” report Highlights:
Baby Care Market Overview
Market by Product Segment
Consumer Purchasing & Spending Behavior
Point of Purchase for Multiple Products
Favorable Market Dynamics
Future Growth Strategies
Preferred Operating Business Model
Key Companies Business Overview & Product Portfolio
Global cancer immunotherapy market outlook 2020KuicK Research
"Global Cancer Immunotherapy Market Outlook 2020" Report Highlight:
Introduction & Classification of Cancer Immunotherapy
Global Cancer Immunotherapy Pipeline by Company, Indication & Phase
Marketed Cancer Immunotherapies Clinical Insight & Patent Analysis by Company & Indication
Global Cancer Immunotherapy Pipeline: 1834 Drugs
Marketed Cancer Immunotherapies: 113 Drugs
Cancer Monoclonal Antibodies Pipeline: 622 Cancer mAb
Cancer Vaccines Pipeline: 312 Vaccines
Marketed Cancer mAb: 36 mAb
Marketed Cancer Vaccines: 12 Vaccines
Global breast cancer monoclonal antibodies market outlook 2020 1KuicK Research
" Global Breast Cancer Monoclonal Antibodies Market Outlook 2020" Report Highlights:
Breast Cancer Monoclonal Antibodies Mechanism
Global Breast Cancer Monoclonal Antibody Market Analysis
Breast Cancer Monoclonal Antibodies Pipeline by Company & Phase
Breast Cancer Monoclonal Antibodies Pipeline: 62 mAb
Majority Breast Cancer Monoclonal Antibodies in Preclinical Phase: 17 mAb
Marketed Breast Cancer Monoclonal Antibodies: 6 mAb
Global breast cancer monoclonal antibodies market outlook 2020KuicK Research
" Global Breast Cancer Monoclonal Antibodies Market Outlook 2020" Report Highlights:
Breast Cancer Monoclonal Antibodies Mechanism
Global Breast Cancer Monoclonal Antibody Market Analysis
Breast Cancer Monoclonal Antibodies Pipeline by Company & Phase
Breast Cancer Monoclonal Antibodies Pipeline: 62 mAb
Majority Breast Cancer Monoclonal Antibodies in Preclinical Phase: 17 mAb
Marketed Breast Cancer Monoclonal Antibodies: 6 mAb
Cancer immunotherapy market & clinical pipelineKuicK Research
“Cancer Immunotherapy Market & Clinical Pipeline Insight” Report Highlights:
Cancer Immunotherapy Market Overview
Cancer Immunotherapy Market Dynamics
Cancer Immunotherapy Pipeline: 1080 Drug in Clinical Pipeline
Cancer Monoclonal Antibodies Clinical Pipeline by Phase & Country
Cancer Vaccine Clinical Pipeline by Phase & Country
Oncolytic Viruses Clinical Pipeline by Phase & Country
Cancer Cytokine Therapy Clinical Trial Insight by Phase & Country
Cancer Cell Therapy Clinical Trial Insight by Phase & Country
Currently there are 605 Cancer Monoclonal Antibodies, 289 Cancer Vaccines, 40
Oncolytic Viruses Drugs, 64 Cytokines Therapies & 82 Cell Therapies are in Clinical
Pipeline
Cancer immunomodulators market & pipeline insight 2020KuicK Research
"Cancer Immunomodulators Market & Pipeline Insight 2020" Report Highlights:
Introduction & Need of Cancer Immunomodulators
Cancer Immunomodulators Mechanism
Cancer Immunomodulators Clinical Pipeline By Company, Indication & Phase
Cancer Immunomodulators Clinical Pipeline: 747 Cancer Immunomodulators Drugs
Majority Cancer Immunomodulators in Preclinical Phase: 300 Marketed Cancer Immunomodulators Clinical Insight
Marketed Cancer Immunomodulators: 47
Cancer Immunomodulators Drug Patent Analysis
Pharmacovigilance Risk Management for BiosimilarsCovance
This paper focuses on pharmacovigilance (PV) and risk management for biosimilars, the issues and challenges faced in monitoring their safety and possible solutions.
Biosimilars or follow-on-biologics are highly similar versions of reference biologics derived from living organisms such as plants and animals. The development of biosimilars and validation with reference biologics play a significant role in the commercialization of biosimilars. Economic pricing of biosimilars, ease in development and a quick approval process are some key driving factors that drive the growth of this market. Effective and timely formulated regulations facilitate the viability and balance between original and biosimilar products. Moreover, a favorable regulatory environment and the establishment of IPR protections are factors that boost the market growth.
Global cancer antibody drug conjugates market and pipeline insight 2022KuicK Research
“Global Cancer Antibody Drug Conjugate Market and Clinical Pipeline Insight 2022” report highlights:
Impetus of Antibody Drug Conjugates
Mechanism of Cancer Antibody Drug Conjugates
Global Cancer Antibody Drug Conjugate Clinical Pipeline Overview
Marketed Cancer Antibody Drug Conjugate Clinical Insight
Global Cancer Antibody Drug Conjugate Pipeline by Company, Indication , Mode of Action, Formulation and Phase
Global antibody drug conjugate market & pipeline insight2020KuicK Research
" Global Antibody Drug Conjugate Market & Pipeline Insight 2020" Report Highlight:
Global Antibody Drug Conjugates Market Overview
Mechanism of Antibody Drug Conjugates
Global Antibody Drug Conjugates Clinical Pipeline by Company, Indication & Phase
Global Antibody Drug Conjugates Clinical Pipeline: 148 ADC
Marketed Antibody Drug Conjugates Clinical Insight: 8 ADC
Antibody Drug Conjugates Patent Analysis
Global Antibody Drug Conjugates Market Future Prospects
Cancer nanomedicine market & pipeline insight 2015KuicK Research
“Cancer Nanomedicine Market & Pipeline Insight 2015” Report Highlight
Nanomedicine for Cancer Therapies
Cancer Nanoparticles Drug Delivery Systems Classification
Mechanism of Cancer Nanomedicine Therapy
Cancer Nanomedicine Clinical Pipeline Overview
Cancer Nanomedicine Clinical Pipeline by Company, Indication & Phase
Cancer Nanomedicine Clinical Pipeline: 79 Drugs
Marketed Cancer Nanomedicine: 8 Drugs
“Europe Biosimilars Market & Pipeline Insight” Report Highlight:
Biosimilars Market Overview & Trend Analysis by Country
Biosimilars Introduction Timeline in Europe
Biosimilars Development & Market Authorization Guidelines
Biosimilars Clinical Pipeline by Phase, Indication, Company & Country
Marketed Biosimilars Clinical Insight by Phase, Indication, Company & Country
Europe Biosimilars Pipeline: 93 Biosimilars
Marketed Biosimilars: 18 Biosimilars (17 Approved by EMA & 1 in Ukraine)
Global cancer monoclonal antibodies marketKuicK Research
“Global Cancer Monoclonal Antibodies Market & Pipeline Insight” Report highlights:
Cancer Monoclonal Antibodies Market Overview
Emerging Market Dynamics: Favorable Parameters, Challenges & Growth Outlook
Cancer Monoclonal Antibodies Pipeline by Phase, Indication, Company & Country
Cancer Monoclonal Antibodies in Pipeline: 605
Majority Cancer Monoclonal Antibodies Preclinical Phase: 258
Marketed Cancer Monoclonal Antibodies: 34
Cancer Monoclonal Antibodies Patent Analysis
“India Baby Care Market Outlook 2018” report Highlights:
Baby Care Market Overview
Market by Product Segment
Consumer Purchasing & Spending Behavior
Point of Purchase for Multiple Products
Favorable Market Dynamics
Future Growth Strategies
Preferred Operating Business Model
Key Companies Business Overview & Product Portfolio
Finger Vein Detection using Gabor Filter, Segmentation and Matched FilterEditor IJCATR
This paper propose a method of personal identification based on finger-vein patterns. An image of a finger captured by the web camera under the IR light transmission contains not only the vein pattern itself; but also shade produced by various thickness of the finger muscles; bones; and tissue networks surrounding the vein. In this paper; we intro-duce preliminary process to enhance the image quality worsened by light effect and noise produced by the web camera; then segment the vein pattern by using adaptive threshold method and matched them using improved template matching. The main purposes of this paper are to investigate finger-vein technology; the applicable fields and whether finger-vein detection can solve the problems fingerprint detection imposes in certain industries
Data Transfer Security solution for Wireless Sensor NetworkEditor IJCATR
WSN is a wide growth area for specific resource limited application. Factor associated with technology like, the encryption
security, operating speed and power consumption for network. Here, we introduce a mechanism for secure transferring of data is WSN
and various security related issues. This energy-efficient encryption is a secure communication framework in which an algorithm is
used to encode the sensed data using like, RC5, AES and CAST Algorithm. The proposed scheme is most suitable for wireless sensor
networks that incorporate data centric routing protocols. An algorithm in sensor network is help to designers predict security
performance under a set of constraints for WSNs. This symmetric key function is used to guarantee secure communications between
in-network nodes and reliable operation cost. RC5 is good on the code point of view, but the key schedule consumes more resource
time for efficient security aspects.
Duplicate Code Detection using Control StatementsEditor IJCATR
Code clone detection is an important area of research as reusability is a key factor in software evolution. Duplicate code
degrades the design and structure of software and software qualities like readability, changeability, maintainability. Code clone
increases the maintenance cost as incorrect changes in copied code may lead to more errors. In this paper we address structural code
similarity detection and propose new methods to detect structural clones using structure of control statements. By structure we mean
order of control statements used in the source code. We have considered two orders of control structures: (i) Sequence of control
statements as it appears (ii) Execution flow of control statements.
HANDLING CROSS-LAYER ATTACKS USING NEIGHBORS MONITORING SCHEME AND SWARM INTE...Editor IJCATR
The standard MAC protocol widely used for Mobile Adhoc Networks (MANETs) is IEEE 802.11.
When attacks in MAC layer are left as such without paying attention, it could possibly disturb channel access and
consequently may cause wastage of resources in terms of bandwidth and power. In this paper, a swarm based detection
and defense technique is proposed for routing and MAC layer attacks in MANET. Using forward and backward ants,
the technique obtains mean value of nodes between the first received RREQ and RREP packets. Based on this
estimation, the source node decides the node as valid or malicious. Moreover the MAC layer parameters namely
number of neighbors identified by the MAC layer, number of neighbors identified by the routing layer, the number of
recent MAC receptions and the number of recent routing protocol receptions are used to determine the node state. The
source node uses these two node state estimation techniques to construct the reliable path to the destination. This
proposed technique improves the network performance and at the same time prevents attackers intelligently.
A Multiparametric Reliable AODV Protocol using Alternate Routing in MANET’s u...Editor IJCATR
In this paper, we design and formulate a trust-based routing protocol for secure transactions, such as military and disaster
relief operations, banking in mobile ad hoc networks (MANETs). The proposed approach is showing the idea of a trust model in the
network layer of MANET.AODV is ad hoc on demand distance vector, this protocol starts the route specially when some node claims
to send data. In AODV whenever a link breaks an error message is sent indicating the link and packet sending is dropped. In our
proposed scheme a packet is sent through alternative path. In this approach a trust node is made with neighbors. Simulation results
shows that proposed scheme has less packet loss and packet ratio delivered is more.
RW-CLOSED MAPS AND RW-OPEN MAPS IN TOPOLOGICAL SPACESEditor IJCATR
In this paper we introduce rw-closed map from a topological space X to a topological space Y as the image
of every closed set is rw-closed and also we prove that the composition of two rw-closed maps need not be rw-closed
map. We also obtain some properties of rw-closed maps.
Download Us biosimilars market opportunity & clinical pipeline analysisKuicK Research
“US Biosimilars Market Opportunity & Clinical Pipeline Analysis” Report Highlight:
* US Biosimilars Market Introduction
* US Biosimilars Regulatory Scenario
* Unique Features of US Biosimilars Market
* Impact of Biosimilars in US Market
* Impact of Reimbursement Policies on US Biosimilars Market
* Zarxio: First Approved Biosimilar in US
* US Biosimilar Clinical Pipeline By Company, Indication & Phase
* US Biosimilar Clinical Pipeline: 104 Biosimilars
* Marketed Biosimilars: 1 Biosimilar*
Download Global breast cancer monoclonal antibodies market outlook 2020KuicK Research
\" Global Breast Cancer Monoclonal Antibodies Market Outlook 2020\" Report Highlights:
Breast Cancer Monoclonal Antibodies Mechanism
Global Breast Cancer Monoclonal Antibody Market Analysis
Breast Cancer Monoclonal Antibodies Pipeline by Company & Phase
Breast Cancer Monoclonal Antibodies Pipeline: 62 mAb
Majority Breast Cancer Monoclonal Antibodies in Preclinical Phase: 17 mAb
Marketed Breast Cancer Monoclonal Antibodies: 6 mAb
Cancer immunomodulators market & pipeline insight 2020KuicK Research
"Cancer Immunomodulators Market & Pipeline Insight 2020" Report Highlights:
Introduction & Need of Cancer Immunomodulators
Cancer Immunomodulators Mechanism
Cancer Immunomodulators Clinical Pipeline By Company, Indication & Phase
Cancer Immunomodulators Clinical Pipeline: 747 Cancer Immunomodulators Drugs
Majority Cancer Immunomodulators in Preclinical Phase: 300 Marketed Cancer Immunomodulators Clinical Insight
Marketed Cancer Immunomodulators: 47
Cancer Immunomodulators Drug Patent Analysis
Global gene therapy market & pipeline insightKuicK Research
“Global Gene Therapy Market & Pipeline Insight” Market Highlight:
Gene Therapy Market Overview
Significance of Gene Therapy in Cancer Therapeutics
Current Applications of Gene Therapy to Cancer Treatment
Gene Therapy Market Dynamics: Drivers, Challenges & Future Outlook
FDA & AMA Guidelines for Gene Therapy
Gene Therapy Pipeline by Phase, Indications, Country & Company
Gene Therapy Pipeline: 246 Drugs
Marketed Gene Therapy: 2 (Gendicine & Rexin-G)
Cancer Gene Therapy Pipeline: 69 Drugs
Download Cancer immunomodulators market & pipeline insight 2020KuicK Research
\"Cancer Immunomodulators Market & Pipeline Insight 2020\" Report Highlights:
Introduction & Need of Cancer Immunomodulators
Cancer Immunomodulators Mechanism
Cancer Immunomodulators Clinical Pipeline By Company, Indication & Phase
Cancer Immunomodulators Clinical Pipeline: 747 Cancer Immunomodulators Drugs
Majority Cancer Immunomodulators in Preclinical Phase: 300 Marketed Cancer Immunomodulators Clinical Insight
Marketed Cancer Immunomodulators: 47
Cancer Immunomodulators Drug Patent Analysis
The Biologics Market was worth USD 267.58 billion in 2014 and is expected to reach approximately USD 373.66 billion by 2023, while registering itself at a compound annual growth rate (CAGR) of 3.78% during the forecast period. Biologics are medicates as hereditarily built proteins, got from human qualities. According to the US FDA, biologics can be made out of sugars, proteins, or nucleic acids or complex blends of these substances, or might live elements, for example, cells and tissues. The biologic medications are taken from an assortment of regular sources, for example, people, creatures, or microorganisms and comprise of items, for example, antibodies, blood and blood parts, allergenic, substantial cells, quality treatment, tissues, and recombinant remedial proteins. Propelled biotechnology strategies and complex procedures are utilized to produce biologics. They are at the cutting edge of biomedical research.
Biopharmaceuticals are medicinal drugs which are produced through biotechnology methods such as recombinant DNA techniques, fermentation, hybridoma techniques, and purification processes. Biopharmaceutical production involves the usage of biological sources, either live organisms or their active components. They are made up of proteins and nucleic acids and target specific diseases and patients groups. Biopharmaceuticals are used in the treatment of various chronic diseases such as cardiovascular, metabolic, neurological, cancer, and other rare diseases for which there are no available treatments.
The present slide focuses on the applications and different uses of biosimilars along with the basic difference in between biosimilars and bioequivalence.
In recent years, the pharmaceutical industry has witnessed increased political interest and attention due to the increased recognition of the economic importance and financial impact of healthcare as a component of national budgets. Biologic drugs (biologics) have attracted the attention of politicians since biologics have moved out of the niche pharmaceutical arena to contribute 17% of global pharmaceutical sales, representing revenues of more than $120bn in 2009. The market for biologics is growing at twice the rate of pharmaceutical drugs, placing significant cost pressures on government, employers, insurers, and patients. Government and insurers are using several strategies to contain costs but must ensure that the financial burden placed on patients does not restrict access to the health care system. Establishing a regulatory pathway for ‘follow-on’ biologics (biosimilars) was therefore felt to be necessary by many stake holders to encourage competition and reduce prices. Many pharmacutical companies both large and small - are expecting their bottom line growth to be driven by biosimilars and are channeling their R&D budgets to compete in what – according to many - is going to be one of the hottest areas in a radically changing global pharmaceutical market.
Download Global cancer immunotherapy market outlook 2020KuicK Research
\"Global Cancer Immunotherapy Market Outlook 2020\" Report Highlight:
Introduction & Classification of Cancer Immunotherapy
Global Cancer Immunotherapy Pipeline by Company, Indication & Phase
Marketed Cancer Immunotherapies Clinical Insight & Patent Analysis by Company & Indication
Global Cancer Immunotherapy Pipeline: 1834 Drugs
Marketed Cancer Immunotherapies: 113 Drugs
Cancer Monoclonal Antibodies Pipeline: 622 Cancer mAb
Cancer Vaccines Pipeline: 312 Vaccines
Marketed Cancer mAb: 36 mAb
Marketed Cancer Vaccines: 12 Vaccines
Download Global antibody drug conjugate market & pipeline insight2020KuicK Research
\" Global Antibody Drug Conjugate Market & Pipeline Insight 2020\" Report Highlight:
Global Antibody Drug Conjugates Market Overview
Mechanism of Antibody Drug Conjugates
Global Antibody Drug Conjugates Clinical Pipeline by Company, Indication & Phase
Global Antibody Drug Conjugates Clinical Pipeline: 148 ADC
Marketed Antibody Drug Conjugates Clinical Insight: 8 ADC
Antibody Drug Conjugates Patent Analysis
Global Antibody Drug Conjugates Market Future Prospects
Similar to Global cancer biosimilars market opportunity outlook (20)
Global cancer cdk inhibitors market & clinical pipeline outlook 2022KuicK Research
“Global Cancer CDK Inhibitors Market and Clinical Pipeline Outlook 2022” report highlights:
* Selectivity and Working Mechanism of a Cancer CDKs Inhibitor
* Recent Advances in the CDKs Related Cancer Therapy
* Global Cancer CDK Inhibitors Clinical Trials Insight: 45 Drugs in Pipeline
* Market Opportunity Assessment: More Than US$ 20 Billion (2022)
* Price Analysis of Cancer CDKs Inhibitors:
* Sales Analysis of Available Drugs: More Than US$ 2 Billion (2017)
Cd antigen cancer therapy market outlook & clinical trials insight 2023KuicK Research
“CD Antigen Cancer Therapy Market Outlook & Clinical Trials Insight 2023” report highlights:
• Market Opportunity Assessment: More than US$ 60 Billion by 2023
• Clinical & Patent Insight on 17 Commercialize CD Antigen Drugs
• Clinical & Licensing Insight on 184 CD Antigens in Clinical Pipeline
• Dosage & Price Analysis on Key Drugs
• Mechanism of CD Antigen Cancer Therapeutics
• Cancer CD Antigens Clinical Pipeline Dominated by CD20 Antigen: 50 Drugs
• Cancer CD Antigen Inhibitors Clinical Pipeline by Company, Indication & Phase
Global orphan drug market designation status clinical pipeline trials insigh...KuicK Research
“Global Orphan Drug Market & Clinical Pipeline Insight 2023” Report Highlights:
• Clinical Insight on 800 Orphan Drugs
• Patent Insight, Orphan Designated Indication & Region/Country
• Marketed Orphan Drugs: More Than 300
• Maximum Orphan Designated Drugs in Phase-II: More Than 200
• Global Orphan Drug Designation Criteria
• FDA & EMA Guidelines
“US Shale Gas Industry Analysis” Report Highlight:
* US Shale Gas Industry Overview
* Shale Gas Exploration, Technical and Technology Aspects
* US Shale Gas Reserve Analysis: Technical & Recoverable Reserves
* Investments in Shale Gas Exploration & Production
* US Shale Gas Sector Dynamics
* Shale Boom to Drive LNG Export Projects
Download Uae nuclear power sector opportunity analysisKuicK Research
“UAE Nuclear Power Sector Opportunity Analysis” Report Highlight:
* UAE Energy Policy beyond Oil & Gas
* UAE Nuclear Power Sector Overview
* UAE Nuclear Power Sector Dynamics
* Nuclear Power Sector Management & Regulatory Framework
* Nuclear Power Sector Regulations
* Details of Nuclear Power Plants in UAE
* UAE Nuclear Power Sector Future Outlook
Download Turkey wind power sector outlook 2017KuicK Research
“Turkey Wind Power Sector Outlook 2017” gives comprehensive insight on following aspect related to wind power sector development in Turkey:
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Download South korea wind power sector analysis 2013KuicK Research
“South Korea Wind Power Sector Analysis 2013” research report discusses following aspect related to emerging wind power sector in South Korea:
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* Onshore & Offshore Wind Potential
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Download Saudi arabia airport privatization opportunity outlook 2022KuicK Research
“Saudi Arabia Airport Privatization Opportunity Outlook 2022” report highlights:
Saudi Arabia Aviation Industry Overview
Privatization in Saudi Arabia
Investment and Expansion Opportunities for International Investors
Civil Aviation Laws and Policies Framework
Ongoing Privatization Projects
Privatization Build - Operateandndash;Transfer (BOT) Business Model
Download Non hodgkin lymphoma therapeutics market & pipeline insightKuicK Research
“Non Hodgkin Lymphoma Therapeutics Market & Pipeline Insight” Report Highlight:
Global Non Hodgkin Lymphoma Market Overview
Mechanism of Non Hodgkin Lymphoma Therapeutics
Global Non Hodgkin Lymphoma Pipeline by Type, Phase & Company
Global Non Hodgkin Lymphoma Pipeline: 204 Drugs
Majority of the Drugs are in Phase-I: 54 Drugs
Marketed Drugs for Non Hodgkin Lymphoma: 30 Drugs
Patent Analysis by Country, Year & Compositions
Download Nanoparticle drug delivery market & clinical pipeline insightKuicK Research
“Nanoparticle Drug Delivery Market & Clinical Pipeline Insight” Report Highlights:
Nanoparticle Drug Delivery Market Overview
Nanoparticle Drug Delivery Mechanism
Clinical Pipeline by Phase & Target Indications
Drug Profiles in Report: 190
Majority of Nanoparticle Drug in Preclinical Phase: 70
Marketed Nanoparticle Drugs: 12
Suspended & Discontinued Drug Profiles
Download Japan generics drug market outlook 2020KuicK Research
“Japan Generics Drug Market Outlook 2020” Report Highlights:
Introduction to Japanese Generic Drug Market
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Super Generics in Japan
Japan Healthcare System & Generic Drugs
Different Parameters for Generic & Branded Drugs
Comparison of Generic Drugs in US & Japan
Japan Generics Drug Market Analysis
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Download India urban and industrial waste to energy marketKuicK Research
The Urban and Industrial waste based power projects have been witnessing upward trend in recent years driven by increasing investments from private sector and ongoing government initiatives to promote generation of power from urban and industrial waste. The overall installed capacity of grid connected waste power projects surpassed 70 MW by end of 2011 as compare to more than 90 MW of off grid waste base power projects.
Considering the huge potential to convert waste to energy in India, the Ministry of Environment and Forests had formulated the Municipal Solid Wastes Management and Handling Rules in 2000. Waste to Energy is understood as a renewable technology, and comes under the overall guidance and facilitation of the Ministry of Non Renewable Energy of India, which has announce finacila incentives and assistance programme in.
Download India nuclear power sector generation and investment opportunity out...KuicK Research
“India Nuclear Power Sector Generation and Investment Opportunity Outlook 2032” report highlights:
India Nuclear Power Sector Overview
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India Existing and upcoming Nuclear Power Plants Overview
Indian Nuclear Power Regulatory and Policy Framework
India Nuclear Power Plants Infrastructure
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...
Global cancer biosimilars market opportunity outlook
1. Global Cancer Biosimilars Market Opportunity Outlook
Cancer incidences are escalating tremendously across the globe due to which burgeoning
pressure has been created on pharmaceutical companies to come forth with viable
products. Moreover, presently available drugs for cancer treatment are known for their
superior pharmacological benefits along with their significantly higher prices. Most of the
cancer patients are unable to afford them due to financial constraints. Simultaneously,
they have also created lot of financial burden on healthcare system due to which various
regulators are unable to offer better facilities to cancer patients. Administration of
biosimilars for various malignancies has been proposed to alleviate patient's medical
condition and development of sustainable healthcare system. They are developed after
expiry of patent protection and associated rights due to which they have lesser cost as
compared to originator molecule. However, cancer biosimilar has not been introduced in
limited markets and other available products are used in supportive cancer care.
Market introduction of cancer biosimilar is required because they have both high
pharmacological and commercialization potential. Chemotherapeutic drugs have
dominated the cancer segment for several decade but various new modalities have been
introduced in past few years. They are biologic in origin and consist of plethora of
therapeutics for numerous cancer indications. They have higher therapeutic efficacy and
lesser side effects as compared to chemotherapeutics. Their cost may be high but
therapeutic benefits offered by them offers lucrative choice to cancer patients. Some of
the cancer biologics are going to lose patent protection and associated rights in coming
years. As a result, path would be paved for the market introduction of cancer biosimilars.
They have been introduced for several disease indications and their better
pharmacological efficacy along with affordable pricing has been widely accepted. Same
benefits are also expected to be offered by them to cancer patients due to which
significant revenues are expected to be generated by pharmaceutical companies.
Investigators are likely to introduce cancer biosimilars for various indications in coming
years that will help them in increasing their market shares. This segment is largely
unexplored and offers significant opportunities in future. Their clinical pipeline is quite
strong and different products are at various stages of clinical trials. Innovative biosimilar
products are expected to be entered in global market as a consequence of strong clinical
pipeline. However, their clinical trials are more rigorous as compared to the biologics
clinical trials because they are copy molecules. They must satisfy the clinical results when
compared to results generated by originator molecules. In this way, their market winding
2. time is increased and due to seriousness of diseases it becomes more important to develop
cancer biosimilars with high safety and efficacy levels.
In recent years, biosimilars have received approval in different parts of world due to their
comparable pharmacological benefits and cost-effectiveness. It is expected that similar
progress would be shown by cancer biosimilars which are at nascent stages of industry life
cycle. Amenable guidelines are also expected to be formulated in coming years leading to
better commercialization opportunities. These changes are expected to be propelled by
escalating cancer patient population and demand for better cancer therapeutics with high
cost effectiveness. This scenario shows that cancer biosimilars are going to play an
important role at both pharmacological and commercial levels. All these facts show that
cancer biosimilars are going to generate significant revenues and have an optimistic future
ahead.
Marketed Cancer Biosimilars in Countries by Country/Region:
Argentina, Europe, Latin America ,India, Thailand, Russia & US
Regulatory Pathways for Development & Marketing of Biosimilars by Country:
Australia, Canada, Europe, Japan, India, Malaysia, Saudi Arabia, Singapore, South Africa,
South Korea, Turkey, US
"Global Cancer Biosimilars Market Opportunity Outlook" Report Highlight & Findings:
Introduction & Mechanism of Cancer Biosimilars
Global Cancer Biosimilars Market Dynamics
FDA & EMA Guidelines on Development & Marketing of Biosimilars
Cancer Biosimilars Clinical Pipeline by Company, Indication & Phase
Cancer Biosimilars Clinical Pipeline: 100 Biosimilars
Marketed Cancer Biosimilars Clinical Insight
Marketed Cancer Biosimilars: 15 Biosimilars
For Report Sample Contact: neeraj@kuickresearch.com
3. Table of Contents
1. Introduction to Cancer Biosimilars
2. Mechanism of Cancer Biosimilars
3. Considerations While Marketing Cancer Biosimilars in Global Market
4. EU & US Regulatory Considerations on Cancer Biosimilars
5. Global Cancer Biosimilars Market Overview
5.1 Current Market Scenario
5.2 Cancer Biosimilars Pipeline Overview
6. Global Cancer Biosimilars Market Dynamics
6.1 Favorable Market Parameters
6.2 Commercialization Challenges
7. Global Cancer Biosimilars Market Future Prospects
8. EMA Guidelines on Development & Marketing of Biosimilars
8.1 Development of Similar Biological Medicinal Products Containing r-hFSH
8.2 Similar Biological Medicinal Products Containing Interferon Beta
8.3 Immunogenicity Assessment of Monoclonal Antibodies Intended For In Vivo
Clinical Use
8.4 Similar Biological Medicinal Products Containing Monoclonal Antibodies
8.5 Similar Biological Medicinal Products Containing Recombinant
Erythropoietins
8.6 Similar Medicinal Products Containing Recombinant Human Soluble Insulin
8.7 Similar Medicinal Products Containing Somatropin
8.8 Similar Biological Medicinal Products Containing Biotechnology Derived
Proteins as Active Substance
8.9 Immunogenicity Assessment of Biotechnology-Derived Therapeutic Proteins
4. 8.10 Comparability of Biotechnology-Derived Medicinal Products After A Change
In The Manufacturing Process
9. FDA Guidelines on Development & Marketing of Biosimilars
9.1 Quality Considerations In Demonstrating Biosimilarity To A Reference
Protein Product
9.2 Scientific Considerations In Demonstrating Biosimilarity To A Reference
Product
10. Regulatory Pathways for Development & Marketing of Biosimilars by
Country
10.1 Australia
10.2 Canada
10.3 Japan
10.4 India
10.5 Malaysia
10.6 Saudi Arabia
10.7 Singapore
10.8 South Africa
10.9 South Korea
10.10 Turkey
11. Cancer Biosimilars Clinical Pipeline by Company, Indication & Phase
11.1 Unknown
11.2 Research
11.3 Preclinical
11.4 Clinical
11.5 Phase-I
11.6 Phase-I/II
11.7 Phase-II
11.8 Phase-III
7. 14.31 Oncobiologics
14.32 Pfizer
14.33 PharmaPraxis
14.34 PlantForm Corporation
14.35 Reliance Life Sciences
14.36 Samsung Bioepis
14.37 Teva Pharmaceutical
14.38 UMN Pharma
14.39 XBiotech
14.40 Yakult Honsha
14.41 Zydus Cadila
List of Figures
Figure 1-1: Benefits of Cancer Biosimilars
Figure 1-2: Limitations of Cancer Biosimilars
Figure 2-1: Mechanism of Trastuzumab Biosimilar
Figure 2-2: Mechanism of Bevacizumab Biosimilar
Figure 2-3: Mechanism of Cetuximab Biosimilar
Figure 2-4: Mechanism of Filgrastim Biosimilar
Figure 5-1: Global Biosimilars Market (US$ Billion), 2013-2020
Figure 5-2: Global Biosimilar Market by Segment (%), 2020
Figure 5-3: Cancer Biosimilars Pipeline by Phase (%), 2015
Figure 5-4: Cancer Biosimilars Pipeline by Phase (Number), 2015
Figure 5-5: No Development Reported in Cancer Biosimilars Pipeline by Phase
(%), 2015
8. Figure 5-6: No Development Reported in Cancer Biosimilars Pipeline by Phase
(Number), 2015
Figure 5-7: Discontinued Cancer Biosimilars in Pipeline by Phase (%), 2015
Figure 5-8: Discontinued Cancer Biosimilars in Pipeline by Phase (Number), 2015
Figure 6-1: Favorable Market Parameters
Figure 6-2: Global Cancer Biosimilars Commercialization Challenges
Figure 14-1: Amgen -Clinical Pipeline
Figure 14-2:Biocon- Clinical Pipeline
Figure 14-3: EPIRUS Biopharmaceuticals- Clinical Pipeline
Figure 14-4: Fujifilm Kyowa Kirin Biologics-Clinical Pipeline
Figure 14-5: Oncobiologics-Clinical Pipeline
Figure 14-6: Zydus Cadila- Clinical Pipeline
List of Tables
Table 1-1: Comparative Analysis between Different Cancers Therapeutic
Categories
Table 2-1: Few Trastuzumab Biosimilars
Table 2-2: Few Bevacizumab Biosimilar
Table 2-3: Biosimilar of Cetuximab
Table 2-4: Few Biosimilar Filgrastim Available for Cancer Patients
Table 4-1: Difference between Biosimilars & Small Molecule Drugs
Table 10-1: Samsung Bioepis -Clinical Pipeline
For Report Sample Contact: neeraj@kuickresearch.com