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Europe Biosimilars Market
Europe Biosimilars Market Page 1
Biosimilars have emerged as one of the most promising segment of the European
pharmaceutical industry in recent years. The biosimilars segment has been experiencing a
steady growth driven by patent expiration of blockbuster drugs, amenable regulatory
framework, economic incentives along with favorable pricing and reimbursement policies
adopted across multiple markets in Europe. The current biosimilars market is highly
fragmented in nature due to their accessibility in various therapeutic categories. The
European biosimilars market is divided into various categories: Granulocyte-colony stimulating
factor (G-CSF or GCSF), erythropoiesis-stimulating agents (ESAs) and somatropin biosimilars,
Insulin, mAbs and follitropin. The present market fragmentation is driven by the availability
of particular biosimilar products which were introduced over a decade ago. These products
created niche among them and resulted in inclination toward a particular segments over a
period of time.
One of the most promising factors responsible for the development of biosimilars market is
the patent expiration of reference drugs. The European biosimilars market is experiencing
tremendous growth as blockbuster biologic drugs are going off-patent. The entry of new
biosimilars due to patent expiry into various therapeutic indications has created a new
category for the biosimilars. For instance, Ely Lily and Boehringer Ingelheim have already got
marketing authorization of their biosimilar insulin in June’2014 even as the current diabetes
drug (Lantus) marketed by Sanofi will go off patent in February’2015.
The competitive pricing and reimbursement policies adopted by country specific regulators
are also promoting the introduction of biosimilars in European market. The newly introduced
biosimilars are approximately 20-30% cheaper and hence results in high level of acceptability
among patients and physicians in comparison to originator molecule. The benefits of using the
biosimilars include reimbursement provided by many governments which further decreases
the financial burden from the patients as result of which they do not revert to originator
molecules.
Currently there are 18 biosimilars available in European market and more than 90 are in
multiple phases of development in clinical pipeline. Majority of the available biosimilars are
Europe Biosimilars Market
Europe Biosimilars Market Page 2
approved for the treatment of indication like Cancer, Kidney Failure and Anemia. Approved
Biosimilars in Europe:
Abseamed (epoetin alfa), Bemfola (follitropin alfa), Binocrit (epoetin alfa), Biograstim
(filgrastim), Epoetin Alfa Hexal (epoetin alfa), Filgrastim Hexal (filgrastim), Grastofil
(filgrastim), Inflectra (infliximab), Nivestim(filgrastim), Omnitrope (somatropin), Ovaleap
(follitropin alfa), Ratiograstim (filgrastim), Remsima (infliximab), Retacrit (epoetin zeta),
Silapo (epoetin zeta), Tevagrastim (filgrastim), Zarzio (filgrastim), Wepox (epoetin alfa)
“Europe Biosimilars Market & Pipeline Insight” Report Highlight:
 Biosimilars Market Overview & Trend Analysis by Country
 Biosimilars Introduction Timeline in Europe
 Biosimilars Development & Market Authorization Guidelines
 Biosimilars Clinical Pipeline by Phase, Indication, Company & Country
 Marketed Biosimilars Clinical Insight by Phase, Indication, Company & Country
 Europe Biosimilars Pipeline: 93 Biosimilars
 Marketed Biosimilars: 18 Biosimilars (17 Approved by EMA & 1 in Ukraine)
For Report Sample Contact: avainash@kuickresearch.com
Table of Contents
1. Europe Biosimilars Market Overview
1.1 Current Market Scenario
1.2 Biosimilars Clinical Pipeline Overview
2. Europe Biosimilars Market Trend Analysis by Country
2.1 Austria
Europe Biosimilars Market
Europe Biosimilars Market Page 3
2.2 Belgium
2.3 France
2.4 Germany
2.5 Hungary
2.6 Italy
2.7 Norway
2.8 Poland
2.9 Spain
2.10 Sweden
2.11 Switzerland
2.12 UK
3. Biosimilars Introduction Timeline in Europe
3.1 Growth Hormones in 2006
3.2 Epoetin in 2007
3.3 G-CSF in 2008
3.4 Monoclonal Antibodies in 2013
3.5 Follitropin in 2013
3.6 Insulin in 2015
4. Europe Biosimilars Risk Management Planning & Safety Regulation
Scenario
5. Europe Biosimilars Market Dynamics
5.1 Favorable Market Parameters
Europe Biosimilars Market
Europe Biosimilars Market Page 4
5.1.1 Bolar Provisions Supporting Biosimilars Development
5.1.2 Patent Expiry to Tap European Biosimilars Markets
5.1.3 Reimbursement Policies
5.1.4 Increasing Level of Investments
5.1.5 Manufacturing Capabilities
5.1.6 R&D Expertise
5.2 Market Growth Challenges
6. Future Prospectus of Biosimilars in Europe
7. Regulatory & Approval Authorities: EMA & CHMP
8. Biosimilars Development & Market Authorization Guidelines
8.1 Development of Similar Biological Medicinal Products Containing r-hFSH
8.2 Similar Biological Medicinal Products Containing Interferon Beta
8.3 Immunogenicity Assessment of Monoclonal Antibodies Intended For In Vivo Clinical Use
8.4 Similar Biological Medicinal Products Containing Monoclonal Antibodies
8.5 Similar Biological Medicinal Products Containing Recombinant Erythropoietins
8.6 Similar Medicinal Products Containing Recombinant Human Soluble Insulin
8.7 Similar Medicinal Products Containing Somatropin
8.8 Similar Biological Medicinal Products Containing Biotechnology Derived Proteins as Active
Substance
8.9 Immunogenicity Assessment of Biotechnology-Derived Therapeutic Proteins
8.10 Comparability of Biotechnology-Derived Medicinal Products After A Change In The
Manufacturing Process
Europe Biosimilars Market
Europe Biosimilars Market Page 5
9. Europe Biosimilars Clinical Pipeline by Phase, Indication, Company &
Country
9.1 Unknown
9.2 Research
9.3 Preclinical
9.4 Clinical
9.5 Phase-I
9.6 Phase-I/II
9.7 Phase-II
9.8 Phase-III
9.9 Preregistration
9.10 Registered
10. Marketed Biosimilars Clinical Insight by Phase, Indication, Company &
Country
11. No Development Reported in Biosimilars Clinical Pipeline
11.1 No Development Reported
11.2 Discontinued
12. Competitive Landscape
12.1 Apotex
12.2 Celltrion Healthcare
12.3 Hexal
12.4 Hospira
Europe Biosimilars Market
Europe Biosimilars Market Page 6
12.5 Finox Biotech
12.6 Medice Arzneimittel Pütter
12.7 Sandoz
12.8 Stada Arzneimittel
12.9 Teva Pharma
List of Figures
Figure 1-1: Europe – Biosimilars Market Opportunity (US$ Million), 2014-2020
Figure 1-2: Factors Responsible for Growth of Biosimilars Market in Europe
Figure 1-3: Europe Biosimilar Pipeline by Phase (%), 2014
Figure 1-4: Europe Biosimilar Pipeline by Phase (Number), 2014
Figure 1-5: No Development Reported in Biosimilar Pipeline by Phase (%), 2014
Figure 1-6: No Development Reported in Biosimilar Pipeline by Phase (Number), 2014
Figure 1-7: Suspended Biosimilar Pipeline by Phase (%), 2014
Figure 1-8: Suspended Biosimilar Pipeline by Phase (%), 2014
Figure 3-1 Biosimilar Product Approval Timeline in Europe
Figure 3-2: Europe Biosimilars Market Emerging Segment
Figure 3-3: Approved Biosimilars by Segment
Figure 3-4: HGH Biosimilars Approved & Available in European Market
Figure 3-5: EPO Biosimilars Approved & Available in European Market
Figure 3-6: G-CSF Biosimilars Approved & Available in European Market
Figure 3-7: mAbs Biosimilars Approved & Available in European Market
Figure 3-8: Follitropin Biosimilars Approved & Available in European Market
Figure 3-9: Insulin Biosimilars Approved & Available in European Market
Europe Biosimilars Market
Europe Biosimilars Market Page 7
Figure 4-1: Safety Evaluation of Biosimilars after Marketing Approval in Europe
Figure 4-2: Risk Management of Biosimilars
Figure 4-3: Overview of Demonstrating Biosimilarity
Figure 5-1: Bolar Provision for the Development of Biosimilars in Europe
Figure 5-2: Effects of Reimbursement Policies on Healthcare System
Figure 5-3: Available Biosimilars in Market by Company & Segment
Figure 5-4: Drivers for Success in European Biosimilars Market
Figure 5-5: Market Growth Challenges
Figure 7-1: Regulatory Timeline for the Approval of Biosimilars
Figure 7-2: Schematic Overview of Biosimilar Approval in EU
Figure 7-3: Biosimilars Development Process

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Europe biosimilars market

  • 1. Europe Biosimilars Market Europe Biosimilars Market Page 1 Biosimilars have emerged as one of the most promising segment of the European pharmaceutical industry in recent years. The biosimilars segment has been experiencing a steady growth driven by patent expiration of blockbuster drugs, amenable regulatory framework, economic incentives along with favorable pricing and reimbursement policies adopted across multiple markets in Europe. The current biosimilars market is highly fragmented in nature due to their accessibility in various therapeutic categories. The European biosimilars market is divided into various categories: Granulocyte-colony stimulating factor (G-CSF or GCSF), erythropoiesis-stimulating agents (ESAs) and somatropin biosimilars, Insulin, mAbs and follitropin. The present market fragmentation is driven by the availability of particular biosimilar products which were introduced over a decade ago. These products created niche among them and resulted in inclination toward a particular segments over a period of time. One of the most promising factors responsible for the development of biosimilars market is the patent expiration of reference drugs. The European biosimilars market is experiencing tremendous growth as blockbuster biologic drugs are going off-patent. The entry of new biosimilars due to patent expiry into various therapeutic indications has created a new category for the biosimilars. For instance, Ely Lily and Boehringer Ingelheim have already got marketing authorization of their biosimilar insulin in June’2014 even as the current diabetes drug (Lantus) marketed by Sanofi will go off patent in February’2015. The competitive pricing and reimbursement policies adopted by country specific regulators are also promoting the introduction of biosimilars in European market. The newly introduced biosimilars are approximately 20-30% cheaper and hence results in high level of acceptability among patients and physicians in comparison to originator molecule. The benefits of using the biosimilars include reimbursement provided by many governments which further decreases the financial burden from the patients as result of which they do not revert to originator molecules. Currently there are 18 biosimilars available in European market and more than 90 are in multiple phases of development in clinical pipeline. Majority of the available biosimilars are
  • 2. Europe Biosimilars Market Europe Biosimilars Market Page 2 approved for the treatment of indication like Cancer, Kidney Failure and Anemia. Approved Biosimilars in Europe: Abseamed (epoetin alfa), Bemfola (follitropin alfa), Binocrit (epoetin alfa), Biograstim (filgrastim), Epoetin Alfa Hexal (epoetin alfa), Filgrastim Hexal (filgrastim), Grastofil (filgrastim), Inflectra (infliximab), Nivestim(filgrastim), Omnitrope (somatropin), Ovaleap (follitropin alfa), Ratiograstim (filgrastim), Remsima (infliximab), Retacrit (epoetin zeta), Silapo (epoetin zeta), Tevagrastim (filgrastim), Zarzio (filgrastim), Wepox (epoetin alfa) “Europe Biosimilars Market & Pipeline Insight” Report Highlight:  Biosimilars Market Overview & Trend Analysis by Country  Biosimilars Introduction Timeline in Europe  Biosimilars Development & Market Authorization Guidelines  Biosimilars Clinical Pipeline by Phase, Indication, Company & Country  Marketed Biosimilars Clinical Insight by Phase, Indication, Company & Country  Europe Biosimilars Pipeline: 93 Biosimilars  Marketed Biosimilars: 18 Biosimilars (17 Approved by EMA & 1 in Ukraine) For Report Sample Contact: avainash@kuickresearch.com Table of Contents 1. Europe Biosimilars Market Overview 1.1 Current Market Scenario 1.2 Biosimilars Clinical Pipeline Overview 2. Europe Biosimilars Market Trend Analysis by Country 2.1 Austria
  • 3. Europe Biosimilars Market Europe Biosimilars Market Page 3 2.2 Belgium 2.3 France 2.4 Germany 2.5 Hungary 2.6 Italy 2.7 Norway 2.8 Poland 2.9 Spain 2.10 Sweden 2.11 Switzerland 2.12 UK 3. Biosimilars Introduction Timeline in Europe 3.1 Growth Hormones in 2006 3.2 Epoetin in 2007 3.3 G-CSF in 2008 3.4 Monoclonal Antibodies in 2013 3.5 Follitropin in 2013 3.6 Insulin in 2015 4. Europe Biosimilars Risk Management Planning & Safety Regulation Scenario 5. Europe Biosimilars Market Dynamics 5.1 Favorable Market Parameters
  • 4. Europe Biosimilars Market Europe Biosimilars Market Page 4 5.1.1 Bolar Provisions Supporting Biosimilars Development 5.1.2 Patent Expiry to Tap European Biosimilars Markets 5.1.3 Reimbursement Policies 5.1.4 Increasing Level of Investments 5.1.5 Manufacturing Capabilities 5.1.6 R&D Expertise 5.2 Market Growth Challenges 6. Future Prospectus of Biosimilars in Europe 7. Regulatory & Approval Authorities: EMA & CHMP 8. Biosimilars Development & Market Authorization Guidelines 8.1 Development of Similar Biological Medicinal Products Containing r-hFSH 8.2 Similar Biological Medicinal Products Containing Interferon Beta 8.3 Immunogenicity Assessment of Monoclonal Antibodies Intended For In Vivo Clinical Use 8.4 Similar Biological Medicinal Products Containing Monoclonal Antibodies 8.5 Similar Biological Medicinal Products Containing Recombinant Erythropoietins 8.6 Similar Medicinal Products Containing Recombinant Human Soluble Insulin 8.7 Similar Medicinal Products Containing Somatropin 8.8 Similar Biological Medicinal Products Containing Biotechnology Derived Proteins as Active Substance 8.9 Immunogenicity Assessment of Biotechnology-Derived Therapeutic Proteins 8.10 Comparability of Biotechnology-Derived Medicinal Products After A Change In The Manufacturing Process
  • 5. Europe Biosimilars Market Europe Biosimilars Market Page 5 9. Europe Biosimilars Clinical Pipeline by Phase, Indication, Company & Country 9.1 Unknown 9.2 Research 9.3 Preclinical 9.4 Clinical 9.5 Phase-I 9.6 Phase-I/II 9.7 Phase-II 9.8 Phase-III 9.9 Preregistration 9.10 Registered 10. Marketed Biosimilars Clinical Insight by Phase, Indication, Company & Country 11. No Development Reported in Biosimilars Clinical Pipeline 11.1 No Development Reported 11.2 Discontinued 12. Competitive Landscape 12.1 Apotex 12.2 Celltrion Healthcare 12.3 Hexal 12.4 Hospira
  • 6. Europe Biosimilars Market Europe Biosimilars Market Page 6 12.5 Finox Biotech 12.6 Medice Arzneimittel Pütter 12.7 Sandoz 12.8 Stada Arzneimittel 12.9 Teva Pharma List of Figures Figure 1-1: Europe – Biosimilars Market Opportunity (US$ Million), 2014-2020 Figure 1-2: Factors Responsible for Growth of Biosimilars Market in Europe Figure 1-3: Europe Biosimilar Pipeline by Phase (%), 2014 Figure 1-4: Europe Biosimilar Pipeline by Phase (Number), 2014 Figure 1-5: No Development Reported in Biosimilar Pipeline by Phase (%), 2014 Figure 1-6: No Development Reported in Biosimilar Pipeline by Phase (Number), 2014 Figure 1-7: Suspended Biosimilar Pipeline by Phase (%), 2014 Figure 1-8: Suspended Biosimilar Pipeline by Phase (%), 2014 Figure 3-1 Biosimilar Product Approval Timeline in Europe Figure 3-2: Europe Biosimilars Market Emerging Segment Figure 3-3: Approved Biosimilars by Segment Figure 3-4: HGH Biosimilars Approved & Available in European Market Figure 3-5: EPO Biosimilars Approved & Available in European Market Figure 3-6: G-CSF Biosimilars Approved & Available in European Market Figure 3-7: mAbs Biosimilars Approved & Available in European Market Figure 3-8: Follitropin Biosimilars Approved & Available in European Market Figure 3-9: Insulin Biosimilars Approved & Available in European Market
  • 7. Europe Biosimilars Market Europe Biosimilars Market Page 7 Figure 4-1: Safety Evaluation of Biosimilars after Marketing Approval in Europe Figure 4-2: Risk Management of Biosimilars Figure 4-3: Overview of Demonstrating Biosimilarity Figure 5-1: Bolar Provision for the Development of Biosimilars in Europe Figure 5-2: Effects of Reimbursement Policies on Healthcare System Figure 5-3: Available Biosimilars in Market by Company & Segment Figure 5-4: Drivers for Success in European Biosimilars Market Figure 5-5: Market Growth Challenges Figure 7-1: Regulatory Timeline for the Approval of Biosimilars Figure 7-2: Schematic Overview of Biosimilar Approval in EU Figure 7-3: Biosimilars Development Process