Taking a thorough patient history is the most important first step in the general patient approach. The history should cover the chief complaint, history of the present illness, past medical history, personal and family history, medication history, and a full systems review. A comprehensive physical examination involves examining the patient's general appearance and vital signs, and evaluating each body system. Appropriate investigations including lab tests, imaging, and pathology help arrive at the top diagnosis. Treatment and management are aimed at curing or relieving the disease. Prevention advice and medications are provided to ensure the disease does not recur.