The role of the fungal microbiota in the human GI tract is not well understood. While fungi are commonly seen as pathogens, the commensal fungal microbiota is an important part of the human GI ecosystem. Advances in metagenomics are helping researchers better characterize the fungal communities present and their interactions with bacteria and the human immune system. Imbalances in the normal fungal microbiota may contribute to various GI disorders, but the potential mechanisms involved are still unclear.
Probiotics are live microorganisms that confer health benefits when colonize the gastrointestinal tract. The various microbial strains are now found to provide therapeutic effects through the metabolites they produce, digestion of dietary fibers, inhibition of pathogen adhesion, provide missing enzyme, maintaining homeostasis and also controlling brain activities which may lead to autism if disturbed.
Human Gut Mycobiota is still a mistery for us. Most of the reasearch on this topichas been conducted in the last 5 years. We are starting to comprehend the interactions with our gastrointestinal system and the virus and bacterial communities. 13% of gut microbiota in weight, about 150 species; most of them can shift from commensalism to virulent parassitosis according to our immune competence. Gut fungal overgrowth is actually underestimated in dignaosis and treatment. Many FGIDS and SIBO are frequently mixed bacteral and fungal dysbiosis
Microbiome of human bodyResearchers currently studying human norm.pdfarccreation001
Microbiome of human body:
Researchers currently studying human normal microbiota such as Escherichia coli (vitamin K
producing), lactobacilli are essential and important to the human health & these microsymbionts
lives in the gut of human with symbiotic relationship. This microbiota is going to generate
vitamins, cofactors (NADH, FADH2) and human body does not synthesize some vitamins but
these microbiota is going to synthesize essential vitamins. These microbiotas are going to digest
cellulose content in fruits and vegetables and whole grains finally improve essential nutrients to
the human body. Health digestion activity of insoluble fibres can ensure that you have a good
health. Local nutrient source: Whole grain bread possesses higher content of insoluble fiber
followed by enzymatic digestion of gut microbiota into n-butyrate. Insoluble fiber digestion into
n-butyrate mediated by coloncocci and streptococci intestinal bacterial species by enzymatic
activity.
Effect of immune system:
M cells: These are called as microfold cell and they are located within the gut epithelium of
payer’s patches. M cell functions mainly samples usual gut flora and enable movement of the gut
microbiota to basolateral side to immune cells in the gastrointestinal tract followed by response
produced by B and T lymphocytes on as usual basis. These cells are acting like border control
and enable pumping T cells and immunoglobulin-A (IgA) across gastro intestinal mucosa. These
cells enable colonizing gut microbiota on the epithelium for appropriate digestion of food bolus.
The normal microbiota is pathogenic and may induce severe effects when they migrated to
another tissue from their native place of living. Nose and mouse microbiota are such as
Staphylococcus epidermis and are nearly 100% occurrence in both nose and mouth. These
microbes are pathogenic if they move other organs. Diversified microbiota was observed and this
microbiota includes both Gram positive and Gram- negative species. Corynebacterium and
Steptococcus pyogenes are at least form 25% of nasal microbiota whereas Spirochaetes and is
highly abundant in mouth & its presence was not mentioned in OSU.
Elders often possess weakened immune system and these circumstances leading to opportunistic
viral infection and gastroinstestinal infections (fungal, protozoan) where microbiota enables
human digestion. These viral particles act as bacteriophages to invade bacterial cells to generate
more virions to propagate further infection leaving the microbiota inactive and dead. Sometimes
excess use of anti-microbial chemotherapeutic agents acts as agents to invade gut microbiota due
to inhibition of their growth via various cell-synthesizing mechanisms for example, inhibiting
cell wall synthesis of bacteria. Some antibiotics inhibit DNA gyrase non- specifically including
host cells and useful microbiota result in death of useful vitamin producing microbiota.
The causes of altered microbiota in the elderly: 1. Aging,.
Human Microbiome Microbiota Faecal transplant.pdfVivekPatil679088
Just like human genome, we have our own microbiome! Take a look into this presentation to get a wholesome picture of the concept. Must know topic for medical graduates and postgraduate students.
Probiotics are live microorganisms that confer health benefits when colonize the gastrointestinal tract. The various microbial strains are now found to provide therapeutic effects through the metabolites they produce, digestion of dietary fibers, inhibition of pathogen adhesion, provide missing enzyme, maintaining homeostasis and also controlling brain activities which may lead to autism if disturbed.
Human Gut Mycobiota is still a mistery for us. Most of the reasearch on this topichas been conducted in the last 5 years. We are starting to comprehend the interactions with our gastrointestinal system and the virus and bacterial communities. 13% of gut microbiota in weight, about 150 species; most of them can shift from commensalism to virulent parassitosis according to our immune competence. Gut fungal overgrowth is actually underestimated in dignaosis and treatment. Many FGIDS and SIBO are frequently mixed bacteral and fungal dysbiosis
Microbiome of human bodyResearchers currently studying human norm.pdfarccreation001
Microbiome of human body:
Researchers currently studying human normal microbiota such as Escherichia coli (vitamin K
producing), lactobacilli are essential and important to the human health & these microsymbionts
lives in the gut of human with symbiotic relationship. This microbiota is going to generate
vitamins, cofactors (NADH, FADH2) and human body does not synthesize some vitamins but
these microbiota is going to synthesize essential vitamins. These microbiotas are going to digest
cellulose content in fruits and vegetables and whole grains finally improve essential nutrients to
the human body. Health digestion activity of insoluble fibres can ensure that you have a good
health. Local nutrient source: Whole grain bread possesses higher content of insoluble fiber
followed by enzymatic digestion of gut microbiota into n-butyrate. Insoluble fiber digestion into
n-butyrate mediated by coloncocci and streptococci intestinal bacterial species by enzymatic
activity.
Effect of immune system:
M cells: These are called as microfold cell and they are located within the gut epithelium of
payer’s patches. M cell functions mainly samples usual gut flora and enable movement of the gut
microbiota to basolateral side to immune cells in the gastrointestinal tract followed by response
produced by B and T lymphocytes on as usual basis. These cells are acting like border control
and enable pumping T cells and immunoglobulin-A (IgA) across gastro intestinal mucosa. These
cells enable colonizing gut microbiota on the epithelium for appropriate digestion of food bolus.
The normal microbiota is pathogenic and may induce severe effects when they migrated to
another tissue from their native place of living. Nose and mouse microbiota are such as
Staphylococcus epidermis and are nearly 100% occurrence in both nose and mouth. These
microbes are pathogenic if they move other organs. Diversified microbiota was observed and this
microbiota includes both Gram positive and Gram- negative species. Corynebacterium and
Steptococcus pyogenes are at least form 25% of nasal microbiota whereas Spirochaetes and is
highly abundant in mouth & its presence was not mentioned in OSU.
Elders often possess weakened immune system and these circumstances leading to opportunistic
viral infection and gastroinstestinal infections (fungal, protozoan) where microbiota enables
human digestion. These viral particles act as bacteriophages to invade bacterial cells to generate
more virions to propagate further infection leaving the microbiota inactive and dead. Sometimes
excess use of anti-microbial chemotherapeutic agents acts as agents to invade gut microbiota due
to inhibition of their growth via various cell-synthesizing mechanisms for example, inhibiting
cell wall synthesis of bacteria. Some antibiotics inhibit DNA gyrase non- specifically including
host cells and useful microbiota result in death of useful vitamin producing microbiota.
The causes of altered microbiota in the elderly: 1. Aging,.
Human Microbiome Microbiota Faecal transplant.pdfVivekPatil679088
Just like human genome, we have our own microbiome! Take a look into this presentation to get a wholesome picture of the concept. Must know topic for medical graduates and postgraduate students.
ORAL MICROBIOME.pptx by UMNA FATIMA- BIOMEDumnajmi123
This PowerPoint presentation provides a thorough exploration of the oral microbiome and its significance in both maintaining health and contributing to disease. Beginning with an introduction to the oral microbiome, the presentation outlines its diverse composition and its crucial role in oral health. It further examines the concept of dysbiosis within the oral microbiome, highlighting the factors contributing to imbalance and its implications for oral and systemic health. The presentation also delves into emerging research linking oral microbiome dysbiosis to systemic diseases, shedding light on potential mechanisms and clinical implications. Methods for studying the oral microbiome are discussed, along with recent advancements in research methodologies and therapeutic strategies targeting microbial dysbiosis. Additionally, the presentation explores the evolving field of precision dentistry and its integration with oral microbiome analysis for personalized treatment approaches. Through case studies and examples, the audience gains insight into the practical applications of oral microbiome research. The presentation concludes with a summary of key points and an invitation for questions and discussion, emphasizing the importance of ongoing research in understanding and harnessing the potential of the oral microbiome for improving health outcomes.
Microbial Pathogens in Non-Clinical Environments (NCE)PallabiChatterjee7
Microbes thrive all over the clinical and non clinical environments, several diseases occur due to these pathogens, the natural remedies are given in these slides.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Oral microbiology/ rotary endodontic courses by indian dental academyIndian dental academy
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
The etiology of a disease refers to the causative trigger(s), whereas pathogenesis refers to the mechanism(s) by which the disease progresses.
In other words, while the microbial biofilm developing on the tooth surface constitutes a necessary etiological factor, its mere presence is insufficient for the initiation of the disease.
Further risk factors, such as host genetics, lifestyle, stress, and systemic conditions, that dictate the immunopathogenesis are crucial for the transition from a healthy to a diseased state.
World Digestive Health Day 2024 and .pptxHasanQamar1
“World digestive Health Day advocates the necessity of a healthy diet in the promotion of optimal gastrointestinal function and microbiome health. The goal is to promote a healthy lifestyle and improve understanding of the importance of a healthy gastrointestinal (GI) tract”
The GI tract is an essential organ that provides nutrients, enhances the immune response, and houses the intestinal microbiota. Comprehending the normal functions of the GI tract and diet can help identify when to seek GI care for symptoms
A biofertilizer is a substance which contains living micro-organisms which, when applied to seeds, plant surfaces, or soil, colonize the rhizosphere or the interior of the plant and promotes growth by increasing the supply or availability of primary nutrients to the host plant.
ECochG is a variant of brainstem audio evoked response (ABR) where the recording electrode is placed as close as practical to the cochlea. We will use the abbreviation ECOG and ECochG interchangeably below. ECOG is preferable to us as it is shorter.
ECOG is intended to diagnose Meniere's disease, and particular, hydrops (swelling of the inner ear). ECOG may also be abnormal in perilymph fistula, and in superior canal dehiscence. The common feature connecting these illnesses is an imbalance in pressure between the endolymphatic and perilymphatic compartment of the inner ear.
ECOG can also be used to show that the cochlea is normal, in persons who are deaf. The cochlear microphonic of ECOG may be normal in auditory neuropathy (Santarelli and Arslan 2002) as well as other disorders in which the cochlea is preserved but the auditory nerve is damaged (Yokoyama, Nishida et al. 1999).
Finally, ECOG's have also been used to as a indicator of the temporary threshold shift that may follow noise injury (Nam et al, 2004).
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ORAL MICROBIOME.pptx by UMNA FATIMA- BIOMEDumnajmi123
This PowerPoint presentation provides a thorough exploration of the oral microbiome and its significance in both maintaining health and contributing to disease. Beginning with an introduction to the oral microbiome, the presentation outlines its diverse composition and its crucial role in oral health. It further examines the concept of dysbiosis within the oral microbiome, highlighting the factors contributing to imbalance and its implications for oral and systemic health. The presentation also delves into emerging research linking oral microbiome dysbiosis to systemic diseases, shedding light on potential mechanisms and clinical implications. Methods for studying the oral microbiome are discussed, along with recent advancements in research methodologies and therapeutic strategies targeting microbial dysbiosis. Additionally, the presentation explores the evolving field of precision dentistry and its integration with oral microbiome analysis for personalized treatment approaches. Through case studies and examples, the audience gains insight into the practical applications of oral microbiome research. The presentation concludes with a summary of key points and an invitation for questions and discussion, emphasizing the importance of ongoing research in understanding and harnessing the potential of the oral microbiome for improving health outcomes.
Microbial Pathogens in Non-Clinical Environments (NCE)PallabiChatterjee7
Microbes thrive all over the clinical and non clinical environments, several diseases occur due to these pathogens, the natural remedies are given in these slides.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Oral microbiology/ rotary endodontic courses by indian dental academyIndian dental academy
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
The etiology of a disease refers to the causative trigger(s), whereas pathogenesis refers to the mechanism(s) by which the disease progresses.
In other words, while the microbial biofilm developing on the tooth surface constitutes a necessary etiological factor, its mere presence is insufficient for the initiation of the disease.
Further risk factors, such as host genetics, lifestyle, stress, and systemic conditions, that dictate the immunopathogenesis are crucial for the transition from a healthy to a diseased state.
World Digestive Health Day 2024 and .pptxHasanQamar1
“World digestive Health Day advocates the necessity of a healthy diet in the promotion of optimal gastrointestinal function and microbiome health. The goal is to promote a healthy lifestyle and improve understanding of the importance of a healthy gastrointestinal (GI) tract”
The GI tract is an essential organ that provides nutrients, enhances the immune response, and houses the intestinal microbiota. Comprehending the normal functions of the GI tract and diet can help identify when to seek GI care for symptoms
A biofertilizer is a substance which contains living micro-organisms which, when applied to seeds, plant surfaces, or soil, colonize the rhizosphere or the interior of the plant and promotes growth by increasing the supply or availability of primary nutrients to the host plant.
ECochG is a variant of brainstem audio evoked response (ABR) where the recording electrode is placed as close as practical to the cochlea. We will use the abbreviation ECOG and ECochG interchangeably below. ECOG is preferable to us as it is shorter.
ECOG is intended to diagnose Meniere's disease, and particular, hydrops (swelling of the inner ear). ECOG may also be abnormal in perilymph fistula, and in superior canal dehiscence. The common feature connecting these illnesses is an imbalance in pressure between the endolymphatic and perilymphatic compartment of the inner ear.
ECOG can also be used to show that the cochlea is normal, in persons who are deaf. The cochlear microphonic of ECOG may be normal in auditory neuropathy (Santarelli and Arslan 2002) as well as other disorders in which the cochlea is preserved but the auditory nerve is damaged (Yokoyama, Nishida et al. 1999).
Finally, ECOG's have also been used to as a indicator of the temporary threshold shift that may follow noise injury (Nam et al, 2004).
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
fungal microbiota and digestive diseases.pptx
1.
2. The role of the fungal microbiota in digestive diseases is poorly
defined, but is becoming better understood due to advances in
metagenomics.
The human gastrointestinal (GI) tract is known to contain a
variable fungal microbiome, but the phylogenetic characteristics
of GI fungal organisms and their specific role as part of the GI
ecosystem have not yet been studied extensively.
Interactions between fungi and bacteria are common, complex &
species dependent, and have dramatic effects on the growth and
pathogenesis of microbes.
Evidence from human epidemiological and animal studies
implicates mycotoxins, generated as fungal metabolites, in GI and
liver cancer development and in other chronic GI disorders.
3. However, the host immune response to exogenous
pathogenic fungi and to potentially harmful indigenous fungal
microbiota in the human GI tract is not well understood.
In recent years, the incidence of invasive fungal infections
(IFI) has experienced a dramatic increase globally, possibly
implying changes in either systemic or local immune
responses.
Some evidence suggests a role for an imbalance between GI
commensal fungal and bacterial microbiota or the invasion of
host niches by pathogenic fungi or fungal metabolites in
inflammatory bowel disease (IBD), peptic ulcers, irritable
bowel syndrome (IBS), antibiotic associated diarrhoea (AAD)
and chemotherapy-induced enteric disorders, but the potential
mechanisms still remain unclear.
4. Fungi as eukaryotic microorganism are widely distributed in nature.
At present, more than 400 species of fungi associated with human beings have
been identified.
Previously, fungi have typically been viewed as pathogenic microbes, and their role
as commensals has been underappreciated.
It is now evident, however, the commensal fungal microbiota is an important part of
the human GI ecosystem.
Early studies based on culture-dependent methods reported that fungi could be
detected in the digestive tract of 70% of healthy adults and that the number of fungi
in the human stomach, jejunum, ileum and colon is 0–100 ,0–100 ,100 –1000 and
100 –10,00,000 CFU/mL respectively.
Most of these are aerobes or facultative anaerobes.
Recently, DNA sequencing analysis is widely used for the classification and
identification of fungal microbes of plants, animals and various natural
environments.
Research on the fungal microbiome of the human oral cavity and skin is an area of
intense investigation.
5. Recent studies based on culture-independent methods showed more
diversity and complexity of residential bacterial microbiota in the
oesophagus with the representation of nine phyla and upto 160 species.
Furthermore, early culture-dependent studies confirmed that Candida sp.
was the most common fungi in the normal oesophagus. Candida
oesophagitis is very common in patients with impaired immunity.
Several studies using culture-independent methods confirmed that large
numbers of acid-resistant fungi exist in the stomach, such as Candida
albicans can grow well in highly acidic environments that increase the
severity of gastric mucosal lesions.
Recently, a study using bacterial and fungal DNA co-sequencing analysis
obtained 19–81 fungal genus-level operational taxonomic units in gastric
juice, but only identified two fungal genera including Candida and
Phialemonium.
6. Small intestinal microbiota play an important role in IBS, coeliac disease,
small intestinal bacterial vergrowth and chemotherapy-induced mucositis.
The gut microbiome of small intestinal transplant recipients is altered due to
the influence of the donor’s commensal bacterial microflora.
Moreover, intestinal transplant recipients are often colonised with
Saccharomyces cerevisiae, Kluyveromyces waltii, Candida spp.,
Cryptococcus neoformans, Fusarium oxysporum and Aspergillus clavatus,
etc.
Small intestinal microbiota play an important role in IBS, coeliac disease,
small intestinal bacterial overgrowth and chemotherapy-induced mucositis.
The gut microbiome of small intestinal transplant recipients is altered due to
the influence of the donor’s commensal bacterial microflora.
Moreover, intestinal transplant recipients are often colonised with
Saccharomyces cerevisiae, Kluyveromyces waltii, Candida spp.,
Cryptococcus neoformans, Fusarium oxysporum and Aspergillus clavatus,
etc.
7. Previous studies based on culture techniques confirmed that
Candida spp. are the most common commensal fungi in the
intestine.
Recently, the metagenomic analysis of 124 individuals reported that
only 0.1% of microbial genes in faeces came from eukaryotic or viral
Origin, which was consistent with previous reports of fungi accounting
for only 0.03% of the faecal microbiota.
Candida spp., S. cerevisiae and Malassezia spp., etc. were thought to be
the predominant commensal fungal species while Aspergillus spp.,
Mucor spp., Cryptococcus spp., Rhodotorula spp., Trichosporon spp.,
Histoplasma spp., Coccidiodes spp., Paracoccidioides spp. and
Blastomyces spp. were classified as transient microbiota or exogenous
pathogenic fungi.
It is well recognised that the human intestine could be the largest
source of fungaemia when systemic or local mucosal immune functions
are disturbed.
8. The fungal microbiota in the human GI tract is affected by age, body mass index,
delivery and feeding methods, diet, ethnicity and geographical environments. In
addition, pH, oxygen, nutrition and bile acids in the GI tract can influence the
composition and function of the microbiota.
Several fungal species contained in fermented foods and beverages can be also
identified in the human GI tract, but whether they are truly indigenous needs to be
elucidated.
In addition, infants may not harbour any gut mycobiome, but their healthy mothers
harbour various intestinal fungi like Saccharomyces spp. and C. albicans.
The intestinal fungal microbiota of an obese individual was investigated by fungal
DNA sequencing, which identified 18 species from the Ascomycota, Basidiomycota
and Chytridiocomycota phyla, but several fungal species mainly originated from
food.
Tobacco use is highly associated with the overgrowth of oral and faecal fungal
microflora.
Furthermore, various iatrogenic factors such as chemotherapy and antibiotic
administration could play an important role in the disruption of GI fungal microbiota.
9.
10. Physical and molecular interactions occur among fungi
themselves.
For example, the morphological transformation between hypha
and yeast forms can influence the adhesion and colonisation of
Candida sp. in host cells as well as their virulence.
In addition, fatty acid metabolites have impacts on the
morphological changes of C. albicans, as well as its
pathogenicity.
Glycerol, the small molecular metabolite in biofilm cells of C.
albicans, is critical for expression of numerous biofilm-regulated
adhesion genes during C. albicans biofilm formation.
11. Some troublesome pathogenic bacteria in hospitals, such as Pseudomonas
aeruginosa, Acinetobacter baumannii, Staphylococcus epidermidis, etc.
commonly co-inhabit with C. albicans.
Polymicrobial infections with C. albicans and these pathogens could cause
a range of infectious syndromes.
Moreover, mixed species biofilms develop through co-aggregation between
C. albicans and several pathogenic bacteria on the surface of exogenous
medical devices and some susceptible sites of the human body, which are
thought to be important for the development of infectious disorders.
These fungal–bacterial interactions can be antagonistic, synergistic,
commensal or symbiotic and influence physical and physiological
characteristics such as the mutual morphology, behaviour and survival
including response to anti-microbial agents.
12. Interactions among C. albicans, Lactobacillus spp., H. pylori and Escherichia coli in
the GI tract have been investigated in vivo and in vitro.
For instance, the co-existence of C. albicans with H. pylori could represent synergy
in the pathogenesis of peptic ulcers.
Furthermore, Lactobacillus spp. could inhibit the growth and virulence of C. albicans
by the production of hydrogen peroxide and organic acids, but could not eradicate
C. albicans.
Also, different Lactobacillus strains have different abilities in inhibiting the growth of
C. albicans in the GI tract.
In addition, the effects of Lactobacillus spp. on host immune response may be
involved in the modulation of fungal virulence.
In addition, several exogenous fungal probiotics, such as Saccharomyces boulardii,
have been widely used as probiotics in clinical practice since the 1950s in Europe
and are strongly recommended for the prevention of AAD.
Overall, the microbial interactions in the human GI tract are complex and undefined;
many interactions remain to be investigated.
13. • Mycotoxins, small-molecule secondary metabolites of fungi, exhibit
diverse structures and can be classified into over 400 species of which
about 30 are pathogenic to human beings.
• The pathogenicity of mycotoxins in humans is mainly caused by the
intake of contaminated food.
• Most food-borne mycotoxins are mainly from Aspergillus spp.,
Penicillium spp. and Fusarium spp., etc.
• Some common mycotoxins such as aflatoxins (AF), sterigmatocystin
(ST), fumonisin B (FB), ochratoxins A (OTA), trichothecenes and patulin
are closely associated with human disease.
• The toxic effects of mycotoxins associated with the digestive system
mainly include carcinogenicity and the disturbance of GI functions.
14. Aflatoxins are mainly produced by Aspergillus spp. and its subtype AFB is
positively associated with hepatocellular carcinoma.
High levels of AFB in food and urine are associated with increased risk of
hepatocellular carcinoma in the high incidence areas when compared with
HBV infection.
Moreover, the detection rate of AFG in food is also high in those regions of
China in which gastric and oesophageal carcinomas are most common.
ST is a late metabolite in the aflatoxin pathway and is also carcinogenic and
mutagenic.
OTA is produced mainly by Aspergillus spp. and Penicillium spp.
The kidney is the primary target organ for OTA, so the renal toxicity is
obvious; in addition to nephrotoxicity, liver toxicity, carcinogenicity and
genotoxicity were shown in animal models.
Trichothecenes, represented by deoxynivalenol (DON), nivalenol (NIV) and
T-2 toxin, are produced mainly by Fusarium spp.
15. The GI tract, as the primary targeting organ of mycotoxins, is exposed directly to
mycotoxins with a higher concentration than other tissues and organs, which can
affect the regeneration, proliferation, differentiation and repair of intestinal epithelial
cells.
Some mycotoxins, such as FB, OTA and DON, could reduce the expression of
zonula occludens protein and increase intestinal mucosal permeability, thus
damaging the barrier functions of intestinal epithelial cells and inducing bacterial
translocation.
Moreover, mycotoxins can influence the immune system of the GI tract.
Mycotoxins could trigger mucosal immunoregulatory mechanisms such as the
secretion of mucus, anti-microbial peptides and immunoglobulins, and directly
induce inflammation by inducing intestinal epithelial cells to secrete chemotactic
factors and pro-inflammatory cytokines.
Mycotoxins may be associated with chronic inflammation of the intestine in
genetically susceptible patients with IBD or coeliac disease.
16. Fungal pathogens elicit innate immune responses at mucosal epithelial cell
surfaces of the GI, respiratory and genito-urinary tracts and in the skin.
Various fungal cell wall components, including b-glucans, zymosans,
mannans, chitin, DNA and RNA are the main sources of pathogen-
associated molecular patterns (PAMPs) that are recognised by host cells.
Immunity to fungi critically requires pattern recognition receptors (PRRs) on
human host cells to recognise and trigger innate and adaptive immune
responses
These PRRs include Toll-like receptors (TLRs), C-type lectin receptors
(CLRs), NOD-like receptors (NLRs), galectin family and retinoic acid-
inducible gene-I-like receptors (RLRs).
These PRRs are mainly present in host phagocytic cells including
monocytes, macrophages and neutrophils, as well as some nonphagocytic
cell types, such as epithelial and endothelial cells, which could contribute to
the anti-fungal innate immune response through phagocytosis and direct
pathogen killing.
17. C-type lectin receptors, including Dectin-1, Dectin-2, DC-SIGN, mannose
receptor and mannose-binding lectin, play a central role in the recognition and
shaping of immune responses to fungal pathogens.
The associated fungal PAMPs recognised by various CLRs. Dectin-1, for
example, is the key CLR-recognised fungal b-glucan.
Dectin-1 gene deletion can enhance the host’s susceptibility to fungi and thus
increase the fungal colonisation and dissemination in animal models.
The two main signalling pathways involved in the activation of Dectin-1 are
spleen tyrosine kinase-caspase recruitment domain-containing protein 9
(CARD9) and serine/threonine protein kinase Raf-1, which may have
synergetic function and induce the activation of NF-jB through cross-talk
mechanism.
Toll-like receptors, particularly TLR2, 3, 4, 6, 7 and 9, the members of the best-
characterised PRRs families, are closely associated with fungal immune
recognition and response. Both the exogenous pathogenic fungi (e.g.
18. Aspergillus sp., Cryptoccocus sp. and Coccidoides sp.) and the commensal
fungi (e.g. Candida sp.) are recognised by TLRs. The contribution of individual
TLRs may vary depending on the fungal species, fungal morphotypes, route of
infection and receptor co-operativity.
With regard to human studies, a polymorphism in TLR4 is associated with
increased susceptibility to pulmonary aspergillosis and bloodstream
candidiasis, and a polymorphism in the promoter of TLR9 is associated with
allergic bronchopulmonary aspergillosis.
NOD-like receptors also contribute to the anti-fungal immunity intracellularly,
although fungal PAMPs forNLRs are not yet clear.
NLRs could induce the production of IL-1b and IL-18 through the formation of
inflammasomes, which are essential for protective anti-fungal immunity,
particularly for driving the development of anti-fungal TH17 and TH1
responses.
The NLRP3 inflammasome plays an important role in the regulation of host
defence against microbial pathogens and intestinal homoeostasis,
The damage of which could impair the integrity of intestinal epithelial cell,
enhance the colonisation of C. albicans, and then promote the formation of
granulomas in the GI tract.
19.
20. The host immune system can tolerate the colonisation of
commensal fungi in the GI tract, but defend against fungal
invasion.
However, this balance is disturbed in systemic immuno-
suppressive states including, for example, the acquired immune
deficiency syndrome (AIDS), leukaemia and HSCT, solid organ
transplantation and immuno-suppressant therapy, anti-microbial
and steroid treatments, total parenteral nutrition, iatrogenic
catheters and mechanical ventilation, malignant tumours,
chemoradiotherapy and diabetes mellitus, all of which are
associated with enhanced fungal colonisation and infection in the
GI tract.
Similarly, localised insults in the digestive system, such as GI
mucosal lesions and surgical procedures, can also lead to GI fungal
infection.
21. Digestive system-related fungal infections may be induced by
both commensal opportunistic fungi and exogenous pathogenic
fungi.
Although IFI associated with digestive diseases are less common,
they can induce fatal outcomes due to less specificity of related
symptoms, signs, endoscopic and imaging manifestations, and the
poor treatment options.
Among oesophageal IFI, Candida sp. is the most frequently
identified species in patients with immunodefi-ciency conditions,
especially AIDS.
Other unusual pathogenic fungi such as Cryptococcus sp.,
Aspergillus sp., Mucor sp., Paracoccidioides sp. and Saccharomyces
sp. have also been isolated. Severe oesophageal IFI could cause
oesophageal stricture and perforation, and often coexists with
reflux oesophagitis, oesophageal cancer and AIDS.
22. Oesophageal fungal infection is one precipitating factors for
oesophageal cancer and can cause local chronic inflammation and result
in the proliferation of epithelial cells and enhanced susceptibility to
carcinogens.
On the other hand, the metabolites produced by fungi could directly act
on the oesophageal epithelial cells, thus resulting in carcinogenesis.
Candida sp. is also the most frequently identified species among patients
with gastric IFI.
More than 50% of patients with gastric ulcers present with gastric fungal
colonisation, which often appears among the elderly population with
low gastric acid.
Moreover, the fungal infection could occur in gastric carcinoma and
residual gastritis, which may be due to the injury of gastric mucosa
barrier functions, the long-term use of antibiotics, chemoradiotherapy,
the stomach tumour itself and the surgical procedures.
In addition, various systemic immunosuppressive disorders can impair
the local immunity of gastric mucous, and gastric fungal infection is not
uncommon.
23. Liver IFI is mainly induced by the systemic immunosuppressive state and
is one manifestation of systemic disseminated fungal infection.
Patients with liver IFI often present with abdominal pain, obstructive
jaundice, abnormal hepatic enzymes, hepatosplenomegaly and liver
abscess.
Pathogenic fungi including Mucor sp., Candida sp., Aspergillus sp.,
Cryptococcus sp., Histoplasma sp., Coccidioides sp., Malassezia sp. and
Paracoccidioides sp., were reported to cause local infection of liver.
On the other hand, some severe liver disorders can also cause the
systemic disseminated fungal infection.
For example, IFI is one of the major complications of patients with
chronic severe hepatitis, liver failure and decompensated cirrhosis;
higher hepatitis B virus DNA levels may be an independent risk factor.
IFI is more common in liver transplant recipients and is associated with
increased morbidity and mortality following liver transplantation.
Candida ssp. are the most common pathogenic fungi after liver
transplantation, and Aspergillus sp., Cryptococcus sp. show a tendency to
increase.
The higher incidence of IFI after liver transplantation is associated with
end-stage liver diseases, operative procedures, hyperglycaemia, post-
operative immunosuppressants, and hormone and antibiotics
treatments.
24. The overgrowth and colonisation of fungi in intestine can
lead to diarrhoea. Although the human intestine is the
largest source of fungaemia in the immunocompromised
host, IFI with intestinal involvement is an uncommon but
serious complication.
Several fungal species such as Saccharomyces sp., Candida
sp., Mucor sp., Basidiobolus sp., Aspergillus sp., Histoplasma
sp., Mucor sp., Cryptococcus sp., Geotrichum sp. and
Actinomyces sp. could cause small intestinal and colonic IFI.
Severe intestinal IFI could produce the clinical presentations
of anorexia, abdominal pain, watery diarrhoea, lethal bowel
necrosis and infarction, GI bleeding, ulcers and perforation.
Intestinal fungi are closely associated with the intestinal
disorders after chemoradiotherapy and antibiotic treatment,
which are also the major concerns of gastroenterologists.
25. Candida-associated peptic ulcers are more common than previously
considered and are characterised by the ulcer’s delayed healing process and
even perforation.
As with H. pylori, Candida sp. may play an aetiologic role in peptic ulcers, as
it can be detected in the H. pylori-negative patients with peptic ulcers.
the co-existence of C. albicans with H. pylori may indicate synergism in
pathogenesis of peptic ulcers, and hypha formation by Candida sp. could
contribute to the mechanism of ulcer perforation.
Several studies found the intracellular occurrence of H. pylori in Candida sp.
and confirmed that H. pylori in the vacuole Candida sp. could be viable and
express several H. pylori-specific proteins such as VacA, urease and
peroxiredoxin.
These interactions between H. pylori and Candida sp. may play a crucial role
in their gastric colonisation.
26. The carcinogenicity of fungi is mainly due to the long-term intake
of exogenous mycotoxins in contaminated food.
As discussed earlier, mycotoxins may be involved in the
development of hepatocellular carcinoma, gastric and
oesophageal carcinoma.
Furthermore, the fungal infection and colonisation in the stomach
is common in patients with gastric cancers.
Helicobacter pylori infection is the definitive risk factor for gastric
cancers, so interactions between Candida sp. and H. pylori may
play an aetiologic role in the gastric carcinogenesis.
the chronic inflammation of GI epithelial cells generated by
dysbiosis contributes to the neoplastic transformation of GI tract
in combination with genetic susceptibility of the host.
27. The intestinal bacterial microbiota and related metabolites can
work together with the host genetic susceptibility and host
systemic and local mucosal immune response to contribute to the
pathogenesis of IBD.
The colonisation of C. albicans can exacerbate intestinal
inflammation in a murine colitis model, and obvious improvement
can be observed after anti-fungal treatment.
Moreover, C. albicans can be isolated from the intestine more
frequently in CD patients and their healthy relatives.
Large amounts of Candida sp. can also be detected in the faeces
or intestinal mucosa among patients suffering from ulcerative
colitis, and the clinical symptoms and intestinal inflammation may
be improved after the anti-fungal treatments.
28. The dominant symptoms of Candida-associated infectious diarrhoea and
those of the so-called ‘candida syndrome’ are similar to IBS associated
symptoms.
Moreover, several studies reported that the fungi-containing foods
combined with intestinal fermentation disturbances could be related to
the IBS-related symptoms and food intolerance.
In addition, some evidence showed that fungal products and antigens
could cause IBS symptoms in sensitised patients.
For example, components (e.g. glycoproteins) and products (e.g.
alcohol) of C. albicans which are potentially immunogenic and allergenic
could provoke mast cell-mediated hyperreactivity and disturb intestinal
immunity and barrier function.
These pathogenic mechanisms are similar to the pathogenesis of IBS.
Regardless, there remains little evidence to support the possible
involvement of fungi in the aetiology of IBS.
29. Invasive fungal infections have emerged as a significant problem in
patients with solid tumours or haematological malignancies undergoing
chemoradiotherapy and HSCT procedures.
The predominant causative fungal species include yeasts such as C.
albicans as well as other Candida species (e.g. C. glabrata, C. parapsilosis,
C. krusei and C. tropicalis), and the filamentous fungi such as Aspergillus
sp. The frequency of isolation of Cryptococcus sp., Scedosporium sp.,
Fusarium sp., Zygomycetes sp. and Trichosporon sp. is currently rising.
Invasive fungal enteropathy is an unusual presentation, which most
often occurs in the setting of disseminated infection and the true
incidence of which may be underestimated.
The diagnosis of enteric fungal infection can be delayed because of its
nonspecific presentation as well as the lack of characteristic imaging.
30. Mucositis following chemotherapy is a major oncological problem which
results in GI ulcers and symptoms such as nausea, vomiting, dysphasia,
abdominal pain, diarrhoea and constipation.
The abundance of the certain commensal bacterial populations is
significantly influenced by chemotherapy that contribute to the
development of chemotherapy-induced mucositis by influencing the
inflammatory process and
oxidative stress, intestinal permeability, resistance to harmful stimuli
and epithelial repair, the intestinal mucus layer, and the activation and
release of immune effector molecules.
Theoretically, chemoradiotherapy could aggravate the GI mucosal
lesion, resulting in mucositis, as the mucosal barrier is the portal of entry
that allows for invasion of fungi.
It is well recognised that the overgrowth of GI fungi could be observed
among cancer patients undergoing chemoradiotherapy, but the
influence of chemotherapy on GI commensal fungal microbiota remains
poorly described, and whether fungi in the GI tract play an important
role in chemotherapy-induced mucositis still remains unclear.
31. Fungal pathogens may play a relevant, but secondary role compared to
pathogenic bacteria such as Clostridium difficile.
The effect of broad-spectrum antibiotics on the intestinal microbiota is
characterised by the decrease in protective bacterial populations and the
increase in fungi.
It has also been hypothesised that fungal virulence factors such as
phospholipases and secreted aspartyl pro- teinases may contribute to AAD, but
some suggested that fungi and their metabolites were the result of antibiotic
treatment or diarrhoea rather than a cause of AAD (Antibiotic-associated
diarrhea).
Candida albicans colonisation in the stomach can antagonise the intragastric
colonisation of lactic acid bacteria after antibiotic treatment, but can make E.
faecalis colonise more easily.
On the whole, the research to date has focused on the disturbance of bacterial
microbiome after antibiotic treatment; however, the GI fungal communities
indeed influence the reassembly of GI bacterial microbiota after treatment with
broad-spectrum antibiotics.
32. Until now, the influence of symbiotic fungal community on human health and
disease has been ignored due to little knowledge about the distribution of the
fungal microbiota and its function in the human digestive tract.
Further studies are needed to explain:
(i) the cross-talk interactions between fungi and bacteria at the species or community
level in the human GI tract, particularly the formation of mixed biofilms and their
role in the maintenance of normal physiological function and pathogenicity;
(ii) the influence of pathogenic fungi and the commensal fungal microbiota on host
systemic immune and local GI mucosal immunity;
(iii) the characteristics of invasive fungi associated with various digestive diseases;
(iv) the involvement of fungi in the host energy homoeostasis and metabolic
functions.
At present, the co-sequencing of fungal and bacterial DNA may be the optimal and
cost-effective method for the metagenomics studies. The application of
metagenomics combined with metabonomics, transcriptomics and proteomics, as
well as human genome-wide association studies, will contribute to our
understanding of the role of the fungal microbiota in human GI health and disease.