1) The gut microbiota plays a key role in host development, physiology, and health by modulating the immune system and influencing organ development and metabolism.
2) The gut microbiota is dominated by anaerobic bacteria and contains over 500-1000 bacterial species from a few bacterial phyla. It outnumbers human cells 10:1 and contains many metabolic functions.
3) The gut microbiota influences the properties of the intestinal mucus layer, induces the development of lymphoid structures, and tailors immune development through effects on both the innate and adaptive immune systems.
VHIR Seminar led by Joel Doré. Research Director. Institut National de la Recherche Agronomique (INRA). Jouy-en-Josas, France.
Abstract: The human intestinal tract harbours a complex microbial ecosystem which plays a key role in nutrition and health. Interactions between food constituents, microbes and the host organism derive from a long co-evolution that resulted in a mutualistic association.
Current investigations into the human faecal metagenome are delivering an extensive gene repertoire representative of functional potentials of the human intestinal microbiota. The most redundant genomic traits of the human intestinal microbiota are identified and thereby its functional balance. These observation point towards the existence of enterotypes, i.e. microbiota sharing specific traits but yet independent of geographic origin, age, sex etc.. It also shows a unique segregation of the human population into individuals with low versus high gene-counts. In the end, it not only gives an unprecedented view of the intestinal microbiota, but it also significantly expands our ability to look for specificities of the microbiota associated with human diseases and to ultimately validate microbial signatures of prognostic and diagnostic value in immune mediated diseases.
Metagenomics of the human intestinal tract was applied to specifically compare obese versus lean individuals as well as to explore the dynamic changes associated with a severe calory-restricted diet. Microbiota structure differs with body-mass index and a limited set of marker species may be used as diagnostic model with a >85% predictive value. Among obese subjects; the overall phenotypic characteristics are worse in individuals with low gene counts microbiota, including a worse evolution of morphometric parameters over a period of 10 years, a low grade inflammatory context also associated with insulin-resistance, and the worst response to dietary constraints in terms of weight loss or improvement of biological and inflammatory characteristics. Low gene count microbiota is also associated with less favourable conditions in inflammatory bowel disease, such as higher relapse rate in ulcerative colitis patients.
Finally, microbiota transplantation has seen a regain of interest with applications expanding from Clostridium difficile infections to immune mediated and metabolic diseases.
The human intestinal microbiota should hence be regarded as a true organ, amenable to rationally designed modulation for human health.
Human Microbiome is the current project in Research field. The importance of Microorganisms in the human body, the importance and novel roe of the microorganisms on a human body is very effective and helpful. Fecal Transplantation is a unique and helpful technique to cure a dreadful disease naturally by means of microorganisms or introducing the normal flora in to the body again.
VHIR Seminar led by Joel Doré. Research Director. Institut National de la Recherche Agronomique (INRA). Jouy-en-Josas, France.
Abstract: The human intestinal tract harbours a complex microbial ecosystem which plays a key role in nutrition and health. Interactions between food constituents, microbes and the host organism derive from a long co-evolution that resulted in a mutualistic association.
Current investigations into the human faecal metagenome are delivering an extensive gene repertoire representative of functional potentials of the human intestinal microbiota. The most redundant genomic traits of the human intestinal microbiota are identified and thereby its functional balance. These observation point towards the existence of enterotypes, i.e. microbiota sharing specific traits but yet independent of geographic origin, age, sex etc.. It also shows a unique segregation of the human population into individuals with low versus high gene-counts. In the end, it not only gives an unprecedented view of the intestinal microbiota, but it also significantly expands our ability to look for specificities of the microbiota associated with human diseases and to ultimately validate microbial signatures of prognostic and diagnostic value in immune mediated diseases.
Metagenomics of the human intestinal tract was applied to specifically compare obese versus lean individuals as well as to explore the dynamic changes associated with a severe calory-restricted diet. Microbiota structure differs with body-mass index and a limited set of marker species may be used as diagnostic model with a >85% predictive value. Among obese subjects; the overall phenotypic characteristics are worse in individuals with low gene counts microbiota, including a worse evolution of morphometric parameters over a period of 10 years, a low grade inflammatory context also associated with insulin-resistance, and the worst response to dietary constraints in terms of weight loss or improvement of biological and inflammatory characteristics. Low gene count microbiota is also associated with less favourable conditions in inflammatory bowel disease, such as higher relapse rate in ulcerative colitis patients.
Finally, microbiota transplantation has seen a regain of interest with applications expanding from Clostridium difficile infections to immune mediated and metabolic diseases.
The human intestinal microbiota should hence be regarded as a true organ, amenable to rationally designed modulation for human health.
Human Microbiome is the current project in Research field. The importance of Microorganisms in the human body, the importance and novel roe of the microorganisms on a human body is very effective and helpful. Fecal Transplantation is a unique and helpful technique to cure a dreadful disease naturally by means of microorganisms or introducing the normal flora in to the body again.
Dr. Tom Burkey - Host-Microbe Interactions: Effects on nutrition and physiologyJohn Blue
Host-Microbe Interactions: Effects on nutrition and physiology - Dr. Tom Burkey, University of Nebraska-Lincoln, from the 2014 Allen D. Leman Swine Conference, September 15-16, 2014, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2014-leman-swine-conference-material
Ellen Kamhi, PhD RN, The Natural Nurse, Leaky Gut is also called Compromised Intestinal Permeability, due to loss of integrity of the tight junctions between cells in the intestinal mucosa, and is well documented in the scientific literature. See my document Role of Intestinal Permeability in the Inflammatory Process. This condition should be addressed by all health care providers.
Mapping the Human Gut Microbiome in Health and Disease Using Sequencing, Supe...Larry Smarr
Invited Talk Delivered by Mehrdad Yazdani, Calit2 Ayasdi Sponsored Lunch & Learn American Society of Human Genetics (ASHG) San Diego Convention Center October 19, 2014
Evolution in the news (BIOL415) Spring 2014Kevin B Hugins
Mini presentation on current news stories for BIOL 415
This news article was about a journal article published in Nature Communications on April 15, 2014. The article is the result of research that was led by scientists from the Max Planck Institute for Evolutionary Anthropology. The purpose of the research was to study the co-evolution of humans and gut microbiota and examine adaptation that resulted in groups that had different diets. The primary group of interest was a hunter-gatherer group located in Tanzania known as Hadza. This is one of the few remaining true foraging populations in the world. The Hadza diet consists of baobab, game meat, honey, berries and tubers. Hadza do not consume any agricultural crops or livestock.
Dr. Heather Allen - The Swine Gut Microbiota: Status and OutlookJohn Blue
The Swine Gut Microbiota: Status and Outlook - Dr. Heather Allen, National Animal Disease Center, USDA, from the 2016 Allen D. Leman Swine Conference, September 17-20, 2016, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2016-leman-swine-conference-material
Dr. Tom Burkey - Host-Microbe Interactions: Effects on nutrition and physiologyJohn Blue
Host-Microbe Interactions: Effects on nutrition and physiology - Dr. Tom Burkey, University of Nebraska-Lincoln, from the 2014 Allen D. Leman Swine Conference, September 15-16, 2014, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2014-leman-swine-conference-material
Ellen Kamhi, PhD RN, The Natural Nurse, Leaky Gut is also called Compromised Intestinal Permeability, due to loss of integrity of the tight junctions between cells in the intestinal mucosa, and is well documented in the scientific literature. See my document Role of Intestinal Permeability in the Inflammatory Process. This condition should be addressed by all health care providers.
Mapping the Human Gut Microbiome in Health and Disease Using Sequencing, Supe...Larry Smarr
Invited Talk Delivered by Mehrdad Yazdani, Calit2 Ayasdi Sponsored Lunch & Learn American Society of Human Genetics (ASHG) San Diego Convention Center October 19, 2014
Evolution in the news (BIOL415) Spring 2014Kevin B Hugins
Mini presentation on current news stories for BIOL 415
This news article was about a journal article published in Nature Communications on April 15, 2014. The article is the result of research that was led by scientists from the Max Planck Institute for Evolutionary Anthropology. The purpose of the research was to study the co-evolution of humans and gut microbiota and examine adaptation that resulted in groups that had different diets. The primary group of interest was a hunter-gatherer group located in Tanzania known as Hadza. This is one of the few remaining true foraging populations in the world. The Hadza diet consists of baobab, game meat, honey, berries and tubers. Hadza do not consume any agricultural crops or livestock.
Dr. Heather Allen - The Swine Gut Microbiota: Status and OutlookJohn Blue
The Swine Gut Microbiota: Status and Outlook - Dr. Heather Allen, National Animal Disease Center, USDA, from the 2016 Allen D. Leman Swine Conference, September 17-20, 2016, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2016-leman-swine-conference-material
Microbiology is the study of a variety of living things, such as bacteria, fungus, and other tiny creatures, that are not visible to the naked eye. However, these little creatures are the foundation of all life on earth.. all types of living things that are invisible to the unaided eye.
Important categories have been divided based on certain traits in the study of bacteria in food. These classifications have no taxonomic relevance.
Food technology, food safety and hygiene, food poisoning, food genomics, and, more generally,
Biological diversity, or biodiversity, is the scientific term for the variety and variability of life on Earth. Biodiversity is the key indicator of the health of an ecosystem. Every living thing, including man, is involved in these complex networks of interdependent relationships, which are called ecosystems.
Like all healthy ecosystems, Richness of microbiota species characterizes the GI microbiome in healthy individuals. Conversely, a loss in species diversity is a common finding in several disease states. Microbiota Biodiversity helps us : 1- Combat aggressions from other microorganisms, 2- Maintaining the wholeness of the intestinal mucosa. 3- Plays an important role in the immune system, 4- Performing a barrier effect.5- A healthy and balanced gut microbiota is key to ensuring proper digestive functioning. A gut out of balance means a body out of balance which means illness including Inflammation, Allergies, Infections, Nutrient deficiencies, Weight Gain, Asthma-allergies – Autoimmunity
• Arthritis, Metabolic Bone disease, Skin problems e.g. eczema, rosacia, Mood disorders - Cognitive decline-Alzheimers and Cancer.
Includes definition, classification, history, formation, salient features, gene transfer( conjugation, transformation, transduction), antibiotic resistance, nutritional influence, quorum sensing, role in pathogenesis, and controversies.
Unit 9: Human Microbiome
LECTURE LEARNING GOALS
1. Describe the human microbiome: how many microbes there are, how you get your microbiome, who’s there, and how it changes over time and by region.
2. Describe the domain eukarya. List the five superkingdoms and a few notable species.
3. Explain how the human microbiome is related to health and disease.