The document discusses the challenges facing medical research funding in the United States, including stagnant and declining budgets at agencies like NIH and CDC due to sequestration and flat funding. It notes that young scientists are being discouraged from entering fields that rely on government grants. The speaker calls on scientists and medical professionals to become advocates for their work by better communicating with Congress, the media, and the public about the importance of research and its impact on health and the economy. The talk emphasizes the need for the research community to change its culture and embrace ongoing advocacy and public outreach.
Research!America President Mary Woolley's presentation to the Board of Trustees of the Association for Research in Vision and Ophthalmology. Washington, DC, October 29, 2009.
My talk to National Breast Cancer Coalition Project LEAD® workshop 2014Gary Schwitzer
Delivered in Washington, DC, on November 16, 2014. These slides also became the basis for a talk I gave via Skype to Doug Starr's class in the graduate Program in Science and Medical Journalism at Boston University on November 19.
Research!America President Mary Woolley's presentation at the Institute of Medicine's Annual Meeting, "Insights from the Public Perspective," October 13, 2008.
Role of the media in preventing or promoting overdiagnosisGary Schwitzer
Seminar presentation at Preventing Overdiagnosis 2015 conference in Washington DC 9/1/15 by Gary Schwitzer, Publisher, HealthNewsReview.org & Adjunct Associate Professor, University of Minnesota School of Public Health
Research!America President Mary Woolley's presentation to the Board of Trustees of the Association for Research in Vision and Ophthalmology. Washington, DC, October 29, 2009.
My talk to National Breast Cancer Coalition Project LEAD® workshop 2014Gary Schwitzer
Delivered in Washington, DC, on November 16, 2014. These slides also became the basis for a talk I gave via Skype to Doug Starr's class in the graduate Program in Science and Medical Journalism at Boston University on November 19.
Research!America President Mary Woolley's presentation at the Institute of Medicine's Annual Meeting, "Insights from the Public Perspective," October 13, 2008.
Role of the media in preventing or promoting overdiagnosisGary Schwitzer
Seminar presentation at Preventing Overdiagnosis 2015 conference in Washington DC 9/1/15 by Gary Schwitzer, Publisher, HealthNewsReview.org & Adjunct Associate Professor, University of Minnesota School of Public Health
How Physicians Can Use Social Media ProfessionallyJoshua Brett
A power point presentation describing how physicians can use Social Media professionally to engage patients and improve health outcomes while complying with legal and ethical guidelines. This highlights my Masters Degree Capstone Project.
“I am a Mother and Care Giver of My Child” Psycho-social needs Looking after ...RSIS International
Background:
Mothers nurture children early in life, in case of illness, she continues to provide caregiving role especially in the neurosurgical conditions like TBI. Psychosocial needs of mothers looking after children with TBI is over looked. Thus, the present study focused to understand the psychosocial needs of mothers providing care for children with TBI.
Methodology:
The study adopted the qualitative approach, 30 care givers were recruited for the study after obtaining informed consent. The data was collected in face to face interviews. All the interviews were audio recorded. Thematic analysis was used to for qualitative data and descriptive statistics were used for quantitative variables. The R software was used for data analysis.
Results:
The study findings reported that average age was found to be 32.13 ± 5.99 years. The majority belong to Below Poverty Line (BPL). All mothers have experienced mild level distress, anxiety and stress. From the qualitative analysis, the major themes were: information about the illness and treatment choices, financial difficulties, mothers personal feelings and concerns, social support and coping, and long term professional supportive care.
Conclusion:
There is an urgent need to provide psychosocial care for mothers’ of children with TBI during hospitalization as well as at home and need to form advocacy group in the community.
Advance Directives & Advance Care Planning | VITAS HealthcareVITAS Healthcare
Learn how healthcare professionals can ensure that their patients’ voices are heard by embracing advance care planning (ACP), defined as honest conversations about how patients want to be cared for at the end of life if they are unable to communicate or make decisions. This webinar explores advance directives, the legal documents that spell out patients’ wishes for family members, caregivers and healthcare teams.
Optimizing your EHR Value through Patient EngagementBrian Ahier
Focusing on the transformed healthcare system enabled by ARRA, hear ideas on how patients can help realize the value of your EHR and help you achieve meaningful use.
Judy Murphy, RN, FACMI, FHIMSS, FAAN
Deputy National Coordinator for Programs and Policy, Office of the National Coordinator for HIT
Teenage pregnancy is pregnancy in human females under the age of 20. A pregnancy can take place after the start of puberty before the first menstrual period but usually occurs after the onset. In well-nourished girls, menarche usually takes place around the age of 12 or 13.
Pregnant teenagers face many of the same obstetrics issues as other women. There are, however, additional medical concerns for mothers aged below 15 years of age. For mothers aged 15–19, risks are associated more with socioeconomic factors than with the biological effects of age. Risks of low birth weight, premature labor, anemia, and pre-eclampsia are connected to the biological age itself, as it was observed in teen births even after controlling for other risk factors (such as utilization of antenatal care etc.).
In developed countries, teenage pregnancies are often associated with social issues, including lower educational levels, higher rates of poverty, and other poorer life outcomes in children of teenage mothers. Teenage pregnancy in developed countries is usually outside of marriage, and carries a social stigma in many communities and cultures. By contrast, teenage parents in developing countries are often married, and their pregnancies welcomed by family and society. However, in these societies, early pregnancy may combine with malnutrition and poor health care to cause medical problems.
Teenage pregnancies appear to be preventable by comprehensive sex education and access to birth control. Abstinence-only sex education does not appear to be effective.
Through generations teenage pregnancy has converted into one of the Philippines' most challenging social issues. Becoming pregnant at such an early age brings multiple obstacles such as, lower expectations of finishing high school, not attending college, and less success in the job industry. Not only do these obstacles regard the teenage parents but harm their unborn child in academic and health issues, for instance tending to score less optimally on assessments of cognitive development and academic achievement, and also tend to exhibit more problem behaviors than other children. Other than social dilemmas there are certain health issues that are more likely to appear in a teenage pregnancy for example the baby is more likely to have a low birth weight, to be born before term, and have developmental delay.
The issue we focus on is premarital sex among teenager that results to teenage pregnancy. Further explanation will be discussed in the parts to follow.
Presentation recapping some of the primary points from a chapter on decisional architectures coming out later this year. Emphasis is on how information environments can be engineered to support better health and medicine in terms that are congruent with behavioral economics & human factors.
Over the past decade, Kenya has made tremendous efforts to enhance maternal and child health. Secure maternity policies such as free maternity care are one of the initiatives that have enhanced maternal and child health in all public health facilities. Despite these attempts, public health facilities for maternal and child health are still underused. This study employed a cross-sectional descriptive study design to identify determinants of free maternal health services by evaluating factors determining perceptions and health-seeking behavior of 384 pregnant mothers in Malava Sub-County, Kakamega County. The study used a mixed-method (quantitative and qualitative approaches). Questionnaires were administered to pregnant mothers selected for the study. The study employed a purposive sampling of research participants. Quantitative data were collected using the questionnaire administered by the research assistants whereas qualitative data were collected by the researcher through interview schedules. Quantitative data analysis was carried out using SPSS 23. However, qualitative data were analyzed through content analysis. Quantitative data representation was done in terms of frequency and percentages. Analysis of chi-square testing was used to assess the association between the variables of socio-economic and health facilities and the provision of free maternity facilities (p<0.05). The study established that the uptake of free maternal service by pregnant mothers was influenced by their level of primitivism and religious beliefs. In addition, this study found out that 53.8% and 77.7% of the pregnant mothers could not attend antenatal and post-natal care because government facilities were located far away from their residences and they also had less access to some information about free maternal health care. The results of this research would be disseminated to the hospital management team, Sub-Country health management team, County health management team, and other stakeholders, thereby demonstrating reasons for low uptake of free maternity services and helping to strategize for better service delivery. Based on the finding, the study recommends that to improve access to free maternal health care, the county government ought to place health services as close as possible to the community where people live. Secondly, there is a need to embrace the usage of the existing media network to sensitize pregnant mothers to the danger signs and the need to have decision-making powers over their safety. Lastly, hospital management ought to increase the awareness of free maternal health care and to include it among the community priorities during dialog days, action days, and other group discussions.
How Physicians Can Use Social Media ProfessionallyJoshua Brett
A power point presentation describing how physicians can use Social Media professionally to engage patients and improve health outcomes while complying with legal and ethical guidelines. This highlights my Masters Degree Capstone Project.
“I am a Mother and Care Giver of My Child” Psycho-social needs Looking after ...RSIS International
Background:
Mothers nurture children early in life, in case of illness, she continues to provide caregiving role especially in the neurosurgical conditions like TBI. Psychosocial needs of mothers looking after children with TBI is over looked. Thus, the present study focused to understand the psychosocial needs of mothers providing care for children with TBI.
Methodology:
The study adopted the qualitative approach, 30 care givers were recruited for the study after obtaining informed consent. The data was collected in face to face interviews. All the interviews were audio recorded. Thematic analysis was used to for qualitative data and descriptive statistics were used for quantitative variables. The R software was used for data analysis.
Results:
The study findings reported that average age was found to be 32.13 ± 5.99 years. The majority belong to Below Poverty Line (BPL). All mothers have experienced mild level distress, anxiety and stress. From the qualitative analysis, the major themes were: information about the illness and treatment choices, financial difficulties, mothers personal feelings and concerns, social support and coping, and long term professional supportive care.
Conclusion:
There is an urgent need to provide psychosocial care for mothers’ of children with TBI during hospitalization as well as at home and need to form advocacy group in the community.
Advance Directives & Advance Care Planning | VITAS HealthcareVITAS Healthcare
Learn how healthcare professionals can ensure that their patients’ voices are heard by embracing advance care planning (ACP), defined as honest conversations about how patients want to be cared for at the end of life if they are unable to communicate or make decisions. This webinar explores advance directives, the legal documents that spell out patients’ wishes for family members, caregivers and healthcare teams.
Optimizing your EHR Value through Patient EngagementBrian Ahier
Focusing on the transformed healthcare system enabled by ARRA, hear ideas on how patients can help realize the value of your EHR and help you achieve meaningful use.
Judy Murphy, RN, FACMI, FHIMSS, FAAN
Deputy National Coordinator for Programs and Policy, Office of the National Coordinator for HIT
Teenage pregnancy is pregnancy in human females under the age of 20. A pregnancy can take place after the start of puberty before the first menstrual period but usually occurs after the onset. In well-nourished girls, menarche usually takes place around the age of 12 or 13.
Pregnant teenagers face many of the same obstetrics issues as other women. There are, however, additional medical concerns for mothers aged below 15 years of age. For mothers aged 15–19, risks are associated more with socioeconomic factors than with the biological effects of age. Risks of low birth weight, premature labor, anemia, and pre-eclampsia are connected to the biological age itself, as it was observed in teen births even after controlling for other risk factors (such as utilization of antenatal care etc.).
In developed countries, teenage pregnancies are often associated with social issues, including lower educational levels, higher rates of poverty, and other poorer life outcomes in children of teenage mothers. Teenage pregnancy in developed countries is usually outside of marriage, and carries a social stigma in many communities and cultures. By contrast, teenage parents in developing countries are often married, and their pregnancies welcomed by family and society. However, in these societies, early pregnancy may combine with malnutrition and poor health care to cause medical problems.
Teenage pregnancies appear to be preventable by comprehensive sex education and access to birth control. Abstinence-only sex education does not appear to be effective.
Through generations teenage pregnancy has converted into one of the Philippines' most challenging social issues. Becoming pregnant at such an early age brings multiple obstacles such as, lower expectations of finishing high school, not attending college, and less success in the job industry. Not only do these obstacles regard the teenage parents but harm their unborn child in academic and health issues, for instance tending to score less optimally on assessments of cognitive development and academic achievement, and also tend to exhibit more problem behaviors than other children. Other than social dilemmas there are certain health issues that are more likely to appear in a teenage pregnancy for example the baby is more likely to have a low birth weight, to be born before term, and have developmental delay.
The issue we focus on is premarital sex among teenager that results to teenage pregnancy. Further explanation will be discussed in the parts to follow.
Presentation recapping some of the primary points from a chapter on decisional architectures coming out later this year. Emphasis is on how information environments can be engineered to support better health and medicine in terms that are congruent with behavioral economics & human factors.
Over the past decade, Kenya has made tremendous efforts to enhance maternal and child health. Secure maternity policies such as free maternity care are one of the initiatives that have enhanced maternal and child health in all public health facilities. Despite these attempts, public health facilities for maternal and child health are still underused. This study employed a cross-sectional descriptive study design to identify determinants of free maternal health services by evaluating factors determining perceptions and health-seeking behavior of 384 pregnant mothers in Malava Sub-County, Kakamega County. The study used a mixed-method (quantitative and qualitative approaches). Questionnaires were administered to pregnant mothers selected for the study. The study employed a purposive sampling of research participants. Quantitative data were collected using the questionnaire administered by the research assistants whereas qualitative data were collected by the researcher through interview schedules. Quantitative data analysis was carried out using SPSS 23. However, qualitative data were analyzed through content analysis. Quantitative data representation was done in terms of frequency and percentages. Analysis of chi-square testing was used to assess the association between the variables of socio-economic and health facilities and the provision of free maternity facilities (p<0.05). The study established that the uptake of free maternal service by pregnant mothers was influenced by their level of primitivism and religious beliefs. In addition, this study found out that 53.8% and 77.7% of the pregnant mothers could not attend antenatal and post-natal care because government facilities were located far away from their residences and they also had less access to some information about free maternal health care. The results of this research would be disseminated to the hospital management team, Sub-Country health management team, County health management team, and other stakeholders, thereby demonstrating reasons for low uptake of free maternity services and helping to strategize for better service delivery. Based on the finding, the study recommends that to improve access to free maternal health care, the county government ought to place health services as close as possible to the community where people live. Secondly, there is a need to embrace the usage of the existing media network to sensitize pregnant mothers to the danger signs and the need to have decision-making powers over their safety. Lastly, hospital management ought to increase the awareness of free maternal health care and to include it among the community priorities during dialog days, action days, and other group discussions.
The Imperatives of Investment Suitabilityfinametrica
Presentation given by Paul Resnik (Co-Founder, FinaMetrica) at the National Institute of Securities Markets (NISM) in Mumbai, India. It emphasizes on the importance of measuring risk tolerance of investors in the process of matching investment products to an individual's needs. Visit www.riskprofiling.com to know more.
Breakthrough Advocacy for Breakthrough ResearchCTSciNet .org
Meeting: Physician-Scientist Career Development Meeting, New York Academy of Sciences, November 3-5, 2010
Presentation: Breakthrough Advocacy for Breakthrough Research
Speaker: Mary Woolley, President and CEO, Research!America
View online with audio at http://community.sciencecareers.org/ctscinet/groups/sessions/2010/12/breakthrough-advocacy-for-breakthrough-research.php
Where Do We Go From Here? Advocacy for Research After the ElectionResearch!America
Research!America President Mary Woolley's presentation at the Association of University Centers on Disabilities' Annual Meeting, "Where Do We Go From Here? Advocacy for Research After the Election," November 10, 2008.
How useful are advance directives in directing end of life care and do people really understand or want to know the true status of their health as the end nears?
Can you teach an old doc new tricks? Techonomy Bio 2015W2O Group
Greg Matthews' presentation at the Techonomy Bio confernce 2015 in Mountain View, CA (http://techonomy.com/conf/bio15/). Introduces the context of the global health ecosystem.
This presentation was given for the staff of King Fahad Medical City in Riyadh, 11-14 May, 2016
Its content included:
Ethics of public health and health promotion
Ethics of disasters and emergency medicine.
Resource allocation.
DISCLAIMER:
This presentation is based on Hussein GM, Alkabba AF, Kasule OH. Professionalism and Ethics Handbook for Residents (PEHR): A Practical Guide. Ware J, Kattan T (eds). 1st Edition. Riyadh, Saudi Arabia: Saudi Commission for Health Specialties, 2015.AND
Training material presented to the East Mediterranean Public Health Network (EMPHNET) course on Public Health Ethics (Amman, 2014)
Similar to From Research Through Delivery of Care: The Imperative for Advocacy (20)
View the slides of a tribute to the late Alan Magill by ASTMH Past President Christopher V. Plowe, MD, MPH, FASTMH, during WRAIR's inaugural Magill Symposium on June 23 in Silver Spring, MD.
Slides from President-Elect Patricia F. Walker, MD DTM&H, FASTMH, keynote adress to the 6th Annual North American Refugee Health Conference , June 12, 2016 in Niagara Falls, NY: “Refugee Healthcare: Imagining our Future.”
Presentation delivered by ASTMH Executive Director Karen A. Goraleski for the National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) Lecture Series at the Centers for Disease Control and Prevention
The slides are from a keynote presentation delivered by ASTMH Secretary-Treasurer David R. Hill, MD, DTM&H, FRCP, FFTM, FASTMH at the 2013 Annual Conference of New Zealand Society of Travel Medicine in Wellington, NZ, 3 August - 4 August.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
From Research Through Delivery of Care: The Imperative for Advocacy
1. From Research Through Delivery of
Care: The Imperative for Advocacy
Internal Medicine Grand Rounds
Sponsored by
Global Health Pathway, Department of Medicine
Division of Global Pediatrics
Center for Global Health and Social Responsibility
University of Minnesota - February 27, 2014
Karen A. Goraleski
Executive Director, ASTMH
2. Disclosure Information
Karen A. Goraleski
Internal Medicine Grand Rounds
I have no financial relationships to disclose.
I will not discuss off-label use and/or
investigational use in my presentation.
3. • Congress is gridlocked
• House Appropriations Committee
hasn’t appropriated any money since 2011
(instead Continuing Resolutions)
• Open seats on House Appropriations Committee
for several months until December — previously
one of most sought after committee assignments
Washington, DC
4. Jan 17, 2014 Omnibus Appropriations
Bill Signed into Law
• Continued funding for all agencies through Sept
30, 2014
• NIH:
o $1 billion increase over FY 2013 post-sequestration
level
o BUT – this is a cut overall from FY 2013 pre-
sequestration
o Since FY 2010 NIH funding mostly stagnant or seen
very slight increases
5. Young Scientists At Risk
• In 1982, scientists under age 36 comprised
18% of all NIH primary investigators
• By 2011, scientists under age 36 comprised
3% of all NIH primary investigators
Source: Society for Neuroscience
6. Jan 17, 2014 Omnibus Appropriations
Bill Signed into Law: CDC
• Mixed results
• $567 million increase over FY 2013 post-
sequestration level
• FY 2014 total agency funding appears much higher
due to inclusion of funding for Prevention and
Public Health Fund
• Since 2004 - Division of Parasitic Diseases and
Malaria has had same funding in terms of
Congressionally appropriated funds
7.
8. ASTMH statement: “The government’s one-size-
fits-all travel policy...is a detriment to our nation’s
scientific enterprise and will result in slow
scientific innovation and a negative economic
impact on the United States and the world."
US Senate Committee on Homeland Security and Governmental Affairs
Senate Hearing: Examining Conference and Travel Spending Across the Federal
Government (January 14, 2014)
Chairman - Sen. Tom Carper (DE)
Ranking member – Sen. Tom Coburn (OK)
Federal Travel Cuts to Conferences
9. Sequestration - Budget Enforcement
Mechanism
• Draconian measure put in place by the 2012
bi-partisan Super Committee
• Was never meant to happen
• Budget Control Act placed budget caps for
discretionary funding for next 10 years
(beginning in 2013)
• Recent budget deal reconfigured the cap
for FY14 and FY15 – coming in under the
cap, thus no additional cut
10. Sequestration’s Toll
2013
• NIH funded fewer new grants in FY13
• Science community furloughed and laid-off
• Patients were denied access to clinical trials
Longer-term
• Uncertainty
• Young scientists leaving the field
• Scientists relocating out of the U.S.
• ASTMH: young scientists looking for other career
options
Source: NIH; ―Unlimited Potential, Vanishing Opportunity‖
(ASBMB)
11.
12. 2013 Nobel Prize: Physiology or Medicine
“Winning made me reflect
on how my original proposal
might have fared in today’s
depressed funding climate.
It would have been
much, much more difficult
to get support.”
~Randy W. Schekman, PhD
1978 - first
major grant
was NIH
13. 2013 Nobel Prize: Physiology or Medicine
“Would I have been able to have the
initiative, to take the risk?
I really am very concerned I would
not have been.”
~James E. Rothman, PhD
14. • Flat Funding
• Sequester
• Federal Travel Cuts to Participate
in Scientific Conferences
The Anti-Innovation Business Plan
16. What Can Fuel Public Confusion?
May 17, 2012
Oct 27, 2011
May 16, 2012
Can drinking too much coffee kill you?
A new study reports that excessive coffee –
four cups a day – is harmful, but only to those
under 55. How likely is this?
17. • Public is understandably confused by the three steps
forward/two steps back dynamic process of science.
• How do you address this?
– “This is science in real time.”
• Medical/Science community has a responsibility to
help clarify – with the media and the public
• If not you, then who?
Result: Frustration with Conflicting
Reports
18. Confusion About ―Tropical‖ Medicine
• Those diseases are far away - we will never have them
here
• “Tropical” – Phew! … that’s not us!
• Hygiene - huh?
• Lack of fundamental knowledge about disease and
transmission
• NOT top of mind for most everyone but you: 24 hours
to anywhere in the world; Peace Corps and military in
parts of the world with endemic tropical disease;
international commerce – eg, shipping containers, old
tires – ripe breeding grounds
19. • Endemic, Pandemic, Epi
demic
• Surveillance
• “Tropical medicine” vs
“global health”
• Phase I, II, III
• Microscopist
• Basic science, bench
science
• Vector
• NIH, Extramural, Intramura
l
• Genetic/Genomic
• Low-income settings
Language of Science is Jargon to Non-
Scientists (just about everyone else)
• Clinical research
20. Prep Pointers
• Know your audience
• Your goal is: improved understanding of what
you do and why you do it
• Why should your audience care about what
you are saying? How does it connect to them?
• Tell your story, not your data
24. Help Journalists Paint a Picture for
the Reader, Viewer, Listener
• “parts of the world that are remote, poor and
often road-less…”
• “fever, malnutrition and a grotesque swelling of
the limbs and genitals…”
• “People were bitten by average of 40,000 to
50,000 mosquitoes a year in the villages
[he]worked in.”
• “Tiny threadlike worms…”
25. “…using two anti-parasitic drugs, ivermectin (which may
sound familiar to dog owners as a heartworm
treatment) and …”
“This is a big issue in infectious disease, because
nobody’s going to support this indefinitely,” he said… It’s
like getting a vaccine every year — you need 80-90%
coverage.
… That’s not going to work in Papua New Guinea, and
it’s not going to work in Cleveland Heights
either, because people are just not going to participate
in it…”
Make the Story Relatable
26. Add to your “what you do”:
• Section written for patients, public, the media
• Why are you doing this work?
• Research: what is the goal? If a incremental
outcome, what is long range goal?
• If federally funded – why is this a good use of
US taxpayer dollars?
• Why is this being done in Minnesota? How will
Minnesota benefit?
Who Looks at Your Faculty/Research
Profile – Make it Work for Others
29. Do you believe that we are making enough progress in medical research
in the U.S.?
25%
55%
20%
Yes
No
Not sure
Majority: Medical Research is Not Making
Sufficient Progress
Source: A Research!America poll of U.S. adults
conducted in partnership with Zogby Analytics in December 2012.
30. Most Agree: Basic Research is Necessary
Do you agree or disagree with the following statement? ―Even if it brings
no immediate benefits, basic scientific research that advances the
frontiers of knowledge is necessary and should be supported by the
federal government.‖
32%
42%
11%
6%
10% Strongly agree
Somewhat agree
Somewhat
disagree
Strongly disagree
Source: A Research!America poll of U.S. adults
conducted in partnership with JZ Analytics in December 2012
32. What is the name of the government agency that funds most of the
medical research paid for by taxpayers in this country?
16%
16%
19%
15%
1%
33%
National Institutes of Health
Food and Drug Administration
Dept. of Health and Human Services
Centers for Disease Control and
Prevention
Other
Don't know
Few Americans Recognize the
National Institutes of Health
Source: A Research!America poll of U.S. adults
conducted in partnership with Zogby Analytics in January 2014
33. Most Americans Don’t Know Where
Research is Conducted
Can you name any institution, company or organization where medical and
health research is conducted?
41%
59%
I can
I cannot
Mayo Clinic 10%
CDC 9%
NIH 7%
Johns Hopkins 6%
St. Jude 4%
Pfizer 3%
American Cancer Society 3%
Merck 2%
Duke Univ./Med. Ctr. 1%
OR Heath & Sci. Univ. 1%
UCSF 1%
Other 52%
Source: National Public Opinion Poll,
October 2011, JZ Analytics for Research!America
34. Most Americans Can’t Name Living Scientist
Can you name a living scientist? (first volunteered responses)
Source: Your Congress – Your Health Survey, March 2011
Charlton Research Company for Research!America
34%66%
Yes
No
Stephen Hawking 15%
James Watson 1%
Jane Goodall 1%
Bill Nye 1%
Michio Kaku 1%
Neil Degrasse Tyson 1%
Other 14%
35. In general, do you believe scientists effectively communicate the impact
of their work on the nation’s health and the economy?
31%
35%
34%
Yes
No
Not sure
Source: A Research!America poll of U.S. adults
conducted in partnership with Zogby Analytics in January 2014
Opinions Split: Do Scientists
Communicate Effectively?
36. A Colossal Disconnect
The public:
–Wants and expects research to deliver for
them and their families
–It’s not making enough progress
But…
–They don’t know where research is conducted
–Don’t know what NIH is
–Many can’t name a living researcher
37. A Colossal Disconnect
And the scientific community doesn’t do a
very good job at informing the public about
medical and science issues.
39. Who are the Key Congressional
Decision Makers, 113th Congress?
Rep. Hal Rogers
(R-KY)
Chair, House
Appropriations
Committee
Rep. Jack Kingston
(R-GA)
Chair, House
LHHS Appropriations
Subcommittee
Sen. Barbara Mikulski
(D-MD)
Chair, Senate
Appropriations
Committee
Sen. Tom Harkin
(D-IA)
Chair, LHHS,
Appropriations
Subcommittee
40. • House Appropriations – Defense Subcommittee
• Congressional Caucus on Global Health Co-Chair
• Congressional Anti-Human Trafficking Caucus
• Peace Corps Caucus
Senator Al Franken
• Committee on Health Education, Labor and
Pensions (HELP)
• Committee on Judiciary
• Strong supporter of immigrant and refugee
health
41. What Resonates Today with Congress?
• Maintaining US leadership on the global stage
in innovation and technology
• National security – keeping America and the
troops safe
• Healthier countries less susceptible to strife
and conflict, more likely to build their
economies which could lead to less
dependence on the US and perhaps one day –
can be economic partners
42. Research Creates Good Jobs
Essential to Make it Local
• Jobs, Jobs, Jobs
• Funding amount brought to your institution
• Employ how many?
• Indirect economic impact:
– Moved from another state? Bought a home?
Bought a car? Kids in local schools? Pay taxes?
– Utilize local lab supplier or other
vendors, contractors?
– Utilize Fed X, UPS,
or local coffee shop?
43. University of Minnesota NIH Funding
FY 2013 $263,576,394 606 grants
Year end 2013 – University of Minnesota
ranked 20th in NIH Funding
44. ―It’s the smart thing to do and it’s
the right thing to do.‖
Addresses public concerns about the use of
taxpayer dollars
Conveys the moral, humanitarian mission which
is the real driver for these efforts
45. A Time of Unprecedented Change
for Medicine and Research
15 years ago – beginnings of now dramatic erosion of
physician autonomy
2009 IOM Report: To Err is Human: Building A Safer
Health System
Outside stakeholders in science and medicine much
more muscular in their involvement in clinical medicine
Skyrocketing and seemingly runaway health care costs
46. Medicine and research now viewed in terms of
limited resources and priorities
A time for competence:
Priorities: examined carefully and through
different lenses
Have to prove you are using resources
wisely
What is the ROI?
Unprecedented Change…
47. • The public has to change
• Congress has to change
• The medical and research
communities have to change
Unprecedented Change…
48. You Have To Change
• YourCalltoAction:Advocacy
o Changethecultureofmedicineandsciencetoone
thatembracesadvocacy
o Modeloutreach-Rewardit-Expectit-Demandit
o Grabthereinsandreshapewhatitmeanstobea
globalhealthprofessionalintoday’sworld
o Activelyengageinnationalpolicydiscussions
o WhathappensinWashington,DCdoesnotstayin
Washington,DC
49. You Have To Change
o Begintoreshapethecultureofwhatitmeansto
beaglobalhealthprofessionalintoday’sworld
o Activelyengageinnationalpolicydiscussions–
whathappensinWashington,DCdoesnotstayin
Washington,DC
o Modeloutreach-Rewardit-Expectit-Demandit
50. “Scientists are obliged to
make the case for science to
lawmakers. …If I had to do it
all over again I would spend
more time talking to general
audiences and public
officials, penning op-eds.”
~J. Michael Bishop, MD
Nobel laureate
March 15, 2011
51. “Every public health
decision is made on a
political decision.”
~William Foege, MD, MPH
2012 Presidential Medal of Freedom
52. We need to do a better job:
• of embracing advocacy
• of communicating with Congress
• of communicating with the media
• of communicating with the public
53. You have a duty and commitment to
lifelong learning and the translation
of that expertise into discourse with
and service to society.
54.
55. Thank you.
Karen A Goraleski
Executive Director, ASTMH
kgoraleski@astmh.org
Editor's Notes
Pleased to be here -- in part because unique opportunity to be here when you are welcoming new Dean Brooks Jackson … global health experience, vision, leadership, excellence, global viewFits so well with U Minn a leader in global health, especially in tropical medicine – so much leadership of ASTMH is here: leadership in medical education and research for global health Continuum – research – delivery of care– health services research
Disappointed to see what is happening in Washington DCWe expect more from our elected leaders Feels like there is inattention to what gridlock is doing to our nationREPUBLICAN House Approps
Science itself is at risk!
Congressionally appropriated funds are VERY low -- does Congress know value of CDC? Division of Parasitic Diseases and Malaria at CDC has had the same budget since 2004 in terms of appropriated funding.
Week sequester hit – UA to DCA
AmerSctyBiochem and Molec Bio
The ONE Campaign
Dr Randy W Schekman Born in St. Paul
Dr. James Rothman
Coffee is good/bad eggs are good/bad recent stories – vitamins help/ don’t really help Spill over effect to all research … go to more of this point on next slide
1 more – next slide --- no acronyms
Make the impact of this easy to findBe the one that connects the dots
Poll result earlier - Those with the most to lose? You - funding; public – better health
Do you know these people? We regularly see Speaker Boehner (R), Majority Leader Eric Cantor (R) and their counterparts in the Senate, Majority Leader Harry Reid (D) and Majority Whip Dick Durbin (D –IL) …. Do you recognize these names and faces – you should. The hold the purse strings for funding for NIH and CDC. FDA under Ag and Army and Navy under DoD
Strong allies in MN – you have a history of leadership in domestic and global health McCollum Democrat, 7th term A big deal -- HELP – oversees key legal issues such as civil rights, consumer protection and judicial nominations Help them to connect the dots – give them the info they need.Thank them for funding!
National, big picture messages
Connect the dots …… Not just your NIH dollars – but the indirect economic impact , too They are elected by their own constituents – help them make the case
IOM report was ground-shaking for the medical community… some refused to accept the report and loudly denounced it and its findings The naysayers were looked upon as irrelevant …. The genie was out of the bottle Add to this the growing attention to costs of health care
Medical EDUCATION community too Last point – goes to next slide
Global health professional – academic, clinician, working in the field at an NGO, or in a government agency …..
Next slide – discourse
Discourse WITH and SERVICE TO society = advocacy From research ….through delivery of care …through health services research….