Seminar presentation at Preventing Overdiagnosis 2015 conference in Washington DC 9/1/15 by Gary Schwitzer, Publisher, HealthNewsReview.org & Adjunct Associate Professor, University of Minnesota School of Public Health
My talk to National Breast Cancer Coalition Project LEAD® workshop 2014Gary Schwitzer
Delivered in Washington, DC, on November 16, 2014. These slides also became the basis for a talk I gave via Skype to Doug Starr's class in the graduate Program in Science and Medical Journalism at Boston University on November 19.
Knight Science Journalism Fellowships at MIT Medical Evidence Boot Camp 2013Gary Schwitzer
This was, I believe, the fifth time I've been asked to speak at this event in Cambridge. Other speakers: Drs. Steven Woloshin and Lisa Schwartz of Dartmouth, Dr. Barry Kramer of NCI, and Dr. Marty Makary of Johns Hopkins.
McGovern Award Lecture - American Medical Writers AssociationGary Schwitzer
The McGovern Award is given by the American Medical Writers Association for "preeminent contributions to medical communications." It was presented at the AMWA annual conference, in Memphis, October 9, 2014.
My talk to National Breast Cancer Coalition Project LEAD® workshop 2014Gary Schwitzer
Delivered in Washington, DC, on November 16, 2014. These slides also became the basis for a talk I gave via Skype to Doug Starr's class in the graduate Program in Science and Medical Journalism at Boston University on November 19.
Knight Science Journalism Fellowships at MIT Medical Evidence Boot Camp 2013Gary Schwitzer
This was, I believe, the fifth time I've been asked to speak at this event in Cambridge. Other speakers: Drs. Steven Woloshin and Lisa Schwartz of Dartmouth, Dr. Barry Kramer of NCI, and Dr. Marty Makary of Johns Hopkins.
McGovern Award Lecture - American Medical Writers AssociationGary Schwitzer
The McGovern Award is given by the American Medical Writers Association for "preeminent contributions to medical communications." It was presented at the AMWA annual conference, in Memphis, October 9, 2014.
Bioethics lecture UMDNJ-RWJ Medical School: "Addressing the Morass at the Int...Gary Schwitzer
I began the talk by expressing my thanks and humility for being invited to speak in a lecture series that had previously hosted George Annas, Art Caplan, Robert Veatch, Linda and Zeke Emmanuel, Daniel Callahan and many others whose work I have followed and admired. I expressed my appreciation for being the first journalist to speak in the series and hoped that I would not be the last.
I noted that one previous speaker in the series had said, ”In the last 30 years, our entire ethical sensitivity has increased substantially.” I began by wondering if the same could be said about increased ethical sensitivity in media messages about health care. And then I launched into my own 30 year retrospective.
I cited a few examples from the epiphany I had in 1984 as a reporter whose eyes were opened to the hype/misinformation disseminated on AIDS, Artificial Heart, Alzheimer's. And then I transitioned to a reflection on how the same or similar issues are covered today. I offered only a few examples; it would have been a 5-hour talk if I'd made the list more complete. CNN, not coincidentally, is cited in many of the examples, some of them from my own first-hand experience. From the ‘80s, the network insisting on hourly live reports of artificial heart patient updates, and the hyping of a trial in 4 Alzheimer’s patients. In ’90, the hype of an AIDS patient (or was he?) claiming cure from a hyperthermia experiment. Then in the current era, CNN lending credence to cloning claims by a UFO-obsessed sect, and claiming an “exclusive” and “breakthrough” on a hospital news release claiming a cancer cure was within reach. The talk emphasized shared responsibilities on the part of all who communicate about medical research and health care claims. It touched on the imbalance in many media messages about screening tests, with journalists sometimes crossing the line from independent vetting into non-evidence-based advocacy. I cited the Statement of Principles of the Association of Health Care Journalists (which I wrote). It pointed to how medical journals can be complicit in the miscommunication of findings, but how many articles are now being published in journals raising questions about “spin” and bias and interpretation and word choice.
My talk to University of Wisconsin event, "Science Writing in Age of Denial"Gary Schwitzer
This is an amended version to reduce file size to allow it to fit on SlideShare.
My main theme was news coverage of screening tests that emphasized only benefits while denying/ignoring/minimizing evidence of potential harms.
The 2014 MDigitalLIfe Social Oncology Project ReportW2O Group
One year ago, the Social Oncology Project 2013 report was published ahead of the American Society of Clinical Oncology’s annual meeting, for the first time quantifying the scope and nature of digital conversations about oncology - over 16 million of them.
In 2014, we're focusing in on the trends in those cancer conversations, paying particular attention to those we've culled from the MDigitalLife data set – the world's first and only database that maps physicians' digital properties to their official government registries.
Research!America President Mary Woolley's presentation to the Board of Trustees of the Association for Research in Vision and Ophthalmology. Washington, DC, October 29, 2009.
Vaccination in an ageing world: Listening to older peopleILC- UK
The slides from the launch of the report Under the skin: Listening to the voices of older people on influenza vaccination.
The research is based on interviews with older people in Australia, Japan, the UK and Canada, with a particular focus on influenza immunisation. It will highlight the gaps that need to be addressed to achieve a better protection of older adults against influenza through vaccination.
Connectivity, Collaboration, and Disruption: Social Media and the OncologistRobert Miller
On 2/4/14, I presented a talk at Memorial Sloan-Kettering Cancer Center "Connectivity, Collaboration, and Disruption: Social Media and the Oncologist." I created a special hashtag - #msk_hcsm14 and used it to schedule a series of tweets to go out during the talk with some of my references.
Barriers still exist in science, especially when it comes to communication. Many admit that scientists should be using simple, everyday language in scientific discussions and at the same time, they want to understand how science can help them live longer, healthier lives or get better-paying jobs. Scientists who tell stories that lead with the benefits to humanity will connect with their audience.
This year’s State of Science Index findings around the need for effective science communication have inspired us to make a difference. Our “scientists as storytellers” guide helps people in STEM fields enhance their communications skills, overcome common challenges, and learn how to make science more accessible, understandable and engaging to others.
Our guide features advice from world-renowned experts in communication—like journalist Katie Couric, actor Alan Alda, and author and former NASA astronaut, Captain Scott Kelly—as well as professional scientists who share proven practices in effective storytelling. Alda has dedicated many years to advancing science communications through the Alda Center for Communicating Science from which about 14,000 scientists have graduated.
If you’ve ever faced challenges when explaining science to non-scientists, this guide is for you. Download now to see how you can better communicate the innovative work you do
credit to
https://www.3m.com/
Population Health Data Science, Complexity, and Health Equity: Reflections fr...Tomas J. Aragon
Annual Population Health Sciences Colloquium at the Stanford Center for Population Health Sciences on October 26, 2015.
This one-day program will showcase population health sciences research from the Stanford community and experts around the world.
This one-day program will showcase population health sciences research from the Stanford community and experts around the world. The PHS Initiative aims to bring together basic, translational and clinical scientists, along with researchers from disciplines across the entire University, to provide resources and facilitate collaborations focused on population-level questions, data and approaches.
We have an exciting full-day session with keynote speakers - Lloyd Minor, Dean of the Stanford School of Medicine; Muin Khoury, Associate Director of Epidemiology and Genomics Research Program at NCI; and Tomas Aragon, Director of Population Health Division at the San Francisco Department of Public Health - and some time to do the vital work of growing our center.
Research!America President Mary Woolley's presentation at the Institute of Medicine's Annual Meeting, "Insights from the Public Perspective," October 13, 2008.
Bioethics lecture UMDNJ-RWJ Medical School: "Addressing the Morass at the Int...Gary Schwitzer
I began the talk by expressing my thanks and humility for being invited to speak in a lecture series that had previously hosted George Annas, Art Caplan, Robert Veatch, Linda and Zeke Emmanuel, Daniel Callahan and many others whose work I have followed and admired. I expressed my appreciation for being the first journalist to speak in the series and hoped that I would not be the last.
I noted that one previous speaker in the series had said, ”In the last 30 years, our entire ethical sensitivity has increased substantially.” I began by wondering if the same could be said about increased ethical sensitivity in media messages about health care. And then I launched into my own 30 year retrospective.
I cited a few examples from the epiphany I had in 1984 as a reporter whose eyes were opened to the hype/misinformation disseminated on AIDS, Artificial Heart, Alzheimer's. And then I transitioned to a reflection on how the same or similar issues are covered today. I offered only a few examples; it would have been a 5-hour talk if I'd made the list more complete. CNN, not coincidentally, is cited in many of the examples, some of them from my own first-hand experience. From the ‘80s, the network insisting on hourly live reports of artificial heart patient updates, and the hyping of a trial in 4 Alzheimer’s patients. In ’90, the hype of an AIDS patient (or was he?) claiming cure from a hyperthermia experiment. Then in the current era, CNN lending credence to cloning claims by a UFO-obsessed sect, and claiming an “exclusive” and “breakthrough” on a hospital news release claiming a cancer cure was within reach. The talk emphasized shared responsibilities on the part of all who communicate about medical research and health care claims. It touched on the imbalance in many media messages about screening tests, with journalists sometimes crossing the line from independent vetting into non-evidence-based advocacy. I cited the Statement of Principles of the Association of Health Care Journalists (which I wrote). It pointed to how medical journals can be complicit in the miscommunication of findings, but how many articles are now being published in journals raising questions about “spin” and bias and interpretation and word choice.
My talk to University of Wisconsin event, "Science Writing in Age of Denial"Gary Schwitzer
This is an amended version to reduce file size to allow it to fit on SlideShare.
My main theme was news coverage of screening tests that emphasized only benefits while denying/ignoring/minimizing evidence of potential harms.
The 2014 MDigitalLIfe Social Oncology Project ReportW2O Group
One year ago, the Social Oncology Project 2013 report was published ahead of the American Society of Clinical Oncology’s annual meeting, for the first time quantifying the scope and nature of digital conversations about oncology - over 16 million of them.
In 2014, we're focusing in on the trends in those cancer conversations, paying particular attention to those we've culled from the MDigitalLife data set – the world's first and only database that maps physicians' digital properties to their official government registries.
Research!America President Mary Woolley's presentation to the Board of Trustees of the Association for Research in Vision and Ophthalmology. Washington, DC, October 29, 2009.
Vaccination in an ageing world: Listening to older peopleILC- UK
The slides from the launch of the report Under the skin: Listening to the voices of older people on influenza vaccination.
The research is based on interviews with older people in Australia, Japan, the UK and Canada, with a particular focus on influenza immunisation. It will highlight the gaps that need to be addressed to achieve a better protection of older adults against influenza through vaccination.
Connectivity, Collaboration, and Disruption: Social Media and the OncologistRobert Miller
On 2/4/14, I presented a talk at Memorial Sloan-Kettering Cancer Center "Connectivity, Collaboration, and Disruption: Social Media and the Oncologist." I created a special hashtag - #msk_hcsm14 and used it to schedule a series of tweets to go out during the talk with some of my references.
Barriers still exist in science, especially when it comes to communication. Many admit that scientists should be using simple, everyday language in scientific discussions and at the same time, they want to understand how science can help them live longer, healthier lives or get better-paying jobs. Scientists who tell stories that lead with the benefits to humanity will connect with their audience.
This year’s State of Science Index findings around the need for effective science communication have inspired us to make a difference. Our “scientists as storytellers” guide helps people in STEM fields enhance their communications skills, overcome common challenges, and learn how to make science more accessible, understandable and engaging to others.
Our guide features advice from world-renowned experts in communication—like journalist Katie Couric, actor Alan Alda, and author and former NASA astronaut, Captain Scott Kelly—as well as professional scientists who share proven practices in effective storytelling. Alda has dedicated many years to advancing science communications through the Alda Center for Communicating Science from which about 14,000 scientists have graduated.
If you’ve ever faced challenges when explaining science to non-scientists, this guide is for you. Download now to see how you can better communicate the innovative work you do
credit to
https://www.3m.com/
Population Health Data Science, Complexity, and Health Equity: Reflections fr...Tomas J. Aragon
Annual Population Health Sciences Colloquium at the Stanford Center for Population Health Sciences on October 26, 2015.
This one-day program will showcase population health sciences research from the Stanford community and experts around the world.
This one-day program will showcase population health sciences research from the Stanford community and experts around the world. The PHS Initiative aims to bring together basic, translational and clinical scientists, along with researchers from disciplines across the entire University, to provide resources and facilitate collaborations focused on population-level questions, data and approaches.
We have an exciting full-day session with keynote speakers - Lloyd Minor, Dean of the Stanford School of Medicine; Muin Khoury, Associate Director of Epidemiology and Genomics Research Program at NCI; and Tomas Aragon, Director of Population Health Division at the San Francisco Department of Public Health - and some time to do the vital work of growing our center.
Research!America President Mary Woolley's presentation at the Institute of Medicine's Annual Meeting, "Insights from the Public Perspective," October 13, 2008.
Covering Cancer News - Lessons from HealthNewsReview.orgGary Schwitzer
This is 1 of 2 presentations I made at the National Cancer Institute's Cancer Research in the Media workshop for Latin American journalists in Guadalajara on November 7, 2011
Learn how the personal choices you make every day can radically influence your health and begin to develop a plan for health and wellbeing for decades to come.
HOW TO SAVE MONEY ON YOUR HEALTHCARE: An Integrative Medicine ApproachLouis Cady, MD
In this webinar, the fourth in a series of five from Dr. Louis Cady and the Cady Wellness Institute, we focus on the actual dollars and cents of health care expenditures, and the societal and PERSONAL costs of poor health maintenance behavior. We examine the essentially passive US medical system, that would rather drug a symptom than fix the underlying problem.
Great attention is paid on not shaming the patient or the doctors as they exist in the current system. Both groups "do not know what they do not know." Confirmation bias is rampant.
This webinar points the way to living a more vital, energetic life, with a minimum of cost, grief, and misery.
a presentation that helps to educate us about the rising incidence of cancer in our environment. it also tells us about the silent nature of some cancers, which at the point of diagnosis is in the late stages
an informed patient is an empowered patient … with the goal of achieving improved health outcomes.
… shared or informed decision-making, evidence-based patient choice, or concordance.
Blueprint for Men's Health - Dr. Chavez & Dr Gallinson - Livingston Library -...Summit Health
Men and women are fundamentally different when it comes to health care needs. Come learn about the uniqueness of the male blueprint. Join us as we shine a light on male-specific health issues and risks and explain the importance of prevention through early detection, diagnosis and routine screenings.
A presentation by Brian D Sites at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All available content from SSAI2017: https://scanfoam.org/ssai2017/
Delivered in collaboration between scanFOAM, SSAI & SFAI.
An Interactive Discussion On Key Issues Affecting Young Adult Colorectal Cancer Patients and Their Caregivers
Powered By Our Survivor Community and Their Families
Similar to Role of the media in preventing or promoting overdiagnosis (20)
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Role of the media in preventing or promoting overdiagnosis
1. Role of the media in preventing
or promoting overdiagnosis
Gary Schwitzer
Adjunct Associate Professor
University of Minnesota School of Public Health
and Publisher
2.
3. Outline of this session
• Background on HealthNewsReview.org
• Painting a big picture – mosaic of examples of
media messages promoting overdiagnosis –
and a few messages that try to prevent it
• Discussion: Your ideas about how to address
the media tsunami
4.
5. • ABL =
• accidental bowel leakage. Ad for new Butterfly Body Liners that
fit discreetly between the buttocks.
• BBS =
• bashful bladder syndrome – or paruresis – or bashful kidneys,
mental cloggery, stage fright, pee fright, urophobia, pee-shyness,
slow dribbles, creeping pee-pee, public piss syndrome, shy
bladder syndrome. And, yes, antidepressants are sometimes
prescribed
• ED =
• erectile dysfunction or impotence. That was the easy one.
• EIB =
• exercise-induced bronchospasm.
• ES caused by SWD or OSA =
• excessive sleepiness caused by shift work disorder or obstructive
sleep apnea. Ads for Nuvigil for ES - a federally-controlled
substance in prescription drug form
6. • GAD =
• generalized anxiety disorder. Yep, antidepressants.
• HSDD =
• hypoactive sexual desire disorder or not in the
mood tonight. Yep, antidepressants again.
• PE =
• premature ejaculation
• PMDD =
• premenstrual dysphoric disorder
• SAD =
• social anxiety disorder. Yep, antidepressants again.
7. • 9.5 years
• >2055 story reviews
• >50 news release reviews
• >2150 blog posts
• The only systematic review and feedback mechanism for
health care media messengers in the U.S.
• Modeled after a pioneering Australian effort – now shelved
• We receive funding from the Laura & John Arnold Foundation
8. We review health care media messages:
• Journalism – that sometimes
looks more like advertising
• Advertising
• Public relations
• Marketing
• Journal policies
9. • 14 MDs
• 6 PhDs
• 13 journalists/science writers
• 5 communication scholars and/or
academic public information officers
• 4 public health grad students
• 3 women with breast cancer (one w/PhD,
two with Master’s degrees)
Every story* is
analyzed by 3
reviewers, each
applying the same
10 criteria
As of April 1, we’re also reviewing health care news
releases
10. • HealthNewsReview.org reviews news stories
that include claims about interventions:
treatments, tests, products, procedures
• We regularly check:
Boston Globe
Los Angeles Times
New York Times
Philadelphia Inquirer
USA Today
Wall Street Journal
Washington Post
Associated Press
Bloomberg News
Websites of ABC, CBS, CNN,
Fox, NBC
NPR health & science page
HealthDay
Reuters Health
Vox.com
Slate.com
FiveThirtyEight.com
BuzzFeed.com
Websites of TIME, Newsweek,
U.S. News & World Report
11. Our criteria: Does the story …
• Discuss the total cost?
• Discuss how often benefits occur?
• Discuss how often harms occur?
• Evaluate the quality of the evidence?
• Discuss alternative choices?
• Avoid disease-mongering?
• Establish the novelty of the approach?
• Establish the availability of the approach?
• Include an independent perspective?
• Explore conflict of interest in sources?
69%
66%
64%
61%
56%
Percent
unsatisfactory
after 2,055
story reviews
12. Most common flaw:
Conveying certainty
that doesn’t exist
• Exaggerating effect size – relative not absolute data
• Using causal language to describe observational studies
• Idolatry of the surrogate: Failing to explain limitations of
surrogate markers/endpoints
• Tyranny of the anecdote: telling success stories but rarely
profiling dropouts, dissatisfied, those who choose conservative
route or lifestyle change instead of treatment
• Single source stories with no independent perspective
• Failing to independently analyze quality of evidence
14. Although the harm isn’t intentional,
it is very real
• Whips “worried well” into a frenzy, making people
anxious about things that will never bother them
• Raises false expectations about health care system
• Promotes undue demand for unproven technologies
which may do more harm than good
• Distracts from the important health care delivery
and health care policy issues that deserve attention
This is avoidable harm.
15. Infoxication • Information intoxication
• Like trying to get a drink from a
firehose
• Like a giant tsunami washing over
the American public every day
• Health care marketing messages
• DTC drug ad disease mongering
• News & Talk shows
• Journals competing for public attention
• Medical center/industry news releases
• Editorial cartoons
• Patient advocacy groups
• Social media messages
16. Drivers of overdiagnosis
Technological changes detecting ever smaller “abnormalities”
Commercial and professional vested interests
Conflicted panels producing expanded disease definitions and writing
guidelines
Legal incentives that punish underdiagnosis but not overdiagnosis
Health system incentives favouring more tests and treatments
Cultural beliefs that more is better; faith in early detection unmodified
by its risks
BMJ. 2012 May 28;344:e3502. doi: 10.1136/bmj.e3502.
Preventing overdiagnosis: how to stop harming the healthy.
Moynihan R, Doust J, Henry D.
17. Media messages promoting overdiagnosis
in women’s health issues
• Menopause
– Cognitive decline
– Vaginal atrophy (“End the
Silent Suffering” ads)
– CNN: “A new study shows
beyond a doubt that
menopause, not the natural
aging process, is responsible for
a sharp increase in cholesterol
levels.” So when did menopause
stop being part of natural
aging?
• Female sexual dysfunction
– including news about An
extra 0.7 "satisfying sexual
events" per month
• Female orgasmic disorder
• Breast cancer screening confusion
• Celebrity breast CA news: Dr. Holly
Phillips, CBS NY – after Christina
Applegate diagnosis/surgery: “What’s
most important is to screen, so as long as
you get in for screening, I’m happy….
generally, we start home breast exam at
age 20. I suggest every month, at the
same time of the month, examine your
breasts at home and get into your doctor
for a breast exam at least every three
years, earlier if you can.”
• Breast reduction surgery – NY Daily
News let plastic surgeon get away
w/saying: “The pain that women with
large breasts can have has been
compared to when someone gets
metastasized cancer of the spine.”
18. more Women’s health issues
• Aging : NYT twice in a week
– ”Never Too Old for
Plastic Surgery”
– and ”Fighting Cleavage
Wrinkles”
• Plastic surgery “fix” for
resting bitch face
• Overactive bladder ads
• Thyroid – “Start having
hormone levels screened
when you’re 35” – Women’s
Health magazine
• Osteopenia:
– Washington Post blogger:
“Glee” was pretty darned
great last night, eh? I was so
wowed by Gwyneth
Paltrow’s singing and also
with her dancing. Paltrow’s
dance performances were
particularly impressive to
me in light of her recent
diagnosis of osteopenia, a
thinning of the bones that
can lead to osteoporosis.”
21. In 2009 after the USPSTF
mammography recommendations,
the editors of the Annals of Internal
Medicine referred to a “media
cacophony” ---
“Confusion, politics, conflicted
experts, anecdote, and emotion ruled
front pages, airwaves, the Internet,
and dinner-table conversations.”
22. Battle for hearts and minds of women…and of journalists
…on mammography & many other issues
23. Impact on journalists may have been seen
in one recent week in imbalanced news
• Many stories about NEJM paper about
International Agency for Research on Cancer
breast CA screening recommendations –
stories that often read “Breast screening
reduces risk of death by 40%”
• Almost no mainstream news media stories
about JAMA Surgery paper suggesting surgery
overdone for “low-grade” DCIS
25. Perfect smile, perfect skin, perfect hair
That’s what the CBS
Early Show promotes.
So if you have fine
lines, wrinkles, eye
dark circles, acne, age
spots – CBS tells you
that “All can be easily
treated to enhance
your overall look in the
new year, prevent signs
of aging for the long-
term, and increase
your self-esteem.”
26.
27. Among the questionable advisories from the Post:
•Telling men in their 30s to sign up for complete physicals”
•Telling men in their 40s to get complete physical every 2 yrs
Telling men in their 40s to start skin cancer screening.
20s, 30s, 40s, 50s…”
Tips for Men in 30s, 40s, 50s
• EKG in 30s
• “Men should visit their doctors annually”
• Men in 50s “should be aware they they
need prostate cancer screening”
28. National Cancer Institute:
• about 8% of men will develop cancer of the prostate between
their 50th and 70th birthdays.
• And the lifetime risk of dying from prostate cancer, according to
the American Cancer Society, is more like 1 in 36.
This is what such campaigns tend to do – use the scariest numbers
to “heighten awareness.”
29. We wrote:
Such promotions might help more men if they
spent more time discussing the poor quality of
shared decision-making that takes place around
prostate cancer issues. The DECISIONS survey
found that “most prostate cancer screening
decisions did not meet criteria for shared
decision making because subjects did not
receive balanced discussions of decision
consequences, had limited knowledge, and were
not routinely asked for their preferences.”
36. Men’s health issues
In 2010, The German drug giant Bayer settled complaints by
three states that it had deceptively used the fear of prostate
cancer to sell One A Day vitamins without proof the pills could
prevent prostate cancer. Illinois’ Attorney General decried Bayer
for trying to increase One A Day sales by “deceptively leveraging
fear of prostate cancer and relied on a promotional campaign
called “Strike Out Prostate Cancer” that enlisted Major League
Baseball as a promotional partner. That effort included
billboards, print and broadcast ads, and testimonials from
baseball players.”
45. We provide you with the opportunity to appreciate and better
understand the inner intricacies of parts of your body such as your
spine, your joints or your pelvis through an MRI scan.
Are you puzzled by why you have been having sinus pain, back pain
or knee pain? Are you tired of ongoing treatments that waste your
time and money? Are you curious about what is really happening
inside you? An MRI-based health screening can help get you on the
right path to appropriate treatment and a healthier life.
46. $299 Laser Toenail Fungus Treatment
$50 MRI scan for headache prevention screening
$35 for one Colon HydroTherapy Session
49. “hope to persuade state legislators to mandate the heart
exams for all students entering middle school in Texas.”
50. Gupta was shown being wheeled into a CT scanner to
undergo a coronary artery calcium scan. The statement was
made – unchallenged - “Unless you do the imaging and
advanced testing, you are really playing Russian roulette with
your life.”
51. "I'm not generally a big fan of direct-to-consumer TV
ads," says Dr. Mark Buchfuhrer. "However, for this
particular disorder, I think they've done a great
service by spending most of the time identifying the
problem."
But in the process, Glaxo also identified a market
and began introducing Americans to a problem
many people didn't realize they had, or had never
mentioned to their physicians.
52. K-Mart blue light special – free aneurysm screening at
900 K-mart pharmacies, sponsored by Medtronic and
3 vascular surgery professional groups
53.
54.
55. Reuters special report on esophageal cancer :
Cancer screening feeds overdiagnosis debate
56. Television news “teases”
Teases – those TV news set-up lines that tell you what’s “still to come”
after the next commercial – are soimportant that a popular TV news
industry website posted a “How To Tease Health Stories” tip. It’s worth
nothing that the column was entitled “Marketing Matters.”
“When teasing these medical breakthrough stories, remember that the
story is about the results of the study, not the technical specifics of the
research. If the story is about a breakthrough in birth defects, show
healthy kids playing, not researchers. If the story is about a
breakthrough in bone density, show people playing tennis or walking
with a cane. Don’t focus on the dull clinical study, focus on the how this
breakthrough may affect real life. Analyze the research story and look
for its potential benefits down the road. The story isn’t about
cholesterol levels, it’s about fewer heart attacks and living longer. The
story isn’t about prenatal blood allergies, it’s about happy families with
smiling healthy children.”
57. No acknowledgement that just 2 months earlier Victor
Montori of the Mayo Clinic and John Yudkin of University
College London wrote in The BMJ, “The epidemic of pre-
diabetes: the medicine and the politics.”
Harms from overdiagnosis—A label of pre-diabetes bring problems
with self image, insurance, and employment as well as the burdens
and costs of healthcare and drug side effects
A diagnosis of pre-diabetes does not mean that you will develop
diabetes. In fact, of 100 people like you, fewer than 50 are likely to
develop diabetes in the next 10 years
USA Today:
“Pre-diabetes rates fuel national health crisis.”
58. How could this happen?
The USA Today story uses an American Diabetes
Association spokesman as a key source. He is
quoted saying:
“We’ve proven (pre-diabetes) is an intervention
time,” said Matthew Petersen, the association’s
managing director of medical information and
professional engagement. “It’s a call to action.”
59. Fear - DCIS
Online comment:
“I am one of thousands of women who have been HARMED with OVER
diagnosis and OVER treatment of DCIS thanks to a mammogram.
Thankfully I took the time to investigate this problem and got an
expert 2nd pathology opinion and said NO to mastectomy, radiation
therapy and tamoxifen….all were being pushed heavily… after a core
needle biopsy and 3 lumpectomies (which did not get clean
margins)……all of these procedures are very invasive and the
emotional toll is even worse. Then come all the bills…very
stressful…and the docs just want to prescribe Xanax! Nobody really
understands what the harms truly mean…unless you live through it.
We must find a better solution than mammograms as they find too
many NON cancers and miss too many aggressive cancers.”
“Breast Cancer Screening: Let Evidence Trump Fear”
– Health Affairs blog by Shannon Brownlee (Lown),
Lisa Simpson (Academy Health)
60. Dr. Richard Lehman –
BMJ journal review blog
• On precision medicine:
“the immense information load threatens to
overwhelm every person—be they healthy, ill,
medical, or technical—with data that leads to
nothing but more data-seeking and more anxiety.
…The latest way to make the luckiest humans in
history anxious during their short stay on Earth.”
Confusion -
Anxiety
61. JOSH BILLINGS (PEN NAME OF HUMORIST
HENRY WHEELER SHAW, 1818 – 1885)
“The trouble with
people is not that they
don't know, but that
they know so much that
ain't so. …
I honestly believe it is
better to know nothing
than to know what ain’t
so.”
Confusion -
Anxiety
62.
63.
64. In order to drown out the cacophony
and not add to it…we need humor
65. The editors of the Annals of
Internal …not even in the urinal ---
“Confusion, politics, conflicted
experts, anecdote, and emotion ruled
front pages, airwaves, the Internet,
and dinner-table conversations.”
We are flooded and there’s no escape….
66. Dr. Willet Whitmore
Sloan Kettering urology chair >30 years
“Is cure possible in those for
whom it is necessary?
And is cure necessary in those for
whom it is possible?”
67. “The current state of prostate cancer may not be
good medicine but it sure is good business.”
“There are more people making a living from
prostate cancer than there are dying from it.”
“The patient may not be dead but he wishes he
was.”
68. More Whitmore wit
“Tell me what you want to hear and I’ll refer you
to someone who will recommend it.”
“When results are good, we tend to say, ‘That’s
a good treatment.’ When treatment fails, we
shake our head and say, ‘That’s a bad cancer.’ “
“Let’s try to replace heated opinion with cold
facts.”