This document provides a framework for thinking about collaboration spaces, both online and in-person, to promote social innovation. It outlines the complex landscape including new policies, networks, technology, and roles. The framework focuses on defining goals, engaging relevant people, choosing appropriate methods, and establishing structures to support solutions. Collaboration spaces can enable connecting different domains, developing new skills and attitudes, and blending online and offline work. Networks are increasingly important as they help define contexts and provide structures for action.