1) The document presents a frame-online DNN-WPE dereverberation method that uses a neural network to directly estimate the power spectral density (PSD) of target speech from observations for use in weighted prediction error (WPE) dereverberation. 2) Experiments on the REVERB challenge and WSJ+VoiceHome datasets show the DNN-based method improves word error rates over unprocessed baselines, particularly for online processing with two microphones. 3) While performance degrades with increased latency constraints and complex background noise, the DNN-WPE still provides an improvement over no enhancement and enables real-time dereverberation.