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As blood flows through capillaries, some plasma leaks out through gaps between capillary cells and into the spaces between tissue cells, forming tissue fluid. Tissue fluid is similar to plasma but contains fewer protein molecules, which are too large to pass through the capillary gaps. Red blood cells also cannot pass through, but some white blood cells such as neutrophils can squeeze into the tissue fluid. Other small molecules in tissue fluid include glucose, urea, amino acids, and water. Tissue fluid is drained by the lymphatic system.









