lecture from chapter 2 of GENERAL PSYCHOLOGY
REFERENCE: Aguirre, Felisa U., Monce, Ma. Rosario E. and Dy, Gary C. Introduction to Psychology (2011). Malabon City: MUTYA Publishing Company, 2012
lecture from chapter 2 of GENERAL PSYCHOLOGY
REFERENCE: Aguirre, Felisa U., Monce, Ma. Rosario E. and Dy, Gary C. Introduction to Psychology (2011). Malabon City: MUTYA Publishing Company, 2012
Ridge infertility treatment center is a group company of Gouri Hospital's Ltd. It is one of the best infertility centers & in vitro fertilization Hospitals in Delhi providing treatment suited to specific needs of the people.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Nutraceutical market, scope and growth: Herbal drug technology
Foetal development and growth in humans
1. Pre-Natal
Development
23 chromosomes from Mom and 23
from dad
Gestation is 280 days or 40 weeks.
Three distinct periods:
Ovum: conception to implantation
at 4-5 days
Embryonic: implantation to 8
weeks
Fetal: 8 weeks to birth (40 weeks)
10. 7-8 weeks
•The tiny baby is protected by the AMNIOTIC
SAC, filled with fluid.
•Inside, the child swims and moves gracefully.
•The arms and legs have lengthened, and fingers can
be seen.
11. 10 weeks –
•The heart is
almost
completely
developed
and very
much
resembles
that of a
newborn baby.
*Twenty tiny
baby teeth
are forming
in the gums
14. Fetus at 12 weeks
•The brain is fully formed,
and the child can feel pain.
•The fetus may even suck his
thumb
15. 14 weeks –
•Muscles lengthen and
become organized.
•The mother will soon
start feeling the child
kicking and moving
within.
15 weeks –
•The fetus has an adult's
taste buds and may be
able to savor the mother's
meals.
•Foods the mother eats
16. Fetus at 4 months
or
about 16 weeks
Face is fully
developed and
A downy hair
covers the skin.
Face is fully
formed.
Eyes are fully
formed but not
yet functional.
19. Smallest baby in the world born
At just 22 weeks
She was 10 OUNCES when born and 9.5 inches. That's just longer than the
length of your hand. She weighed less than a can of soda!
20. 24 weeks – (6
months)
•Seen here at six months,
the unborn child is covered
with a fine, downy hair
called lanugo.
•Its tender skin is
protected by a waxy
substance called vernix.
•The child practices
breathing by inhaling
amniotic fluid into
developing lungs.
21. Seven
Months•Room is getting tight at
this point.
•The baby is less able to
move, squirms and
pushes more than
flutters and kicks.
•Most babies begins to
get into a head down
position getting ready
for birth.
22. 32 weeks –
•The fetus sleeps
90-95% of the day
with sleep
dominating the
sleep cycle, an
indication of
dreaming.
•The baby has
75% or higher
chance of survival.
•Fetus may react to
noises with a
jerking action
23. Birth at 38-42
weeks
•40 weeks is
normal
gestation
•The baby
weighs on
average 7 lbs.
and is 20 inches
long.