This document presents an overview of human embryology and fetal development from conception to birth in 3-sentence stages. It describes the key events from fertilization through cell division and implantation in the first few weeks. The major organ systems then develop throughout the subsequent weeks, with the fetus growing in length and weight. By week 35, the fetus is near its birth length and continues gaining fat in preparation for birth from week 36 to 40, when the fully developed fetus is ready to be delivered.
lecture from chapter 2 of GENERAL PSYCHOLOGY
REFERENCE: Aguirre, Felisa U., Monce, Ma. Rosario E. and Dy, Gary C. Introduction to Psychology (2011). Malabon City: MUTYA Publishing Company, 2012
Pre-natal development of child
A project to promote conceptual learning for all;
Dr. Amjad ali arain; University of Sind; Faculty of Education; Pakistan
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
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- Prix Galien International Awards Ceremony
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
2. DEFINITION OF EMBRYOLOGY
• EMBRYOLOGY IS THE STUDY OF
DEVELOPMENT EVENTS THAT OCCUR DURING
PRENATAL STAGE.
3. DEVELOPMENT STAGES OF FETUS
• 1ST ocuur the maturation where ogenesis and
spermatogenesis occur
• Fertilization occurs where the sperm enters
the ovum, means the fusion of sperm cell with
oocyte and form zygote
4.
5. 1st week
• Zygote undergoes mitotic cellular replication
as CLEAVAGE.
• Cleavage is the formation of smaller cell called
BLASTOMERES
6. • FORMATION OF MORULA
• Zygote undergoes into cell
division.
• 4 cells- at 2days
• 8 cells - at 2.5 days
• 16 cells - at 3 days
7. 2nd week and 3rd week
• No development occurs since fertilization
hasn’t actually occurred
• At 3rd week – embryo will implant to the wall
of uterus . Fertilized egg ( zygote ) begins to
develop into a hollow ball of cells blastocyte.
8. 4TH WEEK AND 5TH WEEK
• FROM PLACENTA AND EMBRYONIC SAC MEMBRANE .
• FORMATION OF YOLK SAC.
• PRIMITIVE STREAK
• DEVELOPS.
• PRIMARY STEM VILLI APPEARS.
• DEVELOPMENT OF BRAIN,
SPINAL CORD,VERTEBRA,
HEART, GASTROINTESTINAL TRACT.
9. WEEK 6TH TO 7TH
• EMBRYO GROWS 4mm TO 9mm IN LENGTH
• BEGINS TO CURVE INTO C- SHAPE
• THE FETAL HEART BULGES , DEVELOPES
FURTHER AND BEGINS TO BEAT IN A REGULAR
RHYTHM.
10. 8TH TO 9TH WEEK
• THE EMBRYO MEASURES ABOUT 13mm TO 18mm
• DURING 8TH WEEK LUNGS BEGINS TO FORM AND ALSO LYMPHATIC
SYSTEM.
• DEVELOPMENT OF EXTERNAL GENITALIA BEGINS AND UPPER AND LOWER
LIMBS CAN BE CLEARLY DISTINGUISH.
• 9TH WEEK ELBOW AND TOES ARE VISIBLE, HAIR FOLLICLES BEGINS TO
FORM.
AFTER 10TH WEEK OF DEVELOPMENT , THE ORGANISM IS CALLED FETUS.
MAJOR STRUCTURE WILL CONTINUE TO GROW.
11. WEEK 10TH TO 12TH
• EMBRYO MEASURES 30-80MM
• Baby's nose, mouth, and eyes starts taking shape. Tooth buds and caps are
becoming recognizable.
• Baby's fingers will soon begin to open and close, his toes will curl, his eye
muscles will clench, and his mouth will make sucking movements.
Your baby has ten fingers and ten toes (no more webbing), and peach-fuzz
hair begins to grow on tender skin.
12. 13TH TO 16TH WEEK
• The baby's fingers and toes have now separated, nails begin to form and
some hair may even be growing. The baby's head can now move and facial
features continue to develop. At this stage, the baby weighs around 25
grams. The mother's uterus is expanding and changing position to be
above the pelvis.
13.
14. 17TH TO 21 WEEK
• Seventeen weeks into your pregnancy, or 15 weeks after conception,
toenails begin developing. Your baby is becoming more active in the
amniotic sac, rolling and flipping. His or her heart is pumping about 100
pints of blood each day.
• FETUS lengths ABOUT 20cm.
• MOTHER CAN FEEL THE FETUS MOVING.
15.
16. WEEK 23
• FETUS IS ABOUT 28cm
• 23 weeks after conception, your baby might be able to
respond to familiar sounds, such as your voice, with
movement.
• Your baby is spending most of his or her sleep time in rapid
eye movement (REM), when the eyes move rapidly even
though the eyelids are closed.
17. WEEK 27
• THE baby weighs almost 2 lbs – about as much
as a head of cauliflower – and is around
15inches long. At this stage, babies sleep and
wake at regular intervals, opening and closing
their eyes and maybe even sucking their
fingers. With more brain tissue developing,
THE baby's brain is very active now.
18.
19. WEEK 31
• THE FETUS IS ABOUT 38-43 CM AND WEIGHS ABOUT 1.5KG.
• BREATHING OCCURS , BONES ARE FULLY DEVELOPED .
• THE AMOUNT OF BODY FATS INCREASE MEANS THE PREGNANT LADY WILL
GAIN WEIGHT.
20. WEEK 35
• During the 35th week of pregnancy, she already might be close to her
birth length, near 18 inches from head to toe, and she continues to build
up necessary fat, especially in her shoulders. Within your now-crowded
uterus, your baby might shift her movements from kicks and punches to
more rolls and wiggles.
21. WEEK 36- 40
• THE FETUS IS FULLY DEVELOPED AND IS ABOUT 48 TO 53CM
• FINGERNAILS EXTEND BEYOND FINGERTIPS
• SMALL BREAST BUD ARE PRESENT ON BOTH SEXES.
• HEAD HAIR IS NOW COARSE AND THICKEST.
• In the last weeks of pregnancy
the rapidly growing fetus turns
head- down:a baby ready to be born.