1) Decontamination refers to practices that limit or minimize a patient's exposure to a ingested toxin. This includes removing clothing with skin contamination, flushing eyes or rinsing skin.
2) Common decontamination methods for ingested poisons include gastric lavage, whole bowel irrigation, and enhanced elimination techniques like hemodialysis or hemoperfusion.
3) Gastric lavage and whole bowel irrigation are controversial and their use is declining, as they carry risks and may not improve outcomes. They are generally only used for significant toxin ingestions that have not been absorbed.
Peritoneal dialysis is a way to remove waste products from your blood when your kidneys can no longer do the job adequately.
A cleansing fluid flows through a tube (catheter) into part of your abdomen and filters waste products from your blood. After a prescribed period of time, the fluid with filtered waste products flows out of your abdomen and is discarded.
Peritoneal dialysis differs from hemodialysis, a more commonly used blood-filtering procedure. With peritoneal dialysis, you can give yourself treatments at home, at work or while traveling.
Peritoneal dialysis is a way to remove waste products from your blood when your kidneys can no longer do the job adequately.
A cleansing fluid flows through a tube (catheter) into part of your abdomen and filters waste products from your blood. After a prescribed period of time, the fluid with filtered waste products flows out of your abdomen and is discarded.
Peritoneal dialysis differs from hemodialysis, a more commonly used blood-filtering procedure. With peritoneal dialysis, you can give yourself treatments at home, at work or while traveling.
Peritoneal dialysis is a treatment for kidney failure that uses the lining of your abdomen, or belly, to filter your blood inside your body. Health care providers call this lining the peritoneum. A more convenient method of dialysis in home itself.
The aim of this lecture is to provide
an overview of the management of various toxic exposures.
emergency medical services that should be immediately contact to provide advanced life support for patient with unstable vital signs resulting from a poisoning exposure.
Bleeding Peptic Ulcer Disease - Does Practice Meet Evidence?Jarrod Lee
Bleeding peptic ulcer is a common medical emergency. Today many good studies and evidence based guidelines have provided doctors with a strong evidence based approach to manage this condition. However, how much of daily practice actually follows the evidence? The presentation goes through common scenarios in hospital medicine, and covers the latest evidence through a case based approach.
Anesthesia in sickle cell disease- a case presentationSunder Chapagain
This is a short case presentation on how we (anesthesia team) managed a case of sickle cell disease with avascular necrosis of neck of femur (left) in our hospital. May be useful to medical students and Medical officers as some special considerations are needed in such type of cases.
A detailed description of diagnosing and managing peritonitis and catheter-related infections in peritoneal dialysis patients.
A practical guide for Nephrologists and health care professionals.
Peritoneal dialysis is a treatment for kidney failure that uses the lining of your abdomen, or belly, to filter your blood inside your body. Health care providers call this lining the peritoneum. A more convenient method of dialysis in home itself.
The aim of this lecture is to provide
an overview of the management of various toxic exposures.
emergency medical services that should be immediately contact to provide advanced life support for patient with unstable vital signs resulting from a poisoning exposure.
Bleeding Peptic Ulcer Disease - Does Practice Meet Evidence?Jarrod Lee
Bleeding peptic ulcer is a common medical emergency. Today many good studies and evidence based guidelines have provided doctors with a strong evidence based approach to manage this condition. However, how much of daily practice actually follows the evidence? The presentation goes through common scenarios in hospital medicine, and covers the latest evidence through a case based approach.
Anesthesia in sickle cell disease- a case presentationSunder Chapagain
This is a short case presentation on how we (anesthesia team) managed a case of sickle cell disease with avascular necrosis of neck of femur (left) in our hospital. May be useful to medical students and Medical officers as some special considerations are needed in such type of cases.
A detailed description of diagnosing and managing peritonitis and catheter-related infections in peritoneal dialysis patients.
A practical guide for Nephrologists and health care professionals.
Infection control in critical care unitAlphyThomas9
This ppt gives adequate information regarding infection control in CCU, common infections in CCU, and the role of a critical care nurse in infection control.
Infection control in critical care unitalphyThomas7
This content gives detailed information regarding infection control in CCU, common hospital-acquired infections in CCU role of a critical care nurse in infection control
UNIT II: Preventive Medicine
General principles of prevention and control of diseases- CHOLERA
#cholera #preventivemedicine #General principles of
prevention and control of diseases such as: CHOLERA
#social and preventive pharmacy
Children are curious and tend to explore their surroundings. While doing so they may run, ingest, or inhale potentially harmful substances. Tens of thousands of cases of childhood poisoning are reported annually and some are associated with major morbidity and mortality.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
3. Best wishes to all the real hero @
crucial exigency of covid pandemic
4. “Poison is everything, and no thing is without
poison, the dosage makes it either a poison or
a remedy “ paracelsus
5. History of poison
• The history of poison stretches from before 4500
BCE to the present day.
• Poisons have been used for many purposes across
the span of human existence
•
Indian surgeon Sushruta defined the stages of
slow poisoning and the remedies of slow
poisoning
6. History of poison
• Today, poison is used for a wider variety of
purposes than it used to be.
• Pesticides: have known to be used in some form
since about 2500 BC.
• The use of pesticides has increased staggeringly
from 1950, and presently approximately
2.5 million tons of industrial pesticides are used
each year.
7. Statistics
• The NCRB recorded 133,623 deaths from suicide
in 2015 , of which 23,930 (17.9%) were due to
pesticides.
• 1995 to 2015, there were 2,451,410 suicides from
all methods and 441,918 pesticide suicides
(18.0% of the total) recorded in India.
• Maharashtra, Andhra Pradesh, Madhya Pradesh,
Tamil Nadu, West Bengal, Kerala, Telangana,
Karnataka, Gujarat, Odisha and Chhattisgarh.
8. Statistics
• States account for approximately 54.1% of the
total population of India, and 84.2% of suicides
by all methods in India.
• In 2015, The Anupam Verma Committee to
review the continued use of 66 pesticides that
have been banned or restricted for farming use in
other countries.
• In 2016, it recommended a ban on 13 pesticides,
phasing out of 6 pesticides by 2020,
9. Prehospital Care Of Firstaid
• Pre hospital care of someone who may have
been poisoned depends on:
• The person's symptoms
• The person's age and body weight
• Whether you know the type and amount of
the substance that caused poisoning
10. When to suspect poisoning
• Poisoning signs and symptoms can mimic various
clinical conditions…
• Burns or redness around the mouth and lips
• Breath that smells like chemicals, such as gasoline
or paint thinner
• Vomiting
• Difficulty breathing
• Drowsiness
• Confusion or altered mental status
11. What to do while waiting for help
• Swallowed poison: Remove anything remaining in the person's
mouth.
• Poison on the skin: Remove any contaminated clothing.
• Poison in the eye: Gently flush the eye with cool or lukewarm.
• Inhaled poison: Get the person into fresh air .
• If possible collect: pill bottles, packages or containers with labels
about the poison to send along with the ambulance team.
13. Decontamination
• Decontamination refers to practice of limiting or
minimizing the exposure of a patient to a
ingested toxin.
• Benefits of Decontamination:
A. Prevention of further exposure
B. Prevention of secondary contamination
C. Prevention of contamination of the health care
facility.
14. Decontamination
• Decontamination efforts are initiated by first
responders, including HAZMAT teams.
• The managing patients with HAZMAT are to
protect the health care providers.
• The level of PPE is classified according to
Environmental protection agency A to Z.
15. Types of decontamination
• Many approaches have been adopted
• Gastric Evacuation
1. Gastric Lavage
2. Intra Gastric Binding
3. Whole Bowel Irrigation
• Enhanced Elimation
1. Hemodialysis
2. Hemoperfusion
3. Hempfiltration
16. Gastric Decontamination
• GI decontamination is a highly controversial
issue in medical toxicology.
• In 1997 Publication of position statement
lavage/induced emesis/WBI by AACT and
EAPCCT.
• The overall trend in decontamination is
continually declining.
17. OGL is done to remove substantial toxin
before absorption or diminish its efforts.
• INDICATIONS
a) Significant amount of toxin in GI tract.
b) Ingested toxin non absorbable.
c) Toxin exceeds the absorbable quantity.
d) No known contraindications.
18. Contraindications
• Doesn’t meet criteria for lavage.
• Risk of airway protection.
• Toxin with higher aspirational protection.
• Ingestion of alkaline caustic.
• Ingestion of foreign body
• Risk of perforation because of underlying
pathology/medical condition.
19. Technique of OGL
• Select correct tube size
• Check airway patency
• Better keep patient in left lateral decubitus
position.
• Proper length of tube to inserted and confirm
the position.
• In adults 250ml and children 10-15ml to max
of 250 ml.
20. Whole Bowel Irrigation
• A method of purging the GI tract in an attempt
to expeditiously achieve gut clearence to
prevent further absorption of toxin.
• No new evidence in position papers on WBI.
• Cant be done if the GI tract is adynamic or
obstructive ileus.
21. WBI remain theoretical because the only support for efficacy
comes from surrogate markers and anecdotal experience
Indications
• Toxins ingestion of
sustained release.
• Toxic amount of toxin not
adsorbed to AC.
• Removal of ilicit drug
packets from body packers.
Contraindications
• Absent airway reflexes.
• GI tract is not intact.
• Persistent vomiting.
• Signs of leakage from
cocaine packets.
23. Enhancing elimination
• Metal chelators.
• Resins
• Hemodialysis
• Hemofiltration
• Hemoperfusion
• Liver support devices
• Plasmapheresis.
24. General Indications
• Patients who fail to respond to comprehensive supportive care.
• Patients in whom the normal route of elimination is impaired.
• Patients in whom the amount of toxin absorbed or its high
concentration in serum indicates that seriously ill.
• Patients with concurrent disease.
• Paitents with concomitant electrolyte disorders that can be
corrected by hemodialysis.