Congestive heart failure occurs when the heart cannot pump enough blood to the body's organs. It can result from narrowed arteries, past heart attacks, high blood pressure, heart valve disease, heart muscle disease, birth defects, or heart infections. As blood flow from the heart slows, blood backs up in the veins causing swelling. Heart failure also affects kidney function.
Hawthorn, foxglove, and strophanthus are used to treat heart conditions. Hawthorn increases cardiac output and blood flow. Foxglove and strophanthus raise blood pressure and have diuretic effects. They can cause side effects like arrhythmias and low blood pressure if overused. Cardioactive glycosides in these plants are
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Shock is a life-threatening condition that occurs when the body is not getting enough blood flow. The Lack of blood flow means that the cells and organs do not get enough oxygen and nutrients to function properly. Multiple organs can suffer damage as a result
The file gives the information of Cardiac Failure. Etiology of cardiac failure, types, stages of cardiac failure. It also covers the multisystem effects of cardiac failure, classification of drugs acting on cardiac failure.
1. Congestive Heart Failure
Congestive heart failure (CHF), or heart failure, is a condition in which
the heart can't pump enough blood to the body's other organs. This can
result from
• narrowed arteries that supply blood to the heart muscle — coronary
artery disease
• past heart attack, or myocardial infarction, with scar tissue that
interferes with the heart muscle's normal work
• high blood pressure
• heart valve disease due to past rheumatic fever or other causes
• Primary disease of the heart muscle itself, called cardiomyopathy.
• Heart defects present at birth — congenital heart defects.
• infection of the heart valves and/or heart muscle
itself — endocarditis and/or myocarditis
As blood flow out of the heart slows, blood returning to the heart through
the veins backs up, causing congestion in the tissues. Often swelling
(edema) results. Most often there's swelling in the legs and ankles, but it
can happen in other parts of the body, too. Sometimes fluid collects in the
lungs and interferes with breathing, causing shortness of breath,
especially when a person is lying down.
Heart failure also affects the kidneys' ability to dispose of sodium and
water. The retained water increases the edema.
2. Hawthorn
Botanical: Crataegus oxyacantha, Family: Rosaceae
Constituents:
It contains a variety of bioflavonoids that appear to be
primarily responsible for the cardiac actions of the plant.
Flavonoids found in hawthorn include oligomeric
procyanidins (OPCs), vitexin, vitexin 4'-O-rhamnoside,
quercetin, and hyperoside.
OPCs
Therapeutics and Pharmacology:
• Mild congestive heart failure - Believed to increase cardiac
output and increase the flow of blood through the coronary
arteries.
• Arrhythmia (irregular heart beat) - Thought to counteract
rhythm disturbances.
• High blood pressure - Believed to cause vasodilatation of
peripheral blood vessels and lower blood pressure.
• Heart Weakness - as caused by infectious diseases e.g.
pneumonia, scarlet fever and diphtheria. Is believed to
restore and support heart function.
Toxicity and side effects:
Overdose can cause cardiac arrhythmia and dangerously lower blood
pressure. Milder side effects include nausea and sedation
3. Strophanthus
Botanical: Strophanthus Kombé, S.Hispidus, Family: Apocynaceae.
Constituents: A glucoside, Strophanthin, an alkaloid, Inoeine, and fixed
oil.
Therapeutics and Pharmacology:
It has an effect on the circulation, especially in
cases of chronic heart weakness.
The action of strophanthus, which is due to the
strophanthin they contain, resembles that of foxglove leaves. It raises the
blood pressure, is an efficient diuretic, and a powerful cardiac poison. It
is not cumulative, and less liable than foxglove to produce gastro-
intestinal irritation; hence is sometimes substituted for foxglove when this
remedy has failed or disagreed.
Toxicity and side effects:
Nausea, vomiting, headache, disturbance of color
vision.
4. Foxglove
Botanical: Digitalis purpurea, D.lanata.
Constituents: the most active constituents
are digitoxin, digoxin, digitalin, digitalein
and digitonin. Of these constituents,
digitoxin is the most powerful and also an
extremely poisonous drug.
Digitoxin
Therapeutics and Pharmacology:
Foxglove is extremely useful in treating heart conditions as heart failure.
The constituents of foxglove increase the activity of the heart, arterioles
and other muscle tissue. An initial dose can raise blood pressure
considerably but a moderate dose can slow the pulse and cause an
irregular pulse to become normal.
Toxicity and Side effects:
Common foxglove is extremely poisonous and if used incorrectly can
cause death.
Symptoms of poisoning by the common foxglove include:
• hallucinations
• blurred vision
• confusion
• fainting
• irregular heart beat
• vomiting
• nausea
• stomach pain
• drowsiness
• Headache.
5. :Conclusion
Cardioactive glycosides are used in cases of CHF and in controlling
.rapid ventricular rate in atrial fibrillation and atrial flutter
:Reference
•The book, Natural medicine 1999.
•www.botanical.com
•www.en.wikipedia.org
•www.americanheart.org