Vasodilators

1. DR SHAHBAZ ALI KHAN(BDS KMU)
Vasodilators

2. Classification
 Pulmonary vasodilators:
 Oxygen.
 Nitric oxide.
 Nitroprusside (Nipride, Nitropress)
 Sildenafil (Revatio,Viagra)
 Tadalafil (Adcirca, Cialis)
 Bosentan (Tracleer)

3. CON…
 Arterial vasodilators:
 calcium channel blockers
 Hydralazine
 minoxidil

4. Con…
 Coronary artery dilators:
 Nitroglycerin
 calcium channel-blocking agents

5. Common Vasodilators
 Hydralazine
 ACE inhibitors
 Minoxidil

6. Mechanism of action:
 vasodilator drugs relax the smooth muscle in
blood vessels.
 which causes the vessels to dilate.
 Dilation of arterial (resistance) vessels leads
to a reduction in systemic vascular resistance.
 leads to a fall in arterial blood pressure.

7. Uses:
 They're used to treat or prevent:
 High blood pressure (hypertension)
 Heart failure
 Preeclampsia (high blood pressure during
pregnancy)
 Angina (chest pain caused by reduced blood flow
to the heart)
 Pulmonary hypertension (high blood pressure that
affects the arteries in your lungs)

8. Side affects:
 Side Effects of vasodilators may include:
 Chest pain
 Heart palpitations (fluttering or pounding heartbeat)
 Rapid heartbeat
 Fluid retention
 Nausea or vomiting
 Dizziness
 Headache
 Flushing
 Excessive hair growth
 Nasal congestion