This document discusses various types of vasodilators including pulmonary, arterial, and coronary vasodilators. It describes their mechanisms of action in relaxing smooth muscle and dilating blood vessels to reduce systemic vascular resistance and blood pressure. Common vasodilators like hydralazine, ACE inhibitors, and minoxidil are used to treat conditions like hypertension, heart failure, preeclampsia, angina, and pulmonary hypertension. Side effects can include chest pain, changes in heart rate, fluid retention, headaches, and flushing.

1. DR SHAHBAZ ALI KHAN(BDS KMU)
Vasodilators

2. Classification
 Pulmonary vasodilators:
 Oxygen.
 Nitric oxide.
 Nitroprusside (Nipride, Nitropress)
 Sildenafil (Revatio,Viagra)
 Tadalafil (Adcirca, Cialis)
 Bosentan (Tracleer)

3. CON…
 Arterial vasodilators:
 calcium channel blockers
 Hydralazine
 minoxidil

4. Con…
 Coronary artery dilators:
 Nitroglycerin
 calcium channel-blocking agents

5. Common Vasodilators
 Hydralazine
 ACE inhibitors
 Minoxidil

6. Mechanism of action:
 vasodilator drugs relax the smooth muscle in
blood vessels.
 which causes the vessels to dilate.
 Dilation of arterial (resistance) vessels leads
to a reduction in systemic vascular resistance.
 leads to a fall in arterial blood pressure.

7. Uses:
 They're used to treat or prevent:
 High blood pressure (hypertension)
 Heart failure
 Preeclampsia (high blood pressure during
pregnancy)
 Angina (chest pain caused by reduced blood flow
to the heart)
 Pulmonary hypertension (high blood pressure that
affects the arteries in your lungs)

8. Side affects:
 Side Effects of vasodilators may include:
 Chest pain
 Heart palpitations (fluttering or pounding heartbeat)
 Rapid heartbeat
 Fluid retention
 Nausea or vomiting
 Dizziness
 Headache
 Flushing
 Excessive hair growth
 Nasal congestion