There are two main causes of skin allergies in horses: environmental allergens and insect bite hypersensitivity. Environmental allergens can cause hives, atopic dermatitis, and may be pruritic or not. Insect bite hypersensitivity is caused by bites from insects like Culicoides midges and causes sweet itch marked by hair loss on the mane, tail, and belly along with intense itching. Diagnosis involves ruling out other causes and doing skin or serum allergy testing to identify specific allergens. Treatment focuses on avoidance of allergens, topical therapies, antihistamines, corticosteroids, and immunotherapy.