Does Serum Lactate and Central Venous Saturation Predict Perioperative Outcom...crimsonpublishersOJCHD
Off-pump coronary artery bypass grafting (OP-CABG) surgery without the use of cardiopulmonary bypass (CPB) has come into practice for surgical treatment of Coronary artery disease (CAD) to reduce the post-operative systemic inflammatory response and post-operative morbidity. However, manipulation of the beating heart during OP-CABG surgery brings significant fluctuations in the patients haemodynamics leading to occult hypo-perfusion and 'Global tissue hypoxia' (GTH) -a decrease in oxygen utilization associated with anaerobic metabolism.
Many tools are nowadays available to monitor patients’ hemodynamics in the intensive care unit (ICU) and in the operating room (OR) settings. Some monitoring tools are invasive such as the pulmonary artery catheter (PAC), some others are less invasive such as transpulmonary thermodilution (TPD) systems, some others are called minimally invasive such as uncalibrated arterial pulse wave analysis (PWA) devices, and some others are non invasive such as volume-clamp method, applanation tonometry, esophageal Doppler, bioreactance, CO2 rebreathing, and pulse wave transit time. Recently, the European Society of Intensive Care Medicine has provided recommendations about the use of hemodynamic monitoring in patients with shock. To summarize, except the PAC and the TPD systems, the other hemodynamic monitoring tools are not recommended for the two following reasons: 1) they provide cardiac output but not other important hemodynamic variables, although some of them also provide stroke volume variation (SVV) or pulse pressure variation (PPV), and 2) their validity has been questioned in cases of shock requiring vasopressors. The uncalibrated PWA devices or esophageal Doppler seem to be more suitable in the OR setting when no vasopressor is used. The advantage of the PAC is to provide pulmonary artery pressure and pulmonary artery occlusion pressure. The advantage of TPD systems is to provide global end-diastolic volume (a measure of global cardiac preload), extravascular lung water (a measure of lung edema), pulmonary vascular permeability index (a measure of lung capillary leak), cardiac function index (a measure of systolic cardiac function), PPV and SVV (dynamic indices of fluid responsiveness). The PAC and TPD systems are indicated in cases of shock either when the patient also has a severe ARDS initially or when the shock state does sufficiently respond to the initial therapy administered on the basis of clinical examination, central venous oxygen saturation, carbon dioxide pressure gap, PPV and echocardiography.
Outcome After Procedures for Retained Blood Syndrome in Coronary SurgeryPaul Molloy
OBJECTIVES:
Incomplete drainage of blood from around the heart and lungs can lead to retained blood syndrome (RBS) after cardiac sur-
gery. The aim of this study was to assess the incidence of and the outcome after procedures for RBS in patients undergoing isolated coronary artery bypass grafting (CABG)-
Does Serum Lactate and Central Venous Saturation Predict Perioperative Outcom...crimsonpublishersOJCHD
Off-pump coronary artery bypass grafting (OP-CABG) surgery without the use of cardiopulmonary bypass (CPB) has come into practice for surgical treatment of Coronary artery disease (CAD) to reduce the post-operative systemic inflammatory response and post-operative morbidity. However, manipulation of the beating heart during OP-CABG surgery brings significant fluctuations in the patients haemodynamics leading to occult hypo-perfusion and 'Global tissue hypoxia' (GTH) -a decrease in oxygen utilization associated with anaerobic metabolism.
Many tools are nowadays available to monitor patients’ hemodynamics in the intensive care unit (ICU) and in the operating room (OR) settings. Some monitoring tools are invasive such as the pulmonary artery catheter (PAC), some others are less invasive such as transpulmonary thermodilution (TPD) systems, some others are called minimally invasive such as uncalibrated arterial pulse wave analysis (PWA) devices, and some others are non invasive such as volume-clamp method, applanation tonometry, esophageal Doppler, bioreactance, CO2 rebreathing, and pulse wave transit time. Recently, the European Society of Intensive Care Medicine has provided recommendations about the use of hemodynamic monitoring in patients with shock. To summarize, except the PAC and the TPD systems, the other hemodynamic monitoring tools are not recommended for the two following reasons: 1) they provide cardiac output but not other important hemodynamic variables, although some of them also provide stroke volume variation (SVV) or pulse pressure variation (PPV), and 2) their validity has been questioned in cases of shock requiring vasopressors. The uncalibrated PWA devices or esophageal Doppler seem to be more suitable in the OR setting when no vasopressor is used. The advantage of the PAC is to provide pulmonary artery pressure and pulmonary artery occlusion pressure. The advantage of TPD systems is to provide global end-diastolic volume (a measure of global cardiac preload), extravascular lung water (a measure of lung edema), pulmonary vascular permeability index (a measure of lung capillary leak), cardiac function index (a measure of systolic cardiac function), PPV and SVV (dynamic indices of fluid responsiveness). The PAC and TPD systems are indicated in cases of shock either when the patient also has a severe ARDS initially or when the shock state does sufficiently respond to the initial therapy administered on the basis of clinical examination, central venous oxygen saturation, carbon dioxide pressure gap, PPV and echocardiography.
Outcome After Procedures for Retained Blood Syndrome in Coronary SurgeryPaul Molloy
OBJECTIVES:
Incomplete drainage of blood from around the heart and lungs can lead to retained blood syndrome (RBS) after cardiac sur-
gery. The aim of this study was to assess the incidence of and the outcome after procedures for RBS in patients undergoing isolated coronary artery bypass grafting (CABG)-
XIII Reunión anual de la sección de Insuficiencia Cardiaca de la SEC
OVIEDO, 16-18 JUNIO 2016 HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS (HUCA)
http://secardiologia.es/insuficiencia/cientifico/ic-oviedo-2016
Simposio: Abordaje integral y multidisciplinar de la Insuficiencia Mitral
VIERNES, 17 DE JUNIO 12:45-14:00 SALA A
Posibilidades del tratamiento percutáneo
Xavi Freixa Rofastes, Barcelona
A pneumatic compression device designed to assist hemostasis of the radial artery was applied immediately after the procedure according to the following protocol. The sheath was initially pulled by approximately
2-4 cm. Three to 5 mL of blood were aspirated through the
sheath to remove any residual thrombus. The device was
applied to the patient, with the green marker (located in
the center of the larger balloon) positioned exactly at the
puncture hole to aid in the location, visualization, and control of possible bleeding. The balloon was inflated with a
proper syringe, injecting 15 mL of air, and then the sheath
was removed, noticing the absence of active bleeding. In the
presence of bleeding, up to 3 mL of additional air was injected to obtain complete hemostasis
Long term outcomes in patients with h fr-ef treated with cabg vs pciRamachandra Barik
RESULTS A total of 12 113 patients (mean [SD] age, 64.8 (11.0) years for the PCI group and 65.6[9.7] years for the CABG group; 5084 (72.5%) male for the PCI group and 4229 (82.9%) malefor the PCI group) were propensity score matched on 30 baseline characteristics: 2397 patients undergoing PCI and 2397 patients undergoing CABG. The median follow-up was 5.2
years (interquartile range, 5.0-5.3). Patients who received PCI had significantly higher rates of
mortality (hazard ratio [HR], 1.6; 95% CI, 1.3-1.7), death from cardiovascular disease (HR 1.4,95% CI, 1.1-1.6), MACE (HR, 2.0; 95% CI, 1.9-2.2), subsequent revascularization (HR, 3.7; 95%
CI, 3.2-4.3), and hospitalization for MI (HR, 3.2; 95% CI, 2.6-3.8) and heart failure (HR, 1.5;95% CI, 1.3-1.6) compared with matched patients who underwent CABG.
Understanding the Translational Value of PV Loops from Mouse to ManInsideScientific
In this exclusive webinar sponsored by Millar, Dr. Navin Kapur, Assistant Professor and Assistant Director of the Interventional Cardiology Center at Tufts Medical Center, discusses how PV loop data can translate over from mouse to man and provide a confident approach to evaluating drug studies, device validation and treatments outcomes. Hemodynamics and measurements of cardiac function from the research bench-top are presented along with findings from the clinical research settings. Furthermore, Dr. Kapur provides perspective on how PV Loops can be used as a tool for the interventional cardiologist and during the evaluation of advanced heart failure.
Dr. Navin Kapur's research interests include the molecular basis of cardiac fibrosis, transforming growth factor-beta signaling in cardiac fibroblasts, and novel imaging modalities of myocardial perfusion.
XIII Reunión anual de la sección de Insuficiencia Cardiaca de la SEC
OVIEDO, 16-18 JUNIO 2016 HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS (HUCA)
http://secardiologia.es/insuficiencia/cientifico/ic-oviedo-2016
Simposio: Abordaje integral y multidisciplinar de la Insuficiencia Mitral
VIERNES, 17 DE JUNIO 12:45-14:00 SALA A
Posibilidades del tratamiento percutáneo
Xavi Freixa Rofastes, Barcelona
A pneumatic compression device designed to assist hemostasis of the radial artery was applied immediately after the procedure according to the following protocol. The sheath was initially pulled by approximately
2-4 cm. Three to 5 mL of blood were aspirated through the
sheath to remove any residual thrombus. The device was
applied to the patient, with the green marker (located in
the center of the larger balloon) positioned exactly at the
puncture hole to aid in the location, visualization, and control of possible bleeding. The balloon was inflated with a
proper syringe, injecting 15 mL of air, and then the sheath
was removed, noticing the absence of active bleeding. In the
presence of bleeding, up to 3 mL of additional air was injected to obtain complete hemostasis
Long term outcomes in patients with h fr-ef treated with cabg vs pciRamachandra Barik
RESULTS A total of 12 113 patients (mean [SD] age, 64.8 (11.0) years for the PCI group and 65.6[9.7] years for the CABG group; 5084 (72.5%) male for the PCI group and 4229 (82.9%) malefor the PCI group) were propensity score matched on 30 baseline characteristics: 2397 patients undergoing PCI and 2397 patients undergoing CABG. The median follow-up was 5.2
years (interquartile range, 5.0-5.3). Patients who received PCI had significantly higher rates of
mortality (hazard ratio [HR], 1.6; 95% CI, 1.3-1.7), death from cardiovascular disease (HR 1.4,95% CI, 1.1-1.6), MACE (HR, 2.0; 95% CI, 1.9-2.2), subsequent revascularization (HR, 3.7; 95%
CI, 3.2-4.3), and hospitalization for MI (HR, 3.2; 95% CI, 2.6-3.8) and heart failure (HR, 1.5;95% CI, 1.3-1.6) compared with matched patients who underwent CABG.
Understanding the Translational Value of PV Loops from Mouse to ManInsideScientific
In this exclusive webinar sponsored by Millar, Dr. Navin Kapur, Assistant Professor and Assistant Director of the Interventional Cardiology Center at Tufts Medical Center, discusses how PV loop data can translate over from mouse to man and provide a confident approach to evaluating drug studies, device validation and treatments outcomes. Hemodynamics and measurements of cardiac function from the research bench-top are presented along with findings from the clinical research settings. Furthermore, Dr. Kapur provides perspective on how PV Loops can be used as a tool for the interventional cardiologist and during the evaluation of advanced heart failure.
Dr. Navin Kapur's research interests include the molecular basis of cardiac fibrosis, transforming growth factor-beta signaling in cardiac fibroblasts, and novel imaging modalities of myocardial perfusion.
This is a very simple presentation prepared for nurses. It will help nurses to understand the need of monitoring and the available methods. The presentation has been constructed on a clinical case base scenario and gradually different methods of monitoring has been introduced.
The Top Skills That Can Get You Hired in 2017LinkedIn
We analyzed all the recruiting activity on LinkedIn this year and identified the Top Skills employers seek. Starting Oct 24, learn these skills and much more for free during the Week of Learning.
#AlwaysBeLearning https://learning.linkedin.com/week-of-learning
Endovascular and surgical treatment of pulmonary embolism 26.11.17Ivo Petrov
Interventional treatment (thrombus fragmentation and supraselective fibrinolysis) of high and intermediate risk patients with pulmonary embolism.
Protocols of intervention, results, clinical cases provided
Presentación de la ponencia "Oclusión Crónica Total (CTO): Intervención Coronaria Percutánea (ICP) vs Tratamiento Médico Óptimo (TMO)" realizada por Tomás Benito González para foroepic.org en los Diálogos EPIC_Cierre Percutáneo de la Orejuela Izquierda el 15 de Marzo de 2018 en Madrid (España)
Safety, risk of complications and the functional feasibility among different kinds of central venous access are still a matter of debate.Not many clinical trials have reported a comparison of complications and patency of CVCs versus Peripherally Inserted Catheters (PICC) as central venous access for indoor patients with advanced gastrointestinal disorder. The aim of the present study was to compare CVCs and PICCs regarding function, complications and convenience in a controlled clinical study on patients aimed for oncology surgery aimed for cure.
Distributions of patients were comparable. Malignant diagnoses were significantly higher among CVC-patients. CVCs and PICCs were used for treatment during equal number of days, without any signifi cant complication rates and with comparable number of days on antibiotics and other potent drugs. The overall cumulative hazard (risk) for treatment interruptions, due to either full-filled clinical indications or due to any complication among the subgroups of patients did not differ.Central Venous Catheter and Peripheral Inserted Central Venous Catheter, for central venous access, did not differ among consecutive unselected patients with serious gastro-intestinal disorders.
Coronary angioplasty has revolutionized the management of coronary artery disease. It has not ceased to develop to become the reference method of myocardial revascularization. The aim of our study is to evaluate the ultrasound parameters of left ventricular function after coronary angioplasty. This is a prospective analytical study including patients with stable coronary artery disease with a known coronary artery anatomy programmed for coronary angioplasty. Transthoracic echocardiography was performed four hours before and seven days after myocardial revascularization.
This presentation discusses the latest evidence for blood transfusion triggers in the intensive care unit of various clinical condition including severe sepsis, GI bleed, post surgical cases, and post cardiac surgery among other cnditions
Thermal Imaging for the Diagnosis of Early Vascular Dysfunctions: A Case Reportasclepiuspdfs
Diseases of blood vessels (referred in this article as vascular dysfunction) cause more morbidity and mortality, than combined impact of any other major non-communicable disease including cancer. We strongly feel that the development of a therapy system based on the management of disease of the vessel than management of the risk factors will yield better results and provide greater opportunity for individualized therapy. Detection of early vascular changes before clinical manifestations of endothelial dysfunction, hardening of the arteries, increased intima-media thickness, is of great importance for early identification of individuals with increased risk of accelerated atherosclerosis.
Let's dive deeper into the world of ODC! Ricardo Alves (OutSystems) will join us to tell all about the new Data Fabric. After that, Sezen de Bruijn (OutSystems) will get into the details on how to best design a sturdy architecture within ODC.
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...UiPathCommunity
💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
Connector Corner: Automate dynamic content and events by pushing a buttonDianaGray10
Here is something new! In our next Connector Corner webinar, we will demonstrate how you can use a single workflow to:
Create a campaign using Mailchimp with merge tags/fields
Send an interactive Slack channel message (using buttons)
Have the message received by managers and peers along with a test email for review
But there’s more:
In a second workflow supporting the same use case, you’ll see:
Your campaign sent to target colleagues for approval
If the “Approve” button is clicked, a Jira/Zendesk ticket is created for the marketing design team
But—if the “Reject” button is pushed, colleagues will be alerted via Slack message
Join us to learn more about this new, human-in-the-loop capability, brought to you by Integration Service connectors.
And...
Speakers:
Akshay Agnihotri, Product Manager
Charlie Greenberg, Host
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. What’s changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
Software Delivery At the Speed of AI: Inflectra Invests In AI-Powered QualityInflectra
In this insightful webinar, Inflectra explores how artificial intelligence (AI) is transforming software development and testing. Discover how AI-powered tools are revolutionizing every stage of the software development lifecycle (SDLC), from design and prototyping to testing, deployment, and monitoring.
Learn about:
• The Future of Testing: How AI is shifting testing towards verification, analysis, and higher-level skills, while reducing repetitive tasks.
• Test Automation: How AI-powered test case generation, optimization, and self-healing tests are making testing more efficient and effective.
• Visual Testing: Explore the emerging capabilities of AI in visual testing and how it's set to revolutionize UI verification.
• Inflectra's AI Solutions: See demonstrations of Inflectra's cutting-edge AI tools like the ChatGPT plugin and Azure Open AI platform, designed to streamline your testing process.
Whether you're a developer, tester, or QA professional, this webinar will give you valuable insights into how AI is shaping the future of software delivery.
JMeter webinar - integration with InfluxDB and GrafanaRTTS
Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
Participants will gain insights into the responsibilities, challenges, and best practices associated with test management in SAP projects. Additionally, the webinar delves into the significance of heatmaps as a visual aid for identifying testing priorities, areas of risk, and resource allocation within SAP landscapes. Through this session, attendees can expect to enhance their understanding of test management principles while learning practical approaches to optimize testing processes in SAP environments using heatmap visualization techniques
What will you get from this session?
1. Insights into SAP testing best practices
2. Heatmap utilization for testing
3. Optimization of testing processes
4. Demo
Topics covered:
Execution from the test manager
Orchestrator execution result
Defect reporting
SAP heatmap example with demo
Speaker:
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
UiPath Test Automation using UiPath Test Suite series, part 4
Epinefrina
1. CRITICAL CARE
Third-generation FloTrac/Vigileo does not reliably track
changes in cardiac output induced by norepinephrine
in critically ill patients
X. Monnet1,2*, N. Anguel1,2, M. Jozwiak1,2, C. Richard1,2 and J.-L. Teboul1,2
1
Hoˆpitaux universitaires Paris-Sud, Hoˆpital de Biceˆtre, service de re´animation me´dicale, 78, rue du Ge´ne´ral Leclerc, Le Kremlin-Biceˆtre
F-94270, France
2
Universite´ Paris-Sud, Faculte´ de me´decine Paris-Sud, EA 4046, 63, rue Gabriel Pe´ri, Le Kremlin-Biceˆtre F-94270, France
* Corresponding author. E-mail: xavier.monnet@bct.aphp.fr
Editor’s key points
† FloTrac/Vigileo and other
devices are available to
measure cardiac output
by pressure waveform
analysis.
† The performance of the
third-generation FloTrac/
Vigileo in measuring
cardiac index (CI) was
assessed in critically ill
patients undergoing
volume expansion
or changes in
norepinephrine dose.
† This device was
moderately reliable for
tracking volume-induced
changes in CI, but poorly
reliable with
norepinephrine dose
titration.
Background. The ability of the third-generation FloTrac/Vigileo software to track changes in
cardiac index (CI) induced by volume expansion and norepinephrine in critically ill patients
is unknown.
Methods. In subjects with circulatory failure, we administered volume expansion (20
subjects) and increased (20 subjects) or decreased (20 subjects) the dose of
norepinephrine. We measured arterial pressure waveform-derived CI provided by the
third-generation FloTrac/Vigileo device (CIpw) and transpulmonary thermodilution CI (CItd)
before and after therapeutic interventions.
Results. Considering the pairs of measurements performed before and after all therapeutic
interventions (n¼60), a bias between the absolute values of CIpw and CItd was 0.26 (0.94)
litre min21
m22
and the percentage error was 54%. Changes in CIpw tracked changes in CItd
induced by volume expansion with moderate accuracy [n¼20, bias¼20.11 (0.54) litre
min21
m22
, r2
¼0.26, P¼0.02]. When changes in CItd were induced by norepinephrine
(n¼40), a bias between CIpw and CItd was 0.01 (0.41) litre min21
m22
(r2
¼0.11, P¼0.04).
The concordance rates between changes in CIpw and CItd induced by volume expansion
and norepinephrine were 73% and 60%, respectively. The bias between changes in CIpw
and CItd significantly correlated with changes in total systemic vascular resistance
(r2
¼0.41, P,0.0001).
Conclusions. The third-generation FloTrac/Vigileo device was moderately reliable for
tracking changes in CI induced by volume expansion and poorly reliable for tracking
changes in CI induced by norepinephrine.
Keywords: cardiac output, measurement; equipment, monitors; measurement techniques,
cardiac output; norepinephrine; shock
Accepted for publication: 24 November 2011
In recent years, efforts have been made to develop devices
that allow beat-to-beat estimation of cardiac output (CO).
Some of these systems compute CO from the arterial pres-
sure waveform, using the principle that stroke volume is
physiologically related to arterial pressure, aortic compliance,
and arterial tone.1
In particular, some ‘uncalibrated’ devices
estimate aortic compliance and arterial tone from an ana-
lysis of the geometric properties of arterial shape and from
some patient characteristic data. These devices are in con-
trast to some ‘calibrated’ systems, which add to this continu-
ous estimation of CO an external calibration by a reference
technique.
The uncalibrated systems have the great advantage of not
requiring a specific system for recalibrating CO measure-
ment. Nevertheless, their ability to track changes in CO has
been questioned,2 – 9
especially when arterial tone changes
to a large extent3
or during hyperdynamic states.7 8 10
In a
previous study, we suggested that the second-generation
FloTrac/Vigileow
device had a poor ability for tracking
changes in cardiac index (CI) induced by norepinephrine in
septic patients.11
We hypothesized that changes in arterial
compliance and arterial tone induced by the vasopressor dis-
torted the arterial pressure wave analysis made by the unca-
librated system. In a recent study, a third generation of this
British Journal of Anaesthesia 108 (4): 615–22 (2012)
Advance Access publication 19 January 2012 . doi:10.1093/bja/aer491
& The Author [2012]. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved.
For Permissions, please email: journals.permissions@oup.com
byguestonApril26,2013http://bja.oxfordjournals.org/Downloadedfrom
2. system has been demonstrated to be as precise, more accur-
ate, and less influenced by systemic vascular resistance (SVR)
than the previous version.12
The third-generation system was
not better than the second for detecting significant changes
in CI over time,12
but these changes were not induced by sys-
tematic therapeutic interventions. Moreover, a recent study
suggested that the third version of the FloTrac/Vigileo
device does not accurately track changes in CO induced
with phenylephrine and ephedrine in the intraoperative
setting.13
In the present study, we tested whether the third-
generation FloTrac/Vigileo device allows tracking trends in
CI induced either by volume expansion or by changes in
the dose of norepinephrine in critically ill patients.
Methods
Subjects
After approval by the Institutional Review Board of our insti-
tution, subjects were enrolled if a volume expansion (20 sub-
jects) or an increase (20 different subjects) or a decrease (20
different subjects) in the dose of norepinephrine was planned
by the attending physician. Subjects’ relatives were informed
about the study at the time of enrolment with the possibility
of refusing participation at that time. Subjects were informed
as soon as their mental status allowed, and the possibility
was given to withdraw their participation in the study.
All subjects had a catheter inserted into the internal
jugular vein and a catheter inserted into the femoral artery
(PV8215 monitoring kit, Pulsion Medical Systems, Munich,
Germany). The arterial line was divided into two branches
through a stopcock, one connected to a PiCCO2 device
(Pulsion Medical Systems) and the other connected to a
third-generation FloTrac/Vigileo device (Edwards Life-
sciences, Irvine, CA, USA).
Measurements and study design
Before each therapeutic intervention, we performed a first
set of haemodynamic measurements, including heart rate,
systemic arterial pressure, CI measured by transpulmonary
thermodilution (CItd), CI measured by pulse-wave analysis
by the third-generation FloTrac/Vigileo device (CIpw), and
SVR. We used the values of CIpw automatically displayed on
the screen of the FloTrac/Vigileo device averaged over a
20 s rolling period. The CItd was measured by the PiCCO2
device by injecting 15 ml of iced saline (,108C) through
the central venous line. The injection was performed in trip-
licate and the values of CItd were averaged. Immediately
before performing thermodilution boluses, the value of CIpw
Table 1 Subject characteristics at baseline. n¼60. Data are
expressed as mean (SD), median (25–75% inter-quartile) or n (%).
SAPS, Simplified Acute Physiologic Score; ARDS: acute respiratory
distress syndrome; MAP, mean arterial pressure; Cltd, cardiac index
measured by transpulmonary thermodilution; PaO2
/FIO2
, ratio of
the arterial oxygen tension over the inspired oxygen fraction
Age (yr) 64 (15)
Gender (M/F) 41/19
SAPS II 45 (11)
ARDS (n, %) 34 (57)
Mechanical ventilation (n, %) 60 (100)
Respiratory variables
Tidal volume (ml kg21
of predicted
body weight)
7 (2)
Respiratory rate (breaths min21
) 20 (4)
Total positive end-expiratory pressure
(cm H2O)
8 (2)
PaO2
/FIO2
(mm Hg) 220 (100)
Shock aetiology
Septic (n, %) 48 (80)
Haemorrhagic (n, %) 6 (10)
Drug poisoning (n, %) 6 (10)
CItd (litre min21
m22
) 3.4 (1.3)
Systemic vascular resistance
(dyn s cm25
)
938 (739–1194)
Vasopressors
Norepinephrine (n, %) 56 (93)
Dose of norepinephrine
(mg kg21
min21
)
0.16 (0.04–0.41)
Dobutamine (n, %) 2 (3)
Table 2 Evolution of haemodynamic parameters during therapeutic interventions. Data are expressed as mean (SD) or as median (25–75%
inter-quartile). *P,0.05 vs before intervention, †
P,0.05 vs volume expansion. MAP, mean arterial pressure; CItd, cardiac index measured by
thermodilution; CIpw, arterial pressure waveform-based cardiac index measured by the FloTrac/Vigileo device; SVR, systemic vascular resistance
Volume expansion (n520) Increase in norepinephrine (n520) Decrease in norepinephrine (n520)
Before After Before After Before After
Heart rate (beats min21
) 102 (23) 98 (23) 82 (16)†
88 (23) 87 (16)†
85 (17)
MAP (mm Hg) 75 (15) 83 (14)* 61 (13)†
82 (13)* 74 (62) 62 (13)*,†
CItd (litre min21
m22
) 3.3 (1.5) 3.8 (1.5) 3.1 (1.1) 3.3 (1.1) 3.7 (1.3) 3.5 (1.3)
CIpw (litre min21
m22
) 3.3 (1.3) 3.7 (1.3) 2.7 (0.6) 3.2 (0.8) 3.4 (0.9) 3.0 (0.9)
SVR (dyn s cm25
) 940 (861–1283) 927 (844–1169) 916 (677–1153) 1149 (929–1367)* 952 (696–1145) 846 (659–1064)*
Dose of norepinephrine
(mg kg21
min21
)
0.47 (0.31–0.84) 0.47 (0.31–0.84) 0.07 (0.02–0.19)†
0.21 (0.19–0.45)* 0.13 (0.07–0.20)†
0.03 (0.00–0.12)*,†
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3. was carried out. The CIpw was recorded immediately before
thermodilution to avoid interference between temperature
drift and accuracy of CIpw. The total SVR was calculated as
SVR¼mean arterial pressure×80/(CItd×body surface area).
After the first set of haemodynamic measurements was
completed, volume expansion was performed (500 ml of
saline over 30 min) or the dose of norepinephrine was
increased or decreased. All other treatments were un-
changed during the therapeutic interventions.
A second set of haemodynamic measurements was
carried out again after the therapeutic intervention (i.e. at
the end of fluid administration and 5 min after stabilization
of mean arterial pressure). This set included heart rate, sys-
temic arterial pressure, CIpw, CItd, and SVR.
Statistical analysis
All data were normally distributed (Kolmogorov–Smirnov
test) except the dose of norepinephrine and are expressed
as mean [standard deviation (SD)] or median [25–75% inter-
quartile range], as appropriate. Comparisons between values
recorded before and values after therapeutic interventions
were performed in both groups by paired Student’s t-test
or paired Wilcoxon’s test, as appropriate. Comparisons
between subjects receiving volume expansion, subjects in
whom the dose of norepinephrine was increased, and
subjects in whom the dose of norepinephrine was decreased
were performed by a two-tailed Student’s t-test or a Mann–
Whitney U-test, as appropriate. Correlations were assessed
by the Pearson coefficient and correlation coefficients were
compared using the Fisher transformation.14
This analysis
was also separately performed in subjects in whom SVR
changed in absolute value by more or less than 15% with
the therapeutic interventions.15
We compared the relative changes of CIpw with those of
CItd during the therapeutic intervention by the Bland and
Altman analysis (for absolute changes) and by linear regres-
sion analysis (for per cent changes). For assessing the trend-
ing ability of CIpw, we constructed a four-quadrant plot.16
This allowed calculation of the percentage of total data
points for which the direction changes of CIpw (increase or
decrease) were concordant with CItd. Since the least signifi-
cant change of CItd is 12% when three thermodilution mea-
surements are performed,17
we applied a 12% exclusion
limit. We also constructed a receiver operating characteristic
(ROC) curve to test the ability of changes in CIpw to detect an
increase in CItd ≥12% induced by volume expansion. We cal-
culated the percentage error of CIpw as 2× SD mean21
of
CItd.18
A P value of ,0.05 was considered significant. The
statistical analysis was performed using MedCalc8.1.0.0 soft-
ware (Mariakerke, Belgium).
Results
Subject characteristics
Subject characteristics at baseline are summarized in Table 1.
Circulatory failure was of septic origin in the majority of sub-
jects. All subjects received norepinephrine at baseline. Sub-
jects deemed as receiving volume expansion received
0 1 2 3 4 5 6 7
–2.0
–1.5
–1.0
–0.5
0.0
0.5
1.0
1.5
2.0
2.5
3.0
(CIpw+CItd)/2 (litremin–1 m–2)
0.26
–1.63
2.15
0 1 2 3 4 5 6 7
CIpw–CItd(litremin–1m–2)
Fig 1 The Bland–Altman plot for the absolute values of CI
obtained by transpulmonary thermodilution (CItd) and by the
third-generation FloTrac/Vigileo device (CIpw) considering all
pairs of measurements performed during the study. n¼60;
straight line, bias; dashed line, +2SD/22SD limits of agreement.
Table 3 Comparison of changes in CI measured by pulse-wave analysis and transpulmonary thermodilution. Data are expressed as absolute
values. CItd, cardiac index measured by thermodilution; CIpw, arterial pressure waveform-based CI measured by the FloTrac/Vigileo device
Volume expansion
(n520)
Increase in norepinephrine
(n520)
Decrease in norepinephrine
(n520)
r2
between per cent changes in CItd and CIpw 0.26 2.5×1023
0.16
P-value for the correlation between per cent
changes in CItd and CIpw
0.02 0.81 0.07
Bias for the absolute changes in CIpw compared
with CItd (litre min21
m22
)
0.11 0.36 0.17
Upper limit of agreement for the absolute
changes in CIpw (litre min21
m22
)
0.98 1.98 0.92
Lower limit of agreement for the absolute
changes in CIpw (litre min21
m22
)
21.20 21.25 21.26
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4. norepinephrine at baseline and this dose was kept un-
changed during the study period (Table 2). The second set
of measurements was recorded 32 (4) min after the first
set in subjects receiving volume expansion and 35 (10) min
after the first set in subjects in whom the dose of norepin-
ephrine was changed.
–20 0 20 40 60 80 100
–20
0
20
40
60
80
100
r 2=0.26
P=0.02
–1.5 –1.0 –0.5 0.0 0.5 1.0 1.5 2.0
–2.5
–2.0
–1.5
–1.0
–0.5
0.0
0.5
1.0
1.5
2.0
2.5
–0.11
0.98
–80
–60
–40
–20
20
40
60
80
–80 –60 –40 0 20 40 60 80
C
Concordance=73%
(Exclusion zone 12%)
(Without exclusion zone=70%)
0
–20
(CIpw+CItd)/2 (litremin–1 m–2)
CItd (%)
CItd (%)
CIpw(%)
CIpw (%)
(CIpw–CItd)(litremin–1m–2)
–1.20
B
A
Fig 2 (A) The Bland–Altman plot for the changes in absolute values induced by volume expansion of CI measured by transpulmonary thermo-
dilution (CItd) and by arterial pressure waveform analysis by the third-generation FloTrac/Vigileo device (CIpw). (B) Correlation between the per
cent changes induced by volume expansion of CI measured by transpulmonary thermodilution (DCItd) and by arterial pressure waveform ana-
lysis by the third-generation FloTrac/Vigileo device (DCIpw). (C) Trending ability of the third-generation FloTrac/Vigileo device (DCIpw) against CI
measured by transpulmonary thermodilution (DCItd) during volume expansion based on four-quadrant concordance analysis. n¼20. The
Bland–Altman plots: straight line, bias; dashed line, +2SD/22SD limits of agreement. Correlation: dashed line, correlation line.
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5. Comparison between CItd and CIpw
Considering the pairs of measurements performed before
and after all therapeutic interventions (n¼60), the bias
between the absolute values of CIpw and CItd was 0.26
(0.94) litre min21
m22
and the percentage error was
54% (Fig. 1).
Comparison of CIpw with CItd in subjects receiving
volume expansion
In subjects receiving volume expansion, mean arterial pres-
sure, CItd, and CIpw significantly increased by 12 (9)%, 23
(23)%, and 19 (22)%, respectively. SVR did not significantly
decrease (Table 2).
The bias between absolute changes in CIpw and CItd
induced by volume expansion was 20.11 (0.54) litre min21
m22
. The coefficient of determination (r2
) between
fluid-induced per cent changes in CIpw and CItd was 0.26
(P¼0.02) (Table 3 and Fig. 2). The concordance rate
between changes in CIpw and CItd induced by volume expan-
sion was 73% (Fig. 2). After volume expansion, the bias
between the absolute values of CIpw and CItd was 20.15
(0.88) litre min21
m22
and the percentage error was 48%.
The area under the ROC curve constructed for the changes
in CIpw for detecting an increase in CItd ≥12% was not sig-
nificantly different from 0.5 (Fig. 3).
Comparison of CIpw with CItd in subjects with a
change in dose of norepinephrine
In subjects in whom the dose of norepinephrine was
increased, mean arterial pressure, SVR, CItd, and CIpw
significantly increased by 22 (25)%, 8 (28)%, 9 (21)%, and
20 (19)%, respectively (Table 2). In subjects in whom the
dose of norepinephrine was decreased, mean arterial pres-
sure, SVR, CItd, and CIpw significantly decreased by 15
(13)%, 8 (17)%, 9 (18)%, and 12 (12)%, respectively (Table 2).
Considering subjects in whom norepinephrine was
increased or decreased as one group (n¼40), the bias
between the absolute changes in CIpw and CItd induced by
norepinephrine decrease/increase was 0.11 (0.68) litre
min21
m22
. The coefficient of determination (r2
) between
the norepinephrine-induced per cent changes in CIpw and
in CItd was 0.11 (P¼0.04) (Fig. 4). The concordance rate
between the changes in CIpw and CItd induced by changing
the dose of norepinephrine was 60% (Fig. 4). After the de-
crease/increase of norepinephrine dose, the bias between
the absolute values CIpw and CItd was 20.30 (1.04) litre
min21
m22
and the percentage error was 61%. Results con-
cerning separate groups of subjects with an increase and a
decrease in the dose of norepinephrine are shown in Table 3.
Effects of changes in SVR on the agreement
of CIpw with CItd
Considering the aggregate of all therapeutic interventions,
changes in SVR ranged from 231% to +73%. The bias
between changes in CIpw and CItd significantly correlated
with changes in SVR (r2
¼0.41, P,0.0001).
In the subset of subjects in whom SVR (absolute value)
changed by less than 15% (n¼33), the bias between the ab-
solute changes in CIpw and CItd was 20.12 (0.43) litre min21
m22
. In these subjects, there was no significant correlation
between SVR and bias between CItd and CIpw (P¼0.29).
In the subset of patients in whom the SVR (in absolute
value) increased by more than 15% (n¼27), the bias
between the absolute changes in CIpw and CItd was 0.22
(0.89) litre min21
m22
. In these patients, the coefficient of
determination (r2
) between SVR and the per cent changes
in CItd and CIpw was 0.49 (P,0.0001).
Discussion
The third-generation FloTrac/Vigileo device was not reliable
for detecting trends in CI, especially when induced by nor-
epinephrine. The higher the total SVR, the higher was the
bias between CI measured by FloTrac/Vigileo and by trans-
pulmonary thermodilution.
Monitoring CO in critically ill patients is recommended
when shock persists despite adequate fluid resuscitation.19
A recent study also suggests that changes in arterial pressure
are unable to reliably monitor the changes in CI induced by
vasopressors,20
reinforcing the message that CO should be
measured in critically ill patients after initial fluid resuscita-
tion. Among the several techniques that are currently avail-
able for measuring CI, the estimation of CI computed from
arterial pressure waveform analysis has the advantage of pro-
viding beat-to-beat estimation of CI. In fact, three elements
influence the relationship between the shape of the periph-
eral arterial wave and stroke volume: arterial compliance,
0 20 40 60 80 100
0
20
40
60
80
100
100-specificity
Sensitivity
Fig 3 An ROC curve constructed for testing the ability of the
changes in CI by the third-generation FloTrac/Vigileo device to
detect an increase in CI obtained by transpulmonary thermodilu-
tion ≥12% induced by volume expansion.
Third-generation FloTrac in critically ill patients BJA
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6. –60 –40 –20 0 20
–1.5 –1.0 –0.5 0.0 0.5 1.0 1.5 2.0
40 60 80 100
–60
–40
–20
0
20
40
60
80
100
0.11
- –1.27
1.48
0
0.11
-
1.48
0
-
0
r2=0.11
P=0.04
–2.5
–2.0
–1.5
–1.0
–0.5
0.0
0.5
1.0
1.5
2.0
2.5
20
40
60
80
C
Concordance=60%
(Exclusion zone 12%)
(Without exclusion zone=63%)
(CIpw+CItd)/2 (litremin–1 m–2)
CItd (%)
CIpw(%)
CIpw (%)
(CIpw–CItd)(litremin–1m–2)
B
A
–80
–60
–40
–20
–80 –60 –40 20 40 60 80–20 0
CItd (%)
Fig 4 (A) The Bland–Altman plot for changes in absolute values induced by changes in the dose of norepinephrine on CI measured by trans-
pulmonary thermodilution (CItd) and by arterial pressure waveform analysis by the third-generation FloTrac/Vigileo device (CIpw). (B) Correlation
between per cent changes induced by changes in the dose of norepinephrine on CI measured by transpulmonary thermodilution (DCItd) and by
arterial pressure waveform analysis by the third-generation FloTrac/Vigileo device (DCIpw). (C) Trending ability of the third-generation FloTrac/
Vigileo device (DCIpw) against CI measured by transpulmonary thermodilution (DCItd) during changes in the dose of norepinephrine based on
four-quadrant concordance analysis. n¼40. The Bland–Altman plots: straight line, bias; dashed line, +2SD/22SD limits of agreement. Correl-
ation: dashed line, correlation line.
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7. arterial vasomotor tone, and pulse-wave amplification phe-
nomenon.1
Thus, estimation of CI by arterial pressure wave-
form analysis is based upon a geometric analysis of the
shape of the arterial pressure curve which is then adjusted
with a factor taking into account the arterial compliance
and tone and the pulse-wave amplification phenomenon.
The devices currently available on the market are fundamen-
tally different. The ‘calibrated’ devices, namely the PiCCO
(Pulsion Medical Systems), EV1000 (Edwards Lifesciences),
and LidCOplus (LidCO) devices calibrate the estimation of
CO made from the arterial pressure curve by an external cali-
bration of CI by a reference method (transpulmonary thermo-
dilution for the PiCCO and EV1000 and lithium dilution for the
LidCOplus). This external calibration requires periodic injec-
tion of an indicator and the use of a specific material for
measuring dilution. In contrast, some ‘uncalibrated’ devices,
like the FloTrac/Vigileo (Edwards Lifesciences), LidCOrapid
(LidCO), or Pulsioflex (Pulsion Medical Systems), continuously
estimate arterial compliance and tone and pulse-wave amp-
lification from a complex geometric analysis of the arterial
wave and from some biometric data.
Reliability of uncalibrated pressure waveform analysis
for measuring CO has been demonstrated in several
studies.12 21 –24
Nevertheless, concerns have been raised
about the validity of the technique when the arterial
tone changes to a large extent,3
during hyperdynamic
states,7 8 10
and when vasopressors are administered, as
we recently showed with the second-generation FloTrac/
Vigileo device.11
To address this problem, a third version of
the FloTrac/Vigileo software has been developed. Compared
with the previous version, estimation of arterial compliance
and tone and pulse-wave amplification has been made
from a human database containing more recordings from
septic and liver transplant patients.12
In a recent study, in
septic shock patients, De Backer and colleagues12
found
that the third-generation FloTrac/Vigileo device is more ac-
curate, as precise as, and less influenced by total SVR than
the previous version. Consistent with this study, we found
that the percentage error for CIpw recorded for all pairs of
measurements was improved compared with results
obtained with the second-generation system11
(54% vs
61%, respectively).
In contrast to De Backer and colleagues, we focused on
the ability of the uncalibrated devices to follow changes in
CI induced by some systematic therapeutic changes. Even
though it was conducted in subjects with total SVR in the
same range as those in the study of De Backer and collea-
gues,12
the present study suggests that the most recent
version of the FloTrac/Vigileo system does not provide a sat-
isfactory track of therapy-induced changes in CO. First, even
though changes in CItd and CIpw were more significantly cor-
related when induced by volume expansion than by norepin-
ephrine, the third-generation FloTrac/Vigileo did not provide
a correct estimation of the response to a standardized fluid
challenge, as defined by an increase in CItd ≥15%. Second
and more importantly, our results suggest that the new
FloTrac/Vigileo device was not reliable for tracking trends in
CI induced by changing the dose of norepinephrine. More-
over, by showing that the accuracy of the third-generation
FloTrac/Vigileo device correlated with total SVR, we suggest
that its estimation of CI is still distorted by a change in vas-
cular tone. The ability to track norepinephrine-induced
changes in CI seems to be improved compared with the pre-
vious version of the system. Indeed, in our previous study,11
we did not find significant correlation between changes in
CIpw and CItd induced by norepinephrine changes, while
this correlation was significant in the present study
(r¼0.35, P,0.05). This suggests substantial but insufficient
improvements in the device software. Importantly, the
present results are in accordance with two recent studies
conducted in other clinical settings. In neurosurgical patients
requiring high-dose vasopressor support, Metzelder and col-
leagues25
showed that the introduction of the third-
generation FloTrac/Vigileo software algorithm did not
improve the insufficient precision for CI measurements
observed with the second software version. In a general
population of anaesthetized subjects, Meng and colleagues13
reported that the newest FloTrac/Vigileo generation accur-
ately tracked changes in CO when preload changed but did
not accurately track changes in CO induced with phenyleph-
rine and ephedrine.
We acknowledge some limitations to our study. First, we
could not perform a direct comparison between the second
and third generations of the FloTrac/Vigileo system since
the previous version is no longer provided by the manufac-
turer. Secondly, as a reference for measuring CI, we used
transpulmonary thermodilution rather than classical thermo-
dilution with the pulmonary artery catheter.26
Nevertheless,
the accuracy of transpulmonary thermodilution in measuring
CO has been repeatedly demonstrated.15 23 27 –33
Thirdly, we
did not test other systems that compute CI from the pressure
waveform without external calibration, so our conclusions
might not apply to these devices.
In conclusion, estimation of CI made from the third-
generation FloTrac/Vigileo device was only moderately reli-
able for detecting the changes in CI induced with volume ex-
pansion and did not allow tracking trends in CI provoked by
changing the dose of norepinephrine in critically ill patients.
As a clinical consequence, this study suggests that this
device should be reserved for patients who are not receiving
vasopressors.
Declaration of interest
J.-L.T. and X.M. are members of the Medical Advisory Board of
Pulsion Medical Systems.
Funding
This study was supported solely by institutional and depart-
mental sources.
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