It is a chronic infectious disease caused by M. leprae, which mainly affects the skin, peripheral nerves, and mucosa. It has left a legacy of social stigma. Global statistics from 2001 show South East Asia has the highest prevalence, with India reporting the most cases. The goal of leprosy programs is elimination by reducing prevalence to less than 1 per 10,000 by 2000, which can be achieved by making multi-drug therapy accessible and treating all cases to interrupt transmission. Diagnosis is based on skin lesions and sensory loss. Multi-drug therapy is highly effective and cures leprosy by treating for a fixed duration.
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. It mainly affects the skin, peripheral nerves, and mucosa. The goal of leprosy elimination programs is to reduce the prevalence rate to less than 1 per 10,000 people. Multi drug therapy (MDT) is highly effective in curing leprosy and reducing transmission by interrupting disease activity in all known cases. Integrating leprosy services into general healthcare helps ensure all cases receive timely treatment to prevent disabilities and further transmission. Monitoring prevalence and detection rates is important to assess program progress toward elimination goals.
This document provides information on leprosy including:
1) Leprosy is a chronic infectious disease caused by Mycobacterium leprae that mainly affects the skin, nerves, and respiratory tract.
2) Global prevalence rates for 2001 show South East Asia had the highest burden with 488,333 cases.
3) Multi-drug therapy (MDT) is the recommended treatment, with regimens depending on classification as paucibacillary (PB) or multibacillary (MB).
4) Integration of leprosy services into general healthcare aims to ensure timely diagnosis and treatment to prevent disabilities.
National Leprosy Eradication Programme
Date of creation- Feb 2019
Authors - Dr. Madhushree Acharya, Junior Resident, Community Medicine and Family Medicine, AIIMS Bhubaneswar; Dr. Durgesh Prasad Sahoo, Senior Resident, Community Medicine and Family Medicine, AIIMS Bhubaneswar
This document summarizes leprosy, including its causes, symptoms, history, classification, treatment, and the national leprosy eradication program in India. It discusses how leprosy is caused by Mycobacterium leprae, affects the skin and nerves, and was recognized in ancient civilizations. Multidrug therapy provided through the WHO has largely cured the 16 million cases treated over 20 years. The national program in India focuses on case detection, treatment, prevention, and social stigma reduction through various strategies including modified leprosy campaigns and special action projects.
This document discusses India's National Leprosy Eradication Programme (NLEP). It summarizes that only 7% of women surveyed had previously participated in leprosy work, though 92% felt they could participate. The main factors preventing participation were lack of financial support, need for family permission, and not working near home. Women suggested delegating work based on skills and providing proper training. Overall, the document examines determinants of rural women's low participation in NLEP and identifies solutions to increase involvement.
Here are some possible responses to the questions:
1. The higher incidence and prevalence of leprosy in males compared to females could be due to various socio-cultural factors. Males may have greater exposure and mobility which increases their risk of contracting the disease. There could also be under-reporting of cases in females due to lack of access to healthcare and social stigma.
2. To reduce stigma and discrimination against leprosy affected persons and their families, sustained awareness programs targeting the general public as well as affected communities are needed. Educating people about the modes of transmission and that leprosy is curable can help reduce misconceptions. Involving affected persons in advocacy can also help normalize the condition and empower those
National Leprosy Eradication Program(NLEP)-1.pptxLavanya122320
The National Leprosy Eradication Program (NLEP) was launched in 1983 with the goals of reducing prevalence of leprosy to less than 1 per 10,000 people and interrupting disease transmission. Key strategies include early detection of new cases, complete treatment with multidrug therapy, reducing disabilities, and increasing awareness. Leprosy classification systems have evolved over time to better understand the disease spectrum and determine appropriate treatment. The Ridley-Jopling system from 1966 is now most commonly used, categorizing leprosy on a spectrum from tuberculoid to lepromatous pole.
1) The document discusses India's National Leprosy Eradication Programme, including its history, strategies, infrastructure, and treatment protocols.
2) Key statistics provided include that India accounts for 60.9% of global leprosy cases, with a prevalence rate of 5.0 per 10,000 people.
3) The program's objectives are to eliminate leprosy through early case detection, short-term multidrug therapy, health education, and rehabilitation. Treatment involves multidrug regimens administered monthly or daily depending on the type of leprosy.
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. It mainly affects the skin, peripheral nerves, and mucosa. The goal of leprosy elimination programs is to reduce the prevalence rate to less than 1 per 10,000 people. Multi drug therapy (MDT) is highly effective in curing leprosy and reducing transmission by interrupting disease activity in all known cases. Integrating leprosy services into general healthcare helps ensure all cases receive timely treatment to prevent disabilities and further transmission. Monitoring prevalence and detection rates is important to assess program progress toward elimination goals.
This document provides information on leprosy including:
1) Leprosy is a chronic infectious disease caused by Mycobacterium leprae that mainly affects the skin, nerves, and respiratory tract.
2) Global prevalence rates for 2001 show South East Asia had the highest burden with 488,333 cases.
3) Multi-drug therapy (MDT) is the recommended treatment, with regimens depending on classification as paucibacillary (PB) or multibacillary (MB).
4) Integration of leprosy services into general healthcare aims to ensure timely diagnosis and treatment to prevent disabilities.
National Leprosy Eradication Programme
Date of creation- Feb 2019
Authors - Dr. Madhushree Acharya, Junior Resident, Community Medicine and Family Medicine, AIIMS Bhubaneswar; Dr. Durgesh Prasad Sahoo, Senior Resident, Community Medicine and Family Medicine, AIIMS Bhubaneswar
This document summarizes leprosy, including its causes, symptoms, history, classification, treatment, and the national leprosy eradication program in India. It discusses how leprosy is caused by Mycobacterium leprae, affects the skin and nerves, and was recognized in ancient civilizations. Multidrug therapy provided through the WHO has largely cured the 16 million cases treated over 20 years. The national program in India focuses on case detection, treatment, prevention, and social stigma reduction through various strategies including modified leprosy campaigns and special action projects.
This document discusses India's National Leprosy Eradication Programme (NLEP). It summarizes that only 7% of women surveyed had previously participated in leprosy work, though 92% felt they could participate. The main factors preventing participation were lack of financial support, need for family permission, and not working near home. Women suggested delegating work based on skills and providing proper training. Overall, the document examines determinants of rural women's low participation in NLEP and identifies solutions to increase involvement.
Here are some possible responses to the questions:
1. The higher incidence and prevalence of leprosy in males compared to females could be due to various socio-cultural factors. Males may have greater exposure and mobility which increases their risk of contracting the disease. There could also be under-reporting of cases in females due to lack of access to healthcare and social stigma.
2. To reduce stigma and discrimination against leprosy affected persons and their families, sustained awareness programs targeting the general public as well as affected communities are needed. Educating people about the modes of transmission and that leprosy is curable can help reduce misconceptions. Involving affected persons in advocacy can also help normalize the condition and empower those
National Leprosy Eradication Program(NLEP)-1.pptxLavanya122320
The National Leprosy Eradication Program (NLEP) was launched in 1983 with the goals of reducing prevalence of leprosy to less than 1 per 10,000 people and interrupting disease transmission. Key strategies include early detection of new cases, complete treatment with multidrug therapy, reducing disabilities, and increasing awareness. Leprosy classification systems have evolved over time to better understand the disease spectrum and determine appropriate treatment. The Ridley-Jopling system from 1966 is now most commonly used, categorizing leprosy on a spectrum from tuberculoid to lepromatous pole.
1) The document discusses India's National Leprosy Eradication Programme, including its history, strategies, infrastructure, and treatment protocols.
2) Key statistics provided include that India accounts for 60.9% of global leprosy cases, with a prevalence rate of 5.0 per 10,000 people.
3) The program's objectives are to eliminate leprosy through early case detection, short-term multidrug therapy, health education, and rehabilitation. Treatment involves multidrug regimens administered monthly or daily depending on the type of leprosy.
The document summarizes leprosy, a contagious disease caused by Mycobacterium leprae bacteria that affects the skin and nerves. It describes the classification, signs and symptoms, diagnosis, multidrug treatment recommendations from the WHO, and strategies of India's National Leprosy Elimination Programme to detect and manage leprosy cases through education, short-term multidrug therapy, and rehabilitation.
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by Mycobacterium leprae. It mainly affects the skin and nerves. The global registered prevalence of leprosy in 2006 was 219,826 cases, with India reporting 1.34 lakh new cases in 2008-09. Key milestones in India's efforts to eliminate leprosy included establishing the National Leprosy Eradication Program in 1983 and introducing multidrug therapy. The program's objectives are to integrate leprosy services into general healthcare and eliminate leprosy at the national level. It utilizes strategies such as early detection, regular treatment, awareness campaigns, and medical rehabilitation.
This document provides an overview of leprosy in India, including its transmission, diagnosis, treatment, and the national program to eliminate leprosy. Some key points:
- Leprosy primarily affects the skin, nerves, and mucous membranes and can cause deformities. It is spread through droplets and untreated patients are the main reservoir. Multi-drug therapy can cure patients and interrupt transmission.
- India's National Leprosy Elimination Program aims to integrate services, provide MDT, conduct surveillance, increase awareness, and prevent disabilities. Through these strategies, the national prevalence rate has declined and most states have achieved elimination targets.
- However, some areas still have high rates and ongoing efforts include training
The Revised National Tuberculosis Control Programme (RNTCP) in India has the following key objectives:
1) To achieve and maintain at least 85% cure rate amongst new smear positive tuberculosis cases and 70% case detection rate.
2) To provide universal access to tuberculosis treatment through the DOTS (Directly Observed Treatment, Short-course) strategy where a treatment observer watches patients take their medication.
3) To introduce programmatic management of drug resistant tuberculosis through standardized regimens using second-line drugs under the DOTS strategy.
"A Study of Clinical Profile of Leprosy in Post Leprosy Elimination Era"iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
The National Leprosy Eradication Programme was launched in India in 1983 with the goal of reducing leprosy prevalence to less than 1 case per 10,000 people. Key strategies included early detection of cases, providing multi-drug therapy, disability prevention, and health education. Through these efforts, prevalence reduced dramatically from 57/10,000 in 1981 to 3.74/10,000 in 2001. The program was also aimed at integrating leprosy services into the general healthcare system to achieve elimination at the national level by 2005. Monitoring and research helped evaluate progress and identify areas needing improvement.
The document summarizes India's National Leprosy Eradication Programme. It began as the National Leprosy Control Programme in 1955 and was renamed the NLEP in 1983 when Multi-Drug Therapy was introduced. The NLEP aims to reduce prevalence to less than 1 case per 10,000 people through early detection, regular MDT treatment, disability prevention, and public awareness campaigns. Key milestones include introducing MDT in 1982 and eliminating leprosy nationally by 2005. The current strategy involves integrating leprosy services into general healthcare and intensifying efforts in high prevalence districts.
Leprosy presentation uploaded by Samrat GurungSamrat Gurung
1) Leprosy is a chronic disease caused by bacteria that mainly affects the skin and nerves. It is transmitted via droplets from the nose and mouth during prolonged contact with untreated cases.
2) Leprosy can be classified based on clinical manifestations and skin smear results as paucibacillary or multibacillary. Multidrug therapy introduced in 1981 consisting of dapsone, rifampicin, and clofazimine cures patients.
3) Nepal has achieved the goal of eliminating leprosy as a public health problem but still faces challenges of sustaining achievements and further reducing disease burden through quality leprosy services while addressing social stigma.
This document summarizes information on tuberculosis (TB), the National Tuberculosis Program (NTP), and strategies for controlling TB in the Philippines. It states that TB is caused by the bacterium Mycobacterium tuberculosis and is transmitted through infectious droplets from coughing, sneezing, talking, or singing. The NTP achieved global targets for TB case detection and treatment success rates. However, emerging issues like drug resistance and co-morbidities need to be addressed to prevent further transmission. The program aims to reduce variations in performance, scale up coverage of DOTS implementation, and reduce out-of-pocket expenses for quality TB services.
This document provides information about yaws, a chronic infectious disease caused by the bacterium Treponema pallidum pertenue. It is transmitted through direct skin-to-skin contact. Yaws primarily affects children in tropical regions. Clinical manifestations range from non-destructive skin lesions to late stage lesions that can be disfiguring. Treatment with single dose antibiotics can cure infections. WHO aims to eradicate yaws globally by 2020 through mass treatment campaigns and surveillance programs. India eliminated indigenous yaws transmission in 2004.
Leprosy is an age-old disease and is described in the literature of ancient civilizations. It is a chronic infectious disease which is caused by a type of bacteria called Mycobacterium leprae. The disease affects the skin, the peripheral nerves, mucosa of the upper respiratory tract, and the eyes. Leprosy is curable and treatment in the early stages can prevent disability. Apart from the physical deformity, persons affected by leprosy also face stigmatization and discrimination
Leprosy - Introduction and EpidemiologyNeyaz Ahmad
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by Mycobacterium leprae that mainly affects the skin and peripheral nerves. It has been known to mankind for thousands of years and remains a public health problem in some parts of the world. While prevalence has decreased significantly worldwide in recent decades, India still accounts for over half of all new leprosy cases detected globally each year. Leprosy is diagnosed based on characteristic skin lesions and loss of sensation and is treated with multidrug therapy regiments of 6-12 months depending on classification. Social stigma surrounding the disease also presents challenges.
The National Leprosy Eradication Programme aims to eliminate leprosy in India through decentralized integrated leprosy services in the general healthcare system. Early detection and complete treatment of new leprosy cases is carried out, along with household contact surveys and involvement of Accredited Social Health Activists. Multidrug therapy is highly effective at curing patients in 6-12 months depending on the form of leprosy. Challenges remain in fully eliminating leprosy due to hidden cases continuing to spread infection, late detection, poor treatment completion, stigma, and limited awareness and expertise in some areas.
This document summarizes the current situation of leprosy in India and discusses future implications. It notes that while prevalence has decreased due to efforts like the National Leprosy Eradication Program, India still accounts for 60% of new global cases each year. The national strategy now focuses on active case detection campaigns in highly endemic areas, increasing awareness to reduce stigma, and exploring preventive approaches like chemoprophylaxis to break transmission chains and reach zero disease status. A single dose of rifampicin administered to contacts has shown up to 57% reduced risk of developing leprosy and is part of the current leprosy post-exposure prophylaxis program.
The document provides a critical review of India's National Leprosy Eradication Programme (NLEP). It summarizes the evolution and strategies of the NLEP, including the introduction of multidrug therapy in 1982. While prevalence of leprosy in India has declined dramatically with NLEP efforts, issues remain around organizational challenges, stigma, integration with the general healthcare system, and ensuring treatment adherence. The review also notes opportunities from partnerships and funding, as well as ongoing threats like stigma and the need for new diagnostic and treatment approaches.
Improving malaria treatment and control through enhanced diagnostic practiceACT Consortium
Professor David Schellenberg, director of the ACT Consortium, presents at the European Congress on Tropical Medicine and International Health in Basel, Switzerland on 7 September 2015.
Yaws is a bacterial infection that affects skin, bone, and cartilage, especially in remote, tribal areas of India. It can be cured by a single dose of penicillin. India launched a Yaws Eradication Programme in 1996 to interrupt transmission of the disease and achieve eradication, as defined by no seropositivity in children, by mass treatment of affected communities. The programme is coordinated nationally and implemented in endemic states, using existing healthcare systems to detect cases and provide penicillin treatment to cases and contacts in order to eliminate the disease from the country.
The document summarizes leprosy, a contagious disease caused by Mycobacterium leprae bacteria that affects the skin and nerves. It describes the classification, signs and symptoms, diagnosis, multidrug treatment recommendations from the WHO, and strategies of India's National Leprosy Elimination Programme to detect and manage leprosy cases through education, short-term multidrug therapy, and rehabilitation.
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by Mycobacterium leprae. It mainly affects the skin and nerves. The global registered prevalence of leprosy in 2006 was 219,826 cases, with India reporting 1.34 lakh new cases in 2008-09. Key milestones in India's efforts to eliminate leprosy included establishing the National Leprosy Eradication Program in 1983 and introducing multidrug therapy. The program's objectives are to integrate leprosy services into general healthcare and eliminate leprosy at the national level. It utilizes strategies such as early detection, regular treatment, awareness campaigns, and medical rehabilitation.
This document provides an overview of leprosy in India, including its transmission, diagnosis, treatment, and the national program to eliminate leprosy. Some key points:
- Leprosy primarily affects the skin, nerves, and mucous membranes and can cause deformities. It is spread through droplets and untreated patients are the main reservoir. Multi-drug therapy can cure patients and interrupt transmission.
- India's National Leprosy Elimination Program aims to integrate services, provide MDT, conduct surveillance, increase awareness, and prevent disabilities. Through these strategies, the national prevalence rate has declined and most states have achieved elimination targets.
- However, some areas still have high rates and ongoing efforts include training
The Revised National Tuberculosis Control Programme (RNTCP) in India has the following key objectives:
1) To achieve and maintain at least 85% cure rate amongst new smear positive tuberculosis cases and 70% case detection rate.
2) To provide universal access to tuberculosis treatment through the DOTS (Directly Observed Treatment, Short-course) strategy where a treatment observer watches patients take their medication.
3) To introduce programmatic management of drug resistant tuberculosis through standardized regimens using second-line drugs under the DOTS strategy.
"A Study of Clinical Profile of Leprosy in Post Leprosy Elimination Era"iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
The National Leprosy Eradication Programme was launched in India in 1983 with the goal of reducing leprosy prevalence to less than 1 case per 10,000 people. Key strategies included early detection of cases, providing multi-drug therapy, disability prevention, and health education. Through these efforts, prevalence reduced dramatically from 57/10,000 in 1981 to 3.74/10,000 in 2001. The program was also aimed at integrating leprosy services into the general healthcare system to achieve elimination at the national level by 2005. Monitoring and research helped evaluate progress and identify areas needing improvement.
The document summarizes India's National Leprosy Eradication Programme. It began as the National Leprosy Control Programme in 1955 and was renamed the NLEP in 1983 when Multi-Drug Therapy was introduced. The NLEP aims to reduce prevalence to less than 1 case per 10,000 people through early detection, regular MDT treatment, disability prevention, and public awareness campaigns. Key milestones include introducing MDT in 1982 and eliminating leprosy nationally by 2005. The current strategy involves integrating leprosy services into general healthcare and intensifying efforts in high prevalence districts.
Leprosy presentation uploaded by Samrat GurungSamrat Gurung
1) Leprosy is a chronic disease caused by bacteria that mainly affects the skin and nerves. It is transmitted via droplets from the nose and mouth during prolonged contact with untreated cases.
2) Leprosy can be classified based on clinical manifestations and skin smear results as paucibacillary or multibacillary. Multidrug therapy introduced in 1981 consisting of dapsone, rifampicin, and clofazimine cures patients.
3) Nepal has achieved the goal of eliminating leprosy as a public health problem but still faces challenges of sustaining achievements and further reducing disease burden through quality leprosy services while addressing social stigma.
This document summarizes information on tuberculosis (TB), the National Tuberculosis Program (NTP), and strategies for controlling TB in the Philippines. It states that TB is caused by the bacterium Mycobacterium tuberculosis and is transmitted through infectious droplets from coughing, sneezing, talking, or singing. The NTP achieved global targets for TB case detection and treatment success rates. However, emerging issues like drug resistance and co-morbidities need to be addressed to prevent further transmission. The program aims to reduce variations in performance, scale up coverage of DOTS implementation, and reduce out-of-pocket expenses for quality TB services.
This document provides information about yaws, a chronic infectious disease caused by the bacterium Treponema pallidum pertenue. It is transmitted through direct skin-to-skin contact. Yaws primarily affects children in tropical regions. Clinical manifestations range from non-destructive skin lesions to late stage lesions that can be disfiguring. Treatment with single dose antibiotics can cure infections. WHO aims to eradicate yaws globally by 2020 through mass treatment campaigns and surveillance programs. India eliminated indigenous yaws transmission in 2004.
Leprosy is an age-old disease and is described in the literature of ancient civilizations. It is a chronic infectious disease which is caused by a type of bacteria called Mycobacterium leprae. The disease affects the skin, the peripheral nerves, mucosa of the upper respiratory tract, and the eyes. Leprosy is curable and treatment in the early stages can prevent disability. Apart from the physical deformity, persons affected by leprosy also face stigmatization and discrimination
Leprosy - Introduction and EpidemiologyNeyaz Ahmad
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by Mycobacterium leprae that mainly affects the skin and peripheral nerves. It has been known to mankind for thousands of years and remains a public health problem in some parts of the world. While prevalence has decreased significantly worldwide in recent decades, India still accounts for over half of all new leprosy cases detected globally each year. Leprosy is diagnosed based on characteristic skin lesions and loss of sensation and is treated with multidrug therapy regiments of 6-12 months depending on classification. Social stigma surrounding the disease also presents challenges.
The National Leprosy Eradication Programme aims to eliminate leprosy in India through decentralized integrated leprosy services in the general healthcare system. Early detection and complete treatment of new leprosy cases is carried out, along with household contact surveys and involvement of Accredited Social Health Activists. Multidrug therapy is highly effective at curing patients in 6-12 months depending on the form of leprosy. Challenges remain in fully eliminating leprosy due to hidden cases continuing to spread infection, late detection, poor treatment completion, stigma, and limited awareness and expertise in some areas.
This document summarizes the current situation of leprosy in India and discusses future implications. It notes that while prevalence has decreased due to efforts like the National Leprosy Eradication Program, India still accounts for 60% of new global cases each year. The national strategy now focuses on active case detection campaigns in highly endemic areas, increasing awareness to reduce stigma, and exploring preventive approaches like chemoprophylaxis to break transmission chains and reach zero disease status. A single dose of rifampicin administered to contacts has shown up to 57% reduced risk of developing leprosy and is part of the current leprosy post-exposure prophylaxis program.
The document provides a critical review of India's National Leprosy Eradication Programme (NLEP). It summarizes the evolution and strategies of the NLEP, including the introduction of multidrug therapy in 1982. While prevalence of leprosy in India has declined dramatically with NLEP efforts, issues remain around organizational challenges, stigma, integration with the general healthcare system, and ensuring treatment adherence. The review also notes opportunities from partnerships and funding, as well as ongoing threats like stigma and the need for new diagnostic and treatment approaches.
Improving malaria treatment and control through enhanced diagnostic practiceACT Consortium
Professor David Schellenberg, director of the ACT Consortium, presents at the European Congress on Tropical Medicine and International Health in Basel, Switzerland on 7 September 2015.
Yaws is a bacterial infection that affects skin, bone, and cartilage, especially in remote, tribal areas of India. It can be cured by a single dose of penicillin. India launched a Yaws Eradication Programme in 1996 to interrupt transmission of the disease and achieve eradication, as defined by no seropositivity in children, by mass treatment of affected communities. The programme is coordinated nationally and implemented in endemic states, using existing healthcare systems to detect cases and provide penicillin treatment to cases and contacts in order to eliminate the disease from the country.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
2. LEPROSY
It is a chronic infectious disease caused by M.leprae,
an acid fast, rod shaped bacillus. It mainly affects the
skin, peripheral nerves, and mucosa of the
respiratory tract etc., It has left behind a terrifying
image in history and human memory of mutilation,
rejection and exclusion from society.
4. Leprosy Situation in South East Asia 2001
Thailand 2251 797 0.4 1.3
Country Point Prevalence Cases detected during the year 2001 Prevalence per 10000 Detection per 100000
Bangladesh 8537 10740 0.6 8.2
Bhutan 40 19 0.2 0.9
India 439782 617993 4.3 60.1
Indonesia 17259 13286 0.8 6.2
Myanmar 8237 9684 1.8 21.0
Nepal 10657 13830 4.4 56.5
Sri Lanka 1570 2309 0.8 12.1
Total 488333 668658 3.2 43.7
5. Global Leprosy Situation in 2001*
Region Point Prevalence Cases detected during the
year 2001
Africa 45170 39612
Americas 83101 42830
East Mediterranean 7007 4758
South East Asia 488333 668658
Western Pacific 7735 4786
Europe 38 53
World 635404 763317
* As reported by 106 countries.
7. GOAL AND OBJECTIVE OF LEPROSY
ERADICATION PROGRAMME
- Goal: elimination of leprosy i.e.to reduce the prevalence
rate to less than I per 10000 population by the year 2000
AD.
- Objective: To arrest disease activity in all the known cases
of leprosy by the year 2000AD
- Strategy: The elimination strategy
9. ERADICATION OF LEPROSY
It is defined as interruption of
transmission of leprosy to attain a stage of
zero level
10. - The elimination of leprosy as a public health means reducing the
prevalence of leprosy to below on case per 10000 population.
- Elimination of leprosy will be achieved by:
- Making MDT accessible to all communities and areas.
- Treating all registered cases with MDT
- Diagnosing and promptly treating all new cases
- Improving quality of patient care, including disability prevention and
management
- Ensuring reqularity and completion of treatment
- Enlisting community support for the programme
ELIMINATION OF LEPROSY
11. INCIDENCE OF LEPROSY
Incidence is the number of new cases
(only the new cases) of a particular disease
that occur in a defined population over a
defined period of time. The time period
used is conventionally one year.
14. Period prevalence
The number of persons with a disease in a
defined population within a specified period of
time
15. SUSPECT CASE OF LEPROSY
- One or more suggestive skin patches with normal sensation
- Extensive loss of sensation in the hands or feet with no other
evidence of leprosy
- One or more grossly enlarged peripheral nerve trunks with no
sensory loss or skin lesion
- Painful nerves with no other evidence of leprosy
- Painless ulcers on hands and/or feet with no other evidence
of leprosy
- Nodules on the skin with no other evidence.
16. WHO IS LIKELY TO REPORT TO THE HEALTH CENTRE
- Leprosy cases who were never treated before
- Leprosy cases who had treatment with dapsone in the
past
- Leprosy cases who had treatment with MDT in the past
Suspect cases
- With other skin lesions
- Other conditions causing nerve damage
- Contacts of leprosy patients for check up
- Normal individual for information
17. How to examine for leprosy?
Examine in a well-lit room
Examine the whole body
Ask since when the patch was noticed
Ask what treatments have been tried
Test for sensation
Look for any visible deformities
18. How to diagnose leprosy
Examine skin
Check for patches
Test for sensation
Count the number of patches
Look for damage to nerves
19. DIAGNOSIS OF LEPROSY
- Hypopigmented or reddish skin lesion(s) with
definite loss of sensation
- Damage to the peripheral nerves, as
demonstated by loss of sensation
- Weakness of the muscles of hands, feet or face
- Positive skin smear
20. FLOW CHART FOR DIAGNOSIS AND
CLASSIFICATION
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21. Leprosy - one of the few diseases which can be eliminated
Leprosy meets the demanding criteria for
elimination
practical and simple diagnostic tools: can be
diagnosed on clinical signs alone;
the availability of an effective intervention to
interrupt its transmission: multidrug therapy
a single significant reservoir of infection:
humans.
22. Elimination strategy
- Providing domicillary MDT to all communities and
areas
- Breaking the chain of transmission by intensive case
detection and promptly treatment activities
- Improving quality of patient care, including
disability prevention and management
- Ensuring regularity and completion of treatment
- Encouraging and ensuring community participation
- Providing rehabilitation to the needy patients
- Organising health education to patients , their
families and community.
23. ADVANTAGES OF MDT
- Highly effective in curing the disease
- Reduces the period of treatment
- Well accepted by patients
- Easy to apply in the field
- Prevents development of drug resistance
- Interrupts transmission of infection
- Reduces risk of relapse
- Prevents disabilities
- Improves community attitude
24. POINTS ON MDT TREATMENT
- Every leprosy patient should receive tratment with more than one
antileprosy drug
- Standard MDT is very safe and effective
- It is available free of charge for leprosy patients
- Standard MDT is for a fixed duration
- At the completion of a full course of MDT the patient is cured
- Use clinical criteria to classify and decide the treatment regimen
- If in doupt of classification, give MB treatment regimen
- Active follow-up after completion of treatment is not necessary
- In case of relapse, re-treat with appropriate standard MDT regimen
26. When treatment is completed
Congratulate the patient
Thank family/friends for their support
Reassure that MDT completely cures leprosy
Any residual lesions will fade away slowly
Show them how to protect anaesthetic areas and/or
disabilities
Encourage to come back in case of any problem
Tell that they are welcome to bring other members
of family or friends for consultation
Remove the patient’s name from the treatment
register
27. According to Official figures from 115 countries show the global registered prevalence of leprosy
at 189 018 at the end of March 2013 and, 232 857 reported new cases against 226 626 in 2012.
The global statistics show that 220 810 (95%) of new leprosy cases were reported from Asia and
Africa while only 5% of new cases are from the rest of the world.
Most countries that were previously highly endemic for leprosy have achieved elimination target
of < 1 case per 10,000 population at the national level and are intensifying their efforts at regional
and district levels.
Pockets of high endemicity still remain in some areas of many countries but a few are mentioned
as reference:
Angola, Bangladesh, Brazil, China, Democatic Republic of Congo, Ethiopia, India, Indonesia,
Madagascar, Mozambique, Myanmar, Nepal, Nigeria, Philippines, South Sudan, Sri Lanka, Sudan
and the United Republic of Tanzania.
Global Scenario
2/27/2023 27
28. 2/27/2023 28
The National Leprosy Eradication Programme is a centrally sponsored Health
Scheme of the Ministry of Health and Family Welfare, Govt. of India.
The Programme is headed by the Deputy Director of Health Services (Leprosy )
under the administrative control of the Directorate General Health Services Govt. of
India.
While the NLEP strategies and plans are formulated centrally, the programme is
implemented by the States/UTs.
The Programme is also supported as Partners by the World Health Organization,
The International Federation of Anti-leprosy Associations (ILEP) and few other Non-
Govt. Organizations.
National Leprosy Eradication Program
INDIA