This document compares interferential current therapy (IFT) and transcutaneous electrical nerve stimulation (TENS), outlining their mechanisms, clinical applications, advantages, and disadvantages. IFT is suited for deeper tissue issues, while TENS targets superficial pain relief, with both modalities applicable for various musculoskeletal conditions. Selection between IFT and TENS should involve individualized assessments, patient preferences, and evidence-based practices to enhance treatment outcomes.