This document provides an overview of endocrine disrupting chemicals (EDCs) and discusses their potential impacts and regulation. It notes that EDCs can interfere with hormone systems and cause adverse health effects. Sources of EDCs include agricultural and industrial chemicals, pharmaceuticals, consumer goods and food/beverage packaging. Regulation of EDCs differs globally. The insurance industry may face increased liability exposures from bodily injury claims related to chronic low-dose EDC exposure given evidence of their environmental persistence and ability to cause long-term health impacts even at low levels. Overall the paper aims to increase awareness of EDCs as an emerging risk that requires monitoring and risk mitigation strategies across industries.
Some chemicals, both natural and man-made, can interfere with the hormonal system. They are called 'endocrine disruptors’. The most controversial issue is whether low level exposures to such chemicals can have adverse effects. Have endocrine disruptors affected wild life and our hormonal system? How much do we know so far?
What are Endocrine-disrupting chemicals (EDCs)?
What products contain endocrine disruptors?
How do endocrine disruptors work?(its Mechanisms of Action).
How are people exposed to endocrine disruptors?
Endocrine disrupting chemicals and their heath effects.
Pesticides:( DDT),human health consequences of exposure to DDT,and its scientific evidence and examples.
Steps to reduce exposure to endocrine disruptors
State of the science of endocrine disrupting chemicals whoEcolife Journal
This document provides a summary for decision-makers of the State of the Science of Endocrine Disrupting Chemicals - 2012 report. It was prepared by an international group of experts for the United Nations Environment Programme and World Health Organization. The summary highlights the key concerns regarding endocrine disrupting chemicals (EDCs) and their potential impacts on human and wildlife health. It reviews the latest scientific understanding of EDCs and evidence of effects in humans and wildlife. The concluding remarks emphasize that protecting vulnerable populations from environmental threats like EDCs is important for achieving development goals.
The document discusses endocrine disruptors and their effects. It defines endocrine disruptors as exogenous agents that interfere with the body's hormone systems and regulation of development. Common sources are personal care products containing phthalates, pesticides, and synthetic and natural hormones. Exposure can affect aquatic and terrestrial organisms as well as humans. Effects in humans include reproductive issues, neurological and immune impacts, and increased cancer risks, especially when exposure occurs during development. Low doses may still have measurable effects, and sensitive periods of exposure can permanently alter endocrine system function. Preventive measures include reducing use of certain products and chemicals.
The document discusses endocrine disrupting chemicals (EDCs) that can interfere with the normal functioning of the endocrine system. It defines EDCs as exogenous agents that interfere with natural hormones in the body. Some key points made in the document include that humans are exposed to thousands of chemicals through various sources like food, water, and products; EDCs can disrupt the reproductive system and development through various mechanisms of action; and examples of hazardous EDCs that affect the female reproductive system are given like DES, PCBs, and pesticides.
An Introduction to the Health Effects of Endocrine Disrupting Chemicals (EDCs)
by @toxipedia
* Toxipedia website;
http://www.toxipedia.org/display/toxipedia/Endocrine+Disruptors
* Endocrine Disruptors: Sexy Stuff:
http://desdaughter.wordpress.com/2012/12/16/endocrine-disruptors-sexy-stuff/
* All our posts about Endocrine Disruptors:
http://desdaughter.wordpress.com/tag/endocrine-disruptors/
This document discusses endocrine disrupting chemicals (EDCs) and their effects. It provides background on how EDCs impact the endocrine system and examples of common EDCs such as bisphenol A, DDT, and phthalates. Sources of EDCs are identified as agriculture, landfills, littering, waterways, and oceans. Case studies demonstrate the bioaccumulation of EDCs in polar bears and sea birds, leading to health effects. Implications for human health are discussed, including concerns about the "cocktail effect" of simultaneous exposure to multiple EDCs and bioaccumulation over a lifetime.
Some chemicals, both natural and man-made, can interfere with the hormonal system. They are called 'endocrine disruptors’. The most controversial issue is whether low level exposures to such chemicals can have adverse effects. Have endocrine disruptors affected wild life and our hormonal system? How much do we know so far?
What are Endocrine-disrupting chemicals (EDCs)?
What products contain endocrine disruptors?
How do endocrine disruptors work?(its Mechanisms of Action).
How are people exposed to endocrine disruptors?
Endocrine disrupting chemicals and their heath effects.
Pesticides:( DDT),human health consequences of exposure to DDT,and its scientific evidence and examples.
Steps to reduce exposure to endocrine disruptors
State of the science of endocrine disrupting chemicals whoEcolife Journal
This document provides a summary for decision-makers of the State of the Science of Endocrine Disrupting Chemicals - 2012 report. It was prepared by an international group of experts for the United Nations Environment Programme and World Health Organization. The summary highlights the key concerns regarding endocrine disrupting chemicals (EDCs) and their potential impacts on human and wildlife health. It reviews the latest scientific understanding of EDCs and evidence of effects in humans and wildlife. The concluding remarks emphasize that protecting vulnerable populations from environmental threats like EDCs is important for achieving development goals.
The document discusses endocrine disruptors and their effects. It defines endocrine disruptors as exogenous agents that interfere with the body's hormone systems and regulation of development. Common sources are personal care products containing phthalates, pesticides, and synthetic and natural hormones. Exposure can affect aquatic and terrestrial organisms as well as humans. Effects in humans include reproductive issues, neurological and immune impacts, and increased cancer risks, especially when exposure occurs during development. Low doses may still have measurable effects, and sensitive periods of exposure can permanently alter endocrine system function. Preventive measures include reducing use of certain products and chemicals.
The document discusses endocrine disrupting chemicals (EDCs) that can interfere with the normal functioning of the endocrine system. It defines EDCs as exogenous agents that interfere with natural hormones in the body. Some key points made in the document include that humans are exposed to thousands of chemicals through various sources like food, water, and products; EDCs can disrupt the reproductive system and development through various mechanisms of action; and examples of hazardous EDCs that affect the female reproductive system are given like DES, PCBs, and pesticides.
An Introduction to the Health Effects of Endocrine Disrupting Chemicals (EDCs)
by @toxipedia
* Toxipedia website;
http://www.toxipedia.org/display/toxipedia/Endocrine+Disruptors
* Endocrine Disruptors: Sexy Stuff:
http://desdaughter.wordpress.com/2012/12/16/endocrine-disruptors-sexy-stuff/
* All our posts about Endocrine Disruptors:
http://desdaughter.wordpress.com/tag/endocrine-disruptors/
This document discusses endocrine disrupting chemicals (EDCs) and their effects. It provides background on how EDCs impact the endocrine system and examples of common EDCs such as bisphenol A, DDT, and phthalates. Sources of EDCs are identified as agriculture, landfills, littering, waterways, and oceans. Case studies demonstrate the bioaccumulation of EDCs in polar bears and sea birds, leading to health effects. Implications for human health are discussed, including concerns about the "cocktail effect" of simultaneous exposure to multiple EDCs and bioaccumulation over a lifetime.
Some chemicals can cause harm to human health. Toxic chemicals include carcinogens that cause cancer, mutagens that cause genetic mutations, and teratogens that cause birth defects. Many chemicals also affect the immune, nervous, and endocrine systems. The toxicity of a chemical depends on factors like dose, route of exposure, and individual susceptibility. Scientists use animal testing and epidemiological studies to estimate toxicity, but these have limitations. More research is needed to understand the health impacts of many chemicals, especially at low exposure levels. Efforts to reduce chemical pollution and require safety testing aim to apply the precautionary principle.
what are EDCs, impacts/effects of EDCs, Sources, treatment of EDC by various methods such as activated carbon, phytoremediation, membrane fouling during ultrafiltration, constructed wetlands, the advanced oxidation process
Environmental pollutants as endocrine disruptorsMaryam Hameed
1. Environmental pollutants like pesticides, PCBs, and dioxins can disrupt the endocrine system and impact human health and development.
2. Exposure to endocrine disrupting chemicals has been linked to adverse reproductive effects, lower IQ, and some cancers like breast cancer.
3. Common sources of exposure include food, plastic, and chemical byproducts in the environment. Reducing use of synthetic chemicals and choosing organic whole foods can help lower exposure.
Endocrine disruptors, sometimes also referred to as hormonally active agents, endocrine-disrupting chemicals, or endocrine-disrupting compounds are chemicals that can interfere with endocrine (or hormonal) systems. These disruptions can cause cancerous tumors, birth defects, and other developmental disorders.
Chemicals called endocrine disruptors can interfere with the body's hormone system and have harmful health effects. Some key points:
- Endocrine disruptors are mostly man-made chemicals found in pesticides, plastics, metals, and personal care products.
- Exposure can occur through food, water, air, and skin contact. Pregnant women and children are especially vulnerable.
- Effects include reproductive issues, increased cancer risk, obesity, diabetes, and neurological or cardiovascular impacts. Some effects may not be seen for years or across generations.
- Common disruptors include bisphenol A, dioxins, phthalates, and flame retardants. They can impact hormone synthesis, male
Toxicology is the study of adverse effects of chemicals on living systems. It involves the assessment of exposure to chemicals, the body's processing and response to those chemicals, and the health effects that may result. Key concepts in toxicology include that the dose and duration of exposure determine whether a chemical acts as a poison or remedy, and that individual susceptibility and factors like genetics, age and nutrition can impact a person's response. The goal of toxicology is to understand these relationships and identify safe exposure levels for humans and the environment.
Breast Cancer - Is there a link to endocrine disrupting chemicals? Breast C...MedicineAndHealthUSA
This document summarizes evidence on potential links between endocrine disrupting chemicals (EDCs) and breast cancer risk. It discusses studies finding associations between breast cancer and exposures like diethylstilbestrol (DES), post-menopausal hormone use, organochlorines like DDT and dieldrin, polychlorinated biphenyls, and chemicals in the home and workplace like phthalates and bisphenol A. While evidence is mixed, some chemicals appear to modestly increase risk, and windows of exposure during development may be important to consider.
Dr. Walter Crinnion, one of the leading experts on environmental medicine and toxicology, shares his observations on the toxic burden we bear in modern society.
Endocrine Disruptors: Child healths
Vichit Supornsilchai, MD, PhD
Endocrine Unit, Department of Pediatric,
Faculty of Medicine,
King Chulalongkorn Memorial Hospital
Endocrine disruptors are substances that interfere with hormone systems and cause harm. They can enter the body through food, drinking water, skin contact, and other ways. Some effects that have been linked to endocrine disruptors include cancer, reduced fertility, obesity, and neurological disorders. However, others argue that natural hormones have a stronger impact and that concentrations of endocrine disruptors are relatively low. The EU finally established criteria in 2016 for identifying substances as endocrine disruptors based on evidence of adverse effects from endocrine modes of action. However, the criteria have not satisfied all parties. The regulation of substances like glyphosate remains controversial as views differ on whether it is an important agricultural product or poses health risks.
This document discusses environmental health and toxicology. It begins by defining environmental health as focusing on external factors like the natural and built environment that can cause disease. It then discusses different types of toxins like endocrine disruptors, neurotoxins, and persistent organic pollutants. These toxins can accumulate in the food chain and cause health issues. The document also examines factors that influence toxicity and how toxicity is measured. It emphasizes that risk is determined by both exposure and individual susceptibility to toxins.
Dose-response is a basic principle of toxicology that evaluates the clinical effects of substances based on the amount of exposure. It establishes a relationship between exposure levels and health effects, with higher doses generally causing more severe responses. Key aspects of dose-response include establishing causality, threshold effects, and the potency of a substance. Dose-response curves graphically depict the relationship, with a typical sigmoid curve showing little effect at low doses and increasing response rates as doses rise. Toxicology addresses various questions through subdisciplines like environmental, occupational, regulatory, and clinical toxicology. Common toxic agents studied include heavy metals, solvents and vapors, radiation, dioxins/furans, pesticides, and
This document discusses occupational hygiene and toxicology. It defines occupational hygiene as anticipating, recognizing, evaluating, controlling and preventing workplace hazards that can cause injury or illness. Toxicology is the study of adverse health effects from exposures to toxins. The document discusses measuring toxicity through various methods including LD50 tests on animals. It also covers classifying substances and toxins based on their health and environmental hazards.
Environmental hazards pose long-term health risks and include infectious agents, toxic heavy metals, organic compounds, radiation, and particulate matter. Toxicology is the study of poisons and their effects. The toxicity of environmental hazards depends on dose, frequency and route of exposure, and individual susceptibility. A risk assessment involves hazard identification, dose-response assessment, exposure assessment, and risk characterization to evaluate health risks and inform risk management.
This document provides an overview of ecopharmacology, which is the study of the effects of pharmaceuticals and personal care products on the environment. It discusses how drugs enter the environment through various routes like excretion, disposal down drains, and agricultural runoff. Once in the environment, drugs can biodegrade, form metabolites, or persist unmodified. Persistent pharmaceutical pollutants can accumulate and have effects on aquatic organisms and microbial communities. The document also outlines some of the ways drugs can impact ecosystems and human health, such as endocrine disruption, autoimmune diseases, epigenetic effects, and toxicity of heavy metals like lead, mercury, and arsenic.
Environmental toxicity Dr prerok regmi 15th May 2018Dr. Prerok regmi
This document discusses environmental toxicity and pollution. It defines key terms like environment, ecosystem, toxicity, toxins, and pollutants. It describes different types of pollution like air, water, soil, and radiation pollution. It discusses how pollution can lead to environmental toxicity and disease. Methods to assess and manage risks of environmental incidents are outlined. Historical examples from ancient texts describe how kings would check for poison in water, food, air and surroundings when entering enemy territories. Various techniques to detect and remove toxins from air and water are also mentioned from ancient texts.
Ecopharmacology is the study of the effects of pharmaceuticals on the environment. Pharmaceuticals can enter the environment through human and veterinary use and waste, impacting both ecosystems and human health. Proper ecopharmacovigilance practices are needed to monitor pharmaceuticals in the environment, detect adverse effects, and limit ecological harm, as drugs have been found in waterways worldwide since the 1970s and certain drugs have caused mass die-offs of vultures in India, feminization of male fish, and increased antibiotic resistance in the environment.
Chemical contaminants form a vast chemical soup in the Great Lakes, and from available data, we know exposure may be cause for concern. This workshop will discuss the threat of “emerging contaminants” in the Lakes, as well as give an overview of research, policy implications and recommendations for moving forward.
Endocrine disruptors are substances that interfere with hormones and can lead to adverse health effects by mimicking, blocking, or indirectly affecting natural hormones. They are found in many products and sources and may cause disorders like cancer, developmental issues, and neurological problems. While evidence suggests certain chemicals can disrupt hormones, fully proving the link between exposure and human health impacts remains challenging. Regulation aims to limit endocrine disruptor use and remove them from waste and drinking water to reduce risks to human and environmental health. Insurers may face increasing liability claims related to endocrine disruptors if causal relationships with diseases can be established.
Who this is for: Health professionals.
Description: Dr. Sheila Bushkin-Bedient will be speaking on the prenatal origins of disease and why we should be focusing on studying possible connections between unconventional natural gas extraction and diabetes, obesity, and cancer.
About the Speaker: Sheila Bushkin is a member of the Institute of Health and the Environment at the State University at Albany, and Concerned Health Professionals of New York. She has been a member of the Medical Society of the State of New York for 15 years. Her specific areas of interest involve environmental health issues, chronic diseases, health concerns of older adults, and CME for physicians.
Some chemicals can cause harm to human health. Toxic chemicals include carcinogens that cause cancer, mutagens that cause genetic mutations, and teratogens that cause birth defects. Many chemicals also affect the immune, nervous, and endocrine systems. The toxicity of a chemical depends on factors like dose, route of exposure, and individual susceptibility. Scientists use animal testing and epidemiological studies to estimate toxicity, but these have limitations. More research is needed to understand the health impacts of many chemicals, especially at low exposure levels. Efforts to reduce chemical pollution and require safety testing aim to apply the precautionary principle.
what are EDCs, impacts/effects of EDCs, Sources, treatment of EDC by various methods such as activated carbon, phytoremediation, membrane fouling during ultrafiltration, constructed wetlands, the advanced oxidation process
Environmental pollutants as endocrine disruptorsMaryam Hameed
1. Environmental pollutants like pesticides, PCBs, and dioxins can disrupt the endocrine system and impact human health and development.
2. Exposure to endocrine disrupting chemicals has been linked to adverse reproductive effects, lower IQ, and some cancers like breast cancer.
3. Common sources of exposure include food, plastic, and chemical byproducts in the environment. Reducing use of synthetic chemicals and choosing organic whole foods can help lower exposure.
Endocrine disruptors, sometimes also referred to as hormonally active agents, endocrine-disrupting chemicals, or endocrine-disrupting compounds are chemicals that can interfere with endocrine (or hormonal) systems. These disruptions can cause cancerous tumors, birth defects, and other developmental disorders.
Chemicals called endocrine disruptors can interfere with the body's hormone system and have harmful health effects. Some key points:
- Endocrine disruptors are mostly man-made chemicals found in pesticides, plastics, metals, and personal care products.
- Exposure can occur through food, water, air, and skin contact. Pregnant women and children are especially vulnerable.
- Effects include reproductive issues, increased cancer risk, obesity, diabetes, and neurological or cardiovascular impacts. Some effects may not be seen for years or across generations.
- Common disruptors include bisphenol A, dioxins, phthalates, and flame retardants. They can impact hormone synthesis, male
Toxicology is the study of adverse effects of chemicals on living systems. It involves the assessment of exposure to chemicals, the body's processing and response to those chemicals, and the health effects that may result. Key concepts in toxicology include that the dose and duration of exposure determine whether a chemical acts as a poison or remedy, and that individual susceptibility and factors like genetics, age and nutrition can impact a person's response. The goal of toxicology is to understand these relationships and identify safe exposure levels for humans and the environment.
Breast Cancer - Is there a link to endocrine disrupting chemicals? Breast C...MedicineAndHealthUSA
This document summarizes evidence on potential links between endocrine disrupting chemicals (EDCs) and breast cancer risk. It discusses studies finding associations between breast cancer and exposures like diethylstilbestrol (DES), post-menopausal hormone use, organochlorines like DDT and dieldrin, polychlorinated biphenyls, and chemicals in the home and workplace like phthalates and bisphenol A. While evidence is mixed, some chemicals appear to modestly increase risk, and windows of exposure during development may be important to consider.
Dr. Walter Crinnion, one of the leading experts on environmental medicine and toxicology, shares his observations on the toxic burden we bear in modern society.
Endocrine Disruptors: Child healths
Vichit Supornsilchai, MD, PhD
Endocrine Unit, Department of Pediatric,
Faculty of Medicine,
King Chulalongkorn Memorial Hospital
Endocrine disruptors are substances that interfere with hormone systems and cause harm. They can enter the body through food, drinking water, skin contact, and other ways. Some effects that have been linked to endocrine disruptors include cancer, reduced fertility, obesity, and neurological disorders. However, others argue that natural hormones have a stronger impact and that concentrations of endocrine disruptors are relatively low. The EU finally established criteria in 2016 for identifying substances as endocrine disruptors based on evidence of adverse effects from endocrine modes of action. However, the criteria have not satisfied all parties. The regulation of substances like glyphosate remains controversial as views differ on whether it is an important agricultural product or poses health risks.
This document discusses environmental health and toxicology. It begins by defining environmental health as focusing on external factors like the natural and built environment that can cause disease. It then discusses different types of toxins like endocrine disruptors, neurotoxins, and persistent organic pollutants. These toxins can accumulate in the food chain and cause health issues. The document also examines factors that influence toxicity and how toxicity is measured. It emphasizes that risk is determined by both exposure and individual susceptibility to toxins.
Dose-response is a basic principle of toxicology that evaluates the clinical effects of substances based on the amount of exposure. It establishes a relationship between exposure levels and health effects, with higher doses generally causing more severe responses. Key aspects of dose-response include establishing causality, threshold effects, and the potency of a substance. Dose-response curves graphically depict the relationship, with a typical sigmoid curve showing little effect at low doses and increasing response rates as doses rise. Toxicology addresses various questions through subdisciplines like environmental, occupational, regulatory, and clinical toxicology. Common toxic agents studied include heavy metals, solvents and vapors, radiation, dioxins/furans, pesticides, and
This document discusses occupational hygiene and toxicology. It defines occupational hygiene as anticipating, recognizing, evaluating, controlling and preventing workplace hazards that can cause injury or illness. Toxicology is the study of adverse health effects from exposures to toxins. The document discusses measuring toxicity through various methods including LD50 tests on animals. It also covers classifying substances and toxins based on their health and environmental hazards.
Environmental hazards pose long-term health risks and include infectious agents, toxic heavy metals, organic compounds, radiation, and particulate matter. Toxicology is the study of poisons and their effects. The toxicity of environmental hazards depends on dose, frequency and route of exposure, and individual susceptibility. A risk assessment involves hazard identification, dose-response assessment, exposure assessment, and risk characterization to evaluate health risks and inform risk management.
This document provides an overview of ecopharmacology, which is the study of the effects of pharmaceuticals and personal care products on the environment. It discusses how drugs enter the environment through various routes like excretion, disposal down drains, and agricultural runoff. Once in the environment, drugs can biodegrade, form metabolites, or persist unmodified. Persistent pharmaceutical pollutants can accumulate and have effects on aquatic organisms and microbial communities. The document also outlines some of the ways drugs can impact ecosystems and human health, such as endocrine disruption, autoimmune diseases, epigenetic effects, and toxicity of heavy metals like lead, mercury, and arsenic.
Environmental toxicity Dr prerok regmi 15th May 2018Dr. Prerok regmi
This document discusses environmental toxicity and pollution. It defines key terms like environment, ecosystem, toxicity, toxins, and pollutants. It describes different types of pollution like air, water, soil, and radiation pollution. It discusses how pollution can lead to environmental toxicity and disease. Methods to assess and manage risks of environmental incidents are outlined. Historical examples from ancient texts describe how kings would check for poison in water, food, air and surroundings when entering enemy territories. Various techniques to detect and remove toxins from air and water are also mentioned from ancient texts.
Ecopharmacology is the study of the effects of pharmaceuticals on the environment. Pharmaceuticals can enter the environment through human and veterinary use and waste, impacting both ecosystems and human health. Proper ecopharmacovigilance practices are needed to monitor pharmaceuticals in the environment, detect adverse effects, and limit ecological harm, as drugs have been found in waterways worldwide since the 1970s and certain drugs have caused mass die-offs of vultures in India, feminization of male fish, and increased antibiotic resistance in the environment.
Chemical contaminants form a vast chemical soup in the Great Lakes, and from available data, we know exposure may be cause for concern. This workshop will discuss the threat of “emerging contaminants” in the Lakes, as well as give an overview of research, policy implications and recommendations for moving forward.
Endocrine disruptors are substances that interfere with hormones and can lead to adverse health effects by mimicking, blocking, or indirectly affecting natural hormones. They are found in many products and sources and may cause disorders like cancer, developmental issues, and neurological problems. While evidence suggests certain chemicals can disrupt hormones, fully proving the link between exposure and human health impacts remains challenging. Regulation aims to limit endocrine disruptor use and remove them from waste and drinking water to reduce risks to human and environmental health. Insurers may face increasing liability claims related to endocrine disruptors if causal relationships with diseases can be established.
Who this is for: Health professionals.
Description: Dr. Sheila Bushkin-Bedient will be speaking on the prenatal origins of disease and why we should be focusing on studying possible connections between unconventional natural gas extraction and diabetes, obesity, and cancer.
About the Speaker: Sheila Bushkin is a member of the Institute of Health and the Environment at the State University at Albany, and Concerned Health Professionals of New York. She has been a member of the Medical Society of the State of New York for 15 years. Her specific areas of interest involve environmental health issues, chronic diseases, health concerns of older adults, and CME for physicians.
Biologist Louis Guillette found alligators at Lake Apopka, Florida with reproductive abnormalities. Research revealed that chemicals contaminating the lake were disrupting the alligators' reproductive hormones. The lake had been contaminated with pesticides that acted as endocrine disruptors.
Endocrine disrupting chemicals (EDCs) interfere with hormone signaling in a variety of ways depending on the chemical and hormone system. Humans are exposed to EDCs everyday through many products and materials in their environment. EDCs have been implicated in numerous health effects through both animal studies and human epidemiological studies. Traditional risk assessment methods do not adequately address the low-dose effects and nonmonotonic dose responses that can occur with EDC exposure. EDCs are a concern because of their ability to affect the body even at very low concentrations during critical periods of development and their potential for multi-generational health impacts through epigenetic changes.
This essay compares and contrasts the organelles found in plant and animal cells. It describes the key organelles common to both cell types, such as the cell membrane, cytoplasm, nucleus, mitochondria and vacuoles. It then highlights some of the unique organelles found in plant cells, including the cell wall, chloroplasts and central vacuole. The functions of these organelles are also outlined.
Animals
in Research
The Importance of
Animals in the Science
of Toxicology
2
Research involving laboratory animals is important to people and to our quality of life. In the past century, most inhabitants
of this planet have experienced an unprecedented
rise in living standards, life expectancy and personal
opportunity, in large part due to the many ways
chemicals have been put to work for us. For example,
drugs whose effects range from curing previously
fatal bacterial infections, reducing the impact of
AIDS, minimizing heart disease, decreasing age-
related wrinkles, to reducing hair loss are widely
available today. The many benefits of the diverse
uses of our natural resources are an outcome of
careful scientific research and of using chemicals
in an appropriate and safe manner. Toxicologists,
the scientists who help determine the limits for safe
use of materials, use modern technological research
methods, including tests on animals, to protect
human and animal health and the environment.
What is toxicology?
Toxicology is the study of how chemical substances
interact with living systems and affect normal
processes, and the use of this information to predict
safe exposure levels. Toxicological research and
testing helps us to live safely and to derive benefit
from natural and synthetic substances while avoiding
harm. Toxicologists are involved in the evaluation
of household products, medicines and the effects of
incidental and occupational exposure to natural and
manufactured substances. Toxicology also helps
us develop the best treatments in the event that
accidental overexposure does occur.
What is safe?
Toxicologists know that no substance is risk-free.
One fundamental tenet of the science of toxicology
is that all chemicals can cause harm at some level of
exposure, summed up in the phrase "the dose makes
the poison." This means that exposure to a specific
small amount of any substance will have no detectable
impact on normal biological processes and is
considered safe. Some doses actually have beneficial
effects, as we all know from use of medicines. But
increasing exposure to most substances will, at
some point, cause harmful effects. Substances are
considered toxic at that level. For example, digitalis is
a plant product that has been used with great benefit
to treat heart irregularities, but too large a dose will
cause death. Oxygen provides another example of how
increasing the dose can turn a safe compound into a
toxic one. Oxygen is essential to life and part of the air
we breathe, but when given at high concentrations it
can cause lung and eye damage in infants.
Sometimes the possible negative effects of a
substance are outweighed by the positive benefits
at that dose. Dogs are treated with heartworm
medication because the risk of death from
heartworms is much greater than the risk of toxicity
of the medication. Similarly, chemotherapeutic
agents ar.
Animals in ResearchThe Importance of Animals in the Sc.docxrossskuddershamus
Animals
in Research
The Importance of
Animals in the Science
of Toxicology
2
Research involving laboratory animals is important to people and to our quality of life. In the past century, most inhabitants
of this planet have experienced an unprecedented
rise in living standards, life expectancy and personal
opportunity, in large part due to the many ways
chemicals have been put to work for us. For example,
drugs whose effects range from curing previously
fatal bacterial infections, reducing the impact of
AIDS, minimizing heart disease, decreasing age-
related wrinkles, to reducing hair loss are widely
available today. The many benefits of the diverse
uses of our natural resources are an outcome of
careful scientific research and of using chemicals
in an appropriate and safe manner. Toxicologists,
the scientists who help determine the limits for safe
use of materials, use modern technological research
methods, including tests on animals, to protect
human and animal health and the environment.
What is toxicology?
Toxicology is the study of how chemical substances
interact with living systems and affect normal
processes, and the use of this information to predict
safe exposure levels. Toxicological research and
testing helps us to live safely and to derive benefit
from natural and synthetic substances while avoiding
harm. Toxicologists are involved in the evaluation
of household products, medicines and the effects of
incidental and occupational exposure to natural and
manufactured substances. Toxicology also helps
us develop the best treatments in the event that
accidental overexposure does occur.
What is safe?
Toxicologists know that no substance is risk-free.
One fundamental tenet of the science of toxicology
is that all chemicals can cause harm at some level of
exposure, summed up in the phrase "the dose makes
the poison." This means that exposure to a specific
small amount of any substance will have no detectable
impact on normal biological processes and is
considered safe. Some doses actually have beneficial
effects, as we all know from use of medicines. But
increasing exposure to most substances will, at
some point, cause harmful effects. Substances are
considered toxic at that level. For example, digitalis is
a plant product that has been used with great benefit
to treat heart irregularities, but too large a dose will
cause death. Oxygen provides another example of how
increasing the dose can turn a safe compound into a
toxic one. Oxygen is essential to life and part of the air
we breathe, but when given at high concentrations it
can cause lung and eye damage in infants.
Sometimes the possible negative effects of a
substance are outweighed by the positive benefits
at that dose. Dogs are treated with heartworm
medication because the risk of death from
heartworms is much greater than the risk of toxicity
of the medication. Similarly, chemotherapeutic
agents ar.
Methods for the assessment of endocrine disruptorsGreenFacts
WHAT ARE ENDOCRINE DISRUPTORS?
Endocrine disruptors are substances, either natural or of human synthetic origin, that have an effect considered to be negative on the endocrine system.
The endocrine system is composed of various glands and organs in the body that play various roles in maintaining the good physiological status of the body. It includes for instance the adrenal glands, the thyroid, the testes and ovaries. The endocrine system influences almost every cell, organ, and function of an organism.
This document discusses several topics related to environmental health and toxicology, including infectious diseases, antibiotic and pesticide resistance, toxic chemicals, and policies around hazardous waste. It covers how toxins move through and impact the environment, human exposure and susceptibility, mechanisms for reducing toxicity, measuring toxicity through testing and risk assessment, and legislation like CERCLA and RCRA for hazardous waste disposal and superfund site cleanups.
The document discusses environmental endocrine disruption and its effects. It presents on the topic by Leslie Carol Botha at the AutismOne 2017 conference. Some key points made include:
- We have failed to consider the impacts of misdiagnosis and increased incidence of illness due to a more toxic environment affecting the endocrine system.
- Most people have little knowledge about the endocrine system and the diseases that can arise when it breaks down. Environmental degradation is even causing abnormal hormone responses in many women.
- Exposure to chemicals like BPA and ethinyl estradiol can cause gene expression changes in turtles' brains and alter their behaviors, indicating long-lasting effects from developmental exposure.
-
Cosmetic pharmacology refers to the use of drugs to improve cognition in normal healthy individuals, for the purpose of enhancement rather than treatment of a formal pathology.
Some case reports with the antidepressant Prozac indicated that patients seemed "better than well," and authors hypothesized that this effect might be observed in individuals not afflicted with psychiatric disorders.
Following these case reports much controversy arose over the veracity and ethics of the cosmetic use of these antidepressants.
Opponents of cosmetic pharmacology state that such drug use is unethical and dangerous, and that the concept of cosmetic pharmacology is a manifestation of naive consumerism resulting from pharmaceutical marketing campaigns.
Proponents state that drugs used to treat many pathologies are just as dangerous, it is an individual's (rather than government's, or physician's) decision whether to use a drug for cosmetic purposes, and there are few if any legitimate ethical qualms with cosmetic pharmacology.
Toxicology is the study of poisons and their effects. There are several branches and types of toxicology. Descriptive toxicology focuses on toxicity testing through hazard identification, dose-response assessment, exposure assessment, and risk characterization. This involves in vitro, in vivo, and in silico testing to evaluate toxic doses, safe exposure levels, and set regulatory standards to protect public health. Mechanistic toxicology studies how toxins interact with living organisms on a molecular level. Regulatory toxicology supports rule making and compliance through standardized testing protocols.
Household products like cleaning solutions, fuels, medicines, and cosmetics are implicated in most poisonings, which often occur at home. Certain animals secrete venomous toxins through bites and stings, while some plants are poisonous to humans and animals. Toxicology is the study of how natural or man-made poisons cause harmful effects in living organisms. Key aspects of toxicology include environmental, occupational, regulatory, food, clinical, descriptive, forensic, analytical, and mechanistic toxicology.
Detoxification of the major organ systems of the body is ever increasingly important. Environment, genetics, nutritional status and lifestyle all play interacting roles that can influence one's quality of life. Learn how to safely detoxify using real food and basic nutrients with the Detox 360 Program. This is an introduction for informational purposes only and is not intended to diagnose or replace medical care.
ENDOCRINE DISRUPTORS (ED): The Challenge of Accessing the ED Regulatory Frame...Covance
Our endocrine system controls many basic body functions and plays a key role in reproduction and development. Disruption of this system can have profound effects on individuals, but also on whole populations and ecosystems. It is for this reason that there is such concern over the use of chemicals with the potential to disrupt the endocrine system and cause adverse toxic effects on animal and human health.
Comparison of Pharmacology and Toxicologyshabeel pn
- Pharmacology is the study of drugs and their effects on the body, while toxicology is the study of harmful chemicals and their health effects.
- Key concepts in both fields include dose, route of exposure/administration, and dose-response relationships, though exposures are often involuntary in toxicology versus voluntary drug administration.
- Both disciplines examine distribution, metabolism, and excretion of substances in the body, and interactions between substances can be additive, synergistic, or antagonistic.
Risk Analysis and Environmental Health HazardsChapter 4.docxSUBHI7
Risk Analysis and Environmental Health Hazards
Chapter 4
Pesticides and ChildrenMore harmful to children than adultsGreater exposurePlaying in contaminated fieldsPutting fingers/things in mouthGreater responseDeveloping bodies, more sensitiveRange of EffectsCancer, mental and/or physical disabilitiesIntelligenceMotor skills
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Pesticides and Children
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Learning Objectives:
Define risk and risk assessment
Explain how risk assessment helps is manage potential health threats
A Perspective on Risks
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A Perspective on RisksRiskThe probability of harm (injury, disease, death, environmental damage) occurring under certain circumstancesInherent in our actions and our environmentWalking on stairs, using household appliances, driving/riding cars, flying, etc.Few of us think twice about it, even though it’s riskyIn order to manage risks, we need to have a sense of their causes, likelihoods, and effects
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A Perspective on Risks
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A Perspective on RisksRisk ManagementThe process of identifying, assessing, and reducing risks.Qualitative and quantitative methodEstimates the probability that an even will occur, so we can determine behavior/actions
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A Perspective on Risks
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A Perspective on RisksCurious dilemma:People accept big risks 1/3 of smokers die of diseases caused by smoking Average life expectancy is 8 yrs less for smokers)Get upset over very small risks1 in 1 million chance of getting cancer from pesticide residues on food)Perhaps due to perception of risks as things we can control smoking, diet, exercise, etc. vs. things we “can’t” controlPlane crashes, pesticides, nuclear waste
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A Perspective on Risks
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Global Climate Change
What are risk and risk assessment?
What are the four steps of risk assessment?
Environmental Health HazardsLearning Objectives:
Define toxicology and epidemiology
Explain why public water supplies are monitored for fecal coliform bacteria despite the fact that most strains of E. coli do not cause disease
Describe the link between environmental changes and emerging diseases, such as swine flu
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Environmental Health HazardsToxicantsChemicals with adverse effects on healthAll chemicals are toxic if exposure is high enoughToxicology studies the effects of toxicants on living organismsstudies the mechanisms that cause toxicitydevelops ways to prevent or minimize adverse effects
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Environmental Health HazardsEpidemiologyThe study of the effects of chemical (toxicants), biological (disease), and physical agents (accidents, radiation) on the health of human populationsStudies large groups of people and investigate range of causes and types of disease and injuries
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Environmental Health HazardsToxicityAcuteImmediate (short-term) effects after a single exposure; dizziness, nausea, deathChronicProlonged effects, to long-term exposure to toxicant
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Environmental Health HazardsDisease-Causing Agents in the EnvironmentPathogens: disease-causing org ...
This document discusses teratogens and endocrine disruptors. It defines teratogens as agents that can permanently alter development, giving examples like thalidomide and rubella virus. Endocrine disruptors are chemicals that interfere with hormone signaling and include many pesticides, plastics, and pharmaceuticals. These chemicals are linked to developmental abnormalities, reproductive issues, cancer risks, and other health impacts due to their effects on hormone receptors and hormone levels during development. While natural hormones have always been present, the abundance of synthetic endocrine disruptors is posing new challenges to human health and physiology.
This document provides an outline of key topics in environmental health and toxicology, including:
1) Infectious diseases, antibiotic resistance, and toxicology are discussed as major factors impacting human health and disease burden globally.
2) Toxins like heavy metals, pesticides, and chemicals can have acute and chronic effects depending on dosage, and their movement and persistence in the environment vary.
3) Risk assessment of toxins involves measuring toxicity, understanding dose responses, and evaluating exposure levels to estimate health risks and set regulatory standards.
Snackificación es el fenómeno que transforma parte de la comida tradicional en formato snack generando nuevas oportunidades de mercado.
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New Sustaineble, funcionalized, and competitive PHB material based in fruit by-products getting advanced solutions for packaging and non-packaging applications.
PHBottle proyect aims to produce a new packaging for fruite juice , wich is biodegradable and has antioxidant properties; a packaging made from sugar and other residues rich in carbon, nitrogen and oxygen present en wastewater from the fruit juice industry. The projet has applied the lastest advances in microencapsulation, biotecnology and packaging technologies
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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2. Content
Authors:
Dr. Michael Held, Dr. Andreas Tacke (Hannover Re)
Prof. Dr. Ina Ebert, Marcel Koos (Munich Re)
Dr. Sandra Burmeier, Dr. Reto Schneider (Swiss Re)
Dr. Florian Hiller (Zurich)
Editor:
Dr. Michael Held (Hannover Re)
Grateful acknowledgment to all CRO Forum Emerging Risk Initiative member companies
for their comments and revisions. We are heavily indebted to Stephen Lawson for his ongoing language support.
Title picture: fotolia
Some pesticides widely used in agriculture are potential endocrine disruptors
1 Executive Summary 3
2 Introduction 4
2.1 Background, History 4
2.2 Hormones and Endocrine System 4
2.3 Types of EDC 6
2.4 Sources of EDC 7
2.4.1 Pharma 8
2.4.2 Consumer Goods 8
2.4.3 Food Beverage 9
2.4.4 AgrICULTURE 9
3 Potential Impacts of EDC 10
3.1 Environment 10
3.2 Human Health 11
4 Removal of EDC from the hydrological cycle 12
4.1 Measures at the source 12
4.2 Removal of EDC during waste water treatment 12
4.3 Removal of EDC from drinking water 14
5 Regulation 15
5.1 EU 15
5.2 US 15
5.3 Rest of the world (ROW) 16
6 EDC and Insurance 17
6.1 Current situation 17
6.2 Claims and litigation 17
6.3 Insurance Loss Scenarios 18
6.3.1 Product Liability / Product Recall 18
6.3.2 Environmental Liability 18
6.3.3 Workmen’s Compensation / Employers Liability 18
6.3.4 DIRECTORS OFFICERS 18
6.3.5 Life Health Insurance 18
7 Conclusion 19
8 References 20
9 Abbrevations 21
3. 3CRObriefing on Endocrine Disruptors
1 Executive Summary
Human and animal life is widely exposed to many artificial substances that interfere with the sensitively
constructed hormonal system. Substances that interfere with hormones are called Endocrine Disrupting
compounds/chemicals (EDC). Harmful effects on fish and amphibian have been proven. Evidence is mounting
that specific substances are connected to human bodily injuries. Liability insurers may therefore be exposed
from affected industries as policies do not exclude these risks.
Many processes in the human and animal body are controlled by hormones. Among such processes are
metabolism, sexual development, reproductive functions, immunity, sleep-wake-cycle, growth, stress-response
and mood regulation. Some of these hormones have slow but long-lasting effects.
EDC can be natural products such as genistein from soy or zearalenone from fungus. Of concern are man-made
chemicals, which are produced and dispersed in large quantities. Some of these reach the human body via direct
food contact; others are stable enough to enter it through the food-chain.
Environmental research and lab- data suggest a high susceptibility of fish and amphibians to the amounts of EDC
stemming from agricultural use, combustion, sewage and smokestacks.
Singular events have spilt large quantities of EDC accidently into the environment (e. g. Dioxin in the Seveso
accident or Corexit after the Deepwater Horizon oil-spill). Dramatic effects of EDC may be observed in humans
after such high level exposure. A direct link between human health problems and chronic low-dose EDC intake
has not yet been established. But concerns regarding the effect on sexual differentiation in fish or amphibians as
well as impaired survival of affected offspring led to precautionary measures. Use of some substances has been
limited if not totally phased out.
Regulation differs among the diverse legal environments. Some specific agreements that require phase-out of the
most problematic substances have been signed across borders.
Liability exposures arise from environmental pollution and have led to successful claims for clean-up costs. The
highest risk for the insurance industry emerges from the probable link between low-level EDC exposure and
bodily injury. Taking into account the environmental stability, the long term exposure and the late disease onset,
bodily injury claims could result.
Beside this casualty catastrophy scenario for all liability insurers, there already exist large settlements for clean-up
costs or upgrades of water-treatment facilities to remove EDC from drinking water. For the risk management of
liability insurers it is crucial to monitor this emerging risk. A greater clarity regarding the associated costs has to
be achieved.
This paper gives a brief introduction to the risk and aims at increasing awareness. A dialogue should be started
taking into account risk-mitigation strategies and the involvement of all stakeholders. We recommend to minimise
the use and release of EDC and we encourage the removal of EDC/micropollutants from waste water and drinking
water taking into account individual circumstances.
Corexit spraying aircraft at the Deepwater Horizon site Picture: fotolia
4. 4
Manufacturing operations, product use and waste disposal derived from industrial activities lead to many
exposures to potentially hazardous materials. Identifying and quantifying risks related to such exposures is of
crucial importance to the insurance industry. If causal links between exposure to certain products and adverse
health or environmental effects are clearly established, manufacturers and consequently insurance companies
can be heavily impacted. This is of special concern in the case where products are on the market for a long time,
various exposure routes to these products exist and there is a lag between exposure and manifestation of
potential adverse effects.
2.1 Background, History
First evidence suggesting that some chemicals could impact processes regulated by hormones was gathered
from observations of adverse health effects following exposures of individuals to high concentrations of certain
substances (see boxes).
The DES case
From the 1940s to the 1970s, pregnant women were treated with the synthetic hormone diethyl stilbestrol (DES)
against miscarriage. As a consequence of in utero exposure to this active pharmaceutical ingredient, offspring
were shown to have an increased risk to develop certain forms of tumors or prostatic diseases later on in life. This
was attributed to the impact of DES on fetal development, a highly sensitive phase in life in which hormonal
activity plays a key role. DES was then banned in the 1970s.
The Seveso catastrophe
In 1976, a chemical plant explosion in Seveso, Italy released high amounts of dioxins to the environment. As a
consequence of the exposure to these environmental pollutants, several health disorders in individuals were
observed. Amongst others, impacts to semen quality as well as to hormonal levels were later on related to
potential endocrine disrupting properties of dioxins.
In the following years, increased efforts were made to investigate the potential endocrine disrupting properties
of chemicals. Research work focused on understanding the mechanisms of endocrine disruption and on
establishing causal links between exposure to certain chemicals and the increased incidence of several serious
human health disorders as well as adverse effects observed in the environment. (Reference 1; Reference 2)
2.2 Hormones and Endocrine System
Hormones (derived from ancient Greek “horman” = to set into motion) are specialised chemical substances
produced naturally in organisms. They are biologically highly active, even in very low concentrations and are
essential for the regulation of many important physiological processes and bodily functions.
2 Introduction
5. 5CRObriefing on Endocrine Disruptors
Examples for processes and bodily functions regulated by hormonal activity:
• Metabolism
• Sexual development and reproductive functions
• Menstruation
• Mood regulation
• Immunity
• Sleep-wake cycle
• Growth
• Response to stress
Hormones are produced in specialised cells and tissues of the body. Under control of the nervous system, they
are secreted into the blood or other body fluids before being transported to their final targets, where they trigger
physiological reactions by binding to specific receptors. Following this action, they can be deactivated by various
biochemical modifications or secretion.
A well-known example, adrenalin, is a stress hormone produced in the adrenal gland. In stressful situations, it is
secreted to the blood stream and reaches blood vessels and the heart amongst others as targets, where it binds
to adreno-receptors triggering increased heart rate, elevated blood pressure and release of energy reserves as
physiological reactions preparing the body for a “fight-or-flight” response.
The system of specialsed glands, cells, tissues and receptors regulating complex bodily functions by the use of
hormones is called the Endocrine System.
The Endocrine System
Hormone releasing glands in the human body Picture: fotolia
6. 6
2.3 Types of EDC
EDC are exogenous substances which upon exposure can disturb the hormonal activities of the organism leading
to adverse health effects. In general, EDC can act by:
• Mimicking natural hormones by binding to their receptors triggering physiological reactions at abnormal times
or amplifying the activity of natural hormones (agonistic effect),
• Blocking hormone receptors preventing the binding of natural hormones consequently leading to a reduction
in their activities (antagonistic effect),
• Indirectly affecting biosynthesis, transport or deactivation of natural hormones (agonistic or antagonistic
effects).
All these modes of actions disturbing the hormonal system can lead to abnormalities and health disorders. In this
regard, exposure during highly sensitive phases of the life cycle (e. g. fetal development and childhood) is of the
highest concern.
Currently, several hundred chemicals are known to show hormonal activity. They are of very heterogeneous types
and origin.
Besides man-made sources, several natural products such as soy beans and linseed contain substances
showing hormonal activities. In general, they are less potent than man made disruptors. However, evaluation of
their potential for endocrine disruption has to take into consideration the consequences from their exposure due
to their extensive use in foodstuffs. (Reference 3)
Targets of endocrine disruptors
Hypothalamic Cells
(Releasing Hormones)
Disruption of
• Synthesis
• Release
Target Organ Cell
• Receptor
• Signalling
• Synthesis
Hypophysis Cell
(Stimulating Hormones)
Disruption of
• Receptor binding
• Receptor effect
• Second messenger
• Cell-metabolism
• Synthesis
• Release
Effector Gland Cell
Disruption of
• Receptor binding
• Receptor effect
• Second messenger
• Cell-metabolism
• Synthesis
• Release
Transport to target glands
• Disturbed binding
kinetics
• Cleavage
• Disrupted metabolic
decay
Feedback impaired
• Receptor
• Transport
• Second messenger
• etc.
Transport to Hypophysis
• Disturbed binding kinetics
to blood-proteins
• Cleavage
Release impaired
• Binding to blood-transport
protein
• Metabolism and excretion
Disruption in steroid
hormone function
7. 7CRObriefing on Endocrine Disruptors
EDC exposure during fetal development is of high concern Picture: fotolia
2.4 Sources of EDC
Special focus has been put on other man made chemicals, with unintentional hormone-like activity. These
chemicals have been used for decades and were spread widely. Some of them are still in use:
• Pesticides such as DDT, vinclozolin, endosulfan, toxaphene, dieldrin, atrazine
• Industrial chemicals and by-products, such as polychlorinated biphenyls (PCBs), dioxins, bisphenol A and
other phenols. Some of these phenols are breakdown products of surfactants, found in soaps and detergents.
• Also implicated are heavy metals, plastics, cosmetics, textiles, paints, lubricants. Sewage treatment effluent
may contain a variety of natural and man made endocrine disruptors, including natural hormones from animal
and human waste.
• Most of these substances have oestrogenic activity and environmental studies usually focus on the
observation of effects of such activity. Nevertheless there are substances with similarities to the thyroid
hormones which interfere with the thyroid metabolism and that can severely affect the thyroid control-loop.
Some of them are widely used even in consumer products. Examples are:
– Perchlorate (ClO4 − formerly used to treat hyperthyroidism, now used as an oxidiser in rocket fuel and
explosives.) It can be found in airbags and fireworks and is increasingly contaminating the global surface.
– Nutritive components from plants, such as C-and O-glycosidic glucosinolates (cruciferacea), cyanates,
isocyanates and thiocyanates (e. g. cassava), which (irreversibly) inhibit thyroperoxidase (TPO), leading to
goitre formation in susceptible individuals.
– Several flavonoids and isoflavonoids, widely used as “green” “natural plant steroids” in postmenopausal
hormone replacement therapy such as genistein
– UV screens (e. g. benzophenone 2) regularly applied as sun protectants to prevent erythema, sun burns and
skin cancer are potent TPO inhibitors and lead to goitre formation if the iodine supply is inadequate as is the
case in many parts of the world.
– Most natural compounds capable of modulating hormonal function are biodegradable and do not
accumulate. Known artificial endocrine disruptors, their use, diffusion, stability and geographical extension
make them prone to being accused of causing many different effects.
8. 8
2.4.1 Pharma
Besides exposure to pharmaceutical doses of EDC (e. g. contraception) there are vaccine-additives, dental
sealants or haemodialysis materials with alleged EDC-properties.
In terms of quantity, (contraceptive-) hormone pills present the highest environmental exposure. Active hormones
are found in large quantities in human urine. For sewage treatment contraceptives appear to be problematic. So
far it is unresolved whether contraceptives are still active after sewage treatment.
2.4.2 Consumer Goods
In recent years the Bisphenol-A (BPA) level in blood and urine samples and its potential EDC-effects has caught
attention. BPA is used in many polymer products and can be found in baby-bottles, pacifiers, food-can linings
and other food containers, thermo-printer paper (e. g. cashier receipt) and cigarette smoke. Consumer awareness
has led to a phase-out of baby-bottles made from polycarbonate- (BPA-containing) materials.
Polyfluorinated chemicals (PFC) have unique properties as repellents of dirt, water and oils. They are increasingly
used as surfactants in various industry- and consumer products. PFC are very active in the environment, some
are global pollutants of air, water, soil and wildlife, and found even in remote polar areas. Bioaccumulation occurs
in humans, traces are found in blood, internal organs and testes. Some of these PFC, such as PFOS and PFOA,
are potential developmental toxicants and are suspected endocrine disruptors with effects on sex hormone levels
resulting in lower testosterone levels and higher oestradiol levels.
The industrial production of PFOS and its derivatives stopped in 2000, and the European Union has banned most
uses from the summer of 2008. However, hundreds of related chemicals (e. g. homologues with shorter or longer
alkyl chains) are not being regulated (Reference 4; Reference 5).
Contraceptives appear as active EDC in sewage
Beverage and food may contain EDC leaking from polymer bottles or linings
Picture: fotolia
Picture: fotolia
9. 9CRObriefing on Endocrine Disruptors
2.4.3 Food Beverage
Natural compounds in plants represent the highest amounts of EDC from food-sources (phyto-oestrogens).
Genistein for example is present in soy products in quantities that prompted regulatory bodies to impose
warnings on soy-milk products. However, a high intake of phyto-oestrogens is linked with a higher life-expectancy
and a lower risk of cardiovascular diseases and prostate pathology.
Besides the natural sources of EDC in food, many man-made substances can be found in food and water at least
in traces. Alleged sources are pesticides from agriculture, cleaning-chemicals (e. g. soaps) from food production,
chemicals from food containers and micro-contaminants from general pollution including dioxin-accumulation via
the food chain in animal products.
There are still some pesticides found in food, which are heavily used in parts of the world and heavily restricted or
forbidden in other parts.
The question, whether or why high amounts of phyto-oestrogens do not harm and why or whether the traces of
artificial EDC do harm still remains unanswered.
2.4.4 AgrICULTURE
Some widely used pesticides are potential EDC. Well known to the public is DDT, a very stable substance that
develops in the environment, particularly in cold areas. Substantial parts of EDC found in food enter the food-
chain from general pollution. Dioxins are mainly unintentional by-products from combustion, found in dairy, eggs
and meat. Other substances have been phased out as a result of several supranational agreements such as the
Stockholm Agreement on persistent organic pollutants (POPs). However, due to their chemical stability they are
still present in soil, water and air.
Animal fat contains significant amounts of EDC Picture: fotolia
10. 10
3 Potential Impacts of EDC
The widespread manufacturing and use of substances with potential endocrine disrupting properties lead to
many exposure routes, in some cases supported by the special properties of these substances: some EDC are
very stable and are not degraded in the environment. Therefore, if released from any sources to soil, air or water,
they lead to long term exposures and furthermore spread unchanged into environments with air and water
streams that are remote from any human activity.
In addition, several EDC can accumulate in adipose tissues of humans and animals. As a consequence they
enter the food chain and finally accumulate in humans where they cause persistent low level exposures.
Consequently, EDC can today be detected virtually in all human individuals as well as everywhere in the
environment.
3.1 Environment
Evidence for potential endocrine disrupting properties of certain substances was mainly obtained from
observations of reproductive disorders in animals.
Feminization of alligators
During heavy rainfalls in 1980, a waste water pond of a pesticide manufacturer in Lake County/FL/USA
overflowed and waste water contaminated with a mixture of pesticides and other chemicals discharged into the
nearby Lake Apopka. Exposure of alligators in the lake to these chemicals was later on related to a population
decrease of about 90%. It was suggested that the hormonal (oestrogenic) effect of the contaminants caused
feminization of male alligators leading to infertility.
Furthermore, malformations, an increased mortality of offspring, retarded growth and changes to immune system
have been observed and associated with EDC.
Some of these disorders followed sudden exposures of species to high concentration levels of contaminants,
whereas others were linked to a longer exposure to lower levels.
Today the causal link between EDC, dysfunction of the hormone system and subsequent health impacts has
been established for animals (Reference 6).
Dioxins climb the food-chain through fat-deposits Picture: fotolia
11. 11CRObriefing on Endocrine Disruptors
3.2 Human Health
The evaluation of the potential impacts of EDC on human health is more complicated.
Health disorders suggested to be related to EDC amongst human are:
• Breast and ovary cancer,
• Testes and prostate cancer,
• Genital malformations,
• Retarded sexual development,
• Declining sperm count,
• Obesity,
• Neurological disorders such as retarded development of memory and intelligence.
Establishing a clear relationship between EDC and human health disorders has been so far very difficult. Insights
into the effects of EDC have been gained mainly from in vitro and in vivo models and epidemiological studies.
However, the validity of these approaches is limited. In addition, research work is complicated due to the highly
complex biochemical mechanisms of endocrine disruption and often due to a considerable latency of their action:
there can be a lag of years between time of exposure (e. g. during fetal development) and manifestation of
adverse health effects (e. g. retarded sexual development during puberty) making the evaluation of type and
extent of exposure almost impossible. The lag can even increase to decades for the cases, where EDC are
suspected to affect subsequent generations of exposed individuals.
Due to the ubiquity of EDC and the diversity of environmental contaminants, people are typically exposed for a
long period to varying mixtures of EDC and other chemicals. Even if individual EDC activities are considered too
low to disturb the hormonal system, long term exposures to mixtures of several contaminants could be critical
due to additive or synergistic effects. Generally, the possible consequences of such multiple long term exposures
have not yet been sufficiently understood.
Beside single cases of health impacts following sudden exposure to high concentrations of EDC (e. g. dioxins), no
clear relationship has been established yet between EDC and human health disorders. However, in view of their
potential effects on human health, their widespread use and ubiquity as environmental contaminants, EDC are
still considered to have a significant hazard potential.
It has to be expected that research efforts will increase to get more insight into the adverse effects of EDC on
human health (Reference 7).
Breast cancer is considered to be one of the possible consequences on EDC impact Picture: fotolia
12. 12
4 Removal of EDC from the hydrological cycle
Measures at various levels are necessary to prevent EDC and other organic micropollutants (OMP) from entering
the hydrological cycle and/or to remove them again. This includes measures at the source as well as measures to
remove EDC during waste water treatment and drinking water purification.
4.1 Measures at the source
Measures at the source seek to prevent micropollutants from entering the hydrological cycle in the first place by
reducing their sale, use and disposal. This includes
• Regulatory measures, e. g. strict approval and/or registration processes for potentially polluting substances
as well as prohibition or restriction measures for certain substances;
• Incentive systems, e. g. encouraging farmers not to use plant protection agents in the immediate vicinity of
surface waters;
• Intelligent product design, e. g. washing machines using less washing detergent;
• Measures to influence consumer behaviour, e. g. targeted information campaigns, deposit systems for
certain products or adjusted disposal pathways;
• Technical measures, e. g. separation and direct disposal of highly contaminated water and/or specific pre-
cleanings to reduce the pollutant freight produced by individual large emitters.
4.2 Removal of EDC during waste water treatment
Since the majority of EDC enter the aquatic environment through a waste water treatment plant (WWTP), it is
appropriate to reduce them at this level. Today’s municipal WWTP generally feature three stages to remove solids,
degradable organic substances and nutrients. As many micropollutants are not biodegradable and are not
absorbed easily into sewage sludge, an additional fourth cleaning stage needs to be established to remove them
during the waste water treatment process.
There are several advanced treatment technologies available for removing EDC from waste water, but not all of
them are economically feasible. The two most promising processes are ozonation and powdered activated
carbon absorption. These processes are already used in drinking water treatment (see below) and industrial
waste water treatment and have the potential for a broader application in municipal waste water treatment (see
Switzerland case study).
Powdered activated carbon (PAC) is a very finely ground activated carbon. It is mixed with the waste water
so that the effluent ingredients can be deposited on the surface of the carbon particles. When loaded with
micropollutants, the PAC has to be separated from the purified waste water and needs to be disposed of. This
can be achieved by means of sedimentation followed by cloth filtration, sand filtration, or membrane-based
ultrafiltration and subsequent incineration along with the sludge.
To ensure water-purity is challenging when it comes to EDC and micropollutants Picture: fotolia
13. 13CRObriefing on Endocrine Disruptors
In the ozonation process, gaseous ozone is added to treated waste water. The dissolved ozone reacts with the
micropollutants and transforms them. It is generally easy to integrate and operate an ozonation stage at an
existing WWTP. Due to the process-related formation of reactive transformation products, it is recommended to
install a stage with biological activity (e. g. sand filter) after ozonation of the wastewater so that these products
can fully biodegrade in the WWTP.
Case study: “Project MicroPoll” – Upgrading sewage treatment plants in Switzerland
In the “MicroPoll” strategy project (2006-2011), the Swiss Federal Office for the Environment (FOEN) has tested
ozonation and powdered activated carbon (PAC) treatment in pilot trials at two Swiss waste water treatment
plants. The results show that it is both technically and economically feasible to remove EDC and other organic
trace substances from municipal wastewater.
The average elimination of organic trace substances was above 80% for both processes. Additional energy
consumption for micropollutant removal was estimated to be 5-30%, and additional total costs were estimated to
be 5-30% (depending on the size of the treatment plant). These costs are considered acceptable given the
additional purification effect of the tested measures. Both ozonation and PAC facilities can be installed relatively
easily in existing plants.
Switzerland now plans to upgrade around 100 of its more than 700 municipal waste water treatment plants
(WWTP) with either of the tested measures. Which measure will be most suitable for upgrading a specific sewage
treatment plants depends on local circumstances and must be determined on a case-by-case basis.
To maximise the effect of the upgrade measures while keeping costs low, a risk-based approach is used for
selecting the WWTP to be upgraded. Priority is given to
• Large WWTP,
• WWTP on watercourses with a high wastewater percentage, and
• WWTP in the catchment area of lakes.
By upgrading the selected plants, around 50% of Swiss waste water will undergo additional treatment. It is
estimated that the measures will result in additional annual waste water treatment costs of around CHF 130 million
(CHF 17 per capita).
To remove EDC and micropollutants WWTP might need upgrades at additional costs Picture: Eawag Switzerland
14. 14
4.3 Removal of EDC from drinking water
As drinking water is possibly the most important source of human body exposure to EDC, there is already a good
awareness of the need for removal of EDC in drinking water. In addition, the removal at the source and in sewage
plants will never be perfect, which means that further cleaning of drinking water will remain necessary. Last but
not least, the levels of EDC or pollutants accepted in drinking water will always be lower than those accepted in
cleaned water discharged into rivers or other water streams.
The removal processes for EDC are not selective, which means these processes are not removing simply EDC,
but equally other micropollutants and even other chemicals or substances. The advantage is that they have been
used already for quite some time to remove other substances, but have the problem that they do not remove all
pollutants.
The process currently used for the removal of EDC and other OMP is activated-carbon filtering (ACF). This
process has already been utilised for a very long time, mainly in areas where the water sources being the raw
material for the production of drinking water were polluted (for example in Germany along the Rhine river). The
removal of the pollutants is based on an adsorption process. The problem is that not all EDC are removed
through this process. For some EDC the removal rates are close to 100%, but some OMP are hardly removed at
all. These are mostly very polar substances, but there are equally chemicals, where it is unclear, why they cannot
be removed by ACF. A further problem is that the concentration of pollutants in the water is very low and large
quantities of water need to be treated. Both are difficult factors for adsorption processes. Nevertheless there are
ongoing efforts to improve these processes mainly by modification of the characteristics of the used activated-
carbon to be able to remove substances that are currently difficult to retain. The cost of this process is relatively
low. It is clear that these costs may vary depending on the nature and extent of the pollution, but in general the
costs are roughly 5 to 10 Cents/m³ water treated. This means for example for Germany, where the mean cost of
drinking water is €1.90/m³ water the increased costs for further treatment of polluted water would be roughly 5%.
As explained before this additional treatment is nowadays already necessary in various cases to remove
substances other than EDC.
Other processes used for the removal of EDC and other OMP are nanofiltration (NF), microfiltration (MF),
ultrafiltration (UF) and reverse osmosis (RO). The problem with these processes is that they remove – depending
on the way they are used – far more substances from the water than ACF, changing therefore the chemistry of the
water, which is not desired. In addition these processes are more expensive than ACF. There is a lot of research
going on in this area, but most of the installations are still in a research stage regarding the removal of EDC and
other OMP, but are standard for other applications (for example desalination). The solution of the problem of
removing EDC might equally be a combination of ACF and filtration processes possibly including other water
treatment processes as well.
As a conclusion it can be said that there are processes available to remove EDC from water to get potable water.
At the moment these processes do not operate perfectly and not all EDC can be removed. Nevertheless research
is going on to improve removal rates and performance by improving single processes or by combining several
techniques. The costs involved are currently acceptable, but depending on the purity of water that needs to be
achieved in the future, these costs may well rise.
15. 15CRObriefing on Endocrine Disruptors
As there is still a lot of uncertainty in regard to the existence and extent of adverse health effects caused by
endocrine disruptors, the focus of regulation has usually been on testing, screening and monitoring chemicals
containing these substances. Another major objective of regulation is preventing or limiting the use of such
chemicals, especially with regard to products mainly used by children, such as baby-bottles or infant plastic toys.
5.1 EU
The EU has been exploring the necessity for improvement in the legislative framework in regard to endocrine
disruptors since 1998. A Community Strategy for Endocrine Disruptors (COM 1999, 706) was agreed in 1999 and
four reports on the implementation of this strategy have since been published (the last one in 2011, SEC 2011,
1001). Since 2007 Regulation (EC) No. 1907/2006 (REACH) has been regulating the registration, evaluation and
authorization of chemicals within the EU. The regulation introduced a complex authorisation process for
substances of very high concern, including endocrine disruptors in general. However at the end of 2012
Octylphenol was the only endocrine disruptor, which was on the candidate list of substances of very high
concern. As a result of the authorisation process the use of the substance can be restricted or even phased out.
With regard to liability for the use of substances containing endocrine disruptors, national tort law and strict
liability regulation remain the basis for action.
Regulation (EC) No. 1907/2006 (18 December 2006)
Art. 138 Review
7. By 1 June 2013 the Commission shall carry out a review to assess whether or not, taking into account latest
developments in scientific knowledge, to extend the scope of Article 60(3) to substances identified under Article
57(f) as having endocrine disrupting properties. On the basis of that review the Commission may, if appropriate,
present legislative proposals.
5.2 US
Due to the broad range of products containing (putative) endocrine disruptors, an equally broad range of
regulation is covering these issues. Based on the Food Quality Protection Act and the Safe Drinking Water Act of
1996 the US Environmental Protection Agency (EPA) has initiated the Endocrine Disruptor Screening Program
(EDSP), aimed at screening and testing chemicals for their impact on human health, fish and wildlife, in 1998. The
US Food and Drug Administration (FDA) is also monitoring (putative) endocrine disruptors and providing
information on their effects, e. g. through the Endocrine Disruptor Knowledge Base (EDKB). In 2010 the FDA
voiced “some concern” about the potential effects of bisphenol-A (BPA) and has since supported stricter regu-
lation of products containing BPA.
Among other federal laws that might be relevant for the use of and liability for endocrine disruptors are the Toxic
Substances Control Act, the Clean Water Act, the Clean Air Act, the Federal Hazardous Substances Act and the
Food, Drug and Cosmetic Act. State legislators have also been very active in regard to regulating endocrine
disruptors recently. Typical examples for such activities are the BPA-Free Kids Act (New York), the Ban Poisonous
Additives Act (Massachusetts) and the Children´s Chemical Risk Reduction Act (Oregon). Similar laws have been
proposed in other US states, most primarily trying to ban BPA from being used in infant-related products.
5 Regulation
16. 16
Bisphenol A-Free Children and Babies Act of New York (2010)
§ 37-0505. Child care products.
1. Beginning December first, two thousand ten, no person, firm, partnership, association, limited liability company
or corporation shall sell or offer for sale any child care product intended for use by a child three years of age or
younger containing bisphenol A.
2. The provisions of this section shall not apply to the sale or distribution of child care products resold or offered
for resale, or distributed by consumers for consumer use.
5.3 Rest of the world (ROW)
Movements to ban the use of BPA in regard to baby-bottles and similar infant products are also active in other
parts of the world. Most notably so in Canada, where the government has declared BPA a toxic substance in
2010.
Japan has developed Strategic Programs on Environmental Endocrine Disruptors ‘98 (SPEED ‘98). Through these
programs scientific studies will be carried out to assess the risks and adopt effective counter measures to tackle
the issue. Environmental risk assessment and risk management are carried out, and research, screening and
testing methods have been developed.
Bisphenole A in child care products prompted legislation in various states Picture: iStockphoto
17. 17CRObriefing on Endocrine Disruptors
6.1 Current situation
Today there is no EDC exclusion in product liability policies. If a causal link between personal bodily injury and
the intake of EDC from consumer products would be proven without doubt some day, a defending producer
would refer to his/her ordinary product liability insurance.
6.2 Claims and litigation
BPA
Especially in the US, claims for a variety of adverse health effects, ranging from cancer to reproductive or
developmental abnormalities and from mental illness to obesity, have been based on the exposure to products
containing endocrine disruptors. Most of this litigation is focused either on polychlorinated biphenyls (PCB) or,
more recently, on bisphenol-A (BPA). While some of the PCB-lawsuits led to high settlements, all, like the
aforementioned BPA-claims, involve numerous legal controversies. Among them are causation aspects (in regard
to medical, general and specific causation) and the evidence standards applicable for scientific experts in court.
As far as plaintiffs did not suffer any personal injury, as in most consumer fraud lawsuits, establishing legal
standing was difficult.
Atrazine
Atrazine is seen as an EDC. Since 2004 it is a subject of litigation on both the federal and state levels of US
courts. The plaintiffs claim that exposure to atrazine at any level is harmful to human health. The lawsuits seek
class-action remedies, financial penalties and payment for water filtration based on their water being harmful to
human health. A recent settlement awarded 105 million USD for the upgrade of water-treatment facilities
(Reference 8).
Corexit
In 2010, Corexit was used in large quantities in the Deepwater Horizon oil spill. The first analysis of the 57
chemicals found in Corexit formulas 9500 and 9527 showed that the dispersant could contain cancer-causing
agents, hazardous toxins and endocrine disrupting chemicals. Part of the massive multidistrict litigation for the oil
spill involves claims by those who have allegedly suffered injuries from exposure to Corexit. The defendants are
BP, Transocean, Halliburton, Cameron International, Nalco – the manufacturer of the dispersant Corexit – and
numerous others (Reference 9).
6 EDC and Insurance
18. 18
6.3 Insurance Loss Scenarios
6.3.1 Product Liability / Product Recall
One scenario could be an established link between plastic by-products in food containers and breast-cancer.
Such proof would allow virtually anybody with breast cancer to claim compensation from food-packers. Should a
scientific proof indicating causality between EDC contamination and bodily injury be established, many actual
product liability-policies of food-packers could be triggered.
6.3.2 Environmental Liability
EDC originating from production processes as well as from agricultural use have been found worldwide in soil,
surface- and groundwater. A proven link between EDC pollution and bodily injury would increase the pressure on
water supply works to refine the treatment for the removal of EDC. The costs of refined treatment can be claimed
from the main and/or identifiable polluters such as the agricultural industry.
6.3.3 Workmen’s Compensation / Employers Liability
Exposure of workers to EDC happens in the production process (chemical industry and manufacturing) as well as
in all sorts of business processes using chemicals (e. g. agriculture, food-storage and -processing).
6.3.4 Directors Officers
If management fails to take preventive measures in order to avoid damages caused by exposure to EDC, the
employees, public authorities or shareholders might start litigation against directors or officers.
Some developments in pharmaceutical liability led to shareholder action against the boards of pharmaceutical
companies in the US. It could well be that shareholders take class action against board-members for insufficient
control of endocrine disruptor claims, false statements and delayed phase-out of dangerous products
(Reference 10).
6.3.5 Life Health Insurance
Further unlimited exposure of consumers in many countries poses a substantial risk of shortening life
expectancies due to a rise in endocrine tumors and other EDC related health problems. Moreover EDC have
epigenetic effects that cause health impairments in first and/or second generation offspring of exposed subjects.
Effects of distorted sex ratios on life-expectancy and health-problems are as yet difficult to estimate. A negative
effect is most probable for cancer incidence. A rising cancer incidence would interfere with health insurance
calculations and affect life insurer’s balance-sheet.
Sophisticated analytic chemical methods may lead to more liability Picture: fotolia
19. 19CRObriefing on Endocrine Disruptors
EDC are a truely emerging risk. There is strong evidence for negative effects on animal organisms and mounting
evidence for effects on human health. A direct proof of human health problems and EDC-pollution has not yet
been established. However results from animal experiments can – to a certain degree – be extrapolated. The
widespread use and the severe negative and long-term harm to life should keep awareness high. Regulation and
e. g. liability for clean-water serve as an example for the precautions that could help to minimise the risk.
Meanwhile the production and release of new EDC is increasing, therefore environmental and human exposure is
not declining.
Environmental liability will lead to an increase in legal actions. Claimants are from a very broad array of potentially
jeopardised groups such as waterworks, farmers, house-owners, tourism/natural reservation agencies, fisheries
etc. Under US-jurisdiction these claims have increased defence costs. When a causal relationship between
human hazard and the discharge of EDC has been established, virtually all lines of liability insurance could be
affected, with amplified impacts on product liability.
Insurers could start to mitigate such exposures by instituting a dialogue with EDC producing industries.
Regulators and suppliers should be supported in their efforts to limit exposure.
We recommend to minimise the use and release of EDC and we encourage the removal of EDC/micropollutants
from waste water and drinking water taking into account individual circumstances.
7 Conclusion
Ubiquitous EDC in modern life require careful consideration of exposure-limiting measures Picture: fotolia
20. 20
8 References
Reference 1: A. L. Herbst, H. Ulfelder, D. C. Poskanzer, N Engl J Med 284 (1971), 878 – 881. (DES Case).
Reference 2: P. Mocarelli et al., Environ Health Perspect 116 (2008), 70 – 77. (Dioxins).
Reference 3: http://www.dailytelegraph.com.au/news/soy-cancer-warning/story-e6frewt0-1111112826510.
Reference 4: Int J Androl. 2008 Apr;31(2):161-9. Emerging endocrine disrupters: perfluoroalkylated substances.
Jensen AA, Leffers H.
Reference 5: La Rocca C, Alessi E, Bergamasco B, Caserta D, Ciardo F, Fanello E, Focardi S, Guerranti C,
Stecca L, Moscarini M, Perra G, Tait S, Zaghi C, Mantovani A.: Int J Hyg Environ Health. 2012
Feb;215(2):206-11. Epub 2011 Dec 23
Reference 6: J. C. Semenza et al., Environ Health Perspect 105/10 (1997), 1030 – 1032 and literature cited
herein. (Lake Apopka)
Reference 7: E. Diamanti-Kandarakis et al., Endocrine Reviews,30/4 (2009), 293 -342
Reference 8: http://atrazinesettlement.com/
Reference 9: http://www.nalco.com/documents/Annual-Reports/Nalco_2010_Annual_Report.pdf Page 36ff
Reference 10: FIDUCIARY GUIDE TO TOXIC CHEMICAL RISK: The Investor Environmental Health Network Rose
Foundation for Communities and the Environment, March 2007, Copies of this report may be
downloaded free from www.iehn.org or www.rosefdn.org
21. 21CRObriefing on Endocrine Disruptors
ACF Activated Carbon-Filtering
BPA Bisphenole A (chemical by-product and solvent)
COM Community Strategy for Endocrine Disruptors (EU)
DDT Very persistent organic Pesticide
DES Diethyl Stilbestrol (estrogen-like pharmaceutical)
EDC Endocrine Disrupting Compounds/Chemicals
EDKB Endocrine Disruptor Knowledge Base
EDSP Endocrine Disruptor Screening Program
EPA US Environmental Protection Agency
FDA US Food and Drug Administration
FOEN Swiss Federal Office for the Environment
MF Micro-filtration
NF Nano-filtration
OMP Organic Micro Pollutants
PAC Powdered Activated Carbon
PCB Polychlorinated Biphenyl (chemical solvent)
PFC Polyfluorinated Chemicals (chemicals used as surfactants)
PFOA Perfluoroctanoic Acid (e. g. industrial solvent for PTFE (Teflon, Gore-tex etc.) synthesis)
PFOS Polyfluorinated Organic Substance
POP Persistant Organic Pollutants (artificial substances regulated in specific treaties)
ROW Rest of the world
SPEED ’98 Strategic Programs on Environmental Endocrine Disruptors ’98;
Japanese Program to gather scientific evidence on EDC
TPO Thyro-Peroxidase (Enzyme in thyroid gland)
UF Ultra-filtration
WWTP Wastewater Treatment Plant
9 Abbrevations
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