Some chemicals, both natural and man-made, can interfere with the hormonal system. They are called 'endocrine disruptors’. The most controversial issue is whether low level exposures to such chemicals can have adverse effects. Have endocrine disruptors affected wild life and our hormonal system? How much do we know so far?
An Introduction to the Health Effects of Endocrine Disrupting Chemicals (EDCs)
by @toxipedia
* Toxipedia website;
http://www.toxipedia.org/display/toxipedia/Endocrine+Disruptors
* Endocrine Disruptors: Sexy Stuff:
http://desdaughter.wordpress.com/2012/12/16/endocrine-disruptors-sexy-stuff/
* All our posts about Endocrine Disruptors:
http://desdaughter.wordpress.com/tag/endocrine-disruptors/
Evaluation of the Toxicity of Dioxins & Dioxin Like PCBs - A Health Risk Appr...v2zq
Evaluation of the Toxicity of Dioxins & Dioxin Like PCBs - A Health Risk Appraisal - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
The American People's Dioxin Report - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~ chej.org
VCE Environmental Science - Unit 4: Pollution. The sources, sinks, human and environmental health effects of DDT and endocrine disruptors, including pthalates, are discussed in this presentation.
Some chemicals, both natural and man-made, can interfere with the hormonal system. They are called 'endocrine disruptors’. The most controversial issue is whether low level exposures to such chemicals can have adverse effects. Have endocrine disruptors affected wild life and our hormonal system? How much do we know so far?
An Introduction to the Health Effects of Endocrine Disrupting Chemicals (EDCs)
by @toxipedia
* Toxipedia website;
http://www.toxipedia.org/display/toxipedia/Endocrine+Disruptors
* Endocrine Disruptors: Sexy Stuff:
http://desdaughter.wordpress.com/2012/12/16/endocrine-disruptors-sexy-stuff/
* All our posts about Endocrine Disruptors:
http://desdaughter.wordpress.com/tag/endocrine-disruptors/
Evaluation of the Toxicity of Dioxins & Dioxin Like PCBs - A Health Risk Appr...v2zq
Evaluation of the Toxicity of Dioxins & Dioxin Like PCBs - A Health Risk Appraisal - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
The American People's Dioxin Report - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~ chej.org
VCE Environmental Science - Unit 4: Pollution. The sources, sinks, human and environmental health effects of DDT and endocrine disruptors, including pthalates, are discussed in this presentation.
What are Endocrine-disrupting chemicals (EDCs)?
What products contain endocrine disruptors?
How do endocrine disruptors work?(its Mechanisms of Action).
How are people exposed to endocrine disruptors?
Endocrine disrupting chemicals and their heath effects.
Pesticides:( DDT),human health consequences of exposure to DDT,and its scientific evidence and examples.
Steps to reduce exposure to endocrine disruptors
America's Choice - Children's Health or Corporate Profit v2zq
America's Choice - Children's Health or Corporate Profit - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
Endocrine Disruption and Immune DysfunctionDES Daughter
by the Collaborative on Health and the Environment
On this first in a series of calls on endocrine disrupting chemicals, Dr. Rodney Dietert discussed how the immune system is a target for endocrine disrupting chemicals, particularly during development. Numerous relatively ‘hidden’ effects can ensue from a single risk factor and emerge over a lifetime. He also discussed how current safety testing fails to appropriately assess misregulated inflammation as the greatest immune based health risk.
Sources: http://www.healthandenvironment.org/partnership_calls/13389
Endocrine disruptors, sometimes also referred to as hormonally active agents, endocrine-disrupting chemicals, or endocrine-disrupting compounds are chemicals that can interfere with endocrine (or hormonal) systems. These disruptions can cause cancerous tumors, birth defects, and other developmental disorders.
Dr. Walter Crinnion, one of the leading experts on environmental medicine and toxicology, shares his observations on the toxic burden we bear in modern society.
Endocrine Disruptors: Child healths
Vichit Supornsilchai, MD, PhD
Endocrine Unit, Department of Pediatric,
Faculty of Medicine,
King Chulalongkorn Memorial Hospital
Dioxins are mainly released by human activities such as incineration and fuel combustion. Some dioxins and some "dioxin-like" PCBs are known to be harmful.
In 2008, the facts presented here are still considered a valid reference. Since 1998, there have been no big changes in our scientific understanding of dioxins - other than to strengthen the conclusions that dioxins are bad actors. General dioxin levels have since continued to drop both in the environment and in people.
Household Hazards - Potential Hazards of Home Cleaning Products v2zq
Household Hazards - Potential Hazards of Home Cleaning Products - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
Sick of Dust - Chemicals in Common Products, A Needless Health Risk in Our Ho...v2zq
Sick of Dust - Chemicals in Common Products, A Needless Health Risk in Our Homes - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~ cleanproduction.org
Chemical Trespass - A Toxic Legacy - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
What are Endocrine-disrupting chemicals (EDCs)?
What products contain endocrine disruptors?
How do endocrine disruptors work?(its Mechanisms of Action).
How are people exposed to endocrine disruptors?
Endocrine disrupting chemicals and their heath effects.
Pesticides:( DDT),human health consequences of exposure to DDT,and its scientific evidence and examples.
Steps to reduce exposure to endocrine disruptors
America's Choice - Children's Health or Corporate Profit v2zq
America's Choice - Children's Health or Corporate Profit - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
Endocrine Disruption and Immune DysfunctionDES Daughter
by the Collaborative on Health and the Environment
On this first in a series of calls on endocrine disrupting chemicals, Dr. Rodney Dietert discussed how the immune system is a target for endocrine disrupting chemicals, particularly during development. Numerous relatively ‘hidden’ effects can ensue from a single risk factor and emerge over a lifetime. He also discussed how current safety testing fails to appropriately assess misregulated inflammation as the greatest immune based health risk.
Sources: http://www.healthandenvironment.org/partnership_calls/13389
Endocrine disruptors, sometimes also referred to as hormonally active agents, endocrine-disrupting chemicals, or endocrine-disrupting compounds are chemicals that can interfere with endocrine (or hormonal) systems. These disruptions can cause cancerous tumors, birth defects, and other developmental disorders.
Dr. Walter Crinnion, one of the leading experts on environmental medicine and toxicology, shares his observations on the toxic burden we bear in modern society.
Endocrine Disruptors: Child healths
Vichit Supornsilchai, MD, PhD
Endocrine Unit, Department of Pediatric,
Faculty of Medicine,
King Chulalongkorn Memorial Hospital
Dioxins are mainly released by human activities such as incineration and fuel combustion. Some dioxins and some "dioxin-like" PCBs are known to be harmful.
In 2008, the facts presented here are still considered a valid reference. Since 1998, there have been no big changes in our scientific understanding of dioxins - other than to strengthen the conclusions that dioxins are bad actors. General dioxin levels have since continued to drop both in the environment and in people.
Household Hazards - Potential Hazards of Home Cleaning Products v2zq
Household Hazards - Potential Hazards of Home Cleaning Products - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
Sick of Dust - Chemicals in Common Products, A Needless Health Risk in Our Ho...v2zq
Sick of Dust - Chemicals in Common Products, A Needless Health Risk in Our Homes - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~ cleanproduction.org
Chemical Trespass - A Toxic Legacy - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
Detoxification of the major organ systems of the body is ever increasingly important. Environment, genetics, nutritional status and lifestyle all play interacting roles that can influence one's quality of life. Learn how to safely detoxify using real food and basic nutrients with the Detox 360 Program. This is an introduction for informational purposes only and is not intended to diagnose or replace medical care.
Chemicals & our Health - 80,000 Chemicals on the Market with No Safety Testing v2zq
Chemicals & our Health - 80,000 Chemicals on the Market with No Safety Testing - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
Child Development & Environmental Toxins - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
Who this is for: Health professionals.
Description: Dr. Sheila Bushkin-Bedient will be speaking on the prenatal origins of disease and why we should be focusing on studying possible connections between unconventional natural gas extraction and diabetes, obesity, and cancer.
About the Speaker: Sheila Bushkin is a member of the Institute of Health and the Environment at the State University at Albany, and Concerned Health Professionals of New York. She has been a member of the Medical Society of the State of New York for 15 years. Her specific areas of interest involve environmental health issues, chronic diseases, health concerns of older adults, and CME for physicians.
This workshop will explore state-level Green Chemistry initiatives and chemicals policy reform efforts, which aim to protect public health and the ecosystems in the Great Lakes basin. Participants will learn how chemicals policy is an integral aspect of Great Lakes restoration, and how green chemistry fits into this discussion.
Contaminated without Consent - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
The Status of the Regulatory and Economic Landscape for Innovation in Big Pha...Lindsay Meyer
The purpose of engaging this topic is to: examine the current regulatory environment for new drugs, gain an understanding of breakthrough innovation in pharmaceuticals, evaluate the efforts of key players, and make projections about the future of this industry. As therapeutics has evolved away from their theistic origins, natural products, synthetic chemistry, and biopharmaceuticals have emerged. Yet many difficulties remain for this specialized industry. The approval process for a new drug can take upwards of eight years and cost $800 million. The progression from test tube to commercial distribution includes preclinical trials followed by three phases of clinical (human) trials, marked by ongoing dialogue between the Food and Drug Administration (“FDA”). Five of largest American pharmaceutical companies have intensified their efforts in Research and Development (“R&D”) in recent years. But in a space marked with competition from generic manufacturers and maturing biotech companies, understanding the dynamics of this highly scrutinized market requires an awareness of the political and economic climate these key players face. Where this industry is headed is much less clear than where it is coming from. Careful analysis is one lens through which to examine all of these intricate elements and is the focus of this research paper.
Endometriosis & Dioxins Body Burden - Information for Physicians, Nurses, & O...v2zq
Endometriosis & Dioxins Body Burden - Information for Physicians, Nurses, & Other Healthcare Professionals - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
Domestic Detox - Pollution is Personal - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
People Safe: The Link Between Declining Fertility & Environmental Contaminants
1. People Safe: The Link Between Declining Fertility and Environmental Contaminants July 31, 2009 Amanda Bowes Reproductive Health Technologies Project Summer Intern Bryn Mawr College
Good afternoon. For those of you who don’t know me, my name is Amanda Bowes and I am a rising senior at Bryn Mawr College. My final project for this summer (as the title strongly suggests) has dealt with the link between declining fertility in the US and exposure to environmental contaminants. This presentation serves to illustrate my findings and subsequent conclusions.
I’ve included a brief table of contents to give you an idea of where I am heading within this presentation. I’ll begin by defining some terms and the context in which I am examining the relationship between chemical contaminants and reproductive health. I’ll then describe various health conditions affecting both men and women, as well as the chemicals associated with them.
I’ll conclude with recommendations for each of the largest parties involved: researchers, manufacturers or chemical industries, and policymakers.
Environmental health and environmental justice are two subcategories of environmentalism. To understand both terms, it’s necessary to place them within an historical context. The “environmental health movement” dates at least to Progressive Era urban reforms including clean water supply, more efficient removal of raw sewage and reduction in crowded and unsanitary living conditions. Today’s movement is more related to nutrition, preventive medicine, aging well, etc.. 17 “ Environmental justice”, by contrast, began in the 1980s as an effort to minimize the disparate impact of air pollution as well as water and food chemical contamination on minority and poverty-stricken populations. 17 Groups from both the environmental health and environmental justice campaigns have emphasized chemical contaminants in our environment and consumer products as a key concern.
So, why should we be concerned about chemicals in our environment to begin with? Well, While chemical production has increased, human and animal health has declined, particularly reproductive health. The sudden and steep rates for infertility as well as physical and behavioral sexual abnormalities suggests an environmental component is at work. 4 Although many of these chemicals have demonstrated a negative effect on cancer incidence and various developmental processes, I would like to focus on infertility as a result of toxic chemical exposure.
But first, how do we define infertility? The Centers for Disease Control and Prevention defines infertility as the inability to get pregnant after trying for one year . The CDC reports that in 2002, of the 62 million American women of reproductive age, about 1.2 million, or 2%, had an infertility-related medical appointment within the previous year, and 8% had an infertility-related medical visit at some point in the past. 7% of married couples in which the woman was of reproductive age (2.1 million couples) were classified as infertile according to the CDC definition. 3 **It’s worth noting that this particular report focused mostly on couples rather than individual male and female infertility.
There are various conditions that either directly or indirectly result in infertility or reduced-fertility: Lower sperm count/decreased sperm quality Hypospadias Cryptorchidisms Shortened/lengthened ano-genital distance Recurrent miscarriage/Fetal loss Endometriosis Polycystic ovarian syndrome (PCOS) Researchers cite exposure to endocrine disruptors as a possible cause of these illnesses.
Endocrine disruptor is a term used to describe thousands of chemicals that interfere with the endocrine system, or “an integrated system of hormone-producing glands that control various body functions”. 6 Researchers point to endocrine disrupting chemicals, or endocrine disruptors, as the cause for conditions such as decreased sperm quality. Endocrine disruptors are present in food, the environment, and consumer products. Many endocrine disruptors affect not only the exposed individual, but also his/her offspring and future generations. 6
While understanding the dangers of exposure to endocrine disruptors and other chemical contaminants, it is important to understand the current and proposed frameworks for regulating chemical production. Toxic Substances Control Act (TSCA) TSCA was passed in 1976. TSCA holds the EPA solely responsible for demonstrating the dangers of a particular chemical. 1 Thus companies are not required to prove the safety of the chemicals used in their products before they are placed on the market. Without manufacturers’ data for the production and use of a chemical, the EPA is often ill-equipped to effectively regulate a potentially dangerous product. There has been a 30% increase in U.S. chemical production since 1979, with 80,000 chemicals now approved for commercial use, many of which exhibit endocrine disrupting qualities. 1 Thus, TSCA is appears to be both outdated and ineffectual.
Kid-Safe Chemical Act (Kid-Safe) In January 2009, the Government Accountability Office placed chemical safety to its “high risk list” of areas that should be addressed immediately. 1 Kid-Safe was introduced in 2008 as an update/reform for TSCA. Advocacy coalitions such as Safer Chemicals, Health Families (of which RHTP is a member) would like it to be reintroduced in 2009. Kid-Safe would require “pre-market testing” by companies and would expand the list of chemicals researched and regulated by the FDA and EPA. 1 Other Chemical Specific Legislation Additionally, there has been federal chemical-specific regulation proposed, including legislation introduced in March 2009 that would remove bisphenol A from all food containers. **by Sen. Frank Lautenberg (D-NJ) and Reps. Hilda Solis (D-CA) and Henry Waxman (D-CA) 1
Kid-Safe encourages the EPA and other agencies to regulate chemical production using the following terms to describe the risk a chemical poses to health: Persistence- how long the chemical remains in the atmosphere or environment before being broken down. This is measured by the chemical’s “half-life”, or “the interval required for the quantity to decay to half of its initial value”. 2 Ubiquitous- the chemical or toxin is everywhere or at least in many different elements of our environment. Bioaccumulative- a chemical or chemicals accumulate in an organism. This occurs when an organism absorbs a toxic substance at a rate greater than that at which the substance is lost. 16 **The longer the half-life, the greater the persistence. The greater the persistence, the longer the chemical will have an effect after the initial intended use.
For the purposes of my research and this presentation, I will examine the relationship between individual or specific groups of chemicals and these conditions. I have highlighted man-made contaminants specifically included in Kids-Safe to demonstrate the importance of passing this piece of legislation. Most of these chemicals are also considered endocrine disruptors.
Sperm counts in Western countries appear to have declined by half in the past 50 years. 4 In addition to lower sperm concentrations, DNA damage in sperm contributes to poorer embryo development and lower pregnancy rates among partners of men undergoing assisted reproductive treatments. 5
Phthalates are a family of endocrine disrupting chemicals that are used in many consumer products to soften plastics, from flooring and wall coverings, to medical devices and personal-care products such as perfumes, lotions and cosmetics. 6 About a billion pounds of phthalates are produced each year. 1 And here are pictures of some of the items containing significant amounts of phthalates.
Unfortunately, There are only a few epidemiological studies on phthalates and semen quality. Even this relatively small amount of research suggests troubling association between phthalates and sperm quality. One large study from an infertility clinic in Massachusetts found associations between monobutyl phthalate (MBP) and decreased sperm motility and sperm concentration. 4 In a study by the Harvard School of Public Health, at least 90% of the male partners in a cohort of infertile couples tested positive for MBP. 5 Men exposed to DBP and/or DEHP (two other phthalates) during puberty or adulthood experienced decreased sperm production. 5
Polychlorinated biphenyls (PCBs) are persistent compounds that were widely used in industrial and consumer products for decades until they were banned in the late 1970s. Used in cutting oils, lubricants, and electrical insulators. 4 PCBs remain ubiquitous environmental contaminants. Again, pictures of PCB-containing-products are included.
In studies done in several different countries, including the U.S., the evidence suggests an “inverse association of PCBs with reduced semen quality, specifically reduced sperm motility,” or the mobility of the sperm towards the egg. 4 Because the associations were found across a broad range of PCB levels, there is believed to be no threshold of exposure/vulnerability. Thus even with the smallest amounts of PCBs, humans are at risk. 4 PCBs can also bio-accumulate up the food chain, so that fish, meat, and dairy products we consume may increase our risk of exposure. 4
Dioxins are a class of chemical contaminants that are formed during combustion processes such as waste incineration, forest fires, and backyard trash burning, as well as during some industrial processes such as paper pulp bleaching and herbicide manufacturing. The most toxic chemical in the class is 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD). 7 The picture to the right is often used by chemical reform advocates to demonstrate the severity of chemicals such as TCDD. That is Viktor Yushchenko, a Ukrainian politician who was poisoned with TCDD. TCDD is also a component used in Agent Orange.
Most exposure to dioxins (roughly 95%) occurs through eating foods contaminated with these toxins. 7,1 Recent studies suggest that the timing of exposure may have an impact upon semen quality. Exposure at some ages may result in decreased sperm count or sperm motility, whereas at other ages there may be a stimulatory or increased effect. 4
Hypospadias is a condition in which the opening to the urethra (the tube through which urine and semen travel) forms on the underside of the penis or below the penis. Hypospadias is the second most common birth defect in the U.S. 6 The Centers for Disease Control and Prevention (CDC) reported a doubling of hypospadias cases from 1968 to 1993 in the U.S.. Rates are currently highest among whites and lowest among Hispanics. 8 Reports of increased rates of hypospadias have coincided with increased rates of testicular cancer, cryptorchidism, and decreasing semen and sperm quality. 8 Thus males with hypospadias often have a vastly diminished fertility.
It is believed that phthalates could interfere with the ability of testosterone to masculinize the male reproductive tract, resulting in many different genital malformations including hypospadias. 10 Animals treated with either DBP or DEHP (phthalates) developed hypospadias. 9 Diethylstilbestrol (DES), a chemical prescribed to pregnant women as a means of preventing spontaneous abortions and promoting fetal growth, instead caused women to give birth to daughters with increased risk for breast, vaginal and cervical cancers, and grandsons with a 20-fold increase in the development of hypospadias. 9
Cryptorchidism is a condition in which one or both of the testes are missing from the scrotum at birth. This usually suggests that the testes have failed to “descend” from the abdominal area during fetal development. 11 Again, increased rates of cryptorchidism have coincided with increased rates of testicular cancer, hypospadias, and decreasing semen and sperm quality. 8 Thus, males with cryptorchidism at birth often have a diminished adult fertility.
Studies show that the prevalence of cryptorchidism is variable and geographically specific, with increasing trends in some studies but not in others. 4 The strongest data suggests that people that either live in primarily agricultural areas or whose parents were exposed to various nonorganochlorine pesticides are at greater risk for cryptorchidism. Cryptorchidism has been observed following exposure to DEHP and DBP (phthalates). 9
Ano-genital distance is the “measurement of the length of the area between the anus and the genitals” 6 and is usually twice as large for males versus females. 12 Because testosterone triggers this area to lengthen as a part of normal male development, a shorter ano-genital distance often suggests an interference with either the production or action of testosterone. 6 The condition is also associated with un-descended testes and/or decreased sperm quality.
BPA is a chemical used in clear and shatter-proof plastic food and drink containers, the lining of metal food and drink cans, pacifiers and baby toys, computers, cell phones, paints, adhesives, enamels and varnishes. 6 Recent studies show that BPA can migrate from the container into the contents, especially when heated. 10 About 6 billion pounds of BPA are produced each year. 1
For many reasons, BPA poses particularly troubling threat. In a 2003-2004 bio-monitoring study by the Centers for Disease Control, 92.6% of over 2500 Americans had BPA in their urine. 4,1 BPA has a longer half-life in humans than previously thought. 4 Thus, even if BPA-containing-products were no longer sold, those already in homes and the environment would continue to have a detrimental effect on human and animal fertility. Also, BPA appears to have an unusual dose-effect, showing an inverted-U dose-response curve. 14 Thus even a very small amount of BPA has a significant and negative impact on fertility.
Bisphenol A (BPA) has been shown to increase ano-genital distance in a study of rats. 6 Although the FDA currently describes BPA as “safe”, Canada and many U.S. states and cities have banned the chemical. According to Heather Patisaul and Heather Adewale, the “fate of BPA may ultimately be decided by politics and public perception, rather than a regulatory action based on a measured evaluation of the scientific evidence”. 10
The number of miscarriages and stillbirths have increased from 14 per 1,000 pregnancies during the 1980s to 16 per 1,000 in the 1990s and 2000s. 1 About 40-70% of miscarriages are linked to chromosomal abnormalities at conception, i.e. unusual numbers of individual or entire sets of chromosomes. 13 Such abnormalities are the result of a mistake in the production of eggs or sperm. Adult humans exposed to dioxins, PCBs, heavy metals such as lead, mercury and cadmium, and various phthalates have demonstrated fetal loss , a shorthand term for early pregnancy loss, miscarriage, or stillbirth. 12
According to recent Japanese study, high in vivo (or after a person is born) exposure to BPA may be associated with recurrent miscarriage. Because measurable amounts of BPA have been found in the amniotic fluid and placental tissue of pregnant women, it is believed that developing fetuses are readily exposed to this chemical. 4
Endometriosis is a chronic disease in which women develop tissue that usually lines the uterus grows abnormally in other locations, such as the ovaries and fallopian tubes, and even in distant organs like the lungs and heart. 12 About 40% of women diagnosed with endometriosis also suffer from infertility. 12 In 2002, the total health care costs in the U.S. for diagnosis and treatment of endometriosis was approximately $22 billion. 4
Elevated serum levels of dioxin-like compounds such as PCBs correlated strongly with endometriosis. 14 Rhesus monkeys treated with TCDD developed acute endometriosis and women with endometriosis also had high plasma concentrations of phthalates in a study in India. 4 In an Italian study, a similar association between plasma concentrations of phthalates such as DEHP and endometriosis was found. 14
Polycystic ovarian syndrome or PCOS can affect a woman's menstrual cycle, ability to have children, hormones, heart, blood vessels, and appearance. Women with PCOS have high level of androgens (a typically male hormone), missed or irregular periods, and many small cysts in their ovaries. 15 The Endocrine Society describes PCOS as a “leading cause of subfertility”. 4 The cost to the health care system for PCOS diagnosis and treatment totals $4.4 billion in the U.S. in 2004. 4
Women with PCOS also have higher levels of BPA. 4 A 5-fold higher level of BPA in the amniotic fluid of mothers of PCOS patients suggests prenatal exposure. 4
Many of the chemicals included in the Kid-Safe legislation have a demonstrated and significant impact on animals’ and humans’ reproductive health, particularly on their fertility. Although we must consider the current research, more can and should be done to fully understand the biological threat these contaminants pose. It is critical that government officials, advocates, and manufacturers work to bring consumers’ expectations and a product’s reality with regard to long-term use and safety in synch by strengthening current chemical regulation.
Because individuals or populations are constantly exposed to multiple industrial chemicals, it can be difficult to establish the effects of one compound at a time. Thus more research should be conducted to explore the effects of a combination of BPA and certain phthalates, for example. Research on possible “green” or safe alternatives must be a priority. Current funding for green chemistry research represents a very small portion of the federal budget. 1
Manufacturers must be required to provide the EPA and the public with basic information with regard to a chemical’s safety for consumers and workers. The chemical industry should be held responsible for demonstrating their product’s safety, similar to pharmaceuticals which are subject to stringent pre-market testing. Such chemical safety data must be published and disseminated to the wider public. Corporations should be encouraged to research “green” or non-harmful alternative chemicals to be used in production.
Rep. Ed Markey (D-MA) and Sens. Dianne Feinstein (D-CA) and Chuck Schumer (D-NY) introduced legislation to ban BPA in all food and beverage containers in March 2009. 1 Similar chemical-specific regulation and overall chemical regulation reform is needed. The EPA should coordinate more effectively with FDA and other agencies to reduce the amounts of persistent, bio-accumulative toxicants (PBTs) in our environment and consumer products. More resources and authority should be given to the FDA and CPSC to protect us from harmful chemicals in cosmetics and consumer products.