Eczema (The Itch that rashes)
•Download as PPTX, PDF•
0 likes•69 views
Eczema is a skin condition in which there is itching. presentation and management of the given condition is stated in the presentation. i hope this will help you somehow.
Report
Share
Report
Share
Recommended
Atopic dermatitis
A 12-year-old female presents with dry, itchy skin on her elbows, behind her knees, and in front of her ankles. She has a family history of atopic dermatitis, asthma, and eczema. Atopic dermatitis is a chronic inflammatory skin disease characterized by dry skin and intense itching. It most commonly presents in infants and young children, with flexural areas of the skin most severely affected. Management involves hydration, topical corticosteroids and antihistamines to reduce inflammation and itching.
Skin tissue engineering
This document discusses skin tissue engineering and skin substitutes. It begins with an overview of skin anatomy and function, the wound healing process, and scar formation versus regeneration. It then covers solutions for non-healing wounds like skin grafting and skin substitutes. Specifics of skin grafts and an example permanent bi-layer skin substitute called Apligraft are provided. The document aims to outline considerations for skin tissue engineering and wound healing solutions.
Leprosy (1).ppt hpe
This document summarizes the histopathogenesis of Hansen's disease (leprosy) through descriptions of key pathological features and microscopic images. It discusses how Mycobacterium leprae has an affinity for Schwann cells in peripheral nerves. The types of leprosy (tuberculoid, borderline, lepromatous) are characterized based on the composition and appearance of granulomas in tissue samples. Immunological reactions and rare conditions like Lucio's phenomenon and histoid leprosy are also outlined.
Psoriasin
Psoriasin is an antimicrobial protein secreted by human skin keratinocytes that protects the skin from Escherichia coli infection. The study identified psoriasin as the main E. coli-killing compound in skin through fractionation and purification of skin wash fluids and stratum corneum extracts. Psoriasin preferentially kills E. coli over other bacterial strains tested. Its antimicrobial activity operates under the pH and salt conditions of skin surfaces. Zinc inhibits psoriasin's activity, suggesting it kills E. coli through zinc sequestration.
Leprosy day
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by Mycobacterium leprae that mainly affects the skin, nerves, respiratory tract, and eyes. It can occur at any age and is transmitted through droplets from the nose and mouth during prolonged close contact with untreated cases. While not very infectious, it has a long incubation period of 1-20 years and can cause discolored skin patches, thickened nerves, and sensory loss if left untreated.
Leprosy
1) Lepra reactions are immunologically inflammatory states that can occur in leprosy patients. There are two main types - Type 1 reactions (downgrading and reversal reactions) and Type 2 reactions (Erythema Nodosum Leprosum or ENL).
2) Type 1 reactions involve the skin and nerves and cause swelling and tenderness. They occur after treatment begins. Type 2 or ENL reactions cause painful swollen skin lesions and other symptoms like fever. They typically occur after treatment in lepromatous patients.
3) Histologically, Type 1 reactions show edema while Type 2 reactions show deep inflammation, necrosis and few bacilli. Both can cause significant morbidity if not properly treated.
Atopic dermatitis exacerbations
The document discusses atopic dermatitis and compares factors related to skin hydration and lipids between patients with atopic dermatitis and healthy controls. It finds that patients with atopic dermatitis have significantly lower water content and ceramides in the stratum corneum. Various triggers that can exacerbate atopic dermatitis are also discussed, including stress, allergens like dust mites, microorganisms like Staphylococcus aureus, and environmental and genetic factors.
Pathophysiology of Leprosy
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by the bacteria Mycobacterium leprae. It primarily affects the nerves, skin, and mucous membranes of the body. The disease is transmitted through droplets from the nose and mouth of infected individuals during close and frequent contact. Symptoms include skin lesions and loss of sensation. Leprosy is classified based on clinical features into paucibacillary or multibacillary types. Diagnosis involves examination of skin and nerve lesions along with skin smears. Treatment involves multidrug therapy to cure the disease and prevent nerve damage and disability.
Recommended
Atopic dermatitis
A 12-year-old female presents with dry, itchy skin on her elbows, behind her knees, and in front of her ankles. She has a family history of atopic dermatitis, asthma, and eczema. Atopic dermatitis is a chronic inflammatory skin disease characterized by dry skin and intense itching. It most commonly presents in infants and young children, with flexural areas of the skin most severely affected. Management involves hydration, topical corticosteroids and antihistamines to reduce inflammation and itching.
Skin tissue engineering
This document discusses skin tissue engineering and skin substitutes. It begins with an overview of skin anatomy and function, the wound healing process, and scar formation versus regeneration. It then covers solutions for non-healing wounds like skin grafting and skin substitutes. Specifics of skin grafts and an example permanent bi-layer skin substitute called Apligraft are provided. The document aims to outline considerations for skin tissue engineering and wound healing solutions.
Leprosy (1).ppt hpe
This document summarizes the histopathogenesis of Hansen's disease (leprosy) through descriptions of key pathological features and microscopic images. It discusses how Mycobacterium leprae has an affinity for Schwann cells in peripheral nerves. The types of leprosy (tuberculoid, borderline, lepromatous) are characterized based on the composition and appearance of granulomas in tissue samples. Immunological reactions and rare conditions like Lucio's phenomenon and histoid leprosy are also outlined.
Psoriasin
Psoriasin is an antimicrobial protein secreted by human skin keratinocytes that protects the skin from Escherichia coli infection. The study identified psoriasin as the main E. coli-killing compound in skin through fractionation and purification of skin wash fluids and stratum corneum extracts. Psoriasin preferentially kills E. coli over other bacterial strains tested. Its antimicrobial activity operates under the pH and salt conditions of skin surfaces. Zinc inhibits psoriasin's activity, suggesting it kills E. coli through zinc sequestration.
Leprosy day
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by Mycobacterium leprae that mainly affects the skin, nerves, respiratory tract, and eyes. It can occur at any age and is transmitted through droplets from the nose and mouth during prolonged close contact with untreated cases. While not very infectious, it has a long incubation period of 1-20 years and can cause discolored skin patches, thickened nerves, and sensory loss if left untreated.
Leprosy
1) Lepra reactions are immunologically inflammatory states that can occur in leprosy patients. There are two main types - Type 1 reactions (downgrading and reversal reactions) and Type 2 reactions (Erythema Nodosum Leprosum or ENL).
2) Type 1 reactions involve the skin and nerves and cause swelling and tenderness. They occur after treatment begins. Type 2 or ENL reactions cause painful swollen skin lesions and other symptoms like fever. They typically occur after treatment in lepromatous patients.
3) Histologically, Type 1 reactions show edema while Type 2 reactions show deep inflammation, necrosis and few bacilli. Both can cause significant morbidity if not properly treated.
Atopic dermatitis exacerbations
The document discusses atopic dermatitis and compares factors related to skin hydration and lipids between patients with atopic dermatitis and healthy controls. It finds that patients with atopic dermatitis have significantly lower water content and ceramides in the stratum corneum. Various triggers that can exacerbate atopic dermatitis are also discussed, including stress, allergens like dust mites, microorganisms like Staphylococcus aureus, and environmental and genetic factors.
Pathophysiology of Leprosy
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by the bacteria Mycobacterium leprae. It primarily affects the nerves, skin, and mucous membranes of the body. The disease is transmitted through droplets from the nose and mouth of infected individuals during close and frequent contact. Symptoms include skin lesions and loss of sensation. Leprosy is classified based on clinical features into paucibacillary or multibacillary types. Diagnosis involves examination of skin and nerve lesions along with skin smears. Treatment involves multidrug therapy to cure the disease and prevent nerve damage and disability.
Lepra reactions
Leprosy reactions occur due to changes in the body's immune response against M. leprae bacteria and can develop at any time during or after treatment. There are two main types of reactions: Type 1 occurs in both tuberculoid and lepromatous leprosy and results from increased cell-mediated immunity that causes inflammation of existing and new skin lesions and nerves. Type 2, also called erythema nodosum leprosum, occurs in multibacillary leprosy patients with high bacterial loads and is caused by an Arthus-type allergic reaction to antigens from dead bacteria, resulting in tender nodules on the skin and potential inflammation of nerves, eyes, testes, joints,
Cutaneous Leprosy
The document provides an in-depth overview of atopic dermatitis (AD), including its pathogenesis, clinical presentation, systemic immune response, and treatment approaches. It discusses several theories for its pathogenesis, including abnormalities in cyclic adenosine monophosphate signaling, the allergy hypothesis involving TH2 cell responses, and genetic factors like filaggrin gene mutations. Diagnosis involves characteristic clinical features along with personal or family history of atopy. Management focuses on emollients, topical corticosteroids, antibiotics, phototherapy, immunomodulators, and avoidance of triggers.
Leprosy
This document provides information about leprosy (Hansen's disease), including:
1. It is caused by Mycobacterium leprae bacteria and primarily affects nerves and skin.
2. It is classified based on clinical features into paucibacillary (tuberculoid) and multibacillary (lepromatous) types.
3. Symptoms vary but commonly include skin lesions and loss of sensation. Diagnosis involves skin smears, biopsy and lepromin testing.
Atopic dermatitis
Atopic dermatitis is a chronic inflammatory skin disease associated with respiratory allergies. It is characterized by recurrent eczematous lesions and intense itch. Genetic factors like filaggrin mutations cause skin barrier defects allowing allergens and microbes to trigger immune responses. The disease involves type 2 immunity cytokines activating neurons to produce itch. Staphylococcus aureus colonization exacerbates inflammation. Clinical features include erythematous patches and plaques with lichenification in chronic cases.
Leprosy
this presentation gives a detailed information about leprosy,its signs and symptoms,treatment,management.
Lepra reactions
Lepra reactions
These are the Sudden episodes of exacerbation occurring during the silent course of leprosy
Enl
This document provides information about Erythema Nodosum Leprosum (ENL), a type 2 reaction that occurs in patients with multibacillary leprosy with a heavy bacterial load. ENL is characterized by red, tender skin nodules and can involve multiple organs. It is caused by an Arthus-type allergic reaction when large numbers of killed leprosy bacteria release antigens. Diagnosis involves clinical presentation of skin and nerve inflammation as well as slit skin smears and histopathology. Treatment focuses on reassurance, continuing multidrug therapy, rest, NSAIDs for mild cases, and oral steroids for severe cases.
Inflammation
This document discusses inflammation and its role in the body's healing process. It describes acute and chronic inflammation. Acute inflammation is the initial rapid response to harmful stimuli and involves increased blood flow, capillary permeability, and migration of neutrophils and macrophages to the injured site. The five cardinal signs of acute inflammation are pain, redness, immobility, swelling, and heat. Chronic inflammation is a prolonged inflammatory response that can last months or years and result from failure to eliminate the initial trigger, an autoimmune response, or persistent irritation. Chronic inflammation can lead to diseases like arthritis and atherosclerosis if not well regulated.
Leprosy (etiopathogenesis ,classification & clinical features)
The document presents an overview of leprosy including its history, epidemiology, classification, clinical features, pathogenesis and immunology. It discusses the different types of leprosy including tuberculoid, borderline, and lepromatous leprosy. The presentation was given by Biniyam Simeneh at ALERT Hospital to review leprosy etiology, transmission, risk factors, and clinical manifestations.
Skin infections
these set of slides are about skin infections particularly cellulitis...they aren't complete, however they can give you clues about these infections. hope you enjoy them
Atypical tinea
Dermatophytosis commonly presents as typical annular lesions but can also present atypically. The document discusses various atypical presentations including those resembling eczema, psoriasis, impetigo and others. It also discusses rare deep dermatophytosis seen in immunocompromised individuals. Predisposing factors for atypical presentations include immunosuppression, environmental conditions, host defenses, and use of topical steroids. Proper diagnosis requires potassium hydroxide preparation, histopathology or culture.
Leprosy
This document provides a review on leprosy, including its epidemiology, causative agent, classification, symptoms, diagnosis, treatment and preventive measures. Some key points:
- Leprosy is caused by Mycobacterium leprae and mainly affects India, which records the highest number of new cases globally each year.
- It can be classified as paucibacillary or multibacillary depending on symptoms. Multibacillary leprosy involves more organs and is more infectious.
- Diagnosis involves skin smear tests and examination under microscopy. Treatment is multidrug therapy including dapsone, rifampicin and clofazimine over 6-12 months depending
Inflammation
Inflammation is the body's complex response to injury or harmful stimuli, involving redness, swelling, heat, pain, and loss of function. There are two main types - acute inflammation occurs shortly after injury and involves conditions like tonsillitis and appendicitis, while chronic inflammation lasts weeks or months and simultaneously involves active inflammation, tissue damage, and attempts at repair, as seen in rheumatoid arthritis and tuberculosis. Signs of inflammation include redness, swelling, heat, pain, and loss of function.
Skin & Skin Infections
The skin has three main layers - the epidermis, dermis and hypodermis. The epidermis is the outer protective layer, the dermis is a lower supporting layer that gives strength and acts as a reservoir to fight infections, and the hypodermis is a layer of fatty tissue that supports the skin. The skin acts as a protective barrier and plays roles in temperature regulation, sensation, and waste excretion. Fungal infections can be superficial or deep, with superficial infections affecting the outer layers and deep infections invading living tissue. Corticosteroids are anti-inflammatory drugs that work by suppressing the immune system and inflammatory response.
Leprosy -BASICS
The information about Leprosy is a basic content intended to share Students of Graduate and postgraduate in Life Sciences.
The up loader has no Commercial interests
Edema & Haemorrhage
Edema and haemorrhage were presented. Edema is the abnormal accumulation of fluid in tissues, and can be localized or generalized. It can be transudate or exudate depending on protein content. Haemorrhage is bleeding from blood vessels. Bleeding can be arterial, venous, or capillary. Arterial bleeding is bright red and emitted in a jet; venous bleeding is darker and steady; capillary bleeding is bright red and oozing. Bleeding can be primary, reactionary, or secondary depending on timing relative to injury or surgery. The causes, effects, and types of edema and haemorrhage were described.
Inflammation
This document provides an overview of inflammation. It defines inflammation and describes the signs and types, including acute and chronic inflammation. For acute inflammation, it details the vascular events of altered microvasculature, including hemodynamic changes and increased vascular permeability. It also describes the cellular events of exudation of leukocytes and phagocytosis. It lists the chemical mediators of inflammation released by cells and originating from plasma. It discusses the regulation of inflammation and factors determining the inflammatory response. It outlines the morphology, systemic effects, and fate of acute inflammation. It defines chronic inflammation and describes its causes, features, types, histological features, and systemic effects.
Atopic dermatitis by Dr.Gamal Soltan
This document provides information on atopic dermatitis (AD), including its definition, epidemiology, pathogenesis, clinical features, complications, diagnosis, and differential diagnosis. AD is defined as an itchy, chronic inflammatory skin condition with a flexural distribution and early age of onset. Genetic and environmental factors contribute to skin barrier dysfunction and immune dysregulation underlying AD. Clinical features vary by age but commonly include dry skin, rashes, and skin thickening/lichenification due to scratching. Secondary infections can occur. Diagnosis is based on characteristic features and history. Differential diagnoses include other eczemas and psoriasis.
01 ahmed omar leprosy -last edition
Leprosy is a chronic infectious disease caused by Mycobacterium leprae that affects the skin and peripheral nerves. It is transmitted through respiratory droplets, skin contact, or feeding. There are different classifications of leprosy depending on clinical presentation and bacterial load. Treatment involves multidrug therapy with dapsone, rifampicin, and clofazimine over 6-12 months depending on type of leprosy. Prevention focuses on isolation of infectious individuals to reduce transmission.
common skin inflammatory diseases.pptx
This is a lecture given at the American University of Beirut for medical students during their dermatology rotation as an elective.
It is an introductory lecture about skin inflammatory diseases.
RUPAM PPT -PEMPHIGUS.pptx
this topic is on pemphigus vulgaris. describes in detail regarding the pemphigus, its causes, pathophysiology, management
Oral pemphigus vulgaris
Three sentences:
This document discusses oral pemphigus vulgaris, an autoimmune disease causing blistering of the mucosa. It defines the disease, describes its pathogenesis involving autoantibodies against desmoglein proteins, and outlines the clinical features, diagnosis using biopsy, immunofluorescence and Tzank smear, and treatment typically involving corticosteroids. Differential diagnoses include bullous pemphigoid and diagnosis is confirmed through histology demonstrating acantholysis and direct immunofluorescence showing intercellular IgG deposits.
More Related Content
What's hot
Lepra reactions
Leprosy reactions occur due to changes in the body's immune response against M. leprae bacteria and can develop at any time during or after treatment. There are two main types of reactions: Type 1 occurs in both tuberculoid and lepromatous leprosy and results from increased cell-mediated immunity that causes inflammation of existing and new skin lesions and nerves. Type 2, also called erythema nodosum leprosum, occurs in multibacillary leprosy patients with high bacterial loads and is caused by an Arthus-type allergic reaction to antigens from dead bacteria, resulting in tender nodules on the skin and potential inflammation of nerves, eyes, testes, joints,
Cutaneous Leprosy
The document provides an in-depth overview of atopic dermatitis (AD), including its pathogenesis, clinical presentation, systemic immune response, and treatment approaches. It discusses several theories for its pathogenesis, including abnormalities in cyclic adenosine monophosphate signaling, the allergy hypothesis involving TH2 cell responses, and genetic factors like filaggrin gene mutations. Diagnosis involves characteristic clinical features along with personal or family history of atopy. Management focuses on emollients, topical corticosteroids, antibiotics, phototherapy, immunomodulators, and avoidance of triggers.
Leprosy
This document provides information about leprosy (Hansen's disease), including:
1. It is caused by Mycobacterium leprae bacteria and primarily affects nerves and skin.
2. It is classified based on clinical features into paucibacillary (tuberculoid) and multibacillary (lepromatous) types.
3. Symptoms vary but commonly include skin lesions and loss of sensation. Diagnosis involves skin smears, biopsy and lepromin testing.
Atopic dermatitis
Atopic dermatitis is a chronic inflammatory skin disease associated with respiratory allergies. It is characterized by recurrent eczematous lesions and intense itch. Genetic factors like filaggrin mutations cause skin barrier defects allowing allergens and microbes to trigger immune responses. The disease involves type 2 immunity cytokines activating neurons to produce itch. Staphylococcus aureus colonization exacerbates inflammation. Clinical features include erythematous patches and plaques with lichenification in chronic cases.
Leprosy
this presentation gives a detailed information about leprosy,its signs and symptoms,treatment,management.
Lepra reactions
Lepra reactions
These are the Sudden episodes of exacerbation occurring during the silent course of leprosy
Enl
This document provides information about Erythema Nodosum Leprosum (ENL), a type 2 reaction that occurs in patients with multibacillary leprosy with a heavy bacterial load. ENL is characterized by red, tender skin nodules and can involve multiple organs. It is caused by an Arthus-type allergic reaction when large numbers of killed leprosy bacteria release antigens. Diagnosis involves clinical presentation of skin and nerve inflammation as well as slit skin smears and histopathology. Treatment focuses on reassurance, continuing multidrug therapy, rest, NSAIDs for mild cases, and oral steroids for severe cases.
Inflammation
This document discusses inflammation and its role in the body's healing process. It describes acute and chronic inflammation. Acute inflammation is the initial rapid response to harmful stimuli and involves increased blood flow, capillary permeability, and migration of neutrophils and macrophages to the injured site. The five cardinal signs of acute inflammation are pain, redness, immobility, swelling, and heat. Chronic inflammation is a prolonged inflammatory response that can last months or years and result from failure to eliminate the initial trigger, an autoimmune response, or persistent irritation. Chronic inflammation can lead to diseases like arthritis and atherosclerosis if not well regulated.
Leprosy (etiopathogenesis ,classification & clinical features)
The document presents an overview of leprosy including its history, epidemiology, classification, clinical features, pathogenesis and immunology. It discusses the different types of leprosy including tuberculoid, borderline, and lepromatous leprosy. The presentation was given by Biniyam Simeneh at ALERT Hospital to review leprosy etiology, transmission, risk factors, and clinical manifestations.
Skin infections
these set of slides are about skin infections particularly cellulitis...they aren't complete, however they can give you clues about these infections. hope you enjoy them
Atypical tinea
Dermatophytosis commonly presents as typical annular lesions but can also present atypically. The document discusses various atypical presentations including those resembling eczema, psoriasis, impetigo and others. It also discusses rare deep dermatophytosis seen in immunocompromised individuals. Predisposing factors for atypical presentations include immunosuppression, environmental conditions, host defenses, and use of topical steroids. Proper diagnosis requires potassium hydroxide preparation, histopathology or culture.
Leprosy
This document provides a review on leprosy, including its epidemiology, causative agent, classification, symptoms, diagnosis, treatment and preventive measures. Some key points:
- Leprosy is caused by Mycobacterium leprae and mainly affects India, which records the highest number of new cases globally each year.
- It can be classified as paucibacillary or multibacillary depending on symptoms. Multibacillary leprosy involves more organs and is more infectious.
- Diagnosis involves skin smear tests and examination under microscopy. Treatment is multidrug therapy including dapsone, rifampicin and clofazimine over 6-12 months depending
Inflammation
Inflammation is the body's complex response to injury or harmful stimuli, involving redness, swelling, heat, pain, and loss of function. There are two main types - acute inflammation occurs shortly after injury and involves conditions like tonsillitis and appendicitis, while chronic inflammation lasts weeks or months and simultaneously involves active inflammation, tissue damage, and attempts at repair, as seen in rheumatoid arthritis and tuberculosis. Signs of inflammation include redness, swelling, heat, pain, and loss of function.
Skin & Skin Infections
The skin has three main layers - the epidermis, dermis and hypodermis. The epidermis is the outer protective layer, the dermis is a lower supporting layer that gives strength and acts as a reservoir to fight infections, and the hypodermis is a layer of fatty tissue that supports the skin. The skin acts as a protective barrier and plays roles in temperature regulation, sensation, and waste excretion. Fungal infections can be superficial or deep, with superficial infections affecting the outer layers and deep infections invading living tissue. Corticosteroids are anti-inflammatory drugs that work by suppressing the immune system and inflammatory response.
Leprosy -BASICS
The information about Leprosy is a basic content intended to share Students of Graduate and postgraduate in Life Sciences.
The up loader has no Commercial interests
Edema & Haemorrhage
Edema and haemorrhage were presented. Edema is the abnormal accumulation of fluid in tissues, and can be localized or generalized. It can be transudate or exudate depending on protein content. Haemorrhage is bleeding from blood vessels. Bleeding can be arterial, venous, or capillary. Arterial bleeding is bright red and emitted in a jet; venous bleeding is darker and steady; capillary bleeding is bright red and oozing. Bleeding can be primary, reactionary, or secondary depending on timing relative to injury or surgery. The causes, effects, and types of edema and haemorrhage were described.
Inflammation
This document provides an overview of inflammation. It defines inflammation and describes the signs and types, including acute and chronic inflammation. For acute inflammation, it details the vascular events of altered microvasculature, including hemodynamic changes and increased vascular permeability. It also describes the cellular events of exudation of leukocytes and phagocytosis. It lists the chemical mediators of inflammation released by cells and originating from plasma. It discusses the regulation of inflammation and factors determining the inflammatory response. It outlines the morphology, systemic effects, and fate of acute inflammation. It defines chronic inflammation and describes its causes, features, types, histological features, and systemic effects.
Atopic dermatitis by Dr.Gamal Soltan
This document provides information on atopic dermatitis (AD), including its definition, epidemiology, pathogenesis, clinical features, complications, diagnosis, and differential diagnosis. AD is defined as an itchy, chronic inflammatory skin condition with a flexural distribution and early age of onset. Genetic and environmental factors contribute to skin barrier dysfunction and immune dysregulation underlying AD. Clinical features vary by age but commonly include dry skin, rashes, and skin thickening/lichenification due to scratching. Secondary infections can occur. Diagnosis is based on characteristic features and history. Differential diagnoses include other eczemas and psoriasis.
01 ahmed omar leprosy -last edition
Leprosy is a chronic infectious disease caused by Mycobacterium leprae that affects the skin and peripheral nerves. It is transmitted through respiratory droplets, skin contact, or feeding. There are different classifications of leprosy depending on clinical presentation and bacterial load. Treatment involves multidrug therapy with dapsone, rifampicin, and clofazimine over 6-12 months depending on type of leprosy. Prevention focuses on isolation of infectious individuals to reduce transmission.
What's hot (19)
Leprosy (etiopathogenesis ,classification & clinical features)
Leprosy (etiopathogenesis ,classification & clinical features)
Similar to Eczema (The Itch that rashes)
common skin inflammatory diseases.pptx
This is a lecture given at the American University of Beirut for medical students during their dermatology rotation as an elective.
It is an introductory lecture about skin inflammatory diseases.
RUPAM PPT -PEMPHIGUS.pptx
this topic is on pemphigus vulgaris. describes in detail regarding the pemphigus, its causes, pathophysiology, management
Oral pemphigus vulgaris
Three sentences:
This document discusses oral pemphigus vulgaris, an autoimmune disease causing blistering of the mucosa. It defines the disease, describes its pathogenesis involving autoantibodies against desmoglein proteins, and outlines the clinical features, diagnosis using biopsy, immunofluorescence and Tzank smear, and treatment typically involving corticosteroids. Differential diagnoses include bullous pemphigoid and diagnosis is confirmed through histology demonstrating acantholysis and direct immunofluorescence showing intercellular IgG deposits.
Acne,eczema and pemphigus.pptx
1. Acne is a common skin condition affecting hair follicles, most often on the face and upper body, caused by changes in hormones, stress, and bacteria. Eczema is a skin inflammation caused by genetic and environmental factors like allergens that results in rashes, itching, and dry skin. Pemphigus is a rare autoimmune blistering disease where the immune system attacks the skin and mucous membranes, causing fluid-filled blisters.
2. Nursing management for these conditions focuses on preventing infection by promoting gentle skin care, avoiding irritants, managing itching and pain, and ensuring adherence to medication regimens which can include topical corticosteroids and oral antibiotics or
BACTWERIAL INFECTIONS OF THE SKIN.pptx
This document outlines a presentation on allergic, inflammatory, and infectious skin conditions. It begins with objectives and an introduction to the integumentary system. It then discusses allergic conditions like hives and contact dermatitis. Inflammatory conditions such as psoriasis and eczema are described. Finally, it covers infectious causes of skin diseases from bacteria, viruses, and fungi like impetigo and fungal infections. Nursing management is also reviewed for some conditions.
Eczema Rangeen
Eczema is an inflammatory skin condition characterized by redness, blistering, weeping, and crusting. It has both acute and chronic stages. There are many types of eczema classified by etiology as endogenous, exogenous, or combined. Common types include atopic dermatitis, contact dermatitis, seborrheic dermatitis, dyshidrotic eczema, and stasis dermatitis. Eczema is diagnosed clinically and treatment involves identifying triggers, moisturizing, topical corticosteroids, oral antihistamines, and managing complications.
Atopic dermatitis1
The document discusses atopic dermatitis (AD), also known as eczema. It defines AD as a pruritic, chronic inflammatory skin condition characterized by dry skin and itchy rashes. AD is common in childhood and often runs in families with other allergic diseases. The pathogenesis involves genetic predisposition, skin barrier defects, and abnormal immune responses. Clinical manifestations vary depending on the stage of life, from facial rashes in infants to thickened plaques on flexural areas in older patients. Treatment focuses on moisturizing the skin, identifying trigger factors, and using topical corticosteroids or calcineurin inhibitors to control symptoms.
oral pemphigus vulgaris effect on systemic health
Three sentences:
This document reports a case of oral pemphigus vulgaris and provides background information on the condition. Pemphigus vulgaris is an autoimmune blistering disease caused by autoantibodies against desmoglein 3, leading to acantholysis and blister formation in the oral mucosa and skin. The case report describes the clinical features, histopathology, direct immunofluorescence findings, and management of a patient diagnosed with oral pemphigus vulgaris.
Bullous diseases(group a)
This document discusses several types of blistering diseases:
1. Pemphigus is an autoimmune blistering disease caused by antibodies against desmoglein proteins, resulting in loss of cell adhesion between keratinocytes. Pemphigus vulgaris primarily affects the mucosa and has a mortality rate of 5-15%.
2. Dermatitis herpetiformis is associated with celiac disease and gluten sensitivity. It is characterized by grouped blisters and erosions on the elbows and knees. Treatment involves a gluten-free diet and dapsone.
3. Staphylococcal scalded skin syndrome and toxic epidermal necrolysis are severe blistering
Microbiota cutaneo
The document discusses the skin microbiome and its role in atopic dermatitis (eczema). It notes that the skin hosts trillions of bacteria that create an ecosystem. Factors like location on the body, moisture levels, and individual characteristics can influence the types of microbes present. In eczema, skin barrier defects allow overgrowth of bacteria like Staphylococcus aureus that secrete toxins exacerbating inflammation. Studies show shifts in skin microbiota during eczema flares and treatment. A healthy microbiome including species like Staphylococcus epidermidis promotes skin immunity, while dysbiosis may increase eczema risk.
Eczema- A Chronic Skin Disease
Eczema, also known as dermatitis, is a chronic skin condition that causes skin inflammation and irritation. There are two main types: contact eczema, which is caused by exposure to irritants, and atopic eczema, which has a hereditary/genetic component. Symptoms include itching, scaling, redness, fluid-filled blisters, and cracking of the skin. Treatment focuses on reducing inflammation with corticosteroid creams and antihistamines, while self-care involves moisturizing and avoiding triggers that can cause flare-ups.
urticaria .pptx
Urticaria, also known as hives, is a vascular reaction of the skin characterized by raised red welts (wheals) that are often surrounded by pale halos. Wheals are caused by localized swelling in the skin (edema). Urticaria can be acute (lasting less than 6 weeks) or chronic (lasting more than 6 weeks). Physical urticarias are induced by stimuli like cold, heat, sunlight, pressure, or water. Treatment involves eliminating the cause, if known, and using antihistamines to reduce symptoms. Anaphylaxis is a severe, potentially life-threatening allergic reaction that requires emergency epinephrine treatment. Erythema multiforme is a
Basic Pathological Reactions of the Skin - Dr Zainab Almossalli
This document summarizes the basic pathological reactions of the skin. It describes the different tissue compartments that make up the skin, including the epidermis, dermal-epidermal junction, papillary dermis, deep dermis, and subcutaneous tissue. It then discusses various pathological processes that can disturb the structure and function of these compartments, such as disturbances in epidermal cell kinetics, differentiation, and cohesion. Specific diseases are provided as clinical correlations for each pathological reaction described. The summary focuses on providing a high-level overview of the key tissue compartments involved and some examples of related pathological processes and diseases.
ERYTHEMA MULTIFORME.pptx
Erythema multiforme is a skin reaction typically caused by infections like herpes simplex virus or medications. It is characterized by target-shaped lesions on the hands, feet, and oral cavity. The lesions begin as red spots or circular blisters that develop concentric rings and resolve within 2-3 weeks. Treatment focuses on treating the underlying cause, antiviral medications, corticosteroids, and relief of symptoms.
Cutaneous Immunology
The document summarizes the structure and immune functions of normal skin. It describes the three layers of skin - epidermis, dermis and subcutis. It details the cells involved in innate and adaptive immunity in skin, including keratinocytes, Langerhans cells, dermal dendritic cells, T cells and cytokines. It explains how the skin provides a physical barrier and contains cells and molecules that protect against pathogens as part of the innate immune system.
ECZEMA 2022.pptx
Eczema is one of those chronic relapsing conditions that one has to live with and with its majorly early onset, it is important to diagnose it early in order to improve one's quality of life.
Eczema .pptx
Eczema and dermatitis are inflammatory skin conditions characterized by itching, redness, and scaling. The document discusses various types of eczema including atopic dermatitis, contact dermatitis, and essential dermatitis. Atopic dermatitis is associated with family history of atopy and shows involvement of flexural areas. Contact dermatitis can be irritant or allergic in etiology and affects areas of contact. Essential dermatitis is a diagnosis of exclusion with no identifiable cause beyond self-perpetuating itching and scratching.
Getting under your skin understanding the root causes of eczema
This document discusses the root causes and treatments of eczema. It begins by providing statistics on the prevalence of eczema in the United States, noting that it affects millions of people including many children and adults. The document then explores the root causes of eczema, which can include both external factors like compromised skin barriers and internal immune responses, as well as deficiencies in vitamins, proteins, and bacteria that protect the skin. Finally, the document outlines several potential solutions for treating eczema both topically through the skin and internally through diet, supplements, probiotics and other lifestyle changes.
Icthyosis
Ichthyosis is a heterogeneous group of inherited disorders characterized by dry, scaly skin due to excessive keratinization. There are many types of ichthyosis including non-syndromic, syndromic, congenital, and acquired forms. The document discusses several specific types in detail such as ichthyosis vulgaris, X-linked recessive ichthyosis, lamellar ichthyosis, epidermolytic ichthyosis, Netherton syndrome, Refsum syndrome, and Conradi-Hunermann-Happle syndrome. The treatment and approach involves addressing skin dryness, scaling, infections, and associated symptoms depending on the specific type and severity of ichthyosis.
Similar to Eczema (The Itch that rashes) (20)
Basic Pathological Reactions of the Skin - Dr Zainab Almossalli
Basic Pathological Reactions of the Skin - Dr Zainab Almossalli
Getting under your skin understanding the root causes of eczema
Getting under your skin understanding the root causes of eczema
More from Ahsan Sajjad
Symptoms of respiratory diseases and their possible Causes.
The given presentation contains the symptoms of respiratory system and their causes. I tried to cover the major causes. I hope it will help you somehow.
Symptoms of cardiovascular diseases and its Causes.
Common Symptoms of Cardiovascular System and the causes. It tried to cover as much symptoms as i can. i hope it will help You somehow.
Symptoms Of Gastrointestinal Tract and its causes. Part 2
Various common Symptoms of GIT are discussed with possible causes. I tried to cover the topic in second presentation as it is extensive enough to cover in single presentation. I hope it will help you somehow.
Symptoms Of Gastrointestinal Tract and its causes.
Various important symptoms of GIT and their causes are discussed in this presentation. i Hope it will help You somehow.
Sick sinus syndrome and its types with causes 2
Sick sinus syndrome describes dysfunction of the heart's sinoatrial node, which can cause abnormal heart rhythms like bradycardia (slow heart rate) and tachycardia (fast heart rate). It is usually seen in older adults and may be caused by non-specific degeneration of the heart's conduction system or conditions like amyloidosis. Symptoms include alternating slow and fast heart rhythms. Heart blocks occur when electrical signals are impaired moving through the heart, and are classified based on the level of impairment from first to third degree blocks.
Sick sinus syndrome presntation and its Types with Causes.
its an easy looking but a difficult topic. I tried to cover it in this presentation. i hope it will help you somehow.
Pulmonaary embolism Case scenario and Its management
Pulmonary embolism is an emergency condition adn its management is very crucial. i tried to cover this topic in this presentation. I hope it helps you somehow.
Introduction to skin and various skin conditions.
Skin is the largest Organ of human body. The given ppt is on general anatomy of skin as well as on the various pathological conditions of skin with pictorial presentation. i hope this will help you somehow.
General Physical Examination Pictures
General Physical examinations is very essential Part of Examination of every system Of human Body.Given are the pictures of abnormalities found in GPE. I hope This will help You Somehow.
General Physical Examination
General Physical Examination is an essential part of all the examinations of human body. a brief knowledge of every step of this examination must be kept in mind. The arrangement is also very important in this examination.
Examination of Nervous System
Examination of central nervous system is a bit tricky. A Brief Anatomy of spinal Cord with different steps of examinations are stated in this Presentation. i hope this will help you guys somehow.
Electrolyte Imbalance and EKG Changes
Electrolytes of the body when gets disturbed then there is a drastic change in the electric activity in the heart. These changes are presented in this Presentation. i hope this will help you guys somehow.
Drug induced hepatitis
hepatitis induced by the usage of drugs. this condition is well stated and presented in this presentation. management and treatment is also stated. i hope this will help you all somehow
Drug treatment of Epilepsy
Drugs which are used in the Epilepsy Disease are stated in the tabular form. i hope this will help you guys somehow
Liver Cirrhosis
Etiology, Pathology and presentation of Cirrhosis of live. signs and symptoms and complication of the disease. Its a basic level Presentation on this given topic to have an idea about the Cirrhosis of Liver.
Approach to a patient with CNS disease
This document provides guidance on approaching and evaluating patients presenting with central nervous system disorders. It outlines the key presenting complaints to assess for and provides a framework for determining the location and etiology of any lesions. The approach involves a thorough history, physical exam focusing on neurological assessment, and selecting appropriate investigations. Common central nervous system disorders and patterns of deficits are discussed.
Approach to a patient with Chronic Diarrhoea
Approach to a patient with chronic diarrhea,diagnosis and managment. different causes are also discussed in this presentation and respective treatment is stated.
Approach to the Patient of Acute Diarrhea
This document discusses the approach to a patient presenting with acute diarrhea. It defines diarrhea and lists the most common causes as infections (90%), food intolerance, and drugs. Infectious diarrhea can be inflammatory (caused by bacteria like Shigella, Salmonella) or non-inflammatory (caused by viruses like rotavirus). The history should inquire about travel, food/water exposure, and drug use. The exam evaluates for dehydration by checking vital signs and skin pinch test. Management involves oral rehydration and antibiotics only for inflammatory cases. Prevention emphasizes handwashing and drinking boiled water.
Uterovaginal prolapse
This document discusses uterovaginal prolapse, including its risk factors, symptoms, diagnosis, and treatment options. It provides details on the different types of prolapse that can occur, such as anterior vaginal wall prolapse, posterior vaginal wall prolapse, and uterine prolapse. Treatment options discussed include prevention strategies, physiotherapy, pessary use, and various surgical procedures. Surgical treatment is described as the only curative option unless contraindicated. Post-surgery considerations for pregnancy are also outlined.
More from Ahsan Sajjad (19)
Symptoms of respiratory diseases and their possible Causes.
Symptoms of respiratory diseases and their possible Causes.
Symptoms of cardiovascular diseases and its Causes.
Symptoms of cardiovascular diseases and its Causes.
Symptoms Of Gastrointestinal Tract and its causes. Part 2
Symptoms Of Gastrointestinal Tract and its causes. Part 2
Symptoms Of Gastrointestinal Tract and its causes.
Symptoms Of Gastrointestinal Tract and its causes.
Sick sinus syndrome presntation and its Types with Causes.
Sick sinus syndrome presntation and its Types with Causes.
Pulmonaary embolism Case scenario and Its management
Pulmonaary embolism Case scenario and Its management
Recently uploaded
Walmart Business+ and Spark Good for Nonprofits.pdf
"Learn about all the ways Walmart supports nonprofit organizations.
You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
The event will cover the following::
Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
Special TechSoup offer for a free 180 days membership, and up to $150 in discounts on eligible orders.
Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...Nguyen Thanh Tu Collection
https://app.box.com/s/y977uz6bpd3af4qsebv7r9b7s21935vdবাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
বাংলাদেশের অর্থনৈতিক সমীক্ষা ২০২৪ [Bangladesh Economic Review 2024 Bangla.pdf] কম্পিউটার , ট্যাব ও স্মার্ট ফোন ভার্সন সহ সম্পূর্ণ বাংলা ই-বুক বা pdf বই " সুচিপত্র ...বুকমার্ক মেনু 🔖 ও হাইপার লিংক মেনু 📝👆 যুক্ত ..
আমাদের সবার জন্য খুব খুব গুরুত্বপূর্ণ একটি বই ..বিসিএস, ব্যাংক, ইউনিভার্সিটি ভর্তি ও যে কোন প্রতিযোগিতা মূলক পরীক্ষার জন্য এর খুব ইম্পরট্যান্ট একটি বিষয় ...তাছাড়া বাংলাদেশের সাম্প্রতিক যে কোন ডাটা বা তথ্য এই বইতে পাবেন ...
তাই একজন নাগরিক হিসাবে এই তথ্য গুলো আপনার জানা প্রয়োজন ...।
বিসিএস ও ব্যাংক এর লিখিত পরীক্ষা ...+এছাড়া মাধ্যমিক ও উচ্চমাধ্যমিকের স্টুডেন্টদের জন্য অনেক কাজে আসবে ...
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...National Information Standards Organization (NISO)
This presentation was provided by Steph Pollock of The American Psychological Association’s Journals Program, and Damita Snow, of The American Society of Civil Engineers (ASCE), for the initial session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session One: 'Setting Expectations: a DEIA Primer,' was held June 6, 2024.DRUGS AND ITS classification slide share
Any substance (other than food) that is used to prevent, diagnose, treat, or relieve symptoms of a
disease or abnormal condition
The Diamonds of 2023-2024 in the IGRA collection
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
Advanced Java[Extra Concepts, Not Difficult].docx
This is part 2 of my Java Learning Journey. This contains Hashing, ArrayList, LinkedList, Date and Time Classes, Calendar Class and more.
Pengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptx
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UP
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
Executive Directors Chat Leveraging AI for Diversity, Equity, and Inclusion
Let’s explore the intersection of technology and equity in the final session of our DEI series. Discover how AI tools, like ChatGPT, can be used to support and enhance your nonprofit's DEI initiatives. Participants will gain insights into practical AI applications and get tips for leveraging technology to advance their DEI goals.
clinical examination of hip joint (1).pdf
described clinical examination all orthopeadic conditions .
How to Manage Your Lost Opportunities in Odoo 17 CRM
Odoo 17 CRM allows us to track why we lose sales opportunities with "Lost Reasons." This helps analyze our sales process and identify areas for improvement. Here's how to configure lost reasons in Odoo 17 CRM
How to Setup Warehouse & Location in Odoo 17 Inventory
In this slide, we'll explore how to set up warehouses and locations in Odoo 17 Inventory. This will help us manage our stock effectively, track inventory levels, and streamline warehouse operations.
The History of Stoke Newington Street Names
Presented at the Stoke Newington Literary Festival on 9th June 2024
www.StokeNewingtonHistory.com
How to Build a Module in Odoo 17 Using the Scaffold Method
Odoo provides an option for creating a module by using a single line command. By using this command the user can make a whole structure of a module. It is very easy for a beginner to make a module. There is no need to make each file manually. This slide will show how to create a module using the scaffold method.
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Dr. Vinod Kumar Kanvaria
Exploiting Artificial Intelligence for Empowering Researchers and Faculty,
International FDP on Fundamentals of Research in Social Sciences
at Integral University, Lucknow, 06.06.2024
By Dr. Vinod Kumar KanvariaRecently uploaded (20)
Walmart Business+ and Spark Good for Nonprofits.pdf
Walmart Business+ and Spark Good for Nonprofits.pdf
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
Pengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptx
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UP
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UP
Executive Directors Chat Leveraging AI for Diversity, Equity, and Inclusion
Executive Directors Chat Leveraging AI for Diversity, Equity, and Inclusion
How to Manage Your Lost Opportunities in Odoo 17 CRM
How to Manage Your Lost Opportunities in Odoo 17 CRM
How to Setup Warehouse & Location in Odoo 17 Inventory
How to Setup Warehouse & Location in Odoo 17 Inventory
How to Build a Module in Odoo 17 Using the Scaffold Method
How to Build a Module in Odoo 17 Using the Scaffold Method
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Eczema (The Itch that rashes)
- 3. From the Greek: ‘to boil over’
- 4. COMMON SKIN CONDITION(MOSTLY IN CHILDREN) MULTIPLE CLINICAL PATTERNS SPONGIONTIC* TISSUE REACTION * Spongiosis is a histological term referring to intercellular swelling of the epidermis, which resembles a sponge.
- 5. ECZEMA and DERMATITIS are often used interchangeably to denote a polymorphic inflammatory reaction pattern involving the epidermis and dermis. However, ‘DERMATITIS' means inflammation of the skin.
- 6. RED SCALY WEEPY IF ITS INFECTED CRACKED IF IT IS QUITE DRY
- 7. TWO HYPOTHESIS 1) INSIDE-OUT: Immunological disturbance causes IgE mediated sensitisation, epithelial barrier dysfunction is secondary 2) OUTSIDE-IN: Epidermal barrier dysfunction allows irritants and allergens into the skin, with immunological disturbance secondary
- 9. Regular desquamation Intercellular lipid bilayers Natural Moisturising Factors Production of antimicrobial peptides
- 10. GENETIC FACTORS: Mutation of Genes involved in production of natural moisturising factors. REDUCED WATER BINDINNG. DECREASED SEBACEOUS SECRETION. IMPAIRED PRODUCTION OF ANTIMICROBIAL PEPTIDES.
- 22. PRURITIS RASH: •FACE AND EXTENSORS IN INFANTS •FLEXURALS IN OLDER CHILDREN CHRONIC OR CHRONICALLY RELAPSING PERSONAL OR FAMILY HISTORY OF ATOPIC DISEASE
- 23. DRYNESS FACIAL PALLOR CONJUCTIVITIS ELEVATED SERUM IgE SKIN PRICK TEST POSITIVITY
- 24. ACUTE ECZEMA SUBACUTE ECZEMA CHRONIC ECZEMA
- 25. MASSIVE INTRACELLULAR OEDEMA OF EPIDERMIS WIDE INTRACELLULAR SPACES INTRAEPIDERMAL MICROVESICLES VESICLES CONTAINS LYMPHOCYTES AND HISTIOCYTES
- 27. IRREGULAR ACANTHOSIS Acanthosis is a histological term referring to thickening of the epidermis. PARAKERATOSIS Parakeratosis is abnormal stratum corneum, in which surface keratinised cells of the skin retain nuclei. SWELLING OF ENDOTHELIAL CELLS
- 29. SPONGIOSIS IS DIFFICULT TO APPRECIATE VESICLES ARE UNCOMMON SIGNIFICANT EPIDERMAT ACANTHOSIS HYPERKERATOSIS HYPERGRANULOSIS FIBROSIS OF PAPILLARY DERMIS
- 32. TYPES • CONTACT DERMATITIS • ATOPIC DERMATITIS • DRUD-RELATED ECZEMATOUS DERMATITIS • ECZEMATOUS INSECT BITE REACTION • PHOTOECZEMATOUS REACTION • PRIMARY IRRITANT DERMATITIS CAUSE • TYPICALLY APPLIED ANTIGENS • UNKNOWN,MAY BE HERITABLE • ADMISINTRATED HAPTENS e.g, PENICILLIN • LOCALLY INJECTED TOXIN • UV LIGHT • REPEATED TRAUMA OR CHEMICAL IRRITANT
- 39. THICKENING OF SKIN DUE TO CHRONIC SCRATING