This document discusses numerical techniques in SWAN (Simulating WAves Nearshore), a wave model. It covers discretization schemes, convergence criteria, source term stability, and interpolation methods. The propagation schemes are fully implicit and use upwind differencing. Convergence is checked using criteria on changes in wave height and period from iteration to iteration. Under-relaxation and action density limiting can improve stability for multi-scale wave simulations. Input data like spectra and environmental fields are interpolated to the computational grid.
The analysis of all of the significant processes that formed a basin and deformed its sedimentary fill from basin-scale processes (e.g., plate tectonics)
to centimeter-scale processes (e.g., fracturing)
The analysis of all of the significant processes that formed a basin and deformed its sedimentary fill from basin-scale processes (e.g., plate tectonics)
to centimeter-scale processes (e.g., fracturing)
Wavelet analysis and its use in signal processing. Applications of wavelets in Image processing. Wavelet transform used in both continuous and discrete cases to get better analysis of signals
WaReS is a code developed by Marine Analytica to calculate loads and responses of floating structures. This memo presents an extract of the verification report.
A two equation VLES turbulence model with near-wall delayed behaviourApplied CCM Pty Ltd
Turbulence is a phenomenon that occurs frequently in nature and is present in almost all industrial applications. Despite significant increase in computational power in modern processors, Reynolds averaged Navier-Stokes (RANS) simulations are still the dominant approach to turbulence modelling of high Reynolds number flows. Hybrid LES/RANS approaches [1] are currently used to offset the cost of Large Eddy Simulation (LES) computations by retaining the RANS characteristics in boundary layers while using the LES model away from walls. The hybrid approach embodied in the Detached Eddy Simulation (DES) methodology has been used with success in industrial flow simulations. However, it should be noted that the DES approach still requires LES-like mesh resolution away from walls. This is a simple consequence of the fact that the DES model defaults to LES at large distances from the walls. This may prove prohibitively expensive in simulations where large turbulent structures persists over most of the computational domain.
In this work, a delayed two equation very large eddy simulation (VLES) model based on three length scales is introduced. The resolution control function used to rescale the Reynolds stresses is based on the ratio of the resolved to unresolved turbulence spectrum. The model constants are selected so that the Smagorinsky subgrid-scale model is recovered in the limit of grids approaching the resolution required for LES computations. The near wall RANS behaviour of the proposed model is obtained using blending functions. The objective was to implement this model using the open source library Caelus [2] and validate the results against two test cases involving turbulent vortex shedding from a bluff-body. The test cases used were flow past a square cylinder at a Reynolds number of 21,400 [3] and the Rudimentary Landing Gear benchmark case for Airframe Noise Computations (BANC) [4].
The numerical simulations were carried out using a transient solver based on the open source computational mechanics library Caelus. The pressure-based solver with second-order bounded spatial discretisation and second-order bounded implicit time marching scheme was applied to obtain a time-accurate solutions. Compressibility effects were negligible for the Mach numbers under consideration and the flow was treated as incompressible. Results from the simulations indicate close agreement between the proposed model and available experimental and numerical results.
Spectral estimation, and corresponding time-frequency representation for nonstationary signals, is a cornerstone in geophysical signal processing and interpretation. The last 10–15 years have seen the development of many new high-resolution decompositions that are often fundamentally different from Fourier and wavelet transforms. These conventional techniques, like the short-time Fourier transform and the continuous wavelet transform, show some limitations in terms of resolution (localization) due to the trade-off between time and frequency localizations and smearing due to the finite size of the time series of their template. Well-known techniques, like autoregressive methods and basis pursuit, and recently developed techniques, such as empirical mode decomposition and the synchrosqueezing transform, can achieve higher time-frequency localization due to reduced spectral smearing and leakage. We first review the theory of various established and novel techniques, pointing out their assumptions, adaptability, and expected time-frequency localization. We illustrate their performances on a provided collection of benchmark signals, including a laughing voice, a volcano tremor, a microseismic event, and a global earthquake, with the intention to provide a fair comparison of the pros and cons of each method. Finally, their outcomes are discussed and possible avenues for improvements are proposed.
Fundamentals of Passive and Active Sonar Technical Training Short Course SamplerJim Jenkins
This four-day course is designed for SONAR systems engineers, combat systems engineers, undersea warfare professionals, and managers who wish to enhance their understanding of passive and active SONAR or become familiar with the "big picture" if they work outside of either discipline. Each topic is presented by instructors with substantial experience at sea. Presentations are illustrated by worked numerical examples using simulated or experimental data describing actual undersea acoustic situations and geometries. Visualization of transmitted waveforms, target interactions, and detector responses is emphasized.
RADAR - RAdio Detection And Ranging
This is the Part 1 of 2 of RADAR Introduction.
For comments please contact me at solo.hermelin@gmail.com.
For more presentation on different subjects visit my website at http://www.solohermelin.com.
Part of the Figures were not properly downloaded. I recommend viewing the presentation on my website under RADAR Folder.
RINA - AOG 2017 - Numerical Modelling of Marine Structure Behaviours in Steep...Nick Bentley
The interaction of steep waves with structures is still not fully
understood, and is of great importance for the design and operation of these structures. A particular difficulty with modelling such interaction lies in necessity of modelling the waves field in a large scale of about 20 kilometers during a seat state (about 3 hours) and nonlinear behaviours of the structures. This presentation will describe how we tackle the difficulty to obtain the results of large scale nonlinear wave fields, to
numerically calculate the wave loading on fixed structures, to simulate the responses of single and two floating bodies to steep waves, and to investigate the effects of sloshing on the motion of floating structures.
The presentation will also discuss the difference between nonlinear wave loadings on a structures moving with a forward speed and on the structure which is fixed but subjected to a current with a speed same as the forward speed when they are all in steep waves. The difference is an issue because the forward speed of a moving structure should not affect the incoming wave field but the current may alter the incoming waves if nonlinearity must be taken into account. This will lead to the difference in wave loadings even though the encountering frequency is the same. This issue has not been well understood so far but would be important for the problems involving steeps waves.
Time-Frequency Representation of Microseismic Signals using the SSTUT Technology
Resonance frequencies could provide useful information on the deformation occurring during fracturing experiments or CO2 management, complementary to the microseismic events distribution. An accurate time-frequency representation is of crucial importance to interpret the cause of resonance frequencies during microseismic experiments. The popular methods of Short-Time Fourier Transform (STFT) and wavelet analysis have limitations in representing close frequencies and dealing with fast varying instantaneous frequencies and this is often the nature of microseismic signals. The synchrosqueezing transform (SST) is a promising tool to track these resonant frequencies and provide a detailed time-frequency representation. Here we apply the synchrosqueezing transform to microseismic signals and also show its potential to general seismic signal processing applications.
Atmospheric flows are governed by the equations of fluid dynamics. These equations are nonlinear. But because atmospheric flows are inhomogeneous and anisotropic, the nonlinearity may manifest itself only weakly through interactions of non-trivial mean flows with disturbances or eddies. In such situations, the quasi-linear (QL) approximation, that retains eddy-mean flow interactions but neglect eddy-eddy interactions, hold promise in resolving large-scale atmospheric dynamics. The statistics of the QL system corresponds to closing the hierarchy of statistical moments at the second order.
Hence, exploring QL dynamics paves the way for the development of direct statistical simulations of geophysical flows.
Using a hierarchy of idealized general circulation models, we identify when the QL approximation captures large-scale dynamics. We show that the QL dynamics fails to capture the flow when the dissipation of large-scale eddies occurs through strongly nonlinear eddy-eddy interactions in upper tropospheric surf zones, as it is often the case on Earth. But we demonstrate that the QL approximation captures eddy absorption when it arises from the shearing by the mean flow, for example when the eddy amplitude is small enough or the planetary rotation rate is large enough.
These results illustrate different classes of nonlinear processes that can control wave dissipation in the upper troposphere and show that in some parameter regimes the QL approximation is accurate to resolve large-scale dynamics.
Wavelet analysis and its use in signal processing. Applications of wavelets in Image processing. Wavelet transform used in both continuous and discrete cases to get better analysis of signals
WaReS is a code developed by Marine Analytica to calculate loads and responses of floating structures. This memo presents an extract of the verification report.
A two equation VLES turbulence model with near-wall delayed behaviourApplied CCM Pty Ltd
Turbulence is a phenomenon that occurs frequently in nature and is present in almost all industrial applications. Despite significant increase in computational power in modern processors, Reynolds averaged Navier-Stokes (RANS) simulations are still the dominant approach to turbulence modelling of high Reynolds number flows. Hybrid LES/RANS approaches [1] are currently used to offset the cost of Large Eddy Simulation (LES) computations by retaining the RANS characteristics in boundary layers while using the LES model away from walls. The hybrid approach embodied in the Detached Eddy Simulation (DES) methodology has been used with success in industrial flow simulations. However, it should be noted that the DES approach still requires LES-like mesh resolution away from walls. This is a simple consequence of the fact that the DES model defaults to LES at large distances from the walls. This may prove prohibitively expensive in simulations where large turbulent structures persists over most of the computational domain.
In this work, a delayed two equation very large eddy simulation (VLES) model based on three length scales is introduced. The resolution control function used to rescale the Reynolds stresses is based on the ratio of the resolved to unresolved turbulence spectrum. The model constants are selected so that the Smagorinsky subgrid-scale model is recovered in the limit of grids approaching the resolution required for LES computations. The near wall RANS behaviour of the proposed model is obtained using blending functions. The objective was to implement this model using the open source library Caelus [2] and validate the results against two test cases involving turbulent vortex shedding from a bluff-body. The test cases used were flow past a square cylinder at a Reynolds number of 21,400 [3] and the Rudimentary Landing Gear benchmark case for Airframe Noise Computations (BANC) [4].
The numerical simulations were carried out using a transient solver based on the open source computational mechanics library Caelus. The pressure-based solver with second-order bounded spatial discretisation and second-order bounded implicit time marching scheme was applied to obtain a time-accurate solutions. Compressibility effects were negligible for the Mach numbers under consideration and the flow was treated as incompressible. Results from the simulations indicate close agreement between the proposed model and available experimental and numerical results.
Spectral estimation, and corresponding time-frequency representation for nonstationary signals, is a cornerstone in geophysical signal processing and interpretation. The last 10–15 years have seen the development of many new high-resolution decompositions that are often fundamentally different from Fourier and wavelet transforms. These conventional techniques, like the short-time Fourier transform and the continuous wavelet transform, show some limitations in terms of resolution (localization) due to the trade-off between time and frequency localizations and smearing due to the finite size of the time series of their template. Well-known techniques, like autoregressive methods and basis pursuit, and recently developed techniques, such as empirical mode decomposition and the synchrosqueezing transform, can achieve higher time-frequency localization due to reduced spectral smearing and leakage. We first review the theory of various established and novel techniques, pointing out their assumptions, adaptability, and expected time-frequency localization. We illustrate their performances on a provided collection of benchmark signals, including a laughing voice, a volcano tremor, a microseismic event, and a global earthquake, with the intention to provide a fair comparison of the pros and cons of each method. Finally, their outcomes are discussed and possible avenues for improvements are proposed.
Fundamentals of Passive and Active Sonar Technical Training Short Course SamplerJim Jenkins
This four-day course is designed for SONAR systems engineers, combat systems engineers, undersea warfare professionals, and managers who wish to enhance their understanding of passive and active SONAR or become familiar with the "big picture" if they work outside of either discipline. Each topic is presented by instructors with substantial experience at sea. Presentations are illustrated by worked numerical examples using simulated or experimental data describing actual undersea acoustic situations and geometries. Visualization of transmitted waveforms, target interactions, and detector responses is emphasized.
RADAR - RAdio Detection And Ranging
This is the Part 1 of 2 of RADAR Introduction.
For comments please contact me at solo.hermelin@gmail.com.
For more presentation on different subjects visit my website at http://www.solohermelin.com.
Part of the Figures were not properly downloaded. I recommend viewing the presentation on my website under RADAR Folder.
RINA - AOG 2017 - Numerical Modelling of Marine Structure Behaviours in Steep...Nick Bentley
The interaction of steep waves with structures is still not fully
understood, and is of great importance for the design and operation of these structures. A particular difficulty with modelling such interaction lies in necessity of modelling the waves field in a large scale of about 20 kilometers during a seat state (about 3 hours) and nonlinear behaviours of the structures. This presentation will describe how we tackle the difficulty to obtain the results of large scale nonlinear wave fields, to
numerically calculate the wave loading on fixed structures, to simulate the responses of single and two floating bodies to steep waves, and to investigate the effects of sloshing on the motion of floating structures.
The presentation will also discuss the difference between nonlinear wave loadings on a structures moving with a forward speed and on the structure which is fixed but subjected to a current with a speed same as the forward speed when they are all in steep waves. The difference is an issue because the forward speed of a moving structure should not affect the incoming wave field but the current may alter the incoming waves if nonlinearity must be taken into account. This will lead to the difference in wave loadings even though the encountering frequency is the same. This issue has not been well understood so far but would be important for the problems involving steeps waves.
Time-Frequency Representation of Microseismic Signals using the SSTUT Technology
Resonance frequencies could provide useful information on the deformation occurring during fracturing experiments or CO2 management, complementary to the microseismic events distribution. An accurate time-frequency representation is of crucial importance to interpret the cause of resonance frequencies during microseismic experiments. The popular methods of Short-Time Fourier Transform (STFT) and wavelet analysis have limitations in representing close frequencies and dealing with fast varying instantaneous frequencies and this is often the nature of microseismic signals. The synchrosqueezing transform (SST) is a promising tool to track these resonant frequencies and provide a detailed time-frequency representation. Here we apply the synchrosqueezing transform to microseismic signals and also show its potential to general seismic signal processing applications.
Atmospheric flows are governed by the equations of fluid dynamics. These equations are nonlinear. But because atmospheric flows are inhomogeneous and anisotropic, the nonlinearity may manifest itself only weakly through interactions of non-trivial mean flows with disturbances or eddies. In such situations, the quasi-linear (QL) approximation, that retains eddy-mean flow interactions but neglect eddy-eddy interactions, hold promise in resolving large-scale atmospheric dynamics. The statistics of the QL system corresponds to closing the hierarchy of statistical moments at the second order.
Hence, exploring QL dynamics paves the way for the development of direct statistical simulations of geophysical flows.
Using a hierarchy of idealized general circulation models, we identify when the QL approximation captures large-scale dynamics. We show that the QL dynamics fails to capture the flow when the dissipation of large-scale eddies occurs through strongly nonlinear eddy-eddy interactions in upper tropospheric surf zones, as it is often the case on Earth. But we demonstrate that the QL approximation captures eddy absorption when it arises from the shearing by the mean flow, for example when the eddy amplitude is small enough or the planetary rotation rate is large enough.
These results illustrate different classes of nonlinear processes that can control wave dissipation in the upper troposphere and show that in some parameter regimes the QL approximation is accurate to resolve large-scale dynamics.
Cired 2015 poster 1045: LV4MV: A CONCEPT FOR OPTIMAL POWER FLOW MANAGEMENT IN...Gaspard Lebel
Presentation of LV4MV, an innovative concept of voltVAR management at the benefit of LV voltage excursion, imagined by Grenoble INP and Schneider Electric
Accelerometers
Accelerometers are devices that produce voltage signals proportional to the acceleration experienced. There are several techniques for converting acceleration to an electrical signal. The most general technique is described first and more recent techniques will be considered later.
DSD-INT 2017 XBeach Past, Present and Future _Keynote - RoelvinkDeltares
Presentation by Dano Roelvink (Deltares, IHE Delft) at the XBeach X (10th Year Anniversary) Conference, during Delft Software Days - Edition 2017. Wednesday, 1 November 2017, Delft.
DSD-INT 2018 Validation test of a solitary wave over an erodible sloped beach...Deltares
Presentation by Giulia Mancini, University of Nottingham, UK, at the XBeach User Day 2018, during Delft Software Days - Edition 2018. Thursday, 15 November 2018, Delft.
DSD-INT 2023 Hydrology User Days - Intro - Day 3 - KroonDeltares
Presentation by Timo Kroon and Nadine Slootjes (Deltares, Netherlands) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
Presentation by Sabrina Couvin Rodriguez (Deltares, Netherlands) at the Climate Adaptation Symposium 2023, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Wednesday, 29 November 2023, Delft.
Presentation by Umit Taner (Deltares, Netherlands) at the Climate Adaptation Symposium 2023, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Wednesday, 29 November 2023, Delft.
Presentation by Daan Rooze (Deltares, Netherlands) at the Climate Adaptation Symposium 2023, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Wednesday, 29 November 2023, Delft.
DSD-INT 2023 Approaches for assessing multi-hazard risk - WardDeltares
Presentation by Philip Ward (Deltares and IVM VU Amsterdam) at the Climate Adaptation Symposium 2023, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Wednesday, 29 November 2023, Delft.
Presentation by Andrew Warren (Deltares, Netherlands) at the Climate Adaptation Symposium 2023, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Wednesday, 29 November 2023, Delft.
DSD-INT 2023 Global hydrological modelling to support worldwide water assessm...Deltares
Presentation by Marc Bierkens (Utrecht University and Deltares, Netherlands) at the Climate Adaptation Symposium 2023, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Wednesday, 29 November 2023, Delft.
DSD-INT 2023 Modelling implications - IPCC Working Group II - From AR6 to AR7...Deltares
Presentation by Bart van den Hurk (WGII Co-Chair, IPCC AR7, Deltares) at the Climate Adaptation Symposium 2023, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Wednesday, 29 November 2023, Delft.
DSD-INT 2023 Knowledge and tools for Climate Adaptation - JeukenDeltares
Presentation by Ad Jeuken (Deltares, Netherlands) at the Climate Adaptation Symposium 2023, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Wednesday, 29 November 2023, Delft.
DSD-INT 2023 Coupling RIBASIM to a MODFLOW groundwater model - BootsmaDeltares
Presentation by Huite Bootsma (Deltares, Netherlands) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
DSD-INT 2023 Create your own MODFLOW 6 sub-variant - MullerDeltares
Presentation by Mike Muller (hydrocomputing GmbH & Co. KG, Germany) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
DSD-INT 2023 Example of unstructured MODFLOW 6 modelling in California - RomeroDeltares
Presentation by Betsy Romero Verástegui (Deltares, Netherlands) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
DSD-INT 2023 Challenges and developments in groundwater modeling - BakkerDeltares
Presentation by Mark Bakker (Delft University of Technology, Netherlands) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
DSD-INT 2023 Demo new features iMOD Suite - van EngelenDeltares
Presentation by Joeri van Engelen (Deltares, Netherlands) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
DSD-INT 2023 iMOD and new developments - DavidsDeltares
Presentation by Tess Davids (Deltares, Netherlands) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
Presentation by Christian Langevin (U.S. Geological Survey (USGS), USA) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
DSD-INT 2023 Hydrology User Days - Presentations - Day 2Deltares
Presentation by several speakers at the Hydrology Suite User Days (Day 2) - wflow and HydroMT, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Wednesday, 29 November 2023, Delft.
DSD-INT 2023 Needs related to user interfaces - SnippenDeltares
Presentation by Edwin Snippen (Deltares, Netherlands) at the Hydrology Suite User Days (Day 1) - Hydrology Suite introduction and River Basin Management software (RIBASIM), during the Delft Software Days - Edition 2023 (DSD-INT 2023). Tuesday, 28 November 2023, Delft.
DSD-INT 2023 Coupling RIBASIM to a MODFLOW groundwater model - BootsmaDeltares
Presentation by Huite Bootsma (Deltares, Netherlands) at the Hydrology Suite User Days (Day 1) - Hydrology Suite introduction and River Basin Management software (RIBASIM), during the Delft Software Days - Edition 2023 (DSD-INT 2023). Tuesday, 28 November 2023, Delft.
DSD-INT 2023 Parameterization of a RIBASIM model and the network lumping appr...Deltares
Presentation by Harm Nomden (SWECO, Netherlands) at the Hydrology Suite User Days (Day 1) - Hydrology Suite introduction and River Basin Management software (RIBASIM), during the Delft Software Days - Edition 2023 (DSD-INT 2023). Tuesday, 28 November 2023, Delft.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
3. Discretization
• Numerical schemes for propagation (fully implicit):
• x,y-space : upwind: BSBT (1st order), SORDUP (2nd),
Stelling-Leendertse (3rd)
• time : backward
• V-space : hybrid central / upwind (first order upwind too
diffusive, central scheme prone to wiggles)
• T-space : hybrid central / upwind
• Implicit propagation scheme is unconditionally stable: robust
• 1st order scheme is rather diffusive (take care on large distances)
• accuracy = f ('t, 'x, 'y, 'V, 'T)
• iterative (4 sweep) solution technique
• x,y-space: regular, curvi-linear or unstructured grids
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4. Propagation (x,y-space)
• To allow for energy crossing the quadrants (refraction,
quads, diffraction):
• Iterative procedure
• Computation is stopped when accuracy criteria are met
(specified by user)
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5. Convergence criteria
Lake George:
2% criteria vs.
fully-converged
Convergence if:
a.
'H ( i ) 0.02 H ( i ) or 'H ( i ) 0.02 H
( average
)
m 0 m 0 m 0 m 0 b.
'T () i 0.02 T () i or 'T () i 0.02 T
( average
)
m 01 m 01 m 01 m 01 c. Conditions a. AND b. are satisfied in 98% of all wet grid points
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7. Convergence criteria
• Check iteration behaviour of output quantities
• TEST output
• DHS, DRTM01
• Default not always effective o significant inaccuracies
• Either stronger accuracy than default (2%) or use different
convergence criterium: based on curvature
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8. Convergence criteria
Curvature-based convergence criteria (Zijlema vd Westhuysen 2005)
i i i i
m m m m
1 1
H H T
T drel
H T
' ( ' H ) / H i [ cur v .ma x ]
and 0 0 ,
0 0
@
i i m 0 m 0 i i
m m
1 1
0 0
in more than [npnts] % of wet points
Haringvliet Estuary Lake George
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9. Convergence enhancing measures
N c N S E
t
( ) g
ª º ª º ª º
« » « » « » « » « » « »
«¬ »¼ «¬ »¼ «¬ »¼
HF waves have much shorter time scales than LF waves Æ AN=b stiff
Mismatch Î additional measures required
Economically, large computational time steps
w
’
w
N b
A
%
%
Many time scales are involved in evolution of wind waves
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10. Convergence enhancing measures
This may lead to numerical instabilities. Two solutions:
1. Action density limiter:
restriction of the total change of action density per iteration at
each wave component
D
PM
2 3
2. Under relaxation
g
N
k c
J
V
'
J 0.1
Phillips equilibrium spectrum
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11. Convergence enhancing measures
2. Under-relaxation: enhancing main diagonal Æ stabilizing effect
G G G G
N i N i
1
ANi b , W
1
DV
W
- pseudo timestep IJ - smaller updates N
- costs computational time
- frequency dependent
- alfa to be set in swan input file (0.002-0.01)
G G G
ADV I
12. Ni b DV Ni1
• Under-relaxation improves iteration behaviour
• Under-relaxation slows convergence
• Not meaningful for nonstationary computations
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13. Convergence enhancing measures
Hm0 deep water, fetch = 12.5 km
J 0.1
U10 = 10 m/s
U10 = 30 m/s
• Effect limiter is clear without
under-relaxation
• Under-relaxation improves
iterative behaviour:
• Smoothed
• Reduction of overshoot
• Alteration of limiter activity
• Under-relaxation slows
convergence
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14. Interpolation
• Boundary conditions where waves enter computational domain
• Measured / computed 2D spectra
• Nesting of SWAN runs
• Nesting with course-grid WAM or WAVEWATCH run
Procedure:
1. Available spectra are normalized first by mean frequency and
direction
2. Linear interpolation of spectra in intermediate locations
3. Resulting spectra are transformed back
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15. Interpolation
(Bi-linear) interpolation of input grids on computational grid :
• Bathymetry
• Wind field
• Current field
• Water level field
• Bottom friction
WARNINGS:
• Resolve relevant spatial and temporal details
• Input grid should cover computational grid entirely
• Bottom: input grid ~ computational grid
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