This document discusses drugs used to treat inflammatory bowel disease (IBD). It describes the differences between ulcerative colitis and Crohn's disease, then outlines the major drug classes used: 5-aminosalicylic acid (5-ASA) compounds, glucocorticoids, immunomodulators like thiopurines and methotrexate, Janus kinase inhibitors, and biologic therapies including anti-TNF drugs, anti-integrins like vedolizumab, and anti-IL 12/23 antibodies like ustekinumab. 5-ASA compounds provide local anti-inflammatory effects while glucocorticoids are used short-term for moderate-severe disease. Immunomodulators
Hello friends. In this PPT I am talking about Anti-viral drugs drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
synthetic antimicrobials having a quinolone structure that are active primarily against gram-negative bacteria, though newer fluorinated compounds also inhibit gram-positive ones.
Introduction TO VOMITING,Pathophysiology of vomiting,Emetics,Anti emetics,classification,pharmacology,Drug treatment in selected circumstances FOR EMETICS were included.
Hello friends. In this PPT I am talking about Anti-viral drugs drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
synthetic antimicrobials having a quinolone structure that are active primarily against gram-negative bacteria, though newer fluorinated compounds also inhibit gram-positive ones.
Introduction TO VOMITING,Pathophysiology of vomiting,Emetics,Anti emetics,classification,pharmacology,Drug treatment in selected circumstances FOR EMETICS were included.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
3. Differences
Ulcerative colitis Crohn’s disease
Continuous without skip areas Segmental with skip areas
(skip the corn)
(C not for C…Continuous and colon)
Commonly rectum, sigmoid colon Commonly terminal ileum and/or
ascending colon
superficial, confined to mucosal layers :
Superficial inflammation
involves the entire thickness of the aff
ected segment of bowel wall :
Transmural inflammation
Fibrosis rare Fibrosis common
Malignant change may occur if > 10 yrs Malignancy rare
5. Group of drugs used
A. 5 ASA (5 Aminosalicylic Acid) compounds
B. Glucocrticoids
C. Immunomodulating Drugs
i. Thiopurines (mercaptopurine and azathioprine)
ii. Methotrexate
iii. Janus kinase inhibitor (Tofacitinib)
D. Biologic Therapies
i. Anti TNF therapies ( Mnemonic… cer goli dali in)
ii. Anti integrins (Vedolizumab)
iii. Anti IL 12/23 antibody (Ustekinumab)
6. 5 ASA
• Differs from salicylic acid only by addition of
an amino group at the 5 (meta) position
• Acts topically (not systemically) in areas of
• Absorbed from the small intestine and does
not reach the distal small bowel or colon
• To prevent absorption from the proximal small
intestine, many formulations are designed to
deliver 5-ASA to distal segments of the small
bowel or the colon
7. 5 ASA preparations
A. Azo compounds
Have Azo bond (N=N) between 5 ASA + carrier
molecule / another 5 ASA molecule
B. Mesalamine preparations
Proprietary formulations of 5-ASA
e.g timed-release microgranules
8. A. Azo Compounds
1. Sulfasalazine = 5 ASA + sulfapyridine
2. Balsalazide = 5 ASA + 4-aminobenzoyl-P-
alanine as the carrier
3. Olsalazine = 5 ASA + 5 ASA
(***Olsalazine is probably the most reliable
preparation for delivery of 5-ASA to the colon)
….MCQ
9. Azo Compounds
• Azo bond… 5ASA not available for absorption
in small intestine
• Colon bacteria break azo bond (azoreductase
enzyme) ..… release active 5-ASA
• High concentration of 5 ASA in the terminal
ileum or colon.
10. B. Mesalamine preparations
1. Pentasa : delayed release capsules ……
5-ASA throughout the small intestine
2. Asacol : Coated with pH sensitive resin
that dissolves at pH 6–7 (distal ileum /
colon pH)
3. Apriso : -do-
4. Lialda : -do-
5. Rowasa : Enema
6. Canasa : Suppositories
12. 5 ASA : Mechanism of Action
• Local anti-inflammatory effect
• Inhibition of COX and LOX
• Inhibition of
– cytokine,
– PAF more important
– TNFa and
– Nuclear transcription factor (NFKB) generation
• Decreased PG and LT production … minor role
• No antibacterial action
13. Clinical Use : 5 ASA
• Maintaining remission in UC, while
corticosteroids are reserved to treat acute
exacerbations
• Selection of formulation depends upon site
affected…
• E.g… 5-ASA suppositories or enemas are
useful in patients with UC confined to the
rectum
14. Group of drugs used in IBD
A. 5 ASA (5 Aminosalicylic Acid) compounds
B. Glucocrticoids
C. Immunomodulating Drugs
i. Thiopurines (mercaptopurine and azathioprine)
ii. Methotrexate
iii. Janus kinase inhibitor (Tofacitinib)
D. Biologic Therapies
i. Anti TNF therapies (goli dali in)
ii. Anti integrins (Vedolizumab)
iii. Anti IL 12/23 antibody (Ustekinumab)
16. Glucocorticoids : Route
• Oral
i. Prednisolone 40–60 mg/d
ii. Budesonide (pH-controlled delayed-release)
• IV
Methyl prednisolone 40- 60 mg (severe disease
with extra-intestinal manifestations and for
rapid relief)
• Topical
Hydrocortisone : enemas, foam, or suppositories
17. Mechanism of action
• Inhibit production of :
– Inflammatory cytokines (TNF A, IL -1)
– Chemokines (IL-8)
• Inhibit gene transcription of :
– Nitric oxide synthase (i NOS)
– Phospholipase A2
– COX - 2
– NF-κB
• Reduce expression of inflammatory cell adhesion
molecules
18. Group of drugs used in IBD
A. 5 ASA (5 Aminosalicylic Acid) compounds
B. Glucocrticoids
C. Immunomodulating Drugs
i. Thiopurines (mercaptopurine and azathioprine)
ii. Methotrexate
iii. Janus kinase inhibitor (Tofacitinib)
D. Biologic Therapies
i. Anti TNF therapies (Mnemonic… cer goli dali in)
ii. Anti integrins (Vedolizumab)
iii. Anti IL 12/23 antibody (Ustekinumab)
19. Mercaptopurine (MP) and
Azathioprine
• Purine antimetabolites with immunosuppressive
properties
• After absorption, azathioprine is converted by to
6-MP
• 6 MP …. Biotransformation… active 6-thioguanine
nucleotides … concentrated in cells
• Median delay of 17 weeks in onset of therapeutic
benefit after oral azathioprine or 6-MP
20. Mercaptopurine and Azathioprine
• In moderate to severe disease
• Alone or with TNF-A inhibitors
• Corticosteroid-dependent cases : May reduce
dose or stop corticosteroid use
• Use with biologic agents (especially anti-TNF
agents) : to reduce antibody formation against
the biologic agent
21. Mercaptopurine and Azathioprine
• Measurement of thiopurine methyl-
transferase (TPMT) functional activity is
recommended prior to start of thiopurine
treatment
• To be stopped in patients with absent TPMT
activity
Immune suppression
22. Azathioprine
• Only antimetabolite that is used as
immunosuppressant but not as an anticancer
drug
• Nucleotide derivative
• It is a prodrug and is activated in the body to 6-
mercaptopurine (anticancer drug).
• Major toxic effect is bone marrow suppression.
• Its dose should be reduced if allopurinol is used
concurrently because 6-MP is metabolized by
xanthine oxidase.(allopurinol inhibits xanthine
oxidase….used in gout)
23. ADR
• Risk of :
Non-Hodgkin lymphomas
Human papillomavirus (HPV)– related cervical
dysplasia
Non-melanoma skin cancer
24. Methotrexate (Mtx)
• Antimetabolite
• Orally, SC, & IM
• Inhibition of dihydrofolate reductase, an enzyme
important in the production of thymidine and
purines
• High dose : Chemotherapy … (inhibits cellular
proliferation… anti-proliferative effect)
• Low dose : No anti-proliferative effect… in IBD
– Anti-inflammatory actions
– Stimulates apoptosis and death of activated T
lymphocytes
25. Mtx
• Methotrexate has 50,000 times higher affinity
for dihydrofolate reductase than the normal
substrate DH FA. – folate antagonist
• Depresses cytokine production
• Antiinflammatory
• Use – Rheumatoid arthritis, psoriasis, IBD
26. Mtx : Use in IBD
• To induce and maintain remission in Crohn’s
disease.
• Use in UC is uncertain
27. Group of drugs used in IBD
A. 5 ASA (5 Aminosalicylic Acid) compounds
B. Glucocrticoids
C. Immunomodulating Drugs
i. Thiopurines (mercaptopurine and azathioprine)
ii. Methotrexate
iii. Janus kinase inhibitor (Tofacitinib)
D. Biologic Therapies
i. Anti TNF therapies (Mnemonic… cer goli dali in)
ii. Anti integrins (Vedolizumab)
iii. Anti IL 12/23 antibody (Ustekinumab)
28. Tofacitinib
• Second-line therapy
• Treatment of moderate to severe ulcerative
colitis (not Crohn disease) that has not
responded to anti-TNF therapy
• Oral adm
• Black box warning … risk of thrombosis
• CMDT 2022
29. Group of drugs used in IBD
A. 5 ASA (5 Aminosalicylic Acid) compounds
B. Glucocrticoids
C. Immunomodulating Drugs
i. Thiopurines (mercaptopurine and azathioprine)
ii. Methotrexate
iii. Janus kinase inhibitor (Tofacitinib)
D. Biologic Therapies
i. Anti TNF therapies (Mnemonic… cer goli dali in)
ii. Anti integrins (Vedolizumab)
iii. Anti IL 12/23 antibody (Ustekinumab)
31. Anti TNF-alfa drugs
• Infliximab
• Adalimumab
• Golimumab
• Certolizumab
• Mnemonic… Cer goli dali in
32. Mechanism
• Bind and neutralize soluble & membrane-
bound TNF on macrophages and activated T
lymphocytes
• Prevent TNF stimulation of effector cells.
33. Group of drugs used in IBD
A. 5 ASA (5 Aminosalicylic Acid) compounds
B. Glucocrticoids
C. Immunomodulating Drugs
i. Thiopurines (mercaptopurine and azathioprine)
ii. Methotrexate
iii. Janus kinase inhibitor (Tofacitinib)
D. Biologic Therapies
i. Anti TNF therapies (Mnemonic… cer goli dali in)
ii. Anti integrins (Vedolizumab)
iii. Anti IL 12/23 antibody (Ustekinumab)
34. Anti-integrins
• Decrease the trafficking of circulating
leukocytes through the vasculature, reducing
chronic inflammation
• Vedolizumab
35. Anti-IL 12/23 antibody
• Ustekinumab
• Binds p40 subunit of IL-12 and IL-23,
interfering with their receptor binding on T
cells, NK cells, and antigen presenting cells
From KdT pg 47 Gen pharm competitive enz inhibibeing recycled after partial degradation….from garg pg 605 qn 6…10th edition
De novo synthesis: synthesis of complex molecules from simple molecules like sugar, amino acid as opposed to their being recycled after partial degradation